As a leading 5-Amino-N,N'-Bis-(2,3-Dihydroxypropyl)-2,4,6-Triiodoisophthalamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 5-amino-n, n '-bis- (2,3-dihydroxypropyl) -2,4, 6-triiodoisophthalamide?
5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is an organic compound with a complex chemical structure. The core of this compound is the isophthalamide structure, with an iodine atom attached to the 2, 4, and 6 positions of isophthalamide. This gives the compound specific chemical and physical properties. The introduction of iodine atoms may affect its reactivity, solubility, and biological activity.
There is a 2,3-dihydroxypropyl group attached to the nitrogen atom of isophthalamide. The presence of this dihydroxypropyl group adds polarity to the compound, which in turn affects its interaction with other substances or enhances its solubility in polar solvents. The 5-position amino group also brings basic properties to the compound and can participate in many chemical reactions, such as salt reactions with acids.
In general, the chemical structure of 5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is composed of isophthalamide skeleton, iodine atom, dihydroxypropyl group and amino group. Each part affects each other, endowing the compound with unique chemical properties and potential application value.
What are the main uses of 5-amino-n, n '-bis- (2,3-dihydroxypropyl) -2,4, 6-triiodoisophthalamide?
5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is an important chemical substance. It has a wide range of main uses and has made great contributions to the field of medical imaging.
In radiological diagnosis, this substance is often used as a contrast agent. Because of its iodine atom, iodine has a high atomic number and has a strong X-ray absorption ability. When introduced into a specific part of the human body, it can change the difference in X-ray absorption between that part and the surrounding tissue, so that the tissue structure with low contrast in the X-ray image can be clearly displayed on the image. For example, in angiography, it can clearly outline the shape of blood vessels and help doctors accurately diagnose vascular diseases, such as stenosis, obstruction or deformity.
During urography, it can clearly image structures such as the renal pelvis, ureter and bladder, and assist in the diagnosis of urinary system stones, tumors and other diseases. It can provide doctors with detailed anatomical information, help accurate diagnosis and treatment planning, and plays a pivotal role in the development of modern medical imaging.
How safe is 5-amino-n, n '-bis- (2,3-dihydroxypropyl) -2,4, 6-triiodoisophthalamide?
5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is the name of a compound. On its safety, it is related to many factors, let me explain in detail.
First of all, the chemical properties of this substance, its structure contains iodine, amino, hydroxyl and other groups. The existence of iodine, when used in organisms, may cause allergic reactions. Cover iodine can easily stimulate human immune reactions, and people with allergies can be exposed to it, which can cause rash, itching, and severe shortness of breath, shock and other life-threatening conditions.
Then look at the safety of its pharmacological effects. If this compound is used in the field of medicine, such as as as a contrast agent, it is necessary to consider its metabolism in the body. It is distributed to various tissues and organs through blood circulation, and it is necessary to ensure that it does not interfere with normal physiological functions. For example, the kidneys are the main excretory organs. If the metabolites of this compound accumulate in the kidneys, or damage the function of the kidneys, causing kidney failure and other diseases.
From the perspective of the preparation process, the residue of impurities also affects the safety. If the preparation process is not refined, impurities are mixed into the finished product, or react with the main components, or they are toxic, thus endangering the health of the user.
However, if rigorous experimental research is conducted, the preparation process is optimized, the quality is strictly controlled, and the clinical application specifications are fully considered, and the appropriate dose and specific population are used reasonably, a certain safety can also be ensured within a controllable range. However, overall, its safety needs to be carefully evaluated and should not be ignored.
What is the production process of 5-amino-n, n '-bis- (2,3-dihydroxypropyl) -2,4, 6-triiodoisophthalamide?
5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide, which is the chemical name of the contrast agent iohexanol. The details of the production process are as follows:
The key intermediate 2,4,6 - triiodine - 5 - nitroisophthalic acid is first prepared. 5 - nitroisophthalic acid is often used as the starting material and nitrified to obtain 5 - nitroisophthalic acid. After reacting with iodine under specific conditions, the catalyst and reaction environment need to be selected for this reaction to obtain high-purity 2,4,6 - triiodine - 5 - nitroisophthalic acid.
Then 2,4,6-triiodine-5-nitroisophthalic acid is reduced to obtain 5-amino-2,4,6-triiodine-isophthalic acid. The commonly used reducing agent and reaction process must be carefully controlled, because the reaction conditions have a great influence on the purity and yield of the product.
Then 5-amino-2,4,6-triiodine-isophthalic acid is reacted with 2,3-dihydroxypropylamine. In this step, the reaction temperature, time and the ratio of reactants are all key factors. It is necessary to find a suitable reaction solvent and catalyst to make the two react efficiently to generate 5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide.
At the end of the reaction, the product must go through multiple purification processes. Such as crystallization, filtration, washing, etc., to remove impurities and improve the purity of the product, so that the product can reach the pharmaceutical standard. Each step requires fine operation, and the quality of the product is not up to standard due to a slight poor pool. Such a complicated process can produce high-quality 5 - amino - N, N' - bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide.
What are the advantages of 5-amino-n, n '-bis- (2,3-dihydroxypropyl) -2,4, 6-triiodoisophthalamide compared to other similar products?
5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is one of the contrast agents. Compared with other similar products, it has many advantages.
The first mention of its safety. This product has been carefully developed and is well tolerated in the human body. After entering the human body, it rarely causes serious adverse reactions and has little toxicity to the body. Therefore, when doctors use it, they can worry less about the patient's serious discomfort caused by the drug, which is a big advantage.
Times and development effect. It contains triiodine structure, which can effectively absorb X-rays in the body, making contrast imaging clearer and more accurate. Whether it is angiography or organ development, it can clearly show the shape and structure of the target part, providing a precise imaging basis for doctors to diagnose diseases. Compared with other similar products, it is better in development clarity and accuracy.
In addition, its metabolic properties in vivo also have advantages. After completing the imaging mission, it can be excreted from the body at a more suitable rate and does not accumulate in the body for a long time, thereby reducing the potential impact on the body. This feature ensures that after the use of drugs, the human body can quickly return to a normal physiological state, which is undoubtedly more ideal than some similar products with slow metabolism and easy residue in the body.
In summary, 5 - amino - N, N '- bis - (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide has significant advantages over other similar products in terms of safety, development effect and metabolism in vivo, and has considerable application value in the field of medical imaging.