5 Amino N1 N3 Bis 2 3 Dihydroxypropyl 2 4 6 Triiodoisophthalamide

This is the name of 5-amino-N1, N3-bis (2,3-dihydroxypropyl) -2,4,6-triiodoisophthalamide, and its chemical structure can be inferred as follows.
First look at the main structure, isophthalamide, with isophthalic acid as the parent nucleus, its two carboxyl groups (-COOH) react with amino groups (-NH2O) to form an amide bond (-CONH -), which is the basic skeleton of the structure.
Looking at the substituent, the 5-amino group indicates that there is an amino substitution at the 5th position of the isophthalamide probenzene ring.
And N1, N3-bis (2,3-dihydroxypropyl), means that on two amide nitrogen atoms (referred to as N1 and N3, respectively), each connected to a 2,3-dihydroxypropyl group. The structure of 2,3-dihydroxypropyl is -CH _ (OH) CH _ (OH) OH, that is, the 2 and 3 positions of the propyl group are each connected to a hydroxyl group (-OH).
As for 2,4,6-triiodine, it means that the 2, 4 and 6 positions of the benzene ring are all replaced by iodine atoms (I).
In summary, the chemical structure of this compound is isophthalamide as the core, with an amino group at position 5 on the benzene ring, iodine atoms at positions 2, 4, and 6, and two amide nitrogen atoms are respectively connected to 2,3-dihydroxypropyl.

5 - amino - n1, n3 - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is an organic compound. Its main uses are quite extensive.
In the field of medical imaging, this compound has many applications. Due to its iodine-containing properties, it can significantly enhance the contrast between tissues and organs during X-ray imaging. In angiography, the injection of a contrast agent containing this substance can clearly show the shape, course, and presence of stenosis, blockage and other lesions of blood vessels, helping doctors to accurately diagnose vascular diseases, such as atherosclerosis, vascular malformations, etc.
This substance also plays a key role in urography. It can make the structure of the urinary system such as the renal pelvis, ureter, bladder and other urinary system clearly develop in the image, which is helpful for the discovery of urinary system stones, tumors, obstruction and other diseases, and provides an important basis for clinical diagnosis and treatment.
In addition, in some special imaging research and diagnostic techniques, 5-amino-n1, n3-bis (2,3-dihydroxypropyl) - 2,4,6-triiodoisophthalamide as a contrast agent component has contributed greatly to the acquisition of more accurate and detailed image information, which has greatly promoted the development and progress of medical imaging, enabling doctors to more accurately understand the internal structure and lesions of the human body, thus laying a solid foundation for the diagnosis and treatment of patients.

5 - amino - N1, N3 - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide, this is the English name of the contrast agent ioparol. Its safety is very critical, and it is related to the effectiveness and health of patients.
Looking at its chemical structure, it contains multiple special groups. 2,3 - dihydroxypropyl can enhance its water solubility, making it easier to disperse and metabolize in the body, reducing the risk of adverse reactions. The iodine atom is the core of contrast imaging, which can effectively absorb X-rays and provide clear images.
In terms of pharmacological properties, ioparol has relatively low osmotic pressure. Hypoosmolality can reduce the damage to vascular endothelial cells and the blood-brain barrier, and reduce the pain, edema and neurotoxicity caused by hyperosmolality. And its chemical stability is quite good, it is not easy to decompose in the body or have adverse reactions with other substances, ensuring the safety of the use process.
It is widely used in clinical applications and is often used in angiography, CT enhanced scanning and other examinations. A large number of clinical studies have shown that it is well tolerated and has a low incidence of allergic reactions. Common adverse reactions are mostly mild and short-lived, such as mild nausea, vomiting, local heat sensation, etc., which can generally be relieved by themselves. Although severe allergic reactions are rare, vigilance is also required.
Overall, 5 - amino - N1, N3 - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide, ioparol, under the premise of reasonable use, is quite safe and provides reliable imaging support for clinical diagnosis. However, it is still necessary to strictly follow the norms when using it, and closely observe the patient's reaction to ensure safety.

5 - amino - n1, n3 - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide is the English name of iodoparanol, which is a non-ionic contrast agent. Its preparation process is complex and requires multiple steps of precision organic synthesis.
The first step is the preparation of raw materials, selecting suitable starting materials, such as iodine-containing aromatics, amines and alcohols, and strict requirements are placed on purity to ensure smooth reaction and product quality.
The next key step is the iodine substitution reaction, which introduces iodine atoms into the aromatic structure, mostly in a specific organic solvent, under a catalyst, suitable temperature and reaction time. This step strictly controls the reaction conditions. Minor differences such as temperature and catalyst dosage may affect the position and degree of iodine substitution, which affects the structure and properties of the product.
Subsequent amidation reaction, the amine-containing group reacts with the carboxyl group compound to form an amide bond, and builds the basic skeleton of the target product. In this step, the appropriate condensing agent and reaction conditions are selected to ensure the efficient progress of the reaction and reduce side reactions.
The product is purified by recrystallization, column chromatography, etc. to remove impurities and obtain high purity 5-amino-n1, n3-bis (2,3-dihydroxypropyl) -2,4,6-triiodoisophthalamide. The purification process is crucial, and impurity residues can affect the safety and effectiveness of contrast agents.
After each step of reaction, analysis methods such as nuclear magnetic resonance, mass spectrometry, and infrared spectroscopy are required to monitor the reaction process, determine the structure and purity of the product, and ensure compliance with Quality Standards. The entire production process needs to strictly follow good production practices to ensure product quality stability and safety before it can be used for medical diagnostic imaging.

5 - amino - n1, n3 - bis (2,3 - dihydroxypropyl) - 2,4,6 - triiodoisophthalamide, this is the chemical name of the contrast agent iodoxanol. Compared with other similar products, its advantages are many, as detailed below.
First, it has excellent safety. Iodoxanol is an isotonic contrast agent, and the osmotic pressure is similar to that of human plasma. As in the past, other contrast agents have high osmotic pressure. After being injected into the human body, it is easy to cause vascular endothelial damage, changes in blood cell morphology and function, and cause adverse reactions such as pain, swelling, and allergic reactions. Iodoxanol greatly reduces such risks due to its isotonic properties, and has little damage to the blood vessels and organs of patients, especially for those with poor renal function. It can also significantly reduce the probability of contrast agent nephropathy and increase the safety of patients.
Second, the image quality is quite good. Iodoxanol has a high iodine content and is evenly distributed. During contrast examination, the outline, shape and internal structure of human tissues and organs can be clearly outlined. Compared with some congeneric products, the imaging is clearer, the contrast is better, and the fine lesions can be clearly presented. Physicians can diagnose diseases more accurately, avoid missed diagnosis and misdiagnosis, and improve the accuracy and reliability of disease diagnosis.
Third, it is well tolerated. Iodoxanol has high chemical stability and rarely binds to human tissue and biomacromolecules during metabolism in the body. After use, the incidence of nausea, vomiting, fever and other uncomfortable symptoms is low, and the body tolerates it well. This makes the patient more comfortable during the examination and facilitates the smooth completion of the examination.