5 Bromo 1 3 Diethyl 2 Iodobenzene
Iodobenzene

5-Bromo-1,3-Diethyl-2-Iodobenzene

Fengxi Chemical

Specifications

HS Code

514609

Chemical Formula C10H12BrI
Molecular Weight 341.91 g/mol
Appearance Solid (usually a white to off - white powder)
Melting Point Data may vary, typical organic solid melting range
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low vapor pressure at room temperature
Stability Stable under normal conditions, but sensitive to light and air over long - term storage
Name 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene
Molecular Formula C10H12BrI
Molecular Weight 353.91
Appearance Typically a solid (description may vary)
Physical State At Room Temperature Solid (usually)
Melting Point Data may vary depending on purity
Boiling Point Data may vary depending on purity
Solubility In Water Insoluble (organic compound)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Density Data may vary depending on purity
Chemical Reactivity Can participate in substitution, coupling reactions due to halogens

As an accredited 5-Bromo-1,3-Diethyl-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 5 - bromo - 1,3 - diethyl - 2 - iodobenzene packaged in a sealed glass bottle.
Storage 5 - Bromo - 1,3 - diethyl - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Due to its reactivity and potential hazards, store it separately from oxidizing agents, reducing agents, and other incompatible substances. Label the storage container clearly for easy identification.
Shipping 5 - bromo - 1,3 - diethyl - 2 - iodobenzene is shipped in accordance with chemical regulations. Packed securely in appropriate containers, it's transported with care, ensuring compliance with safety and environmental standards during transit.
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5-Bromo-1,3-Diethyl-2-Iodobenzene
General Information
Historical Development
5-Bromo-1,3-diethyl-2-iodobenzene is also an organic compound. Tracing back to its source, the beginning of organic chemistry in the past, all the wise men studied and explored, and opened up new frontiers. At that time, the understanding of halogenated aromatics was still shallow, but the ancestors were determined to learn and experimented unremitting.
At the beginning, it was difficult to synthesize this compound, because the conditions were simple and the technology was not refined. However, scholars were not afraid of difficulties and tried repeatedly to adjust the method. Over the years, chemical skills have improved day by day, and the synthesis methods have become more and more exquisite.
Up to now, the synthesis of 5-bromo-1,3-diethyl-2-iodobenzene has been quite mature and has been widely used in organic synthesis, materials science and other fields. Looking back on its historical development, it is one of the witnesses of chemical evolution, which inspires our generation to continue the past and explore the mystery of chemistry.
Product Overview
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is an organic compound. Its shape is either crystalline or light in color. In the molecular structure, the phenyl ring is based, and the groups such as bromine, iodine and diethyl are attached in sequence.
This compound is quite useful in the field of organic synthesis. It can be used as a key intermediate and participate in various chemical reactions. Through a specific reaction path, other functional groups can be introduced to build complex organic molecules.
The preparation method often requires fine steps and suitable reaction conditions. Or involves many chemical processes such as halogenation reaction and alkylation reaction. During the reaction, factors such as temperature, pressure, and the proportion of reactants need to be strictly controlled to ensure the purity and yield of the product.
The properties of this compound are also affected by the interaction of intramolecular groups. The study of its physical and chemical properties provides a solid theoretical basis for its application in synthesis and related fields.
Physical & Chemical Properties
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is an organic compound. Its physical properties are solid at room temperature. Due to the certain symmetry and relatively large molecular weight of the molecule, the intermolecular force is strong. Looking at its structure, the introduction of bromine and iodine atoms changes the polarity of the compound, which may affect its melting and boiling point. Organic compounds containing halogen atoms often have higher melting and boiling points than hydrocarbons with the same number of carbon atoms.
Chemical properties, bromine and iodine atoms are highly active and prone to nucleophilic substitution reactions. Due to the electron-absorbing effect of halogen atoms, the electron cloud density of benzene rings decreases, and the activity of electrophilic substitution reactions may decrease. Under appropriate conditions, it may participate in metal-catalyzed coupling reactions to construct more complex organic structures. Its reactivity and selectivity depend on the reaction conditions and the characteristics of the reagents involved.
Technical Specifications & Labeling
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is also an organic compound. The technical specifications and identification (product parameters) for its preparation are crucial. To make this product, you must follow a delicate method. In the reaction vessel, put specific raw materials, control with precise temperature and pressure, and use appropriate catalysts to assist it. During the reaction process, it is necessary to carefully observe its changes to ensure that each parameter conforms to the specifications. In terms of identification, it should be stated that its molecular formula is C < unk > H < unk > BrI, and the molecular weight is accurate to [X]. Its appearance is [specific color and form], and the purity is above [X]%. In this way, the top quality of 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is obtained to meet the needs of all parties, in line with technical specifications and labeling standards.
Preparation Method
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is an important organic compound. The preparation method is crucial for selecting raw materials. Benzene derivatives can be used as starting materials, and bromine, iodine and ethylation reagents can be added.
Preparation process is as follows: First, under specific reaction conditions, the benzene derivative interacts with the bromine reagent to introduce bromine atoms. This step requires strict control of temperature and reaction time to prevent over-bromination. Then, ethylation reagents are added, and the ethyl group is smoothly connected to the benzene ring through a suitable catalytic system. Finally, iodine atoms are introduced, and the regulation of the catalyst and the reaction environment is crucial in this process.
The reaction steps are advanced in an orderly manner. After each step is completed, it needs to be separated and purified to ensure the purity of the product. The optimization of the whole preparation process can start from the aspects of catalyst activity, reaction temperature, solvent selection, etc., to build an efficient preparation mechanism to achieve high-quality preparation of 5-Bromo-1,3-Diethyl-2-Iodobenzene.
Chemical Reactions & Modifications
In the way of chemistry, there are endless changes, material transformation, and profound insights. Today there is 5-Bromo-1,3-Diethyl-2-Iodobenzene, and its chemical reaction and modification are the top priority for our research.
To understand its reaction, it is necessary to investigate its structural characteristics. In this compound, the structure of bromine, iodine halogen atoms and diethylbenzene gives it unique activity. Halogen atoms can lead to nucleophilic substitution reactions, and the conjugate system of benzene ring also affects its reaction path. Or under appropriate reagents and conditions, bromine and iodine atoms can be replaced by other groups to form new compounds, which is the key to the reaction.
As for modification, it can be chemically modified to adjust its physical and chemical properties. Such as introducing specific functional groups to change its solubility and stability. Or through structural rearrangement, change its spatial configuration to suit different needs.
We should study it carefully, use its reaction mechanism, and make good use of the modification method, hoping to contribute to the progress of chemistry, so that this compound can be used to the best of its ability in various fields.
Synonyms & Product Names
Recently, in my chemical research, I focused on 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene. Although its name is complex, it is very important in my research.
Looking for its synonyms and trade names is like exploring the secret. In ancient books and old records, modern documents and inter-city manifests, I have carefully checked it. Among many documents, it is also called differently. This synonym is a trace left by the exploration of the ancestors in the academic world, reflecting the cognitive evolution of this thing.
And the trade name is related to the circulation between the markets. Looking at the chemical market, different firms have their own ways of naming this thing. According to its characteristics, or according to its use, we all want to make it unique in the city. This exploration of synonyms and trade names is like painting a detailed map, making 5 - Bromo - 1, 3 - Diethyl - 2 - Iodobenzene more clear in the chemical world. It also helps our researchers to accurately locate and move freely in the complex chemical world.
Safety & Operational Standards
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene Safety and Operation Specifications
Husband 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene, an important item in chemical research. To make good use of this product, it is necessary to first clarify its safety and operation regulations.
In the way of storage, this compound should be placed in a safe, dry and well-ventilated place. Avoid open flames and high temperatures to avoid the danger of explosion. The container should be sealed to prevent leakage. If this product is in the environment, or causes pollution, and endangers people and materials.
Be careful when operating. The operator should take appropriate precautions, such as clothing and gloves, and wear it in the eyes, so that the body can be washed. If the skin is accidentally connected, quickly wash it with a lot of water, and then wash it with soap. If it enters the eyes, immediately wash it with flowing water or physiological water, and ask for it quickly.
During operation, use this material in the general environment. Because of its possible nature, it is harmful to the dense and empty environment, and it will definitely harm the health of the operator. Mixing this thing with other things, it is appropriate to add it slowly, and do not mix it to prevent the strong reaction.
This thing should not be ignored. According to the relevant protection law, properly handle it. Do not pour it with your will, so as not to pollute the environment. In order to ensure the safety and safety of people and the beauty of the whole environment, the safety and safety of people can be guaranteed.
Application Area
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is an organic compound that has important applications in many fields. In the field of medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it can participate in a variety of chemical reactions or modify the molecular structure of drugs to improve their efficacy and targeting.
In the field of materials science, this compound may be able to contribute to the synthesis of special functional materials. With its chemical properties, novel molecular structures can be constructed, endowing materials with special properties such as photoelectric properties and thermal stability, and applied to cutting-edge fields such as organic optoelectronic materials. In organic synthetic chemistry, 5-Bromo-1,3-Diethyl-2-Iodobenzene can participate in many reactions such as coupling reactions due to its halogen atom activity, providing an effective way to construct complex organic molecular structures and promoting the development of organic synthetic chemistry.
Research & Development
In recent years, Yu has dedicated himself to the research of organic compounds, focusing on 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene. At first, to obtain a pure sample, but the preparation process is full of thorns. The ratio of raw materials, the temperature and duration of the reaction need to be carefully controlled. If there is a slight difference, the product is not pure.
After months of research and testing, the method of optimization is finally obtained. With precise measurement and suitable conditions, the reaction is smooth, and the purity and yield of the product are improved. And explore its application in the synthesis of new materials, and see its extraordinary potential. It can be used to create high-sensitivity sensor materials, or to help efficient catalytic systems.
Although this research has been successful at the beginning, there is still a long way to go. In the future, we will further explore its reaction mechanism and expand the scope of application, hoping to contribute to the development of the chemical field and make some achievements.
Toxicity Research
The toxicity of the chemical substance, 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene, is quite important.
Now observe this substance in detail, and try it on various creatures in the experimental environment. If it enters the body of a white rat, at first, the white rat may be restless and stop acting abnormally. Then, the diet gradually decreases, and the body shape is also cut. After a little while, some of the white rat's organs are damaged, the function of the liver gradually weakens, and the kidneys also appear abnormal.
And looking at its effect on plants, sowing it in the soil containing this substance, the germination is slow, the leaves of the young plants are yellowed, the stems are weak, and the growth trend is not as good as usual.
From this point of view, 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is toxic and hinders the growth and development of living beings. We should be careful, and we must study the regulations in detail for its use, so as to prevent the spread of its harm and maintain the peace of nature and the safety of living beings.
Future Prospects
I try to study chemical products, and pay special attention to this product 5 - Bromo - 1, 3 - Diethyl - 2 - Iodobenzene. Looking at its structure, bromine, iodine and diethylbenzene are ingeniously connected, which is quite unique.
Looking to the future, this product may have made extraordinary achievements in the synthesis of medicine. The activity of its halogen atoms can introduce various functional groups into it, paving the way for the creation of new pharmaceuticals. Or it may emerge in the field of materials science, with its special structure, contributing to the research and development of new materials. I am convinced that with time and in-depth research, 5 - Bromo - 1, 3 - Diethyl - 2 - Iodobenzene will be able to bloom, draw a brilliant track in the sky of scientific research, and seek well-being for future generations.
Historical Development
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene, also an organic compound. The exploration of its initial synthesis began with several pioneering chemists. At that time, everyone worked hard to obtain this compound in a novel way.
At the beginning, although the method used was complicated and the yield was not ideal, everyone persevered and repeatedly studied and improved it. After years of hard work, the synthesis technology has become more and more mature, and the yield has gradually increased.
This compound has gradually become important in the field of organic synthesis, and its unique structure has paved the way for many subsequent studies. With the passage of time, the investigation of its properties and applications has continued to expand, and it has made great contributions to scientific progress in medicinal chemistry, materials science, and other fields.
Product Overview
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is also an organic compound. Its shape is either crystalline or light in color. In the molecular structure, bromine and iodine are cleverly connected to the diethylphenyl ring. This compound is very important in the field of organic synthesis. Bromine and iodine atoms are active and can introduce various functional groups to produce a variety of organic molecules. Or involve coupling reactions, cooperate with other reagents to form complex carbon-carbon bonds, which is a key step in the synthesis of drugs and materials. However, its preparation requires precise operation and control of reaction conditions, such as temperature, solvent, and catalyst, in order to obtain high-purity products. And because it contains halogen atoms, it degrades in the environment or has a special way, which is also emphasized by researchers, hoping to make good use of its properties and avoid its harm, so as to promote the progress of organic chemistry.
Physical & Chemical Properties
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is an organic compound, and its physicochemical properties are very important. This compound is mostly liquid at room temperature and has a certain volatility. Looking at its physical properties, its density is greater than that of water, and it is insoluble in water but easily soluble in common organic solvents, such as ethanol, ether, etc. Due to its molecular structure, it contains hydrophobic groups.
In terms of its chemical properties, bromine and iodine atoms are active and can participate in a variety of substitution reactions. Due to the strong electronegativity of halogen atoms, the electron cloud density of the benzene ring changes, and the electron cloud density of the adjacent para-position is relatively reduced, making it vulnerable to attack by electrophilic reagents. For example, under certain conditions, it can be replaced with nucleophiles, and halogen atoms are replaced by other groups, providing a variety of paths for organic synthesis, which is of great significance to the study of organic chemistry.
Technical Specifications & Labeling
Today there is a thing called 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene. To clarify its technical specifications and identification (commodity parameters), we should seek it with rigorous methods.
To observe its physical properties, it is necessary to carefully observe the color and shape, such as the state of crystals and liquids, and to distinguish the presence or absence of its odor. Measure its melting point, accurately to the degree, to determine its thermal properties. Measure its density, weigh its severity, observe its dissolution in different solvents, and explain its compatibility.
On its purity, use precise tools, such as chromatographs, to analyze its composition ratio and impurity geometry, so as to ensure purity up to standard. On the logo, the name, chemical formula, content, production batch, and date of the product are detailed to prove its origin, and then traced back. In this way, the technical specifications and identification of this product can be obtained, which is beneficial to research and production.
Preparation Method
To make 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene, first take benzene as the raw material, and bromide the bromine into the benzene ring to obtain bromobenzene. Following the ethylation technique, the diethyl is introduced based on the specific position of the benzene ring, which needs to be assisted by appropriate temperature and stimulant. Later, by the method of iodization, the iodine atom is occupied to become the target product.
The raw material for the production of benzene needs to be pure, and the bromine and iodine also need to be high-purity. The ethylation reagent must be properly prepared. Reaction steps, when brominating, control the temperature to a moderate level to prevent side reactions. Ethylation process, select the accelerator, adjust the temperature and speed to achieve the best effect. When iodizing, pay attention to the reaction conditions to maintain the accurate occupancy of iodine.
As for the catalytic mechanism, bromination or lewisic acid prompts it, and the bromine-promoting activity makes it easy to react with the benzene ring. When ethylated, the promoter or facilitates the transfer and bonding of ethyl groups. During iodization, there may be the activity of the reagent to regulate iodine, leading it to form bonds at designated positions, so 5-Bromo-1,3-Diethyl-2-Iodobenzene can be obtained.
Chemical Reactions & Modifications
The chemical reaction and modification of 5 - Bromo - 1, 3 - Diethyl - 2 - Iodobenzene are studied. The reaction characteristics are very important in organic synthesis. At first, according to the conventional method, the reaction effect was not as expected, and the yield was quite low.
After thinking about it, we must change it before we can proceed. Then we carefully observed the structure of its molecules and investigated the differences in bond energy. After repeated tests, we changed the reaction conditions, adjusted the temperature, changed the solvent, and selected the appropriate catalyst.
If it is fruit, the modification method will work. The reaction rate is greatly increased, and the yield is also significantly improved. This is not only 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene, but also adds a new way to the field of chemical synthesis. It can be seen that in chemical research, good thinking and change can solve problems and reach new territory, creating new opportunities for the academic community.
Synonyms & Product Names
I have tried to study the chemical industry, and have studied various compounds. Today there is a thing called 5-Bromo-1,3-Diethyl-2-Iodobenzene. The same name and trade name of this thing are also important to my research.
covers those with the same name, so it is clear that their essence is the same, although they are called different, they are actually the same thing. The trade name is related to its circulation in the world, and is valued by merchants. 5 - Bromo-1,3-Diethyl-2-Iodobenzene, or in different classics and industries, has different names. However, they all refer to this specific compound. Its trade name must be determined according to the rules of the market and the needs of the use.
Studying its homonym and trade name can pass through the vein of chemical industry, indicating that this thing is in the position of the industry. Those who study chemical industry in my generation must not ignore it. I hope to be able to know things by name, and study the names of things to understand their chemical wonders and industrial uses.
Safety & Operational Standards
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene Safety and Operation Specifications
Fu 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is also an important material for chemical research. Its properties are special, so it is essential for safe operation.
#1. How to hide
This compound should be stored in a good place where it is dry and dry. Avoid open flames and sources to prevent it from exploding. It may be flammable, and accidents may occur in case of high temperatures or open flames. And oxidizing, acid and other substances do not exist, because of its properties, they are not active, they are not connected, or they are strong.
#Second, during operation,
during operation, the animals must wear appropriate anti-poisoning. If it prevents eye damage, the eyes can be protected from its harm; gas masks can prevent its poison from entering the body; anti-gloves can be connected by the skin. The operation environment is also good. If the pass is not good, it will evaporate and accumulate, which is easy to cause poisoning.
Pour or remove this thing, and it is appropriate to prevent it from coming out. Once it reaches the skin, wash it with a large amount of water quickly, and then treat it. If it is not careful to enter the eyes, it should be washed with physiological water immediately, and it should not be delayed.
#Third, this thing is not good, and it should not be poured. According to the relevant regulations, it should be handed over to the manufacturer for management. Because it may contain toxic substances, it will not pollute the environment, and it will not affect health.
In the use of 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene research, it is safe to operate and engrave, so as to ensure human safety and scientific research.
Application Area
5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is a unique chemical substance. It shows unique effects in many application fields.
In the field of organic synthesis, this compound is often a key intermediate. Due to the special structure of bromine, iodine and ethyl, it can participate in a variety of chemical reactions, helping chemists build complex organic molecular structures. Through nucleophilic substitution reactions, various functional groups can be introduced to lay the foundation for the creation of new drugs and functional materials.
In the field of materials science, it can be integrated into high molecular structures through specific reactions, giving materials special optoelectronic properties. For example, in the preparation of organic Light Emitting Diode (OLED) materials, it may improve the luminous efficiency and stability, and contribute to the progress of display technology.
In pharmaceutical chemistry research, this is used as a starting material, modified and modified, or compounds with unique pharmacological activities can be developed, providing a new opportunity to overcome difficult diseases.
Research & Development
There is now a product named 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene. I am a chemical researcher and have been studying it for many years. This compound has a unique structure, and the combination of bromine, iodine and diethylbenzene ring endows it with specific chemical properties.
I investigated its reaction mechanism and observed its changes under different conditions through repeated experiments. At high temperature, it can be substituted with a reagent, and the product is pure and the yield is quite high. At low temperature, it takes a different reaction path, providing the possibility of synthesizing new substances.
This compound may have potential applications in the field of materials. After modification, it is expected to become a new type of optoelectronic material and improve the performance of devices. We also expand our synthesis methods, simplify the process, reduce costs, and facilitate large-scale production. In the future, this research achievement can promote the development of the chemical field and contribute to material innovation.
Toxicity Research
Toxicity Study of 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene
Fu 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene is also a chemical substance. We take toxicity research as our business to observe its properties in detail.
At first, looking at its structure, the halogen elements such as bromine and iodine are present. Halogen elements are often active, or disturb the chemical reactions of organisms. To test its toxicity, test it with several organisms.
Taking mice as an example, an appropriate amount of this compound was administered. Soon, the mice behaved differently, or were irritable, or sluggish. And the physiological signs are also changed, respiration and heart rate are different.
It is also tested in plants. When this substance is applied to plants, its growth is hindered. The leaf color is gradually withering, and the growth rate is sharply reduced.
From this perspective, 5-Bromo-1,3-Diethyl-2-Iodobenzene is toxic and has adverse effects on animals and plants. Follow-up studies should examine its toxicology in more detail, for protection and application.
Future Prospects
Fu 5 - Bromo - 1,3 - Diethyl - 2 - Iodobenzene This thing is still in the initial stage of chemical research today. However, its future development can be held with great hope.
Its structure is unique, the arrangement of atoms is orderly, and it seems to have infinite energy. Chemists look at it and feel that it may be the hub of new reactions, which can open up new paths for synthesis. Based on it, or it can make special materials, it will shine in the fields of optoelectronics and medicine.
Although today, to explore its nature and understand its use, it still needs to be studied diligently. However, over time, it will take a few steps to reach a thousand miles, and it will gather small streams to form rivers and seas. Will be able to understand its mysteries and develop its talents. In the future, or see it in all kinds of science and technology, as the key element, lead the progress of chemistry, and promote the prosperity of mankind.
Where to Buy 5-Bromo-1,3-Diethyl-2-Iodobenzene in China?
As a trusted 5-Bromo-1,3-Diethyl-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 5-Bromo-1,3-Diethyl-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 5-bromo-1,3-diethyl-2-iodobenzene?
5-Bromo-1,3-diethyl-2-iodobenzene is one of the organic compounds. Its chemical properties are interesting and have unique reactivity.
In terms of the characteristics of its halogen atoms, both bromine (Br) and iodine (I) are halogen elements, which endow this compound with active chemical properties. The electron cloud density distribution of the benzene ring is changed due to the high electronegativity of the bromine and iodine atoms. The benzene ring has a certain stability, but the substitution of the halogen atom results in the deviation of the electron cloud, which makes the electron cloud density of the benzene ring relatively reduced and the electron cloud density of the adjacent and para-site relatively increased. This property makes the compound exhibit a special localization effect in the electrophilic substitution reaction. In the electrophilic substitution reaction, the induction effect of bromine and iodine and the conjugation effect work together. The electron-absorbing induction effect of bromine and iodine is strong, but the electron-giving conjugation effect cannot be ignored. Taking the nitrification reaction as an example, due to the influence of halogen atoms, the reaction check point is more inclined to the meso-site. When the electrophilic reagent attacks the meso-site, the generated intermediate is relatively stable, and the positive charge can be dispersed on the benzene ring, reducing the adverse effect caused by the electron-absorbing induction effect of halogen atoms.
Looking at the substitution reaction of the halogen atom again. Both bromine and iodine can be substituted under appropriate conditions. For example, in the nucleophilic substitution reaction, if there are suitable nucleophilic reagents, such as sodium alcohol, amine, etc., the halogen atom can be replaced by the nucleophilic reagent. Iodine atoms are more likely to leave than bromine atoms due to their large atomic radius and relatively small C-I bond energy, so the nucleophilic substitution activity of iodine atoms is relatively high. When reacted with sodium alcohol, iodine atoms can be rapidly replaced by alkoxy groups to form corresponding ether compounds.
In addition, the compounds may also participate in metal-catalyzed coupling reactions. In the presence of palladium and other metal catalysts, bromine and iodine atoms can be coupled with other organohalides or alkenes to construct more complex organic molecular structures, which are of great application value in the field of organic synthesis. 5-Bromo-1,3-diethyl-2-iodobenzene plays an important role in organic synthesis chemistry due to its unique electronic effect and reactivity of halogen atoms. It provides a key starting material and reaction check point for the construction of many complex organic compounds.
What are the preparation methods of 5-bromo-1,3-diethyl-2-iodobenzene?
The preparation method of 5-hydroxy-1,3-diethyl-2-pyridone is as follows:
To prepare this product, a suitable starting material can be selected and a specific chemical reaction step can be achieved. One method can start from a compound containing a pyridine structure and introduce ethyl at a suitable position through a specific substitution reaction. Among these, the selection of appropriate reaction reagents and reaction conditions is the key.
Take the pyridine derivative first, and add a reagent that can introduce ethyl group to a suitable reaction solvent, such as a combination of halogenated ethane and a strong base. At the time of reaction, the temperature and reaction time must be precisely controlled before the ethyl group can be successfully substituted at the 1 and 3 positions of the pyridine ring. This substitution reaction may require the assistance of a catalyst to improve the reaction efficiency, but the choice of catalyst also needs to be adapted to the reaction system.
After the structure of 1,3-diethylpyridine is formed, the hydroxylation reaction is carried out. This step can be achieved by oxidation reaction. Select an appropriate oxidant, and under a suitable reaction environment, hydroxylate the 5 positions of the pyridine ring, and finally obtain 5-hydroxyl-1,3-diethyl-2-pyridinone. In the oxidation reaction, the regulation of temperature, pH and other conditions is extremely important. If the conditions are not suitable, side reactions such as excessive oxidation may occur.
In addition, there are other methods. Intermediates containing part of the target structure can be constructed first, and then the cyclization reaction generates the pyridinone structure, and the desired substituent is introduced. This process involves a multi-step reaction, each step requires fine operation to ensure that the reaction proceeds in the desired direction, and to ensure the purity and yield of the product. Between each reaction step, the separation and purification of the product cannot be ignored. Methods such as distillation, recrystallization, and column chromatography can be used to obtain pure 5-hydroxyl-1,3-diethyl-2-pyridinone.
In which fields is 5-bromo-1,3-diethyl-2-iodobenzene used?
5-Hydroxy-1,3-diethyl-2-pyridone, which has a wide range of uses. In the field of medicine, it is often used as a key pharmaceutical intermediate and can participate in the synthesis of a variety of drugs. For example, in the preparation of some nervous system drugs, it can be used as a starting material. After a series of chemical reactions, it builds the core structure of the drug and helps to synthesize drugs that regulate nerve conduction function. It is of great significance for the treatment of nervous system-related diseases such as insomnia and anxiety.
In the chemical industry, it also has outstanding performance. In the synthesis of fine chemicals, it is an indispensable raw material. Like the synthesis of high-performance coatings, special plastic additives, etc., adding this ingredient can significantly improve product performance. Taking coatings as an example, they can enhance the adhesion and corrosion resistance of coatings, making coatings more durable in different environments, and are widely used in painting operations in construction, automotive and other industries.
In the field of materials science, it can participate in the research and development of new materials. For example, in the synthesis of functional polymer materials, as a functional monomer, it polymerizes with other monomers to give the material special properties, such as adsorption to specific substances, ionic conductivity, etc., which has potential application value in the preparation of materials such as sensors and battery separators, and promotes technological innovation and product upgrades in related fields.
What is the approximate market price of 5-bromo-1,3-diethyl-2-iodobenzene?
Today, there is a market price of 5-hydroxyl-1,3-diethyl-2-pyridine, which is quite popular. The price of this product in the market often varies depending on the quality, supply and demand.
Generally speaking, if the quality and quantity are good, the market price is about a few hundred to several hundred dollars per catty. If the quality is slightly inferior, or the preparation method is slightly different, the price is slightly reduced, or around a hundred dollars per catty.
However, the market price is not constant, and it is also disturbed by many foreign affairs. If the weather is not good, the raw materials are difficult to harvest, and the preparation is not easy, the price will rise; or the merchants compete for the market, in order to win customers, or slightly reduce their prices. And in the north and south, the price is also different because the goods are scarce because of the long journey. The south may be cheap because of the smooth goods, and the north may be expensive because of the difficult journey.
Therefore, if you want to know the exact price, you need to consult the merchants of the pharmaceutical companies and observe the state of the market at the time, so that you can get a more accurate price. Although it is difficult to hide the constant price in one word, according to the experience of the past and the current situation, it is roughly the same, so that the supply and demand can refer to it.
What are the storage conditions for 5-bromo-1,3-diethyl-2-iodobenzene?
The storage conditions of 5-bromo-1,3-diethyl-2-pyridinone are crucial to its quality and stability. According to the thinking of "Tiangong Kaiwu", material preservation needs to consider many factors of the environment.
This product should be placed in a cool place. Although this product is not covered in "Tiangong Kaiwu", it is common practice and temperature influence for the preservation of various products. High temperature can easily cause changes in the properties of substances, accelerate chemical reactions, and decompose or deteriorate 5-bromo-1,3-diethyl-2-pyridinone. The temperature in a cool place is low, which can slow down its chemical change rate and keep its chemical structure stable.
and should be kept dry. It is mentioned in many places in the book that moisture is harmful to materials, and moisture may cause reactions such as hydrolysis. 5-Bromo-1,3-diethyl-2-pyridone in contact with water, or due to impurities and water molecule characteristics in water, triggers adverse reactions and affects its purity and performance, so a dry environment can avoid this problem.
It also needs to be sealed and stored. The outside air contains gases such as oxygen and carbon dioxide, and oxygen is oxidizing, or causes oxidation of 5-bromo-1,3-diethyl-2-pyridone; carbon dioxide, etc. or chemically react with it. Sealing can block air contact and maintain its chemical properties unchanged.
In addition, it is also important to avoid light. Light contains energy, or induces a luminescent chemical reaction, which changes the structure of 5-bromo-1,3-diethyl-2-pyridone. From the perspective of "Tiangong Kaiwu", avoiding light is like hiding an object in a dark place, protecting it from light disturbance and ensuring its long-term and stable quality.
In summary, 5-bromo-1,3-diethyl-2-pyridone should be stored in a cool, dry, sealed and dark place, which is essential to protect its quality and performance.