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What are the main uses of 5-bromo-3-iodine-1H-indazole?
1H-indole is an important class of organic compounds with a wide range of main uses.
In the field of medicine, 1H-indole and its derivatives have shown significant efficacy. Many drugs containing 1H-indole structure have antibacterial, anti-inflammatory, anti-tumor and other pharmacological activities. For example, some indole compounds can act on specific biological targets, regulate cell physiological functions, inhibit the proliferation and spread of tumor cells, and provide a new way for cancer treatment. In terms of antibacterial, they can interfere with the metabolic process of bacteria and destroy the synthesis of their cell walls or cell membranes, so as to achieve the purpose of antibacterial and provide effective drug options for the clinical treatment of bacterial infectious diseases.
In the field of materials science, 1H-indole also plays an important role. Due to its unique electronic structure and chemical properties, it can be used to prepare materials with special properties. For example, organic optoelectronic materials synthesized from 1H-indole have potential applications in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells. Such materials can efficiently absorb and emit photons, improve the performance of optoelectronic devices, and promote the development of display technology and new energy fields.
In the dye industry, 1H-indole can be used as a key intermediate for synthesizing dyes. The dyes synthesized from it have the advantages of bright color and good stability, and are widely used in dyeing processes such as textiles and leather. Dyes derived from 1H-indole can form a strong bond with fibers and other materials, and are not easy to fade, meeting the market demand for high-quality dyes.
In addition, 1H-indole is an extremely important building block in the field of organic synthesis. With its active reaction check point, it can be structurally modified and derived through various chemical reactions to construct complex organic molecular structures, providing a rich material basis and reaction path for the development of organic synthetic chemistry, helping scientists to create more organic compounds with unique functions and properties.
What are the physical properties of 5-bromo-3-iodine-1H-indazole?
1H-acetylene is a kind of alkyne, which has the following physical properties:
First, in terms of state, under room temperature and pressure, 1H-acetylene is in a gaseous state. Because of its relatively small molecular mass and weak intermolecular forces, it is difficult to condense into a liquid or solid state.
Second, color and odor, 1H-acetylene is a colorless and odorless gas. However, the acetylene actually prepared is often slightly odor due to impurities. For example, when acetylene is prepared by calcium carbide method, because calcium carbide contains impurities such as calcium sulfide and phosphate, it reacts with water to form hydrogen sulfide, phosphine and other gases, causing acetylene to have a special odor.
Third, in terms of density, the density of 1H-acetylene is less than that of air. Its relative molecular weight is about 26, while the average relative molecular weight of air is about 29. According to Avogadro's law, under the same conditions, the ratio of gas density is equal to the ratio of relative molecular weight. Therefore, 1H-acetylene can be collected by the downward air method. However, due to the similar density of acetylene and air, the purity of the collected gas is poor, and it is generally collected by the drainage method.
Fourth, in terms of solubility, 1H-acetylene is slightly soluble in water and easily soluble in organic solvents, such as benzene, carbon tetrachloride, etc. This is because acetylene is a non-polar molecule. According to the principle of "similar miscibility", it has better solubility in non-polar or weakly polar organic solvents.
What are the chemical properties of 5-bromo-3-iodine-1H-indazole?
1H-alkynes have unique chemical properties. Its carbon-carbon triple bond is the center of reactivity, which makes alkynes exhibit a variety of chemical reactions, and plays a very important role in the field of organic synthesis.
First of all, 1H-alkynes are acidic. Because its triple bond carbon atom is a sp hybrid, the electronegativity is stronger than that of the sp ² and sp ³ hybrids, causing the hydrogen atom connected to the triple bond to have a certain acidity. It can react with strong bases, such as sodium amino (NaNH ²), to form alkynyl negative ions. This alkynyl anion is a strong nucleophilic reagent, which can react with halogenated hydrocarbons and other electrophilic reagents to form carbon-carbon bonds, which are used to grow carbon chains. This is an important means to build carbon skeletons in organic synthesis.
Furthermore, 1H-alkynes can undergo addition reactions. Similar to olefins, they can be added with halogens, hydrogen halides, water, etc. However, due to the existence of three bonds, the addition reaction can be carried out in steps, first adding to alkenes, and then further adding to alkanes. For example, under the catalysis of mercury salts, 1H-alkynes are added with water to form carbonyl compounds. This reaction is called the hydration reaction of alkynes. The hydration products of alkynes with different substituents are different. Mono-substituted acetylene is hydrated to produce methyl ketones, and disubstituted acetynes are hydrated to produce alcaldes or ketones.
In addition, 1H-alkynes can also participate in oxidation reactions. With appropriate oxidants, such as ozone or potassium permanganate, alkynes can be oxidized and broken. After the three bonds are broken, corresponding carboxylic acids, carbon dioxide and other products are generated according to the different structures of alkynes. This reaction is helpful for analyzing the structure of alkynes and is also one of the ways to prepare carboxylic acid compounds in organic synthesis.
In addition, 1H-alkynes can be polymerized. Under specific conditions and catalysts, alkynes can be interconnected to form polymer compounds, providing new polymer materials for the field of materials science.
In summary, 1H-alkynes have a variety of chemical properties such as acidity, addition, oxidation, and polymerization due to their special structure of carbon-carbon bonds. They are widely used in many fields such as organic synthesis and material preparation. They are indeed important objects of organic chemistry research.
What are the synthesis methods of 5-bromo-3-iodine-1H-indazole?
To prepare 5-bromo-3-nitro-1H-indole, the following methods can be used:
First, indole is used as the starting material. First, indole and bromine are brominated in a suitable solvent, such as dichloromethane, in a low temperature environment to obtain 5-bromo-indole. Among them, the low temperature setting is to control the reaction check point, so that the bromine atom selects 5 positions and connects. Then, 5-bromo-indole is co-arranged with mixed acid (mixed with nitric acid and sulfuric acid), and 5-bromo-3-nitro-1H-indole can be obtained through nitrification reaction. In this step, it is necessary to pay attention to the ratio of mixed acids and the reaction temperature to prevent side reactions such as hypernitrification.
Second, take o-nitroaniline as the starting material. First, through diazotization, it is co-prepared with sodium nitrite and hydrochloric acid to obtain diazonium salt. Then, it is reacted with cuprous bromide, and the Sandmeyer reaction is performed to introduce bromine atoms to obtain 2-nitro-4-bromoaniline. After the ring-closing reaction, under appropriate conditions, such as co-heating with a suitable dehydrating agent, the intramolecular ring is formed, and 5-bromo-3-nitro-1H-indole can be obtained. In this process, the conditions of diazotization and cyclization are the key, which are related to the yield and purity of the product.
Third, phenylhydrazine and ethyl bromopyruvate are used as raw materials. The two are condensed first to obtain hydrazone intermediates. Then, under the action of appropriate catalysts, the intramolecular cyclization reaction is carried out to generate 5-bromo-3-nitro-1H-indole. In this way, the reaction conditions of condensation and cyclization, such as the choice of catalyst, reaction temperature and time, need to be carefully regulated to make the reaction smooth and obtain the target product with higher yield.
What is the price range of 5-bromo-3-iodine-1H-indazole in the market?
5 -% E6% BA% B4 - 3 -% E7% A2% 98 - 1H -% E5% 90% B2% E5% 94% 91. This refers to chemical substances. However, I have searched all over the classics and have not heard of the price of this product in the market. Because of the things in the world, their prices often change with the time of day, geographical location, and supply and demand, it is difficult to generalize.
And these substances are either rare products, or used in specific fields and specific industries. Their transactions are not as widely known as ordinary corn cloth, and few people in the market say their prices.
If you want to know the price range of this product in the chemical business of this world, you must carefully investigate the market situation of chemical raw materials, and consult merchants and workshops specializing in this industry, or refer to the market data of chemical transactions. However, as far as I know, there are no conclusive ancient books and regulations as a basis, so it is difficult to determine its price range. Although I want to help you solve your doubts, I can't help but look to Haihan.
