5 Bromo 3 Iodopyridine

5-Bromo-3-iodopyridine is an important compound in organic chemistry. Its unique physical properties are described as follows:
1. ** Appearance and Properties **: Under normal conditions, 5-bromo-3-iodopyridine is mostly white to light yellow crystalline powder. This appearance characteristic can be used as a preliminary basis for identification in chemical experiments and industrial production. The shape of the powder is also conducive to its dispersion in the reaction system and promotes the progress of chemical reactions.
2. ** Melting Point and Boiling Point **: The melting point is about 88-92 ° C. As an important physical constant of the substance, the melting point is of great significance for the identification of its purity. If the melting point of the sample is consistent with this value and the melting range is narrow, it indicates that the purity is high. As for the boiling point, due to the limited relevant data, although it is difficult to give accurately, it is speculated that the boiling point should be in a higher temperature range based on its molecular structure and the properties of similar compounds. This is due to the presence of van der Waals forces between molecules and the influence of halogen atoms, which increases the intermolecular force and increases the energy required for gasification.
3. ** Solubility **: 5-bromo-3-iodopyridine is slightly soluble in water. This property is attributed to the fact that although the molecule contains nitrogen atoms and has a certain polarity, the presence of bromine and iodine atoms enhances the hydrophobicity of the molecule as a whole. However, it has good solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In organic synthesis reactions, suitable solvents are often selected according to this solubility characteristic to construct a homogeneous reaction system to facilitate the smooth development of the reaction.
4. ** Density and stability **: Although density-related data are not easy to obtain, from a structural point of view, due to the relatively large atomic masses of bromine and iodine atoms, their density should be higher than that of water. In terms of stability, 5-bromo-3-iodopyridine is relatively stable under conventional storage conditions. However, it should be noted that it is more sensitive to light and heat. When exposed to light or heat, halogen atoms may dissociate, causing molecular structural changes. Therefore, store in a cool, dry and dark place.
The physical properties of 5-bromo-3-iodopyridine have a profound impact on its application in organic synthesis, medicinal chemistry and other fields. Researchers must fully consider these properties during use to achieve the best experimental and production results.

5-Bromo-3-iodopyridine is also an organic compound. Its chemical properties are unique and valuable to explore.
In this compound, the presence of bromine and iodine atoms endows it with active reactivity. Both bromine and iodine are halogen elements with strong electronegativity, which makes the molecular electron cloud unevenly distributed, making it easy to participate in nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. Nucleophilic reagents such as alcohols and amines can react with 5-bromo-3-iodopyridine in this way. The oxygen atom of the alcohol or the nitrogen atom of the amine can provide electron pairs to attack the carbon atoms attached to the halogen atom on the pyridine ring, and the halogen atom leaves in the form of ions, which is a common nucleophilic substitution mechanism.
Furthermore, the pyridine ring is aromatic, and although the electron cloud density distribution is uneven compared with the benzene ring, it can also participate in the aromatic electrophilic substitution reaction. Only the reaction check point is selected. Due to the localization effect of bromine and iodine, the electrophilic reagents often attack the specific position of the pyridine ring. For example, when an electrophilic group such as nitro is introduced, it is affected by the halogen atom, and the substitution reaction may occur preferentially at a specific carbon
In addition, 5-bromo-3-iodopyridine can be used as a key intermediate in organic synthesis. Through various chemical reactions, its structure can be modified to build more complex organic molecules. In the field of medicinal chemistry, it may be used to synthesize compounds with specific biological activities; in the field of materials science, it can also provide a basic structural unit for the synthesis of functional materials. Due to its unique chemical properties, it provides a broad operating space for organic synthesis chemists to create diverse and practical compounds.

5-Bromo-3-iodopyridine is an important intermediate in organic synthesis. There are several common synthesis methods, which are described in detail as follows:
First, pyridine is used as the starting material and obtained by halogenation reaction. First, bromine atoms can be introduced into the pyridine ring by reacting with an appropriate brominating agent, such as bromine (Br ²) and pyridine under suitable conditions. When reacting, pay attention to the choice of reaction temperature, solvent and catalyst. Usually, with an appropriate organic solvent, such as dichloromethane, slowly adding bromine dropwise at low temperature can make the reaction more controllable. After that, the obtained bromine-containing pyridine derivatives are iodized with a system composed of iodizing agents, such as potassium iodide (KI) and oxidizing agents, such as hydrogen peroxide (H2O) or nitric acid (HNO), and iodine atoms are introduced at suitable positions. This process requires precise control of the reaction conditions to achieve high yield and selectivity.
Second, the corresponding substituted pyridine derivatives can also be used as starters. If there are already suitable substituents at specific positions in the pyridine ring, 5-bromo-3-iodine can be obtained by functional group transformation. For example, if there is a group on the pyridine ring that can be replaced by a halogen atom, such as a hydroxyl group (-OH), etc., the hydroxyl group can be replaced with a bromine atom or an iodine atom by a halogenated reagent, such as phosphorus tribromide (PBr) or phosphorus triiodide (PI). The reaction conditions need to be adjusted according to the specific characteristics of the reagent and the substrate, and the requirements of anhydrous and anaerobic reaction environment should be paid attention to to to avoid side reactions.
Third, metal-catalyzed coupling reactions are also commonly used. Bromopyridine derivatives and iodine-containing reagents are coupled in the presence of ligands and bases under the action of metal catalysts, such as palladium (Pd) catalysts, such as tetra (triphenylphosphine) palladium (Pd (PPh)), etc. This reaction requires harsh reaction conditions. The activity of the catalyst, the selection of ligands, the type and dosage of bases all have a significant impact on the reaction results. Suitable solvents, such as N, N-dimethylformamide (DMF), are also key factors for the smooth progress of the reaction.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, cost, yield and selectivity, and choose the best one to synthesize 5-bromo-3-iodopyridine efficiently.

5-Bromo-3-iodopyridine has a wide range of functions in the field of organic synthesis. It has a unique structure, contains bromine and iodopyridine dihalogen atoms, and has active chemical properties. It is often a key raw material for the construction of complex organic molecules.
In the field of pharmaceutical chemistry, this compound also has extraordinary performance. Through its participation in the reaction, a variety of biologically active compounds can be prepared, or it can be a new drug lead structure. Its active halogen atoms can be introduced into a variety of functional groups through reactions such as nucleophilic substitution to meet the needs of drug design for specific structures and activities.
In the field of materials science, 5-bromo-3-iodopyridine has also emerged. It can be used as an important intermediate for the preparation of special functional materials. By organic synthesis, it can be integrated into the polymer structure, which may endow the material with special electrical and optical properties. For example, it can be used in the field of optoelectronic materials to help the research and development of materials such as Light Emitting Diode and solar cells.
Furthermore, it is also indispensable in the field of fine chemical synthesis. It can be used to prepare high-end pigments, fragrances and other fine chemicals. With its unique reactivity, it can achieve specific structure construction and improve product quality and performance. In conclusion, 5-bromo-3-iodopyridine, with its unique structure and reactivity, plays an important role in many fields such as organic synthesis, medicinal chemistry, materials science, and fine chemical synthesis, promoting the development and innovation of various fields.

The market price of 5-bromo-3-iodopyridine is difficult to sum up. Its price often varies due to many factors, as described below.
The first example is the situation of supply and demand. If there is a strong demand for 5-bromo-3-iodopyridine in the market, but the supply is limited, its price will rise. Just like all rare things, if there are many applicants and few suppliers, the price will be high. On the contrary, if the supply is abundant and the demand is weak, the price will drop in order to sell quickly.
Furthermore, the price of raw materials is also the key. The preparation of 5-bromo-3-iodopyridine requires specific raw materials. If the price of the raw material rises, the production cost will increase, and the price of the product will also increase accordingly. For example, if the raw material is rare, or its procurement is so difficult that it is expensive, then 5-bromo-3-iodopyridine will also be difficult to lower its price.
The method and cost of production also determine its price. If there are new and ingenious methods, the consumption of production can be reduced, the cost can be reduced, and in the midst of competition, the price can be reduced. However, if the production method is outdated and the cost is high, the price will also be difficult to drop.
In addition, the state of market competition also affects its price. If there are many people in the city competing to sell 5-bromo-3-iodopyridine, in order to compete for customer profit, or there may be a price reduction. However, if the market is almost monopolized and the merchant controls the goods, the price will be higher.
There are regional differences, which also affect the price. Different places have different prices due to different transportation costs and taxes. In remote places, transportation is inconvenient, costs increase, and prices may be higher than passageways.
Therefore, if you want to know the exact market price of 5-bromo-3-iodopyridine, you can get a more accurate price when you observe the chemical market in real time and consult various suppliers.