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What is the chemical structure of 5-fluoro-1- (2-fluorobenzyl) -3-iodo-1h-pyrazolo [3,4-b] pyridine
This is the question of 5-fluoro-1- (2-fluorobenzyl) -3-iodine-1H-pyrazolo [3,4-b] pyridine. This compound, according to its naming convention, can be known in summary of its chemical structure.
The nucleus of prepyrazolo [3,4-b] pyridine, which is formed by fusing the pyrazole ring with the pyridine ring. The pyrazole ring contains two adjacent nitrogen atoms, which are fused with the pyridine ring in a specific way to form a unique ring structure.
At position 1, a (2-fluorobenzyl) group is connected. The benzyl group is benzyl, that is, the benzene ring is connected to methylene (-CH 2O -), and the second position of the benzyl group is connected with a fluorine atom. At the
3 position, there is an iodine atom. The fifth position is occupied by a fluorine atom.
In this way, the chemical structure of this compound is clearly presented. 5-Fluoro-1- (2-fluorobenzyl) -3-iodine-1H-pyrazolo [3,4-b] pyridine uses pyrazolo [3,4-b] pyridine as the core to connect specific substituents at different positions to construct a unique chemical structure, which endows it with specific chemical and physical properties and may be of unique use in chemistry and related fields.
What are the main uses of 5-fluoro-1- (2-fluorobenzyl) -3-iodo-1h-pyrazolo [3,4-b] pyridine
5 - fluoro - 1 - (2 - fluorobenzyl) - 3 - iodo - 1H - pyrazolo [3,4 - b] pyridine is an organic compound. This compound has a wide range of uses and can be used as an intermediate in drug development in the field of medicinal chemistry. Due to its unique molecular structure, it can provide a basis for the construction of drug molecules with specific biological activities. For example, it can be chemically modified to make it show affinity and activity to biological targets related to specific diseases, and it is expected to be used to create new drugs for the treatment of specific diseases.
In the field of materials science, this compound may be used to synthesize materials with special functions. Because it contains fluorine, iodine and other halogen elements, it is endowed with unique electronic properties and physical properties. Or it can be used to prepare materials with specific photoelectric properties, such as in organic Light Emitting Diodes (OLEDs), solar cells and other devices, to improve the charge transport and luminous efficiency of materials by their structural properties.
In organic synthetic chemistry, this compound is a key building block for the construction of complex organic molecules. Its diverse reaction check points enable chemists to connect it with other organic fragments through various organic reactions, such as coupling reactions, substitution reactions, etc., to expand the complexity and functionality of molecules, and open up paths for the synthesis of organic compounds with novel structures and properties.
What are the synthesis methods of 5-fluoro-1- (2-fluorobenzyl) -3-iodo-1h-pyrazolo [3,4-b] pyridine
The synthesis of 5-fluoro-1- (2-fluorobenzyl) -3-iodine-1H-pyrazolo [3,4-b] pyridine is an important topic in the field of organic synthetic chemistry. Its synthesis often follows a multi-step reaction path.
The first step may require the preparation of key intermediates. It can be started by a suitable pyridine derivative, and fluorine atoms can be introduced through a halogenation reaction to obtain fluorine-containing pyridine intermediates. This halogenation reaction, or an electrophilic halogenation reagent, under suitable reaction conditions, precisely introduces fluorine atoms into the designated position of the pyridine ring.
The second step is to construct the structure of the pyrazole ring. Pyrazolo [3,4 -b] pyridine skeletons can be formed by condensation reaction between nitrogen-containing compounds and the aforementioned fluoropyridine intermediates. This process requires careful regulation of reaction conditions, such as temperature, solvent and catalyst, to ensure the smooth progress of the reaction and good selectivity of the product.
Furthermore, the benzyl moiety is introduced. Through nucleophilic substitution, 2-fluorobenzyl is introduced into the first position of the pyrazolo [3,4 -b] pyridine structure. In this step, 2-fluorobenzylation reagents with suitable activity, and matching bases and solvents are selected to improve the reaction efficiency and yield.
Finally, iodine atoms are introduced at the third position. Or use iodizing reagents and achieve halogenation reaction. Also pay attention to the reaction conditions to avoid adverse effects on other functional groups.
Each step of the synthesis of this compound requires fine control of conditions and optimization of reaction parameters to obtain the target product with ideal yield and purity. And after each step of the reaction, it is often necessary to separate and purify methods, such as column chromatography, recrystallization, etc., to remove impurities and obtain pure intermediates and final products.
What is the market outlook for 5-fluoro-1- (2-fluorobenzyl) -3-iodo-1h-pyrazolo [3,4-b] pyridine?
5 - fluoro - 1 - (2 - fluorobenzyl) - 3 - iodo - 1H - pyrazolo [3,4 - b] pyridine is a rather specific organic compound. Looking at its market prospects, it is really multi-faceted.
From the perspective of pharmaceutical research and development, such heterocyclic compounds containing fluorine and iodine often have unique biological activities. The introduction of fluorine atoms can significantly change the lipid solubility and metabolic stability of compounds, while iodine atoms may participate in specific chemical reactions under certain circumstances to facilitate the precise combination of drugs and targets. Therefore, in the field of innovative drug development, it may be a promising lead compound. In recent years, many pharmaceutical companies and scientific research institutions have favored compounds containing such structures, and have invested a lot of resources to explore their applications in the research and development of anti-cancer, antiviral and other drugs. From this perspective, in the pharmaceutical research and development market, its prospects seem quite bright, and it is expected to give rise to many new special drugs, thereby creating considerable economic benefits.
However, from the perspective of chemical production, its synthesis process may pose challenges. The reaction conditions of fluoride and iodine often need to be carefully controlled, and the cost of raw materials may be high, and the synthesis steps may be complicated, which will push up the production cost. To achieve large-scale industrial production, many technical problems must be overcome in order to improve yield and reduce costs. At present, although some studies have been dedicated to optimizing its synthesis route, it has not yet reached a very mature and efficient state. Therefore, in the field of chemical production, its large-scale promotion and application still takes time, and the road to market expansion may be full of thorns.
In summary, 5-fluoro-1- (2-fluorobenzyl) -3-iodo-1H-pyrazolo [3,4-b] pyridine has great potential in the pharmaceutical R & D market and has a promising future; however, in the chemical production market, due to the shackles of synthesis problems, the market prospect is still unclear, and further technological breakthroughs are needed to usher in a broad development space.
What are the relevant safety precautions for 5-fluoro-1- (2-fluorobenzyl) -3-iodo-1h-pyrazolo [3,4-b] pyridine?
5-Fluoro-1- (2-fluorobenzyl) -3-iodine-1H-pyrazolo [3,4-b] pyridine is a chemical that should not be ignored due to its safety precautions.
This chemical may be toxic and may harm the human body after contact. When the skin touches it, rinse it with plenty of water as soon as possible, and rinse it carefully to see if the skin is abnormal. If you feel unwell, seek medical attention. If the eyes are contaminated, you need to rinse them with running water immediately. When rinsing, be sure to turn the eyelids, try to wash them, and then rush to the ophthalmology department for medical treatment.
Breathing in the vapor or dust of this chemical is very likely to endanger breathing. In this case, leave the place where the incident occurred quickly and go to a place where the air is fresh. If breathing is already difficult, you need to use oxygen inhalation equipment as soon as possible. Do not delay for a moment. You should seek medical attention as soon as possible. If you accidentally take it by mistake, do not induce vomiting by yourself. You should seek medical attention immediately. When seeking medical attention, bring the relevant information of this chemical to help medical judgment.
In terms of storage, it should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it may be chemically active, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent dangerous chemical reactions. When handling, be sure to be careful and unload lightly to avoid leakage due to damaged packaging.
When handling this chemical, protective measures are essential. Wear protective clothing, which can effectively block the chemical from coming into contact with the body and reduce the risk of injury. At the same time, wear protective gloves, which must be made of materials that can resist the erosion of the chemical. Protective glasses or masks should also be worn to fully protect the eyes from damage. At the operation site, emergency treatment equipment and suitable containment materials should be equipped. In the event of a leak, it can be dealt with quickly to prevent the harm from expanding.