5 Iodo 1h Imidazole

5-Iodo-1H-imidazole is an organic compound. In its molecular structure, the first position of the imidazole ring is a hydrogen atom, and the fifth position is replaced by an iodine atom.
On its chemical properties, first of all, because it contains nitrogen heterocycles, it has certain basicity. The nitrogen atom in the imidazole ring has a lone pair of electrons, can accept protons, and can form salts in an acidic environment. This basic property makes it possible to react with acids to form corresponding salt compounds.
Furthermore, the iodine atom at the fifth position has higher reactivity. Iodine atoms can undergo nucleophilic substitution reactions due to electronegativity and atomic radius. When encountering nucleophilic reagents, iodine atoms are easily replaced, resulting in the derivation of many different compounds. For example, the reaction with reagents containing hydroxyl, amino and other nucleophilic groups can form new carbon-hetero atomic bonds and expand the variety of compounds.
And because it is an aromatic heterocyclic compound, the imidazole ring is aromatic, relatively stable, and is not easy to be oxidized or added. However, under certain conditions, such as strong oxidizing agents or special catalysts, aromatic rings may also react, or other functional groups may be introduced into the ring to enrich its chemical structure and properties.
In addition, 5-iodo-1H-imidazole is widely used in the field of organic synthesis. It can be used as an intermediate to transform into more complex organic molecules through various reactions, and has potential applications in many fields such as medicinal chemistry and materials science.

5-Iodo-1H-imidazole, or 5-iodo-1H-imidazole, has a wide range of uses. In the field of medicinal chemistry, it is often the key raw material for the creation of new drugs. The genimidazole ring structure is common in many bioactive molecules. The introduction of 5-iodo-1H-imidazole into iodine atoms can significantly change the physical, chemical and biological properties of compounds, and help to develop antibacterial, antiviral, antitumor and other drugs.
In the field of materials science, it also has outstanding performance. It can be used as an intermediate in organic synthesis to prepare functional materials with special properties, such as optoelectronic materials. Due to its structural properties, it may endow materials with unique optical and electrical properties, making it popular in the fields of organic Light Emitting Diodes (OLEDs) and solar cells.
Furthermore, in the field of organic synthetic chemistry, 5-iodine-1H-imidazole is an important building block for the construction of complex organic molecules. The existence of iodine atoms allows it to participate in a variety of chemical reactions, such as coupling reactions, so that it can efficiently form carbon-carbon and carbon-heteroatom bonds, expand the structural diversity of organic molecules, and provide a powerful means for the synthesis of various fine chemicals and natural products.

5-Iodine-1H-imidazole is an important organic compound. Its synthesis methods are diverse and have their own advantages. The details are as follows:
1. ** Using imidazole as the starting material **:
- ** Halogenation reaction **: This is a commonly used method. Dissolve imidazole in suitable solvents, such as dichloromethane, chloroform, etc., and slowly add iodine-containing reagents, such as N-iodosuccinimide (NIS), iodine elemental substance (I ²) and oxidizing agent mixture (such as hydrogen peroxide, perchloric acid, etc.). Taking N-iodosuccinimide as an example, the nitrogen-iodine bond of N-iodosuccinimide is broken during the reaction, and the iodine positive ion attacks the imidazole ring to form 5-iodine-1H-imidazole. This reaction condition is mild and the yield is quite high.
- ** Metal-catalyzed halogenation **: Imidazole can also be halogenated with an iodine source in the presence of a metal catalyst. Commonly used catalysts include copper salts (such as cuprous iodide CuI), palladium salts (such as palladium acetate Pd (OAc) -2), etc. Taking cuprous iodide as an example, in the reaction, cuprous iodide first forms a complex with ligands (such as o-phenanthroline), which enhances the activation ability of the iodine source, and then prompts the selective introduction of iodine atoms into the fifth position of the imidazole ring. Such methods require harsh reaction conditions and require an oxygen-free and anhydrous environment, but can effectively improve the reaction selectivity.
2. ** Construction of an imidazole ring **:
- ** Using 1,2-dicarbonyl compounds, formamide and iodine sources as raw materials **: 1,2-dicarbonyl compounds (such as glyoxal, butanedione, etc.) and formamide under the action of acidic catalysts (such as p-toluenesulfonic acid), first condensate to form an imidazole ring precursor, and then add an iodine source (such as iodine elemental substance, potassium iodide, etc.). In the presence of an oxidizing agent (such as ammonium cerium nitrate CAN), cyclization and iodization are carried out simultaneously to directly generate 5-iodine-1H-imidazole. This route step is streamlined and the raw materials are easy to purchase. However, the reaction conditions need to be
- ** Using nitrile compounds and iodoacetamide as raw materials **: Under the action of strong bases (such as sodium hydride NaH), nitrile compounds and iodoacetamide first undergo nucleophilic addition reaction to generate nitrogenous carbon negative ion intermediates. This intermediate is then cyclized within the molecule to construct an imidazole ring, and iodine atoms are introduced to generate the target product. This method is suitable for the synthesis of 5-iodine-1H-imidazole with a specific structure. The reaction conditions are relatively harsh and the purity of the reactants is very high.

When I look at the world of commerce, the price of goods often varies with changes in time, place, quality and supply and demand. As for the item "5-iodo-1h-imidazole", its market price also follows this law.
At that time, if a new product is first released and there is no competition in the market, its price may be high. The capital for research and development and the novelty of the process all need to be paid for. After a long time, there will be more and more imitators, the process will become more and more mature, and the price may gradually drop.
In terms of location, in a prosperous city, there are many commercial ports, smooth transportation, and convenient logistics, the cost may be slightly lower, and the price may also be cheaper. However, in remote places, transportation is difficult and supplies are inconvenient, so the price will increase.
The quality is different, and the price is also very different. With high purity, few impurities, and strict quality, the price must be higher than usual.
The way of supply and demand is also the reason. If the market is wide and the supply is small, the merchant will raise the price to obtain a big profit; if the supply exceeds the demand, in order to sell the inventory, the price must be reduced to lure.
It is difficult to say the price of "5-iodo-1h-imidazole". For more information, you can consult a chemical material dealer, visit a professional trading platform, or refer to industry reports, so that you can get a near-real price.

5-Iodo-1H-imidazole is an organic compound, and its storage conditions are crucial, which is related to the stability and quality of this compound. Storage of this substance is the first to dry the environment. Because of its certain hygroscopicity, if the environment is humid, it is easy to cause chemical reactions such as hydrolysis, which will damage its structure and purity. Therefore, when placed in a dry place, such as in a sealed container equipped with a desiccant.
It is secondary to temperature control. It should be stored in a cool place to avoid high temperature. High temperature will greatly increase the activity of molecules, or initiate reactions such as decomposition and polymerization. Usually it is better not to exceed 30 ° C, and it is best to maintain it between 15 ° C and 25 ° C.
Furthermore, it should be protected from light. This substance may be sensitive to light, under light, or cause luminescent chemical reactions, which affect its chemical properties. It should be stored in an opaque container, such as a brown glass bottle, and placed in a dark place.
In addition, the storage place should be away from fire sources, oxidants, etc. Because it is an organic compound, it is flammable and prone to danger in case of fire sources; contact with oxidants, or react violently.
In short, the storage of 5-iodo-1H-imidazole needs to be dry, cool, protected from light, and away from dangerous items, so as to ensure the quality and safety of this substance.