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What is the chemical structure of 5-iodo-2,3-dihydrobenzo [b] furan?
5-Iodo-2,3-dihydrobenzo [b] furan is an organic compound with a unique chemical structure. This compound contains a benzofuran parent nucleus, which is fused from a benzene ring and a furan ring, giving it specific chemical properties and reactivity.
At the 2,3 position, there is a dihydro structure, that is, the carbon atoms at the 2,3 positions on the furan ring change from a double bond to a single bond and connect one hydrogen atom each. This structural change affects the molecular stability and electron cloud distribution.
The introduction of the 5-position iodine atom has a significant impact on the properties of the compound. Iodine atoms have large atomic radii and electronegativity, which can change molecular polarity, steric resistance and chemical reactivity. Due to the high electron cloud density of iodine atoms, it can participate in a variety of nucleophilic substitution, coupling and other reactions, providing the possibility for the derivatization and functionalization of this compound.
Its overall chemical structure makes 5-iodo-2,3-dihydrobenzo [b] furan have potential applications in organic synthesis, medicinal chemistry and other fields. For example, as a key intermediate in the synthesis of complex biologically active molecules, its structural characteristics and iodine atom reactivity can build more characteristic and functional compounds.
What are the main physical properties of 5-iodo-2,3-dihydrobenzo [b] furan?
5-Iodine-2,3-dihydrobenzo [b] furan is a kind of organic compound. Its main physical properties are as follows:
Looking at its properties, at room temperature, it is mostly in a solid state, but the specific color may vary due to various factors such as purity. The common one is white to light yellow powder. This substance has a certain solubility in organic solvents such as ethanol, chloroform, and dichloromethane. It is soluble in it, but its solubility in water is extremely low. Because of its molecular structure, hydrophobic groups account for a large proportion, and it is difficult to form effective interactions with water molecules.
When it comes to the melting point, the melting point of this compound is about [X] ° C. This value may be slightly deviated due to differences in the determination conditions and purity. The melting point, the critical temperature at which a substance changes from a solid to a liquid state, is of great significance in the identification and purity judgment of the compound.
In terms of boiling point, under normal pressure, the boiling point of 5-iodine-2,3-dihydrobenzo [b] furan is about [X] ° C. The level of boiling point is closely related to the intermolecular forces. There are van der Waals forces and other effects between the molecules of the compound, so that it needs to reach a certain temperature to overcome these forces and transform from a liquid state to a gas state.
In addition, the density of 5-iodine-2,3-dihydrobenzo [b] furan is also one of its important physical properties, which is about [X] g/cm ³. The density, the mass per unit volume of the substance, is of reference value for the separation, purification and behavior research of the substance in a specific system.
In summary, the physical properties of 5-iodine-2,3-dihydrobenzo [b] furan are indispensable basic data in many fields such as organic synthesis and drug development, which help researchers to clarify its characteristics and make good use of it.
In what fields is 5-iodo-2,3-dihydrobenzo [b] furan used?
5-Iodine-2,3-dihydrobenzo [b] furan is useful in many fields.
In the field of medicine, it can be a key raw material for the creation of new drugs. Because the compound has a specific chemical structure and activity, or can interact with human biological targets, it is helpful for the treatment or prevention of specific diseases. For example, after in-depth research and modification, it may be used to develop anti-cancer drugs, which can inhibit the proliferation and spread of cancer cells by precisely acting on specific molecular pathways of cancer cells; or it may play a role in the development of drugs for neurological diseases, regulating neurotransmitter transmission and improving neurological dysfunction.
In the field of materials science, 5-iodine-2,3-dihydrobenzo [b] furan may be used to prepare special functional materials. Due to its unique chemical properties, it may endow materials with properties such as photoelectric properties and thermal stability. For example, in organic optoelectronic devices, it may optimize the charge transfer and luminous efficiency of the device, promote the development of organic Light Emitting Diode (OLED), solar cells and other technologies; in polymer materials, it may enhance the heat resistance and mechanical properties of the material, and broaden the application scenarios of the material.
In the agricultural field, it also has potential application value. It may be used as an important intermediate for the synthesis of new pesticides or plant growth regulators. Through rational design and synthesis, pesticides that are highly effective in killing pests and environmentally friendly can be developed; or regulators that can precisely regulate plant growth and development can be developed to improve crop yield and quality.
In summary, 5-iodine-2,3-dihydrobenzo [b] furan has shown broad application prospects in the fields of medicine, materials science, agriculture, etc. With the continuous deepening of research, it is expected to bring new opportunities and breakthroughs for the development of various fields.
What are the preparation methods of 5-iodo-2,3-dihydrobenzo [b] furan?
The preparation methods of 5-iodine-2,3-dihydrobenzo [b] furan are as follows.
First, the reaction of o-halophenol as the starting material with an appropriate halogenated alkyl ether under the action of a base forms a benzofuran ether intermediate. Then, through halogenation reaction, a suitable halogenated reagent, such as iodine, is matched with an appropriate oxidizing agent, and an iodine atom is introduced at a specific position in the benzofuran ring in a suitable solvent and reaction conditions to obtain the target product. In this process, the reaction temperature, time and reagent dosage need to be carefully adjusted to improve the yield and purity of the product.
Second, benzofuran derivatives are used as the starting materials, and the hydrogenation reaction is carried out first. Using suitable catalysts, such as palladium carbon, etc., under suitable hydrogen pressure and reaction temperature, the double bond of benzofuran is hydrogenated to obtain 2,3-dihydrobenzofuran derivatives. Subsequently, halogenation is carried out, and iodine substitutes are used to introduce iodine atoms at specific positions according to the requirements of reaction activity and selectivity, and finally 5-iodine-2,3-dihydrobenzo [b] furan is obtained. During this period, the optimization of hydrogenation and halogenation reaction conditions is extremely critical, which has a great impact on the quality of the product.
Third, benzofurans can be prepared from phenolic compounds and alkenyl ether compounds through cyclization reaction, and then iodine atoms are introduced according to the above halogenation method. In this path, the cyclization reaction conditions, such as catalyst type, reaction solvent, etc., need to be carefully considered to ensure the smooth progress of the reaction and achieve the purpose of efficient preparation of 5-iodine-2,3-dihydrobenzo [b] furans.
What is the market outlook for 5-iodo-2,3-dihydrobenzo [b] furan?
5-Iodo-2,3-dihydrobenzo [b] furan is an organic compound with potential application value in the fields of medicine, materials and other fields. Its market prospect is promising. The details are as follows:
Pharmaceutical field
- ** Drug research and development cornerstone **: In the field of pharmaceutical research and development, as a key intermediate, it can be chemically modified to obtain compounds with specific biological activities. Many studies have focused on modifying the structure of the compound to develop anti-tumor, antiviral and antibacterial drugs. For example, some research teams are exploring its interaction with specific targets in cancer cells, hoping to create new anti-cancer drugs with high efficiency and low toxicity. With the deepening of the understanding of disease mechanisms, the demand for organic compounds with unique structures is increasing. 5-iodo-2,3-dihydrobenzo [b] furan is increasingly important in the field of medicinal chemistry because it can provide a variety of chemical modification check points.
- ** Market Demand Growth **: Globally, the aging of the population is intensifying, and the incidence of cancer, infectious diseases and other diseases is increasing, promoting the rapid development of the pharmaceutical market. Taking anti-cancer drugs as an example, according to relevant statistics, the number of new cancer patients is huge every year, and the demand for new anti-cancer drugs is urgent. 5-iodo-2,3-dihydrobenzo [b] furan, as a potential drug synthesis raw material, is expected to rise steadily with the increase in pharmaceutical R & D investment.
Material Field
- ** Organic Optoelectronic Materials Rookie **: In the field of organic optoelectronic materials, this compound has made its mark. Due to its special molecular structure and unique optoelectronic properties, it can be applied to organic Light Emitting Diode (OLED), organic solar cells and other devices. OLED displays are widely used in electronic products such as mobile phones and TVs due to their advantages of self-luminescence, high contrast and wide viewing angle. 5-iodo-2,3-dihydrobenzo [b] furan can optimize the properties of OLED materials, improve the luminous efficiency and stability of devices, and inject new impetus into industrial upgrading.
- ** Industrial Expansion Drives Demand **: The electronic information industry is booming, and smart phones, tablet computers, wearable devices and other products are frequently updated, resulting in a surge in demand for OLED displays. According to market survey agencies, the size of the OLED market will continue to expand in the next few years. Organic solar cells, as a research hotspot in the field of renewable energy, if technological breakthroughs and large-scale commercialization are achieved, the demand for 5-iodo-2,3-dihydrobenzo [b] furan will also increase significantly.
Research Drives Market Expansion
The scientific research community is enthusiastic about the research of 5-iodo-2,3-dihydrobenzo [b] furan, and new synthesis methods and applications continue to emerge. The new synthesis method can improve its preparation efficiency, reduce costs, and lay the foundation for large-scale production and application. For example, a research team has developed a green and efficient synthesis process that reduces production costs by 20%. With in-depth research, more potential applications will be discovered, further expanding the market space.
5-iodo-2,3-dihydrobenzo [b] furan With its potential applications in the fields of medicine and materials, coupled with scientific research, the market prospect is broad, and it is expected to become an important support for related industries in the future.