5-iodo-2,3-dihydrobenzofuran

5-Iodo-2,3-dihydrobenzofuran is an organic compound with a unique chemical structure. In this compound, the benzofuran ring system is the key structure, in which the furan ring is fused to the benzene ring, and it is in the dihydro state at the 2nd and 3rd positions, which means that there is a hydrogen atom at the 2nd and 3rd positions of the furan ring, reducing the number of double bonds, resulting in a change in the degree of unsaturation of the ring system.
Furthermore, the iodine atom is introduced at the 5th position, and the iodine atom is relatively large and has a certain electronegativity, which has a great impact on the physical and chemical properties of the compound. From the perspective of spatial structure, the iodine atom is large in size, which will change the spatial shape and steric resistance of the molecule; at the electronic effect level, the electronegativity of the iodine atom can change the electron cloud distribution on the benzofuran ring, thereby affecting the reactivity and stability of the compound.
Overall, the chemical structure of 5-iodo-2,3-dihydrobenzofuran is composed of benzofuran ring system and 5-position iodine substituent. These structural characteristics determine that it may show unique properties and application potential in organic synthesis, medicinal chemistry and other fields.

5-Iodine-2,3-dihydrobenzofuran has a wide range of uses in the field of organic synthesis.
First, it can be used as a key intermediate in pharmaceutical synthesis. When creating a specific drug, this compound can be chemically modified to build a biologically active molecular structure. Because of its unique chemical structure, it can interact with specific targets in organisms to demonstrate therapeutic efficacy. For example, in the development of neurological drugs, its structure can assist in the construction of molecules that conform to neurotransmitter receptors or enzyme activity checking points to regulate nerve signaling, or provide the possibility of treating neurodegenerative diseases, mental disorders, etc.
Second, it also has important uses in the field of materials science. Due to its special electronic and optical properties, it can be used to prepare functional organic materials. For example, in the development of organic Light Emitting Diode (OLED) materials, the structure of 5-iodine-2,3-dihydrobenzofuran can be adjusted to optimize the luminous efficiency and stability of the material, thereby improving the performance of OLED devices and making the display screen clearer and brighter.
Furthermore, in the synthesis of pesticides, it is also possible. Through reasonable chemical transformation, compounds with high control effect on specific pests can be derived. Its structure can be precisely designed to target key physiological processes in pests, such as interfering with the growth and development of pests, destroying their nervous system functions, etc., to achieve green and efficient pest control with little impact on the environment.
In short, 5-iodine-2,3-dihydrobenzofuran is an important basic substance in many fields such as medicine, materials, and pesticides, and its potential value needs to be further explored and utilized by researchers.

The synthesis of 5-iodine-2,3-dihydrobenzofuran involves multiple methods. One method can also be started with o-hydroxyphenylacetic acid. The o-hydroxyphenylacetic acid is first interacted with a suitable halogenating agent, such as phosphorus tribromide or thionyl chloride, to convert the carboxyl group into a haloacetyl halide. This haloacetyl halide is acylated by intramolecular Fu-gram, and under the catalysis of a suitable Lewis acid catalyst, such as aluminum trichloride, the ring is closed to form a benzofuran ring system. Subsequently, under suitable reaction conditions, an iodine atom is introduced at the 5-position. Iodine can be used to react with appropriate oxidants, such as hydrogen peroxide or nitric acid, in an acidic medium, so that the benzofuran ring system undergoes an electrophilic substitution reaction to obtain 5-iodine-2,3-dihydrobenzofuran.
Another method is to use 2,3-dihydrobenzofuran as a raw material. It is first modified with a protective group to protect the hydroxyl group or other easily reactive groups from unnecessary side reactions in subsequent reactions. After that, iodine atoms are introduced by a halogenation reaction. N-iodosuccinimide (NIS) can be selected as the iodine source. In the presence of appropriate solvents and catalysts, an electrophilic substitution reaction is carried out to selectively introduce iodine atoms at the 5-position. After the reaction is completed, the protective group is removed to obtain the target product 5-iodine-2,3-dihydrobenzofuran.
In addition, benzofuran derivatives are also used as starting materials. 2,3-dihydrobenzofuran derivatives are obtained by reduction reaction, and then iodine atoms are introduced by halogenation reaction. This reduction reaction can be carried out under suitable reaction conditions with suitable reducing agents, such as sodium borohydride or lithium aluminum hydride. The halogenation reaction is similar to the above, and the appropriate iodine source and reaction conditions are selected to achieve the synthesis of 5-iodine-2,3-dihydrobenzofuran.

5-Iodo-2,3-dihydrobenzofuran is an organic compound. Its physical properties are unique and related to many properties of this compound.
Looking at its appearance, under room temperature and pressure, it often takes a white-like to light yellow solid form. This form is stable and easy to store and operate.
When it comes to melting point, it is about a certain temperature range. Melting point is an important physical property of a substance, reflecting its lattice structure and intermolecular forces. The melting point of this compound indicates that at a specific temperature, its lattice structure begins to disintegrate, and the molecular motion intensifies, changing from solid to liquid.
In terms of solubility, organic solvents exhibit different solubility. Generally speaking, in organic solvents such as dichloromethane and chloroform, it has a certain solubility. Due to the molecular structure characteristics of the compound, suitable interactions can be formed with these organic solvent molecules, such as van der Waals forces, hydrogen bonds, etc., to promote its dissolution. In water, the solubility is very small. Due to the hydrophobicity of the compound molecule, the interaction between water molecules and compound molecules is weak, making it difficult to overcome the intermolecular force of the compound to disperse in water.
Furthermore, its density is also a specific value. The density reflects the mass per unit volume of the substance and is related to the degree of close accumulation of compound molecules. This value determines its position and distribution in the mixed system. The physical properties of 5-iodo-2,3-dihydrobenzofuran, such as its appearance, melting point, solubility, density, etc., play a key role in its application in organic synthesis, drug development, and other fields, providing an important basis for related research and practice.

5-Iodo-2,3-dihydrobenzofuran is one of the organic compounds. Its market price is difficult to determine quickly, covering the fluctuation of prices, subject to many factors.
First, the cost of raw materials is also. The price of various raw materials required for the preparation of this compound fluctuates from time to time. If the source of raw materials is scarce, or the process of producing raw materials encounters difficulties, resulting in higher costs, the price of 5-iodo-2,3-dihydrobenzofuran will also be affected and rise.
Second, the complexity of the preparation process is related to the cost. If the preparation process is extremely complex, high-end equipment, special reagents are required, and the steps are numerous, time-consuming, and require a lot of manpower and material resources, the production cost will increase greatly, and the market price will also be high.
Third, the state of market supply and demand is also the key. If the market has strong demand for 5-iodo-2,3-dihydrobenzofuran, but the supply is limited, the supply exceeds the demand, the price will go up; on the contrary, if the demand is weak and the supply is sufficient, the price will tend to decline.
Fourth, the scale and positioning of the manufacturer. Large-scale manufacturers, by virtue of economies of scale, may be able to reduce unit costs, and their prices may be more competitive; while manufacturers focusing on high-end quality and small batch production may have relatively high product prices.
In addition, market competition, transportation costs, storage conditions, etc., will also have an impact on their prices. Therefore, in order to determine the exact market price of 5-iodo-2,3-dihydrobenzofuran, it is necessary to carefully observe the current market conditions, consult relevant suppliers, chemical product trading platforms, etc., to obtain more accurate price information.