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What are the physical properties of 5-iodine-2-methyl-1H-imidazole?
5-%E7%A2%98-2-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91, it has unique physical properties. The state of this substance is often gaseous, colorless and odorless, lighter than air, and its density is about 0.0899g/L, which is only about one-fourteenth of the density of air, so it can float lightly in the air.
5-%E7%A2%98-2-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91 is highly flammable, and it is easy to burn and explode when exposed to open flames and hot topics in the air. When burned, it combines with oxygen to generate water and releases a lot of heat energy. It burns violently and is often accompanied by a bright flame. This combustion reaction equation is: 2H ² + O ² $\ stackrel {ignited }{=\!=\!=}$ 2H ² O.
Its solubility is also special, 5-%E7%A2%98-2-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91 extremely insoluble in water, this characteristic makes it easy to collect by drainage gas collection method.
Furthermore, 5-%E7%A2%98-2-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91 has excellent thermal conductivity, far exceeding many gases, and can quickly transfer heat. At very low temperatures, 5-%E7%A2%98-2-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91 can be converted into liquids, the temperature of liquid hydrogen is extremely low, about -252.87 ° C, and the density in the liquid state is also low, only 0.0708g/cm ³.
5-%E7%A2%98-2-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91 has an extremely fast diffusion rate and can be rapidly dispersed in air. Because of its many special physical properties, it has important uses in many fields such as aerospace and energy.
What are the chemical properties of 5-iodine-2-methyl-1H-imidazole?
1H-imidazole is a common organic compound that has important uses in many fields. Its chemical properties are quite unique. In ancient Chinese, it is described as follows:
1H-imidazole is weakly basic. Because of its five-membered ring structure, there is a nitrogen atom, which has a lone pair of electrons and can accept protons, so it is weakly basic. When exposed to acid, this nitrogen atom can combine with the proton of the acid to form a corresponding salt. If it encounters hydrochloric acid, it becomes a hydrochloride salt, which can be dissociated in water and exhibit certain ionic properties.
1H-imidazole is also nucleophilic. The lone pair of electrons of the nitrogen atom in its molecular structure makes imidazole a good nucleophilic reagent. In the reaction of organic synthesis, it can often attack electrophilic reagents. For example, in the substitution reaction of halogenated hydrocarbons, the nitrogen atom of imidazole can attack the carbon atom of halogenated hydrocarbons, and the halogen atom leaves, thereby forming a new carbon-nitrogen bond to form a derivative of imidazole.
1H-imidazole also has coordination properties. Because of its lone pair of electrons of nitrogen atoms, it can form coordination bonds with metal ions. Many metal ions, such as copper ions, zinc ions, etc., can coordinate with imidazole. The formed metal-imidazole complexes have outstanding performance in the field of catalysis and materials science. In catalytic reactions, such complexes can be used as efficient catalysts to accelerate the reaction process, and have certain selectivity, allowing the reaction to proceed according to a specific path and obtain the desired product.
In addition, 1H-imidazole is also quite significant in tautomerism. There can be two tautomers in the molecule, namely 1H-imidazole and 3H-imidazole, which can be converted into each other under certain conditions. This tautomerism has a great impact on the chemical properties and reactivity of 1H-imidazole. Under different reaction conditions, different tautomers may participate in the reaction, resulting in different reaction products and reaction rates.
What is the common synthesis method of 5-iodine-2-methyl-1H-imidazole?
There are many common synthesis methods of 5-bromo-2-methyl-1H-indole, which are described in the following details:
One of them is the Fischer indole synthesis method. This is a classic method, using phenylhydrazine and aldehyde or ketone as raw materials. First, the phenylhydrazine and the corresponding aldehyde or ketone undergo condensation reaction under acidic conditions to form phenylhydrazone. Subsequently, under the catalysis of protonic acid (such as polyphosphoric acid, concentrated sulfuric acid, etc.) or Lewis acid (such as ZnCl ², AlCl 🥰, etc.), the phenylhydrazone undergoes intramolecular cyclization and rearrangement to construct the indole ring. For example, if a suitable substituted phenylhydrazine is reacted with methyl ketone, after condensation and cyclization steps, 5-bromo-2-methyl-1H-indole can be obtained. The advantage of this method is that the raw materials are relatively easy to obtain, and the reaction conditions are controllable to a certain extent; however, its disadvantages cannot be ignored. Some reaction conditions are more harsh, and there are certain requirements for the structure of the substrate, and many side reactions may occur during the reaction process.
The second is the transition metal catalytic synthesis method. Among them, palladium catalysis is widely used. Usually halogenated aromatics (such as 5-bromo halogenated aromatics) and enamines are used as raw materials. In the presence of palladium catalysts (such as Pd (PPh)
, etc.) and suitable ligands and bases, intramolecular cyclization reactions occur. For example, selecting appropriate 5-bromo halogenated aromatics and enamines with suitable substituents, in the palladium catalytic system, by optimizing the reaction conditions, the indole ring is realized. This method has the advantages of good reaction selectivity and can be carried out under relatively mild conditions, but the price of palladium catalysts is expensive, which limits its large-scale application to a certain extent.
The third is the o-amino acetophenone method. Using the o-amino acetophenone derivative as the starting material, the amino group is properly protected first, and then the bromination reaction is carried out under suitable conditions, and bromine atoms are introduced at the specified position. The target product 5-bromo-2-methyl-1H-indole was obtained by intra-molecular cyclization reaction. The route of this method is relatively clear, and the operability of each step is relatively strong, but there are relatively many steps, and the overall yield may be affected by the multi-step reaction.
In which fields is 5-iodine-2-methyl-1H-imidazole used?
5-% E7% A2% 98 involves 1H-imidazole, which is used in many fields. In the field of medicine, this is a key intermediate in organic synthesis. Many drugs are prepared by 1H-imidazole as a raw material or structural unit. For example, some antifungal drugs contain 1H-imidazole groups in their structures, which inhibit the growth and reproduction of fungi by interacting with specific targets in fungal cells, providing an effective means for the treatment of fungal infections. In the research and development of antibacterial drugs, 1H-imidazole also shows important value, which can destroy bacterial physiological processes and achieve antibacterial effect through unique chemical structure and bacterial interaction.
In the field of materials science, 1H-imidazole can be used to prepare functional materials. Due to its special chemical properties and structure, it can participate in material synthesis reactions and endow materials with special properties. For example, the preparation of adsorption materials with specific adsorption properties, the 1H-imidazole structure can interact with specific substances to achieve efficient adsorption and separation of specific substances, and has potential application prospects in the treatment of environmental pollutants and resource recycling. In the preparation of conductive polymer materials, 1H-imidazole can be used as a structural modification unit to improve the electrical properties of materials and expand its application in the field of electronic devices.
In the field of chemical production, 1H-imidazole is an important chemical raw material and catalyst. In organic synthesis reactions, it can be used as a catalyst to accelerate the reaction process and increase the reaction yield. For example, in some esterification reactions and cyclization reactions, 1H-imidazole can effectively catalyze the reaction, optimize the chemical production process and reduce production costs. At the same time, 1H-imidazole can also be used to synthesize a variety of fine chemicals, such as fragrances, dyes, etc., to enrich product types and enhance product added value for the chemical industry.
In the field of coordination chemistry, 1H-imidazole can be used as a ligand to form complexes with metal ions. Such complexes often have unique structures and properties, showing potential application value in catalysis, optics, magnetism and other fields. For example, some 1H-imidazole metal complexes can be used as high-efficiency catalysts, showing high activity and selectivity in organic synthesis reactions; some complexes can be used in luminescent materials, fluorescent probes and other fields due to their special optical properties. Overall, 1H-imidazolium plays an important role in many fields due to its unique structure and chemical properties. With the development of science and technology, its application prospects will be even broader.
What is the market price of 5-iodine-2-methyl-1H-imidazole?
The price of methyl ether in the market is related to all kinds of reasons, which is not easy to say.
First, the balance between supply and demand is also necessary. If the demand of the market is prosperous, and the supply is small, the price will rise. For example, in this season, a certain domain is using methyl ether as a burning device. Everyone wants it, but the product is not enough to meet its needs, which will cause the price to rise. On the contrary, if the supply exceeds the demand, the product will be produced in large numbers, and the use will be rare, and the price will drop from time to time.
Second, the cost of production also affects the price. The production of methyl ether requires the cost of raw materials, manpower, and equipment. If the price of raw materials is too high, such as the price of materials used to make methyl ether, or the increase in manpower and equipment consumption, the cost of production will be high, and its price in the market will have to be higher.
Furthermore, the rules and regulations of the government and the system of laws also have an impact on its price. If the government issues a policy to reward the production and use of methyl ether, and to reduce or increase the tax, the producer will be helped, and the price will be stable or reduced. On the contrary, if strict regulations are established, taxes will be increased, and production will be limited, the price may change accordingly.
The competition in the market of methyl ether is also a variable in price. The city of methyl ether is fought by all merchants. Those who are good at business will compete for the market with high quality and low price. If the same industry is good at their own things and competes on price, the price will drop. If there is a unique skill to control a corner of the market, the price may be determined independently.
Overall, the price of 1H-methyl ether in the market is determined by supply and demand, cost, political regulations, market competition and other things. It becomes impermanent, and it is necessary to observe the situation carefully before we can know the trend of its price.
