5-iodo-2-methylphenyl-5-(4-fluorophenyl)-2-thienyl Ketone

5-Benzyl-2-methylfuran-5- (4-ethylfuran) -2-furfuryl ether, this is a class of organic compounds with important uses in organic synthesis and medicinal chemistry. Its main uses cover the following ends:
Medicinal Chemistry
1. ** Construction of Active Molecular Skeleton **: In many drug development processes, the compound's unique chemical structure can serve as a core skeleton. Due to its specific spatial configuration and electronic properties, it can precisely fit with targets in vivo. For example, when exploring anti-tumor drugs, researchers will use it as a basis to modify side chains or introduce specific functional groups to create new drug molecules with high selective inhibitory activity on tumor cells. This is like building a delicate building. 5-benzyl-2-methylfuran-5- (4-ethylfuran) -2-furfuryl ether is the solid foundation on which a "building structure" with unique functions can be built to achieve effective treatment of diseases.
2. ** Improves drug properties **: This compound can affect the physicochemical properties of drugs, such as solubility, stability and bioavailability. If the drug is not well soluble, it is difficult to transport it smoothly in the body and reach the target of action. The proper introduction of 5-benzyl-2-methylfuran-5- (4-ethylfuran) -2-furfuryl ether can optimize the solubility of drugs, just like putting on a pair of "convenient shoes" for drugs, so that they can travel freely in the body, thereby improving the efficacy of drugs.
Organic Synthesis Field
1. ** Key Intermediates **: As a key intermediate in organic synthesis, it can participate in a variety of chemical reactions, such as nucleophilic substitution, cyclization reactions, etc., to build more complex organic molecular structures. For example, when synthesizing materials with special optical or electrical properties, it can be used as a starting material to gradually build the required complex macromolecular structure through a series of carefully designed reaction steps. This is like in a precise jigsaw puzzle, it is one of the important basic puzzles, and through clever splicing with other puzzles, a complete and complex pattern is finally formed.
2. ** Guide to organic synthesis routes **: Its unique structural characteristics can provide guidance for the design of organic synthesis routes. Chemists can plan efficient and concise synthesis strategies based on its reactivity and check point selectivity, reduce synthesis costs and steps, and improve synthesis efficiency. This is like drawing a precise map for the synthesis journey, guiding the chemist along the right path to reach the other side of the target compound.

To prepare 5- (4-hydroxybenzyl) -2-benzyl furanate, there are many synthesis methods, the following are the common ones:
Esterification method
First, the esterification reaction between 5- (4-hydroxybenzyl) -2-furanic acid and benzyl alcohol is carried out in the presence of a catalyst. Commonly used catalysts are protonic acids such as sulfuric acid, p-toluenesulfonic acid, or Lewis acids such as scandium trifluoromethanesulfonate. During the reaction, the two are placed in a reaction vessel in a certain proportion, an appropriate amount of catalyst is added, and toluene or benzene is used as a water-carrying agent, and heated to reflux. In this process, the acid and alcohol are dehydrated and condensed to form esters. For example, p-toluenesulfonic acid is used as a catalyst, toluene is used as a water-carrying agent, and the reaction is heated to 110-120 ° C for several hours. After the reaction is completed, the product can be obtained by washing with water, alkali washing, drying, and vacuum distillation. This method is relatively simple to operate and the raw materials are easy to obtain.
Acyl chloride method
First 5- (4-hydroxybenzyl) -2-furanic acid is made into acyl chloride, and chlorination reagents such as dichlorosulfoxide and phosphorus trichloride are commonly used. Taking dichlorosulfoxide as an example, the acid is mixed with an appropriate amount of dichlorosulfoxide, a little N, N-dimethylformamide is added as a catalyst, and the excess dichlorosulfoxide is heated and refluxed. After the reaction, the acid chloride is reacted with benzyl alcohol in the presence of acid binding agents (such as pyridine, triethylamine, etc.) to generate 5- (4-hydroxybenzyl) -2-benzyl furanate. This method has high reactivity and the yield is usually good, but it should be noted that the chlorination reagent is corrosive and irritating.
Transesterification method
If there are suitable 5- (4-hydroxybenzyl) -2-furanoic acid lower esters (such as methyl ester, ethyl ester), the transesterification reaction can be carried out with benzyl alcohol under the action of catalyst. The catalyst can be basic catalysts such as sodium methoxide and sodium ethanol, or organometallic compounds such as tetrabutyl titanate. During the reaction, the two are mixed with the catalyst, heated to an appropriate temperature, and the generated lower alcohol is continuously evaporated to promote the positive reaction. For example, sodium methoxide is used as the catalyst, heated to 120-130 ° C for reaction, and the product can be obtained after separation and purification. The conditions of this method are relatively mild, but the raw material selectivity is high.

"Tiangong Kaiwu" has a saying: "The genus of hardware has different types, but they are all formed by yin and yang." Today, glutaric anhydride, this is an organic compound, and its physical and chemical properties are unique.
Glutaric anhydride, at room temperature, is in a white crystalline state. It looks like frost and snow, with a fine texture. Its melting point is quite distinct, about 50 to 52 degrees Celsius. When it is slightly warm, it melts into a flowing liquid, like ice disappearing in the warm sun. The boiling point is between 280 and 282 degrees Celsius. It turns into a gaseous state in a high temperature environment and rises.
Its solubility also has characteristics. In water, glutaric anhydride can react to form glutaric acid, just like a salt melts in water and quietly changes its form. In organic solvents, such as ether, ethanol, benzene, etc., it can dissolve better, just like a fish entering water and fusing freely, which facilitates its use in many chemical synthesis and industrial applications.
In terms of chemical properties, glutaric anhydride has the typical characteristics of acid anhydride, which is active and easy to react. When it encounters alcohols, it can undergo an alcoholysis reaction to form an ester compound, just like two delicate components fit together to form a new structure. When it encounters amines, an aminolysis reaction occurs to produce amides, which are all important reactions in organic synthesis, like a key step in building a chemical building.
Furthermore, glutaric anhydride has a certain stability, and when it encounters strong acids and alkalis, it will also be affected by it and the structure will change. Under suitable conditions, it can also participate in the polymerization reaction to form a polymer, which is like countless small beads in series to form chains, expanding its field application. Glutaric anhydride has emerged in many fields such as chemical industry, medicine, and materials due to its unique physical and chemical properties, adding luster to human production and life.

The prices of drugs on the Guanfu market are related to people's livelihood and cannot be ignored. Today, there is a 5-% question - 2-methylpyridine - 5 - (4-chloropyridine) - 2-aminopyrimidine drug. The price range of this drug on the market should be explored in detail.
The price of the drug can be determined in different ways. The production of raw materials, the difficulty of procurement, and the simplicity of preparation are all involved. The source of methyl itself is wide or narrow. If it is easy to obtain, the price should not be too high; if it is difficult, the price will rise. The same is true for chloropyridine. As for the combination of the two to 5- (4-chloropyridine) -2-aminopyrimidine, the preparation method, the coarse process, and the cost of manpower are all related to the price.
Also looking at the market supply and demand, if this product is urgently needed by doctors, there are many applicants and few suppliers, and the price will increase; if the supply exceeds the demand, although the quality is beautiful, the price will not be able to rise. Furthermore, the regulations of the government and the tax system also affect the price of medicine. If the tax is heavy, the merchant will turn it to the price, causing the price to rise; if the tax is light, the profit will be wide, and the price may drop.
However, it is not easy to determine the price range of 5- (4-chloropyridine) -2-aminopyrimidine in the market. Those who have not personally dealt with the cities and consulted the merchants, considering the classics, it is difficult to determine the number. Roughly speaking, based on the normal conditions of raw materials, production methods and supply and demand, if the raw materials are easy to obtain, the production method is not complex, and the market supply and demand are slightly uniform, the price may be within a certain range. However, the market changes, the impermanent situation can be followed, or due to the sudden shortage of raw materials, or the large increase in demand due to epidemics, the price will also change accordingly. Therefore, in order to obtain an accurate price, it is necessary to conduct field research and carefully observe the market conditions before we can obtain it.

Mercury is a commonly used thing in the world, and when it is used, there are many taboos and must not be ignored.
Mercury is lively and can evaporate at room temperature, and its gas is highly toxic. Therefore, when using mercury, the first thing to pay attention to is the place where you are. It must be well ventilated so that the mercury gas dissipates quickly and does not gather in the room. If you are in a secret room, mercury gas accumulates, and if you inhale it for a long time, it will damage people's internal organs and disrupt people's minds. It will cause illness to be invisible, and there will be no great disaster.
Furthermore, the use of mercury should be handled with care. Its mass is slippery and easy to spill and lose. Once scattered, it is difficult to collect and difficult to find, and it is scattered everywhere, and it continues to evaporate, which is harmful for a long time If it is accidentally sprinkled, it should be covered with sulfur as soon as possible, so that mercury and sulfur combine to form non-toxic mercury sulfide, and then it can be eliminated.
Also, people who handle mercury must wear protective gear, such as special clothes and gloves, to prevent mercury from getting on the body. Mercury touches the skin and can seep into the body, harming the viscera and meridians. And do not let mercury enter the mouth by mistake. If mercury enters the stomach, the poison will be rapid, and the viscera will be injured, endangering life.
Although mercury is an important substance for medicinal stones, alexandrite refining, etc., it is poisonous and cannot be used carelessly. It is necessary to abide by the above things to ensure the safety of mercury and prevent it from being harmed. This is a matter of life and must not be ignored.