5 Iodo 2 Pyridinamin
Iodobenzene

5-Iodo-2-Pyridinamin

Fengxi Chemical

    Specifications

    HS Code

    637016

    Chemical Formula C5H5IN2
    Molar Mass 219.99 g/mol
    Appearance Solid (usually)
    Melting Point Data dependent on purity, typically in a certain range
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, dichloromethane
    Density Data may vary based on form and purity
    Pka Related to its acidic - basic properties, specific value depends on conditions
    Stability Stable under normal conditions, but may react with strong oxidizing agents
    Chemical Formula C5H5IN2
    Molar Mass 218.01 g/mol
    Odor Odor likely faint and characteristic of pyridine - amine - iodine derivatives
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents
    Reactivity Can participate in substitution reactions due to iodine and amine groups

    As an accredited 5-Iodo-2-Pyridinamin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 5 - iodo - 2 - pyridinamine in 100 - gram bottles, well - sealed for chemical storage.
    Storage 5 - iodo - 2 - pyridinamine should be stored in a cool, dry place, away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Store it separately from oxidizing agents and incompatible substances. Ideal storage temperature is around 2 - 8°C in a refrigerator if long - term stability is required.
    Shipping 5 - iodo - 2 - pyridinamine is shipped in sealed, corrosion - resistant containers. Special care is taken to ensure it's isolated from incompatible substances. Shipment follows strict chemical transportation regulations for safe delivery.
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    5-Iodo-2-Pyridinamin
    General Information
    Historical Development
    5-Iodo-2-Pyridinamin, chemical things are also. Tracing its origin, at the beginning, the researchers explored the subtle chemical world and observed it. At that time, the technology was not as good as it is today, and the research was difficult.
    However, the sages were not discouraged. After years of study, they gradually understood its nature. Began to seek a simple method, although they have been frustrated many times, they are still unremitting. With the passage of time, science and technology have advanced day by day, and the method of making has become more and more refined. In the past, the materials used were rare, the steps were complicated, and the amount of production was thin. Not so now, the new method has come out, the materials used are easy to obtain, the process is orderly, and the output is gradually abundant.
    From this point of view, the development of 5-Iodo-2-Pyridinamin is the blood coagulation of the researchers, after years of tempering, before they have today's appearance, in the field of chemistry, gradually showing its importance.
    Product Overview
    5-Iodine-2-pyridylamine is also a chemical I have recently studied. This substance has unique properties, light yellow in color, like a crystal powder, and is quite stable at room temperature. Its melting boiling point has been accurately determined, and there is an exact number.
    Its use is in the field of pharmaceutical synthesis, with extraordinary potential. It can be used as a key intermediate to help create new drugs, which is expected to add a sharp edge to the treatment of many diseases.
    The preparation method has been tested and improved repeatedly, and an effective path has been obtained. Starting with specific pyridine derivatives, after several delicate reactions, this product can be controlled and the yield is considerable.
    For follow-up research, I will focus on optimizing its synthesis process to improve yield and purity. I will also delve into more potential applications in the field of medicine, hoping to save the world and contribute what I have learned.
    Physical & Chemical Properties
    5-Iodo-2-Pyridinamin, organic compounds also. It has unique physical and chemical properties. In terms of physical properties, at room temperature, it is either solid, its color, or white to yellowish, and the texture is crystalline, with a certain melting point, which can be measured by precise instruments. Regarding its solubility, in some organic solvents, it may have a certain solubility, but in water, its solubility may be limited.
    As for chemical properties, in its molecular structure, iodine atoms and pyridine amines give it active reactivity. It can react with nucleophiles, and iodine atoms are easily replaced by other groups. And pyridylamine can also participate in many reactions, such as salting with acids, or condensing with aldars, ketones and other compounds under specific conditions to form novel compounds. These physicochemical properties may have important applications in the field of organic synthesis.
    Technical Specifications & Labeling
    5-Iodo-2-Pyridinamin, the quality of the product is also important.
    If you want to clarify the quality of the product, the degree of research and refinement, and the content of the product must be controlled in a low environment. Its shape, or powder, or crystal, is clear. Physicality, such as melting, boiling, etc., are all important to measure.
    As for the quality of the product, the product needs to be outside. The name and formula cannot be used, and the place, batch, etc. On the package, warnings are also indispensable to inform users of their characteristics and things to pay attention to. In this way, the product can be properly used in research, production, etc., to ensure its effectiveness, to ensure safety and promote progress.
    Preparation Method
    The raw materials, production process, reaction steps and catalytic mechanism of 5-Iodo-2-Pyridinamin are the key. First, pyridine is taken as the base material, and a halogenating agent is added. After halogenation, iodine atoms are conducted at the two positions of the pyridine ring to obtain 2-iodine pyridine. Then, under the conditions of ammonia or amine reagents, under the condition of temperature and pressure and the assistance of catalysts, 2-iodine pyridine and ammonia or amine undergo nucleophilic substitution, and the two iodine atoms of pyridine are substituted with amino groups, and finally 5-Iodo-2-Pyridinamin is obtained. In the reaction, temperature, pressure and reagent ratio are precisely controlled, and high-efficiency catalysts, such as palladium catalysts, are selected to promote the reaction, increase the rate and purity of the product, and ensure the efficiency and quality of production.
    Chemical Reactions & Modifications
    I try to study the reaction and properties of the 5-Iodo-2-Pyridinamin. The reaction of this compound often needs to be adapted to the temperature and the appropriate agent in order to get the best effect. In the past, when I tried it by the usual method, the yield was not good, and the side should be proliferated.
    After thinking about it, I changed the environment, adjusted the temperature, and changed the agent. There is progress. The control of temperature is related to the speed and purity of the product. The choice of agent is also important, because it can promote the process.
    In the chemical property, 5-Iodo-2-Pyridinamin unique, and can be used with all things to form new compounds. The way it should be opens up a new path for researchers. After many attempts, gradually understand its nature, and should know all the reasons, after the period can be better, expand its use, for the world to add new color.
    Synonyms & Product Names
    It is common sense to taste the names of things in the world. In today's words 5 - Iodo - 2 - Pyridinamin, its proper name is established, but it is also interesting to call it another name.
    5 - Iodo - 2 - Pyridinamin, or some colleagues call it by different names. Although it is one thing, the name varies often due to region and research emphasis. Like the ancient medicinal pills, there are many who have the same name but different names.
    In the field of our chemical research, 5 - Iodo - 2 - Pyridinamin may have a similar common name in addition to its correct name, so that it should be studied for convenience. These nicknames, although not officially determined, are passed down by word of mouth among researchers, and are also a corner of the inheritance of chemical knowledge. Just as the names of medicines contained in ancient books, one place has one place, but they all refer to the same thing. 5 - Iodo-2 - The nickname of Pyridinamin, or hidden in research records, or in the conversation of scholars, will be explored in detail by us.
    Safety & Operational Standards
    5 - Iodo - 2 - Pyridinamin is an important chemical. It is important for its experimental operation and safety. We should adopt a prudent attitude and abide by the established norms.
    In the operating area, it is first necessary to ensure good ventilation. This is to disperse harmful gases that may escape, so as not to accumulate in the space and endanger the health of the experimenter. Furthermore, the lighting must be sufficient and stable to provide a clear field of vision for the experimental operation and avoid operation errors due to dim light.
    The experimenter's own protection should not be underestimated. When entering the operation area, you must wear a professional laboratory suit, which can not only resist the erosion of chemical substances, but also has fire protection and other characteristics. At the same time, wear suitable protective gloves. According to the specific situation of the experiment, choose acid-resistant and alkali-resistant materials to protect your hands from damage. Eye protection is also indispensable. Protective glasses can effectively block splashing chemicals and prevent them from causing damage to the eyes.
    During operation, when using 5-Iodo-2-Pyridinamin, be sure to use clean and accurate equipment. Weighing needs to be carried out on an accurate balance to ensure the accuracy of the dosage, so as to avoid the deviation of the dosage affecting the experimental results or even causing danger. When dissolving the substance, the solvent should be added slowly and stirred continuously. Pay attention to the speed and strength of stirring. It is necessary to ensure that the solution is fully dissolved and not too violent to cause the solution to splash out.
    If you accidentally come into contact with 5 - Iodo - 2 - Pyridinamin and touch the skin, you should immediately rinse with a large amount of water, and then proceed to further treatment according to the specific situation, such as applying the corresponding ointment. If it enters the eyes, you need to race against time, rinse the eyes with a large amount of water continuously, and seek medical attention quickly.
    After the operation is completed, the remaining 5 - Iodo - 2 - Pyridinamin and related waste must be stored and disposed of in accordance with regulations. Do not discard it at will to avoid pollution to the environment and unpredictable consequences. In short, when dealing with 5 - Iodo - 2 - Pyridinamin, safety and standardized operation are the top priority, and no slack should be allowed.
    Application Area
    5 - Iodo - 2 - Pyridinamin is a special chemical substance. Its application field is quite wide. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize drugs with specific curative effects, or to develop new drugs for some difficult diseases. In the field of materials science, its unique chemical structure may endow materials with different properties, such as improving material stability and conductivity. In the field of organic synthesis, with its active groups, it can participate in multiple reactions, build complex organic molecular structures, and lay the foundation for the creation of new organic materials. It is an important substance that cannot be ignored in chemical research and application, and has potential application value in many fields, which needs to be further explored and explored.
    Research & Development
    I am committed to the study of 5-Iodo-2-Pyridinamin. This substance has unique properties and has great potential in many fields. At the beginning, I explored its chemical structure, and after repeated experiments and analysis, I learned the subtlety of its molecular structure. Then I studied its reaction characteristics and observed its changes under different conditions.
    In order to expand its application, I tried to improve the synthesis path in various ways, hoping to improve the yield and purity. In the process, although I encountered many difficulties, such as harsh reaction conditions and complicated side reactions, I did not give up and constantly adjusted my strategy.
    Today, I have obtained some results, and the application in specific fields has shown initial results. However, we are well aware that the road ahead is still far away, and we will continue to explore it in the future, hoping to further tap its potential, achieve greater development, and contribute to the progress of related fields.
    Toxicity Research
    Taste the harm of poisons in the world, even more than tigers. Today's research 5-Iodo-2-Pyridinamin this substance, the study of toxicity is very important. Examine its properties in detail, explore changes in various media, observe its contact with other substances, and the resulting transformation. There are non-toxic substances escaping, and harmless gas rising.
    After various experiments, it can be known that it is under high temperature, or in contact with strong acids and alkalis, and the toxicity changes cannot be ignored. Its molecular structure, iodine is connected to pyridine amino groups, and this structure may be one of the root causes of toxicity. And in living organisms, it may interfere with the normal metabolism of cells, hinder its growth, and damage its function.
    However, to fully understand its toxicity, it is necessary to collect extensive data and analyze it in detail. It is necessary to use a rigorous attitude to clarify the depth and scope of its toxicity, which is the right path for the academic community and can also be used to avoid harm for the world.
    Future Prospects
    5-Iodo-2-Pyridinamin, it is also a thing of transformation. We study it here, observe its nature, think about its unfinished development, and hope for it.
    Now this thing has been used for its usefulness, but there is no way to do it, and there is no world. Or it can be used in the research of new materials to relieve the pain of the world. Its unique features may lead to the exploration of new and anti-chemical, and expand the new realm of research.
    Or in the material science, develop its wonders and help the performance of materials to improve. We, the researchers, work hard to clarify its secrets, so that 5-Iodo-2-Pyridinamin can be greatly used and benefit the world. This is my unseen vision.
    Historical Development
    5-Iodo-2-Pyridinamin, chemical substances are also. The historical development of its matter has been studied more and more deeply in the academic community in the past. At the beginning, people explored the field of organic synthesis, hoping to obtain new compounds to expand their understanding. After many experiments and several years of research, this 5-Iodo-2-Pyridinamin was obtained at a certain time. At that time, scholars studied its properties and structures in detail to clarify its characteristics. Since then, with the evolution of science and technology, the methods of analysis have become more refined and its understanding has deepened. Many chemists have also devoted themselves to related research, or explored new methods of synthesis, or studied its effectiveness in different reactions. As the years passed, this compound has gradually developed its use in medicine, materials and other fields, adding to the development of science, and its historical development has become what it is today.
    Product Overview
    5 - Iodo - 2 - Pyridinamin is a special substance involved in the process of chemical research. Its shape or crystalline state, color or light, pure and stable. Looking at its structure, iodine and amino groups in the pyridine ring are ingeniously intertwined, and this unique structure gives it specificity.
    In the reaction, the activity of iodine can lead to the change of nucleophilic substitution, and amino groups can also participate in many reactions, and merge with other phases to form new bonds. This substance has great potential in the field of pharmaceutical research and development, or is the basis for the creation of new agents. Also in the synthesis of materials, it can be used as a key intermediate to help create new materials.
    I dedicate myself to studying it, hoping to explore its secrets and expand its uses, so as to benefit the chemical and pharmaceutical industries, so that this wonderful thing can bloom and contribute to human well-being.
    Physical & Chemical Properties
    5 - Iodo - 2 - Pyridinamin is also a chemical substance. Its physical and chemical properties are relevant to our research. The appearance of this substance may be in a specific state, or as a powder, or as a crystal, and the color is also characterized. Its melting point and boiling point are key physical properties. The level of melting point is related to the temperature range of its physical state change; the boiling point shows what temperature it gasifies at.
    The solubility is also not negligible. It is different in various solvents. It is soluble or insoluble in solvents such as water, ethanol, and ether. This property affects its application in different reaction systems.
    Chemically, it contains iodine and pyridylamine structures. The activity of iodine makes this substance participate in halogenation-related reactions. The nitrogen atom of the pyridylamine part has lone pairs of electrons, which can undergo nucleophilic or coordination reactions with other substances. Such physical and chemical properties lay a solid foundation for the in-depth study and application of this substance.
    Technical Specifications & Labeling
    5-Iodo-2-Pyridinamin is the chemical product we are studying. Its technical specifications and identification (product parameters) are crucial.
    In terms of technical specifications, the purity must be of the highest standard, and the impurity content should be minimal. This is related to the performance of the product in various reactions and applications. Parameters such as crystal structure and particle size distribution also affect its physical and chemical properties.
    As for the identification, the name "5-Iodo-2-Pyridinamin" should be clearly marked, indicating the exact chemical formula to ensure that its chemical composition is correct. Product grades and batch numbers are also indispensable for traceability. In addition, safety labels are indispensable to warn potential hazards, so that users can properly protect and ensure safe operation. This is the essence of 5-Iodo-2-Pyridinamin technical specifications and labels.
    Preparation Method
    5-Iodo-2-Pyridinamin is an important chemical substance, and the preparation method is related to the raw materials, production process, reaction steps and catalytic mechanism, all of which need to be considered in detail.
    Preparation of raw materials requires careful selection. Select the appropriate pyridine derivative, use it as the starting substrate, and match the iodine source. The quality and purity of the two are very important and directly affect the quality of the product.
    In the production process, first place the pyridine derivative in a suitable reaction vessel, control the temperature moderately, slowly add the iodine source, stir evenly, and promote the reaction to proceed fully. The reaction steps should be carefully operated, and the reaction should be initiated first. After the system is stable, specific additives should be added in sequence to adjust the reaction environment.
    In terms of catalytic mechanism, specific catalysts can be introduced, which can effectively reduce the activation energy of the reaction, speed up the reaction rate, and improve the yield of the product. However, the amount of catalyst needs to be precisely controlled, and excess or insufficient will affect the reaction effect. In this way, high-quality 5-Iodo-2-Pyridinamin products can be obtained.
    Chemical Reactions & Modifications
    5-Iodo-2-Pyridinamin is an important substance in chemistry, which is related to many chemical reactions and property changes. In the field of chemical synthesis, its reaction path is often the focus of scholars' research.
    Past experiments have found that under the initial reaction conditions, the yield of the reaction involving 5-Iodo-2-Pyridinamin is not ideal. However, after repeated scrutiny, chemists have changed the proportion of reactants, adjusted the reaction temperature and duration, just like a craftsman, carefully regulated various factors.
    After this adjustment, the reaction showed a positive change. The yield was significantly improved, and the side reactions were effectively suppressed. The properties of this substance also showed a different style, the stability was enhanced, and the solubility in specific solvents was better. Chemists are like treasure hunters who relentlessly explore 5-Iodo-2-Pyridinamin potential hidden in chemical reactions to achieve better chemical results.
    Synonyms & Product Names
    5 - Iodo - 2 - Pyridinamin is very important in our chemical research. It also has many synonymous names. Although the names are different, they all refer to this thing.
    As far as its trade name is concerned, there are also many expressions. This is because the field of chemical research is wide, different regions, different research groups, or based on habits, or based on specific research needs, give different names to the same substance.
    However, regardless of how its synonymous name and trade name change, its essential characteristics remain unchanged. In the process of chemical synthesis, researchers need to clarify its many terms in order to use them accurately and avoid research bias due to name confusion. In this way, we can move forward steadily on the path of chemical exploration, and conduct in-depth research on 5-Iodo-2-Pyridinamin to explore its potential value and uses.
    Safety & Operational Standards
    5 - Iodo - 2 - Pyridinamin is an important chemical and is essential for its safety and handling practices.
    Handling this chemical should be carried out in a well-ventilated place. Due to its toxicity and irritation, operators must wear appropriate protective equipment, such as protective gloves, goggles and protective clothing, to ensure their own safety. During operation, diet and smoking are strictly prohibited to prevent harmful substances from ingesting into the body.
    Store 5 - Iodo - 2 - Pyridinamin in a cool, dry and ventilated place away from fire and heat sources. It needs to be stored separately from oxidants, acids, etc., and must not be mixed to avoid dangerous chemical reactions. The temperature and humidity of the storage environment should also be strictly controlled and recorded.
    If you accidentally come into contact with this chemical, you need to take appropriate measures immediately. If it comes into contact with the skin, you should quickly rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment; if you come into contact with the eyes, you should also rinse with a large amount of water, lift the eyelids, and ensure thorough cleaning, and then seek medical attention as soon as possible.
    When transporting 5 - Iodo - 2 - Pyridinamin, it is necessary to follow the relevant regulations on the transportation of hazardous chemicals, select suitable transportation tools, and make corresponding protection and labeling to ensure the safety of the transportation process, avoid leakage and other accidents, and then maintain public safety and environmental safety. In this way, we can ensure that 5 - Iodo - 2 - Pyridinamin can be safely and properly handled in all aspects, effectively reducing latent risks.
    Application Area
    5-Iodo-2-Pyridinamin, the wonders of chemistry. Its application field is worth exploring. In the field of medicine, it can be used as an active ingredient to help heal diseases. Doctors hope it has special pharmacology, treats all kinds of diseases, and relieves pain for people suffering from diseases. And in the world of materials, it can add new qualities and make materials have specific properties. Craftsmen or hope to make new materials for utensils and increase their functions. Moreover, in the process of scientific research, it can be an important reagent and help students explore the mysteries of chemistry. Scholars use it to experiment, to clarify the nature of matter, and to expand the knowledge of chemistry. Its application in various fields has infinite possibilities, waiting for my generation to study it in depth, so as to develop its ability and benefit the world.
    Research & Development
    In recent times, the art of chemistry has advanced day by day, and all kinds of new things have come out. I have been focusing on the research of 5-Iodo-2-Pyridinamin for a long time.
    At the beginning, the method to obtain this substance was cumbersome and ineffective. We studied the classics day and night, and tried various paths. After months of hard work, we found a feasible method to obtain this product stably.
    Looking at its properties, 5-Iodo-2-Pyridinamin exhibits unique activity in specific reactions, and can interact ingeniously with a variety of reagents to generate novel structural products.
    As for its development, this substance has great potential in the field of medicinal chemistry. Or we can use its unique structure to develop new drugs and add a weapon to the cure of various diseases. We will continue to explore in depth, hoping to expand its application, take a wider step in the road of science, and benefit the world and promote the development of this field.
    Toxicity Research
    The taste of chemical substances is related to people's livelihood, but the study of its toxicity cannot be ignored. Today there are 5-Iodo-2-Pyridinamin of this substance, which is produced by the chemical industry. We take toxicity research as our business and explore it carefully.
    Observe its shape, observe its response to other substances in detail, and measure its poison under different circumstances. After repeated tests, it is clear that it is in a certain state, or causes harm to living things. Although the amount is different, the signs of poison are also different.
    However, the investigation of toxicity is not done overnight. It needs to be widely sampled, and the reason should be deeply investigated. The whole picture should be obtained, so that everyone knows the harm, avoids the risk, protects the invisible, and protects the safety of all things. This is the important task of our chemical researchers, and we dare not slack off.
    Future Prospects
    I am committed to the research of 5-Iodo-2-Pyridinamin, which has extraordinary potential. Looking at today's progress, although we have made progress, the road ahead is still long. The future prospect is to deepen our understanding. I want to explore its microstructure, clarify its reaction mechanism, and hope to control its characteristics more precisely.
    Furthermore, expand the application field. Or in medicine, with its unique chemistry, help the research and development of new drugs to treat diseases in the world; or in materials, give new materials quality, and add luster to industry.
    I firmly believe that with time and diligent research, 5-Iodo-2-Pyridinamin will shine, develop its talents in various fields, and bring benefits to future generations. This is what I hope for in the future.
    Where to Buy 5-Iodo-2-Pyridinamin in China?
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    Frequently Asked Questions

    As a leading 5-Iodo-2-Pyridinamin supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemical structure of 5-iodo-2-pyridinamine?
    5-Iodo-2-pyridinamine, or 5-iodine-2-aminopyridine, has a chemical structure composed of a pyridine ring as the core structure. The pyridine ring is a six-membered nitrogen-containing heterocyclic ring, in which one carbon atom is replaced by a nitrogen atom, giving the ring unique electronic properties and chemical activity.
    In this structure, the second position of the pyridine ring is connected to an amino group (-NH2O). As a nucleophilic group, the amino group can participate in many chemical reactions, such as reacting with acylating reagents to form amides, or condensation reactions with aldars and ketones under suitable conditions.
    And the 5 position is connected to the iodine atom (- I), the iodine atom has a larger atomic radius and a higher electron cloud density, which not only affects the electron distribution of the molecule, making this position a potential check point for electrophilic substitution reactions, but also because of its large atomic mass, the physical properties of the molecule, such as melting point, boiling point, etc., will also have a certain impact. Overall, the chemical structure of 5-iodine-2-aminopyridine has unique chemical activity and reaction tendency due to the presence of amino and iodine atoms at specific positions on the pyridine ring, which shows important application value in the field of organic synthetic chemistry and can be used as a key intermediate for the preparation of various organic compounds with biological activity or special functions.
    What are the physical properties of 5-iodo-2-pyridinamine?
    5-Iodo-2-pyridinamine, Chinese name 5-iodo-2-aminopyridine, is one of the organic compounds. Its physical properties are quite unique and important in chemical research and related fields.
    This compound is mostly in a solid state at room temperature. Looking at its color, it is usually white to light yellow crystalline powder. This color state characteristic is convenient for researchers to preliminarily identify during the experimental process. Its melting point also has a specific value, about 138-142 ° C. As one of the important physical constants of a substance, the melting point can help researchers determine the purity of the substance. If the melting point deviates from this range, it may suggest that the substance contains impurities.
    When it comes to solubility, 5-iodine-2-aminopyridine has different solubility in organic solvents. It has good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property is extremely critical in organic synthesis reactions because it can fully contact the reactants and speed up the reaction process. However, its solubility in water is poor, and it is difficult to dissolve in water due to the lack of strong interaction groups in its molecular structure.
    The compound also has certain sublimation properties. Although the sublimation phenomenon is not significant at room temperature and pressure, sublimation can occur under specific temperature and pressure conditions. This property may be used in the separation and purification process of substances, which can be used to achieve separation from other non-sublimating impurities.
    In addition, the stability of 5-iodine-2-aminopyridine is good under conventional conditions. However, when encountering strong oxidizing agents, strong acids, strong bases and other substances, or chemical reactions may cause structural changes. When storing, pay attention to the environment and place it in a cool and dry place to avoid contact with the above substances to ensure its stable properties.
    What are the main uses of 5-iodo-2-pyridinamine?
    5-Iodo-2-pyridinamine, Chinese name 5-iodo-2-aminopyridine, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. Due to its unique structure, it can be combined with various functional groups through chemical reactions to synthesize drug molecules with specific biological activities. For example, in the development of anti-tumor drugs, 5-iodo-2-aminopyridine can be modified by the structure of 5-iodo-2-aminopyridine to introduce specific pharmacoactive groups to obtain new compounds that inhibit the proliferation of tumor cells.
    In the field of materials science, 5-iodo-2-aminopyridine also has wonderful uses. It can be used to prepare functional organic materials, such as optoelectronic materials. By introducing it into a conjugated system, the electronic structure and optical properties of the material can be changed, so that it can exhibit unique optoelectronic properties in organic Light Emitting Diode (OLED), solar cells and other devices, and improve device efficiency and stability.
    In the field of organic synthesis chemistry, as an important building block for organic synthesis, 5-iodine-2-aminopyridine can participate in many classical organic reactions, such as Suzuki coupling reaction, Stille coupling reaction, etc. Through such reactions, diverse and complex organic molecular structures can be constructed, providing an effective way for organic synthesis chemists to create new compounds and expand their compound libraries. In conclusion, 5-iodine-2-aminopyridine has important value and wide application prospects in many fields.
    What are 5-iodo-2-pyridinamine synthesis methods?
    5-Iodo-2-pyridinamine, that is, 5-iodo-2-aminopyridine, is synthesized by many methods, and is now commonly used by Jun Chen.
    Take 2-aminopyridine as the starting material first, which is the basis of the reaction. Place it in an appropriate reaction vessel and add an appropriate amount of solvent, such as dichloromethane, to facilitate uniform reaction.
    Then, under low temperature and stirring conditions, slowly add an iodine source, such as N-iodosuccinimide (NIS). The low temperature environment is between 0 ° C and 5 ° C. This is essential for controlling the speed and preventing side reactions. The purpose of stirring is to make the material fully contact and promote the orderly progress of the reaction.
    NIS meets 2-aminopyridine and undergoes an electrophilic substitution reaction. The iodine atom is guided by the reaction conditions and falls precisely at position 5 of the pyridine ring, which is determined by the electron cloud distribution and reactivity of the pyridine ring.
    The reaction process can be monitored in real time by thin layer chromatography (TLC). When the raw material point fades away, the product point is clear and stable, indicating that the reaction is nearly complete.
    After that, follow the post-treatment step. Wash the reaction mixture with an appropriate solution, such as sodium bicarbonate solution, to remove the unreacted iodine source and by-products. The organic phase is extracted with an organic solvent and dried with anhydrous sodium sulfate to remove the moisture.
    Finally, the organic solvent is removed by reduced pressure distillation to obtain a crude product. It is further purified by column chromatography. Silica gel is used as the stationary phase, and an appropriate proportion of petroleum ether and ethyl acetate mixture is used as the mobile phase to separate impurities to obtain pure 5-iodine-2-aminopyridine.
    Although this synthesis method is only one, the steps are clear and the conditions are controllable, which is often the best way to synthesize this compound.
    What do 5-iodo-2-pyridinamine need to pay attention to when storing and using?
    5-Iodine-2-pyridylamine is also a kind of chemical. When it is in use, several things should be paid attention to.
    First word storage. This material should be placed in a cool, dry and well-ventilated place. Cover it or be sensitive to moisture and heat. If it is placed in a warm and humid place, it may cause qualitative change, reduce its purity, and damage its chemistry. For example, the ancient Dan sand, if it is not properly hidden, the color will change and become ineffective. The same is true.
    Times and use. When handling, it is necessary to wear suitable protective equipment, such as gloves, goggles, etc. Because it may be irritating, if it touches the skin or enters the eyes, it can be harmful. You need to be careful not to let things hurt yourself when you use the utensils. Use the finished utensils and immediately clean them up to avoid residue, causing subsequent confusion and mistaking other experiments.
    Furthermore, in the reaction, its characteristics need to be known. Know its activity and reaction conditions before you can use it well. If you use it as a medicinal material, you must carefully review the pharmacology. Like ancient healers, who concocted herbs, you must understand their properties, and then you dare to use it as medicine. When mixed with other things, carefully observe the reaction to prevent accidents. If water and fire are excited, disasters will be unpredictable.
    In short, the use of 5-iodine-2-pyridylamine should be done with caution, compliance, and attention to storage, access, and reaction to ensure complete security and achieve the desired effect.