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What are the main uses of 5-iodo-2-pyridinol~ 5-iodo-2 (1h) -pyridone?
5-Iodo-2-pyridinol (5-iodo-2-pyridinol) and 5-iodo-2 (1H) -pyridone (5-iodo-2 (1H) -pyridone) are organic compounds with similar structures and are tautomeric. Their main uses are as follows:
1. Pharmaceutical field
These two are of great significance in pharmaceutical research and development. 5-iodo-2-pyridinol and 5-iodo-2 (1H) -pyridinone have unique chemical structures and can be used as key intermediates for the synthesis of many drugs. In the creation of antimicrobial drugs, they can be integrated into drug molecules through specific chemical reactions to give drugs stronger antibacterial activity, or optimize their targeting of specific bacteria, improve therapeutic effects, and help fight various infectious diseases. In the exploration of anti-tumor drugs, studies have found that such compounds may have inhibitory effects on the growth and proliferation of tumor cells. Based on them, new anti-tumor drugs can be designed and synthesized, providing new ways to conquer cancer.
II. Field of Materials Science
In the field of materials science, 5-iodine-2-pyridol and 5-iodine-2 (1H) -pyridol are also used. They can be used as ligands to participate in the construction of metal-organic framework materials (MOFs). MOFs materials have attracted much attention in the fields of gas adsorption and separation, catalysis and other fields due to their high specific surface area and adjustable pore structure. 5-iodine-2-pyridyl alcohol and 5-iodine-2 (1H) -pyridyl ketone as ligands can be combined with metal ions through coordination bonds to construct MOFs materials with novel structures and unique properties. For example, MOFs materials with specific structures exhibit excellent adsorption properties for gases such as carbon dioxide, which is of great significance for greenhouse gas capture and separation, and helps environmental protection and resource recycling.
Third, the field of organic synthesis
In organic synthetic chemistry, 5-iodine-2-pyridyl alcohol and 5-iodine-2 (1H) -pyridyl ketone are extremely important synthetic building blocks. Due to the activity of iodine atoms and pyridine rings, they can participate in many organic reactions, such as coupling reactions. By coupling with other organic halides under the action of suitable catalysts, carbon-carbon bonds and carbon-heteroatom bonds are realized, and complex organic molecules are synthesized. It provides effective methods for the total synthesis of natural products and the synthesis of new functional materials, and promotes the development of organic synthetic chemistry.
What are the physical properties of 5-iodo-2-pyridinol~ 5-iodo-2 (1h) -pyridone?
5-Iodine-2-pyridyl alcohol and 5-iodine-2 (1H) -pyridyl one are both organic compounds, and there is a tautomeric relationship between the two. Their physical properties are interesting and worth exploring.
Let's talk about the appearance and properties first. The two are usually in solid form, and the specific appearance may vary depending on the purity and crystallization conditions. 5-Iodine-2-pyridyl alcohol may be white to pale yellow crystalline powder, while 5-iodine-2 (1H) -pyridyl one may also have similar appearance, and both have certain crystal characteristics.
As a solid organic compound, the melting point is an important physical property. The melting point of 5-iodine-2-pyridyl alcohol depends on factors such as intermolecular forces and hydrogen bonds. The specific value needs to be accurately determined by experiments. The melting point of 5-iodine-2 (1H) -pyridyl ketone may be different from that of 5-iodine-2-pyridyl alcohol due to its different molecular structure. This difference can be used to identify and separate the two.
In terms of solubility, the two behave differently in different solvents. In common organic solvents such as ethanol and acetone, the molecules have a certain polarity or solubility. However, in water, the solubility may be limited due to the large hydrocarbon part in the molecule and the relative hydrophobicity of iodine atoms. However, the ability of 5-iodine-2-pyridyl alcohol hydroxyl and 5-iodine-2 (1H) -pyridyl ketone carbonyl to form hydrogen bonds with water molecules is different, and the solubility details are also different.
When it comes to density, although the exact density data needs to be determined experimentally, it can be speculated that because the two molecules contain iodine atoms, the relative atomic weight of iodine atoms is large, so their density may be higher than that of similar pyridine compounds without iodine.
In addition, the two have significant differences in spectral properties such as infrared spectroscopy and nuclear magnetic resonance spectroscopy. 5-iodine-2-pyridyl alcohol hydroxyl and 5-iodine-2 (1H) -pyridyl ketone carbonyl have unique absorption peaks in infrared spectroscopy, which In nuclear magnetic resonance spectroscopy, the chemical shifts of hydrogen atoms at different positions vary depending on the surrounding chemical environment, which helps to accurately analyze the molecular structure.
What are the synthesis methods of 5-iodo-2-pyridinol~ 5-iodo-2 (1h) -pyridone?
There are several methods for the synthesis of 5-iodo-2-pyridinol (5-iodo-2-pyridinol) and 5-iodo-2 (1H) -pyridone (5-iodo-2 (1H) -pyridone).
One is to use pyridine as the starting material, and first undergo a halogenation reaction to introduce an iodine atom at the 5-position of the pyridine ring. Appropriate halogenating reagents, such as iodine elemental (I _ 2), can be used in combination with a suitable oxidizing agent to selectively replace the hydrogen atom at a specific position of the pyridine ring. Subsequently, the 2-position of the pyridine ring is hydroxylated. This step of hydroxylation can be achieved by nucleophilic substitution reaction. A suitable nucleophilic reagent is selected to attack the 2-position, and 5-iodine-2-pyridyl alcohol is obtained after a series of reactions. If you want to obtain 5-iodine-2 (1H) -pyridyl ketone, 5-iodine-2-pyridyl alcohol can undergo tautomerism reaction. Under appropriate acid-base conditions, the hydroxyl group is converted into a ketone group to complete the synthesis of 5-iodine-2 (1H) -pyridyl ketone.
The second method is to use a pyridine derivative containing a suitable substituent as the starting material. If the starting material has a suitable substituent at the 2-position of the pyridine ring, it can be converted into an active group that is easy to follow up 5-Iodine-2-pyridyl alcohol and 5-iodine-2 (1H) -pyridyl ketone were synthesized through a series of reactions, iodine atoms were introduced at the 5-position, and then the substituents at the 2-position were transformed.
Thirdly, the strategy of constructing a pyridine ring can be considered to synthesize the target product. For example, with suitable nitrogenous and carbonaceous raw materials, pyridine rings are formed by cyclization reaction. During or after the reaction, iodine atoms are introduced at the 5-position, and hydroxy groups or ketones are based on the 2-position. Depending on the reaction conditions and the reagents used, 5-iodine-2-pyridyl alcohol and 5-iodine-2 (1H) -pyridyl ketone are obtained respectively. This process requires precise control of reaction conditions, such as temperature, pH, and reactant ratio, to ensure the selectivity and yield of the product.
What are the applications of 5-iodo-2-pyridinol~ 5-iodo-2 (1h) -pyridone?
5-Iodine-2-pyridyl alcohol and 5-iodine-2 (1H) -pyridyl ketone are genera of organic compounds. They have significant applications in various fields.
In the field of pharmaceutical research and development, such compounds can be used as key intermediates. Taking the creation of antibacterial drugs as an example, their unique chemical structure may interact with specific targets in bacteria. With reasonable molecular modification and design, new and efficient antibacterial agents may be developed to help humans fight bacterial infections. In the study of anticancer drugs, it is also expected that the optimization of their structures will lead to the discovery of molecules with targeted anticancer activity, providing new avenues for cancer treatment.
In the field of materials science, it can be used to prepare functional materials. For example, it can be used as a component of organic semiconductor materials. Due to its special electronic structure, it may endow materials with unique electrical properties. It can be used in the manufacturing of organic field effect transistors, organic Light Emitting Diodes and other devices, or it can improve device performance, enhance its luminous efficiency, stability, etc., and promote the development of organic electronics.
In the agricultural field, it also has potential applications. Or it can be developed as a new type of pesticide. Based on its special action mechanism against certain pests or pathogens, it can be reasonably designed to make green, environmentally friendly, efficient and low-toxicity pesticides, which can not only effectively prevent and control pests and diseases, but also reduce the harm to the environment and ensure the safe production of crops.
Both of these have broad application prospects in many fields such as medicine, materials, agriculture, etc. With the deepening of research, they will surely be able to demonstrate more outstanding performance.
What is the market outlook for 5-iodo-2-pyridinol~ 5-iodo-2 (1h) -pyridone?
5-Iodo-2-pyridinol (5-iodo-2-pyridinol) and 5-iodo-2 (1H) -pyridone (5-iodo-2 (1H) -pyridone) have considerable market prospects today.
5-iodo-2-pyridinol is often an important intermediary in the field of pharmaceutical and chemical industry. Looking at the current trend of pharmaceutical research and development, the creation of many new drugs depends on these compounds as the basis. In the organic synthesis path, it can participate in a variety of reactions with unique chemical activities, helping to build complex drug molecular structures. Due to the hunger for innovative drugs in the pharmaceutical industry, the market demand for 5-iodine-2-pyridyl alcohol is expected to rise steadily.
As for 5-iodine-2 (1H) -pyridyl ketone, it has emerged in the field of materials science. With the rapid advancement of science and technology, the research and development of new materials is on the rise. This compound can endow materials with specific properties, such as optical and electrical properties. Its potential application value is gradually emerging in cutting-edge fields such as electronic devices and optical materials. And with the expansion of related industries, the demand for 5-iodine-2 (1H) -pyridone will also rise.
Although the market prospect is good, there are still challenges. The process of synthesizing the two needs to be refined to reduce costs and increase output. And the market competition is also fierce. If you want to stand out in it, you must pay attention to R & D innovation and improve product quality. To sum up, the market prospects for 5-iodine-2-pyridol and 5-iodine-2 (1H) -pyridone are promising, but practitioners also need to work hard to meet various challenges.