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What is the main use of 5-iodo-2-pyrimidone?
5-Iodo-2-pyrimidone, Chinese name 5-iodine-2-pyrimidone, is a key compound in organic synthesis and has important uses in many fields.
First, in the field of medicinal chemistry, it is often used as an intermediate in drug synthesis. Its structure contains iodine atoms and pyrimidone rings, which endow unique chemical and biological activities. In the process of many drug development, different functional groups can be introduced by modifying the structure of 5-iodine-2-pyrimidone to construct compounds with specific pharmacological activities. For example, in the development of anti-cancer drugs, ingeniously modifying this compound may enable the acquisition of new drug molecules that inhibit the growth of cancer cells.
Second, in the field of materials science, 5-iodine-2-pyrimidinone is also used. Due to its special molecular structure, it may participate in the synthesis of some functional materials. For example, when preparing organic semiconductor materials, it may be used as a structural unit to affect the electronic transport properties and optical properties of the materials, thus providing the possibility for the development of new organic optoelectronic materials.
Third, in the field of organic synthesis chemistry, 5-iodine-2-pyrimidinone, as an important intermediate, can participate in many organic reactions. The activity of the iodine atom makes the compound prone to nucleophilic substitution, and the pyrimidine ketone ring provides a unique check point for the reaction. Through various organic reactions, it can be converted into organic compounds with more complex and diverse structures, greatly enriching the types of organic compounds and injecting vitality into the development of organic synthetic chemistry.
In short, 5-iodine-2-pyrimidinone plays an important role in the fields of medicinal chemistry, materials science and organic synthetic chemistry due to its unique structure, which is of great significance to promote the development of related fields.
What are the physical properties of 5-iodo-2-pyrimidone?
5-Iodine-2-pyrimidinone is one of the organic chemicals. Its physical properties are unique, let me tell you one by one.
Looking at its appearance, at room temperature, it often shows a white to off-white crystalline powder, delicate and pure, like the first snow in winter, pure and elegant. This form is easy to observe and use, and it is easy to measure and operate accurately in many chemical experiments and industrial production processes.
When it comes to melting point, the melting point of 5-iodine-2-pyrimidinone is in a specific range. After rigorous determination, it is between 200-204 ° C. As one of the important physical properties of a substance, the melting point is like its "identity mark". This melting point characteristic makes it undergo a phase transition at a specific temperature during heating, and gradually melts from a solid state to a liquid state. This characteristic is of great significance in the purification, identification and quality control of substances. When its purity is in doubt, the melting point determination is a reliable method. The melting point range of pure products is narrow and stable. If it contains impurities, the melting point decreases and the melting range becomes wider.
In addition to solubility, 5-iodine-2-pyrimidinone exhibits unique solubility in organic solvents. It can be better dissolved in polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF). This is because the polarity of these organic solvents matches the polarity of 5-iodine-2-pyrimidinone molecules, and the principle of "similar miscibility" is caused. In DMSO, like a wanderer returning home, the molecules are uniformly dispersed to form a uniform and stable solution. In water, its solubility is relatively limited. Although water is a polar solvent, in the molecular structure of 5-iodine-2-pyrimidinone, hydrophobic groups play a significant role, hindering its full integration with water molecules and only slightly soluble.
The physical properties of 5-iodine-2-pyrimidinone lay the foundation for its application in organic synthesis, drug development and other fields. Its appearance is conducive to operation, its melting point helps to control quality, and its solubility determines its behavior in different systems. It is an important substance that cannot be ignored in the field of organic chemistry.
Is 5-iodo-2-pyrimidone chemically stable?
5-Iodine-2-pyrimidinone, the properties of this substance are still stable. In its structure, the iodine atom has unique characteristics. Although many organic chemicals are active, the structure of iodine and pyrimidinone in this substance checks and balances each other. The pyrimidinone ring has a certain conjugate stability. Although the iodine atom has a high electronegativity, it does not cause extreme reactions in this structure.
In the common chemical environment, if there is no strong acid, strong base, strong oxidizing agent or reducing agent, 5-iodine-2-pyrimidinone rarely changes spontaneously. Under normal temperature and pressure, it can last for a long time without deterioration.
However, the beauty of chemistry exists in the change of conditions. In case of high temperature, the thermal motion of the molecule intensifies, or the bond energy changes, triggering decomposition or rearrangement reactions. Or in specific organic solvents, the solvent interacts with the solute, affecting the intermolecular force, or changing its stability.
Re-examining the chemical reaction, because it contains iodine atoms, or can participate in nucleophilic substitution and other reactions, at this time, its stability is affected by the reaction reagents and conditions. However, only in terms of normal conditions, the chemical properties of 5-iodine-2-pyrimidinone are quite stable, and it can be stored and used with peace of mind. However, when operating, it is still necessary to follow chemical norms to prevent unexpected conditions from causing it to change.
What are the synthesis methods of 5-iodo-2-pyrimidone?
5-Iodine-2-pyrimidinone is an important compound in the field of organic synthesis. The synthesis methods vary, and the details are as follows.
One is the method using 2-pyrimidinone as the starting material. First, 2-pyrimidinone is mixed with a suitable base, such as sodium hydride, in a suitable solvent, such as N, N-dimethylformamide (DMF), which can form the corresponding negative ion of 2-pyrimidinone. After that, iodine-containing reagents are added, such as iodomethane or a combination of iodine elements and oxidizing agents (such as iodine and hydrogen peroxide). The iodine reagent undergoes a substitution reaction with the negative ion of pyrimidinone, so that the iodine atom is introduced into the fifth position of pyrimidinone, and 5-iodine-2-pyrimidinone can be obtained. This process requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it is easy to produce side reactions and reduce the purity of the product.
Second, it can be started from pyrimidine derivatives. If there is a suitable pyrimidine derivative, its 5 positions have groups that can be substituted, such as halogen atoms (non-iodine) or other active groups. The nucleophilic substitution reaction can be used to select iodine ion sources, such as potassium iodide, etc. Under appropriate reaction conditions, iodine ions can be used to replace the original 5-position group to achieve the purpose of synthesizing 5-iodine-2-pyrimidinone. During the reaction, the choice of solvent is very critical. Polar aprotic solvents, such as acetonitrile, are often helpful for the reaction because they can promote the dissolution and reactivity of ions.
Or start with the construction of pyrimidine rings. Through a multi-step reaction, a pyrimidine ring containing a suitable substituent is first constructed, and then in the subsequent steps, iodine atoms are selectively introduced at the 5-position. For example, a compound containing nitrogen and carbonyl is first condensed to form a pyrimidine ring skeleton, and then iodine atoms are introduced through halogenation and other reactions. Although this path has many steps, it can flexibly control the reaction of each step, which may be beneficial to improve the purity and yield of the product.
The above methods have their own advantages and disadvantages. In actual synthesis, the most suitable method should be selected according to the availability of raw materials, the difficulty of reaction, cost and the requirements for product purity.
What is the price range of 5-iodo-2-pyrimidone in the market?
5-Iodine-2-pyrimidinone is on the market, and its price range is difficult to determine. The price of this compound often changes due to multiple reasons.
First, the amount is very important. If the purchase quantity is very large, the merchant may give a discount to promote the sale, and the price can be reduced; if only a small amount is needed, in order to ensure profit, the price may be higher.
Second, the quality is also the key. Those with high purity are not easy to prepare, the cost is also high, and the price must be high; those with less purity are slightly cheaper, and may not be suitable for some experiments or production that require strict purity.
Third, the supply and demand of the city has a great impact. If there are many people seeking for a while, but the supply is limited, the price will rise; if the supply exceeds the demand, the merchant will sell the inventory or reduce the price.
Fourth, the difficulty of making is related to the cost. If the preparation process is complicated and special reagents and equipment are required, the cost is high and the price is also high; if the preparation is relatively simple, the price may be low.
There are also different suppliers. Different merchants have different pricing due to their different operating costs and business strategies. Therefore, if you want to know the exact price range of 5-iodine-2-pyrimidinone, you need to consult the suppliers in detail, compare their quotations, and comprehensively consider the quantity, quality, supply and demand. Roughly speaking, the price per gram may range from a few yuan to a few dozen yuan, but this is only an approximation. The truth should be determined according to the above factors.