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What are the chemical properties of 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one?
5-Iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one is an organic compound with interesting chemical properties and important significance in the fields of organic synthesis and medicinal chemistry.
Looking at its structure, this compound contains iodine atoms. Iodine atoms significantly affect molecular properties due to their large atomic radius and electronegativity. Iodine atoms can improve molecular lipid solubility, which is conducive to drug penetration through biofilms and improved bioavailability in drug design. And iodine atoms can be used as nucleophilic substitution reactions or coupling reactions to provide rich possibilities for organic synthesis, such as participating in Suzuki coupling, Stille coupling and other reactions to construct complex molecular structures.
The core structure of pyrrolopyrimidinone it contains endows the compound with unique electronic properties and spatial configuration. This structure is common in many bioactive molecules and may interact with specific targets in organisms. For example, it binds to biological macromolecules such as proteins and nucleic acids, and then exhibits various biological activities, or has pharmacological activities such as antibacterial, antiviral, and antitumor, depending on the substituent and the overall molecular conformation.
In terms of physical properties, the melting point and boiling point of the compound are affected by intermolecular forces, including van der Waals force, hydrogen bonds, etc. Due to the presence of electronegative atoms such as nitrogen and oxygen in the structure, or intermolecular hydrogen bonds can be formed, which affects its aggregate state properties and solubility. The solubility in organic solvents may vary depending on the degree of matching between molecular polarity and solvent polarity. Generally, the solubility in polar organic solvents may be better than that in non-polar solvents.
In terms of chemical stability, the stability of the compound to acid-base and redox conditions depends on the strength of each chemical bond in the molecule and the reactivity of the active check point. Nitrogen, oxygen heteroatoms and iodine atoms may undergo hydrolysis, redox and other reactions under specific conditions. Such factors need to be considered when synthesizing and storing.
What are the synthesis methods of 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one?
The synthesis method of 5-iodine-3,7-dihydro-pyrrolido [2,3-d] pyrimidine-4-one is quite complicated, so let me go through it in detail.
One method starts with a suitable nitrogen-containing heterocyclic precursor. First take a nitrogen-containing heterocyclic compound, put it in a specific reaction vessel, and add an appropriate amount of halogenated reagent. This halogenated reagent needs to be adapted to the iodine atom to be introduced. During the halogenation reaction, the reaction temperature, duration and ratio of reactants must be precisely regulated. If the temperature is too high, side reactions will multiply; if the temperature is too low, the reaction will be slow or even stagnant. After the halogenation reaction is properly completed, the iodine precursor compound is obtained.
Next, the iodine precursor is cyclized. Select an appropriate catalyst, which is essential to promote the formation of pyrrolidone pyrimidine rings. The iodine precursor and the catalyst are co-placed in a suitable solvent system, and the temperature is slowly increased to rearrange the atoms in the molecule and form a ring. In this process, the polarity of the solvent and the activity of the catalyst have a great influence on the reaction process and the purity of the product.
Another method is to gradually build the target molecular structure through a multi-step reaction. The prototype of the pyrimidine ring is first constructed through a series of reactions, and the appropriate substituent is introduced at a specific position of the pyrimidine ring to reserve the activity check point for the subsequent reaction. Then, through an ingenious reaction strategy, the pyrrole ring is spliced on the pyrimidine ring, and the iodine atom is introduced at the designated position of the pyrrole ring. This process requires fine control of the conditions of each step of the reaction, from the selection of reactants, the amount of reagents, and even the pH of the reaction environment, there should be no slack.
Synthesis of this compound requires chemists to be familiar with the mechanism of organic synthesis and to be careful when operating to obtain pure 5-iodine-3,7-dihydro-pyrrolido [2,3-d] pyrimidine-4-one products.
In which fields is 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one used?
5-Iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one is an organic compound. It has applications in many fields and is described below.
In the field of medicine, this compound may have unique biological activities. Many compounds with nitrogen-containing heterocyclic structures are often key targets for drug development. The specific structure of 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one may interact with specific receptors, enzymes, etc. in organisms. For example, it can be used as an enzyme inhibitor to regulate the activity of certain enzymes involved in the occurrence and development of diseases, and then it is expected to become a potential drug lead compound for the treatment of diseases such as cancer and inflammation. Researchers can improve its efficacy and reduce toxic and side effects by modifying and optimizing its structure, laying the foundation for the creation of new drugs.
In the field of materials science, this compound also shows potential value. Organic compounds are widely used in the field of optoelectronic materials. 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one has unique optical and electrical properties due to its special electronic structure. Or it can be used to prepare organic Light Emitting Diode (OLED) materials, which endow devices with specific luminous properties, improve luminous efficiency and color purity; or it can play a role in organic solar cell materials to enhance the absorption of light and charge transport capacity, and improve the photoelectric conversion efficiency of batteries.
Furthermore, in the field of organic synthesis chemistry, 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one can be used as a key intermediate. Due to its unique structure, it can participate in a variety of organic reactions, such as nucleophilic substitution reactions, cyclization reactions, etc. Through these reactions, chemists can construct more complex and diverse organic molecular structures, providing an effective way for the synthesis of organic compounds with specific functions, and promoting the development and innovation of organic synthesis chemistry.
What is the market outlook for 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one?
5-Iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one is an organic compound. Its market prospects are related to many aspects.
From the perspective of the pharmaceutical field, such nitrogen-containing heterocyclic structures often have unique biological activities, or can become key intermediates for the development of new drugs. Today, the demand for innovative drugs is increasing, and many pharmaceutical companies and scientific research institutions are engaged in the exploration of new target drugs. If this compound can be studied to show potential activity for specific diseases, such as cancer, neurological diseases, etc., it will surely attract a lot of attention. Many examples have shown that novel heterocyclic compounds often play an important role in the process of drug development. After modification and optimization, new drugs with excellent efficacy and few side effects may be developed, and their market potential may be immeasurable.
In the field of materials science, organic compounds are also widely used. If this compound can exhibit unique photoelectric properties, such as good fluorescence properties or charge transport ability, it is expected to be applied to organic Light Emitting Diodes (OLEDs), organic solar cells and other fields. Today, the electronic device and renewable energy markets are developing rapidly, and the demand for high-performance organic materials continues to rise. Once the application of this compound in the field of materials is realized, its market demand may grow rapidly.
However, its market prospects also face challenges. It may be difficult to synthesize the compound. If efficient and low-cost synthesis cannot be achieved, large-scale production will be limited, which will affect its marketing activities. And when new compounds enter the market, they need to undergo strict regulatory approval, especially in the pharmaceutical field, which takes a long time and costs to evaluate safety and effectiveness. If the approval is not smooth, it will also hinder its market process.
In summary, 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one has potential opportunities in the field of medicine and materials due to its structural characteristics, but it needs to overcome the problems of synthesis and regulations in order to fully tap its market potential.
Is the production process of 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one complicated?
5 - iodo - 3,7 - dihydro - pyrrolo [2,3 - d] pyrimidin - 4 - one, the synthesis process of the chemical, and the complexity and simplicity vary from method to method.
Looking at the ancient chemical formula, at the beginning, it relied on natural materials to take it, but if you want to get it, the natural source is dilute and difficult to continue. After the great prosperity of chemistry, the way of artificial synthesis gradually emerged.
If you want to make this product by ordinary organic synthesis methods, the steps or complex. The basic skeleton needs to be constructed first. For example, with suitable nitrogen-containing and carbon-containing compounds, through condensation and cyclization, the structure of pyrrolido-pyrimidine is initially obtained. In this process, the control of reaction conditions is crucial, and the choice of temperature, pressure, and catalyst all affect the yield and purity of the product.
It is not easy to introduce iodine atoms in one step. The method of electrophilic substitution can be selected. However, depending on the activity and positioning effect of other groups in the molecule, the appropriate time and reagent should be selected, otherwise side reactions will easily occur, resulting in complex products, and separation and purification will be difficult.
Nowadays, chemistry and technology are changing day by day, and there are various new tools. For example, reactions catalyzed by transition metals can introduce iodine atoms precisely, and the conditions are mild and the steps are simple. There are also emerging technologies such as flow chemistry, which can continuously produce, improve efficiency, and reduce the complexity of the process.
The production process of 5-iodo-3,7-dihydro-pyrrolo [2,3-d] pyrimidin-4-one was difficult in the past, but now it is due to changes in the law, or there is a way to simplify it, but the specifics still depend on the method adopted and the actual situation.
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