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What is the chemical structure of 5-iodo-3-methyl-pyridin-2-ylamine?
5-Iodo-3-methyl-pyridin-2-ylamine is one of the organic compounds. Its chemical structure is as follows:
This compound is based on a pyridine ring. Pyridine is a nitrogen-containing six-membered heterocyclic compound with aromatic properties. At the 2-position of the pyridine ring, it is connected to an amino group (-NH2O). The amino group is a common functional group in organic chemistry. It is basic and can participate in many chemical reactions, such as salting with acids, or participating in nucleophilic substitution under appropriate conditions.
In the 3-position of the pyridine ring, there is a methyl group (-CH 🥰) connected. The introduction of methyl group will change the electron cloud density distribution of the pyridine ring, affecting its chemical activity and physical properties. Because methyl group is the power supply group, the electron cloud density of the adjacent and para-position of the pyridine ring can be relatively increased, resulting in changes in its electrophilic substitution reactivity.
And in the 5-position of the pyridine ring, there is an iodine atom (-I) connected. The iodine atom has a large relative atomic weight and has a certain steric resistance effect, and its electronegativity affects the electron cloud of the pyridine ring, which makes the reactivity and selectivity of this compound unique. For example, in some nucleophilic substitution reactions, the iodine atom can act as a leaving group, causing other groups to replace its position.
In summary, the chemical structure of 5-iodo-3-methyl-pyridin-2-ylamine is composed of a pyridine ring and amino, methyl and iodine atoms connected to the 2-, 3- and 5-positions, respectively. This unique structure endows it with specific chemical properties and reactivity.
What are the physical properties of 5-iodo-3-methyl-pyridin-2-ylamine?
5-Iodine-3-methyl-pyridine-2-ylamine is also an organic compound. It has various physical properties, which are described in detail as follows:
Looking at its properties, under normal temperature and pressure, 5-iodine-3-methyl-pyridine-2-ylamine is mostly in a solid state, and the color may be white to light yellow. The characteristics of this color state are determined by its molecular structure and electronic transition characteristics.
In terms of its melting point, it is within a certain range. This value is due to the force between molecules. The atoms in the molecule are connected by covalent bonds to form a specific structure, and there are Van der Waals forces and hydrogen bonds between molecules. When heated, it is necessary to absorb energy to overcome these forces, causing the disintegration of the lattice structure and reaching the melting point.
As for solubility, 5-iodine-3-methyl-pyridine-2-ylamine has a certain solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. Because the molecule of the compound has a certain polarity, it can form a similar and soluble effect with organic solvent molecules, such as dipole-dipole interaction. However, in water, its solubility is relatively low, and due to the tight hydrogen bond network between water molecules, the interaction between the compound and water molecules is difficult to effectively destroy this network, so it is difficult to dissolve.
Its density is also an important physical property, which is determined by the molecular mass and the way of molecular accumulation. The molecular mass is given, and the density varies when the molecules are arranged in a solid or liquid state.
In addition, the stability of this compound also belongs to the category of physical properties. Under normal conditions, its structure is relatively stable, and it may change when exposed to high temperature, strong oxidants or specific chemical reaction conditions. This is due to the change of the stability of the chemical bonds in the molecule under different energies and chemical environments.
In summary, the physical properties of 5-iodine-3-methyl-pyridine-2-ylamine are shaped by many factors such as its molecular structure, atomic composition and intermolecular interactions.
What are the main uses of 5-iodo-3-methyl-pyridin-2-ylamine?
5-iodo-3-methyl-pyridin-2-ylamine, the Chinese name or 5-iodine-3-methylpyridine-2-amine, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of compounds with specific biological activities. Due to the structural properties of pyridine and amine groups, it can interact with many targets in organisms, such as specific enzymes or receptors, so it has great potential in the development of new drugs.
In the field of materials science, this compound also has its uses. The presence of pyridine rings gives it certain stability and conjugate structure, or it can participate in the preparation of materials with special electrical and optical properties, such as organic semiconductor materials. These materials have broad application prospects in electronic devices such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs).
In addition, in the field of organic synthetic chemistry, 5-iodo-3-methyl-pyridin-2-ylamine as an important synthetic building block. With the reactivity of iodine atoms and amine groups, more complex organic molecular structures can be constructed through many organic reactions, such as coupling reactions, substitution reactions, etc., to facilitate the creation and development of new organic compounds.
What are 5-iodo-3-methyl-pyridin-2-ylamine synthesis methods?
The synthesis method of 5-iodine-3-methyl-pyridine-2-amine has been known in ancient times, and now it is detailed by you.
First, 3-methyl-2-aminopyridine is used as the starting material. This pyridine derivative is active and can be substituted with iodine sources. 3-methyl-2-aminopyridine is placed in a suitable solvent, such as dichloromethane, N, N-dimethylformamide, etc. The solvent needs to be dry and free of impurities to ensure a smooth reaction. Then, slowly add an iodine source, such as iodine elemental substance and N-iodosuccinimide (NIS). The reaction process requires strict temperature control, usually in a low temperature environment, such as 0-5 ° C, to make the reaction more selective. During the reaction, stirring is also the key, and it is necessary to stir evenly to make the reactants fully contact. After the reaction is completed, the product can be separated and purified by conventional separation methods, such as column chromatography, to obtain 5-iodine-3-methyl-pyridine-2-amine.
Second, it can also be started from 2-halo-3-methyl-pyridine. First, 2-halo-3-methylpyridine is reacted with a suitable amination reagent to introduce an amino group. Commonly used amination reagents such as ammonia, amine compounds, etc. The reaction conditions depend on the characteristics of the amination reagent. Generally, under heating and pressure, the reaction rate is accelerated. Subsequently, the obtained product is subjected to iodine substitution reaction. As in the above method, a suitable iodine source and reaction conditions are selected to achieve the introduction of 5-position iodine atoms. Finally, the target product is obtained by separation and purification.
Furthermore, with the help of transition metal catalysis. Metal-containing catalysts, such as palladium catalysts, are used to catalyze related reactions. This method has mild conditions and high selectivity. Appropriate pyridine substrates, iodine sources and amination reagents are reacted in a specific solvent and reaction atmosphere under the action of palladium catalyst. The reaction atmosphere is usually protected by inert gas to prevent the catalyst from deactivation. The reaction process is optimized by precisely regulating the reaction parameters, such as temperature, time, catalyst dosage, etc., and finally the pure 5-iodine-3-methyl-pyridine-2-amine is obtained through post-processing steps.
5-iodo-3-methyl-pyridin-2-ylamine What are the precautions during storage and transportation?
5-Iodine-3-methyl-pyridine-2-ylamine is an organic compound. When storing and transporting, many matters need to be paid careful attention.
First, when storing, choose a dry, cool and well-ventilated place. This compound may be sensitive to humidity and temperature, high humidity may cause it to deliquescent, and if the temperature is too high, it may cause a chemical reaction and cause it to deteriorate. Therefore, it should be stored in a temperature-controlled environment. Generally speaking, the temperature should be maintained between 2 and 8 degrees Celsius. If the conditions are not allowed, it is also necessary to ensure that the temperature is not too high and away from heat sources and direct sunlight.
Second, because it is an organic amine compound, or has certain corrosive and toxic properties. Storage containers must be made of corrosion-resistant materials, such as glass or specific plastic containers, and must be tightly sealed to prevent leakage and volatilization, to avoid harm to the environment and personnel. Storage areas should also be kept away from food, beverages and other incompatible substances to avoid accidental reactions.
Third, during transportation, ensure that the packaging is stable to prevent vibration and collision from causing damage to the container. It needs to be classified as hazardous chemical transportation in accordance with relevant regulations, and equipped with corresponding protective and emergency equipment. Transportation personnel should also be professionally trained and familiar with the characteristics of the compound and emergency treatment methods.
Fourth, whether it is storage or transportation, it is necessary to strictly follow relevant regulations and standards. Make detailed records, including the source, quantity, storage and transportation conditions and time of the compound, so as to trace and manage. In the event of an unexpected situation such as a leak, an emergency plan should be activated immediately, and effective measures should be taken, such as evacuating people, blocking the scene, cleaning up the spill, etc., to prevent the harm from expanding.
