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What is the chemical structure of 5-iodo-3- (trifluoromethyl) -2 (1h) -pyridinone?
5-Iodo-3- (trifluoromethyl) -2 (1H) -pyridinone is an organic compound. Its chemical structure can be analyzed according to its naming rules.
"pyridinone" shows that it is a derivative of pyridinone. Pyridine is a nitrogen-containing hexamembered heterocyclic compound. Its ring has a conjugated structure and has unique properties. "2 (1H) " indicates that the ketone group (C = O) is located at the 2nd position of the pyridine ring, and 1H implies that the hydrogen atom at this position has a specific chemical environment.
"5-iodo" indicates that there is an iodine atom attached to the 5th position of the pyridine ring. The iodine atom has a large relative atomic weight and has a certain electronegativity. It is attached to the ring, which affects the physical and chemical properties of the compound, such as increasing the molecular polarity and affecting the intermolecular forces.
"3- (trifluoromethyl) " means that trifluoromethyl is connected to the 3rd position of the pyridine ring (-CF 🥰). In trifluoromethyl, the fluorine atom is extremely electronegative, and this group has strong electron absorption, which significantly changes the electron cloud distribution of the pyridine ring, which in turn affects the reactivity and stability of the compound.
The chemical structure of this compound is formed by the introduction of iodine atom and trifluoromethyl at a specific position in the pyridone ring as the core. The interaction of various components endows it with unique chemical and physical properties, which may have potential applications in organic synthesis, medicinal chemistry, and other fields.
What are the main uses of 5-iodo-3- (trifluoromethyl) -2 (1h) -pyridinone
5-Iodo-3- (trifluoromethyl) -2 (1H) -pyridinone is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to produce drugs. This compound has a unique chemical structure, containing iodine atoms and trifluoromethyl groups, which give it special physical and chemical properties. In the process of drug development, this structure can be modified to improve drug activity, selectivity and pharmacokinetic properties.
For example, it can be used to create new drugs with antibacterial, antiviral or anti-tumor activities. Medicinal chemists can use this compound structure modification to optimize its interaction with biological targets, thereby enhancing drug efficacy and reducing side effects.
In the field of materials science, 5-iodo-3- (trifluoromethyl) -2 (1H) -pyridinone is also used. Because it contains fluorine atoms, it can improve the surface properties of materials, such as improving corrosion resistance, water resistance and low surface energy characteristics of materials. Therefore, it can be used to prepare special coating materials to make the surface of materials better protective properties and self-cleaning ability.
Furthermore, in the field of organic synthetic chemistry, as an important intermediate, it participates in many organic reactions and provides the possibility for the construction of complex organic molecular structures. Chemists can use its activity check point to introduce other functional groups through halogenation reactions, nucleophilic substitution reactions, etc., to expand the structural diversity of organic molecules to meet the needs of specific structural organic compounds in different fields.
What are the synthesis methods of 5-iodo-3- (trifluoromethyl) -2 (1h) -pyridinone?
The method for the synthesis of 5-iodine-3- (trifluoromethyl) -2 (1H) -pyridone is described in ancient books. The method is as follows:
First, a specific pyridine derivative is used as the starting material. Choose a suitable pyridine precursor, whose structure must be compatible with the target product, or have a transformable functional group on the pyridine ring. At a specific position of this pyridine precursor, introduce iodine atoms and trifluoromethyl.
The introduction of iodine atoms can be by nucleophilic substitution or electrophilic substitution. If it is an electrophilic substitution, an iodine source such as iodine is often used, supplemented by suitable catalysts and reaction conditions. In an appropriate solvent, adjust the temperature, reaction time and other factors to precisely replace the iodine atom to the desired position of the pyridine ring.
The introduction of trifluoromethyl can be used with reagents containing trifluoromethyl. For example, some metal-organic reagents, such as trifluoromethyl copper-lithium reagent, etc. In a specific reaction system, this reagent and pyridine derivatives connect trifluoromethyl to the pyridine ring through coordination, addition and other steps.
Or adopt a multi-step reaction strategy. First construct a pyridine framework containing trifluoromethyl, and then introduce iodine atoms in subsequent steps. During this period, attention should be paid to the selectivity and yield of each step of the reaction, and the reaction conditions should be carefully regulated.
In addition, the protective group strategy cannot be ignored. If there are other sensitive functional groups on the pyridine ring, in order to prevent it from being affected in the reaction, the protective group can be introduced first, and then the protective group can be removed after the target reaction is completed. In this way, after many steps and fine operation, 5-iodine-3- (trifluoromethyl) -2 (1H) -pyridone can be prepared.
What are the physical properties of 5-iodo-3- (trifluoromethyl) -2 (1h) -pyridinone
5-Iodine-3- (trifluoromethyl) -2 (1H) -pyridone is an important compound in the field of organic chemistry. Its physical properties are interesting and worth exploring in detail.
Looking at its appearance, under room temperature and pressure, this compound often takes a white to light yellow solid form, just like the minerals contained in ancient books, with unique color and quality. When it is in the solid state, it has a certain crystalline form, and the crystal structure has a great influence on its physical properties. For example, the ancients cherished and studied the crystal structure of ores. Although their understanding was limited at that time, they also paid attention to the physical structure.
When it comes to solubility, this compound has a certain solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, it can dissolve well, just like salt dissolves in water, forming a uniform dispersion system. In water, the solubility is extremely low, just like oil is insoluble in water. This property is due to the influence of hydrophobic groups in its molecular structure. Trifluoromethyl and pyridinone rings give molecules strong hydrophobicity.
Its melting point is also a key physical property. After experimental determination, the melting point is in a certain temperature range. This temperature range is like the "critical state" of a compound. When this temperature is reached, the compound gradually melts from the solid state to the liquid state, and undergoes a phase transition. Although the ancients did not have an accurate means of measuring the melting point, the observation of the change of the heat of the substance is also recorded, which is similar to this phase transition.
In addition, the boiling point is also an important characterization. Although the exact boiling point is affected by many factors, under specific conditions, its approximate boiling point range can be determined. The boiling point reflects the energy required for the conversion of a compound between the gaseous state and the liquid state, and is closely related to the intermolecular forces. This is just like the ancient people who knew things needed to explore their internal relationships.
In addition, the density of 5-iodine-3- (trifluoromethyl) -2 (1H) -pyridone has also been involved in related studies. Density, as one of the properties of substances, reflects the mass distribution per unit volume. It may vary slightly under different conditions, but it has a relatively stable value under standard conditions, just like the inherent "weight attribute" of an object.
In summary, the physical properties of 5-iodine-3- (trifluoromethyl) -2 (1H) -pyridone, including appearance, solubility, melting point, boiling point, density, etc., are of great significance for its application in organic synthesis, drug research and development, just as the ancient people studied the properties of various substances, laying the foundation for today's scientific exploration, and today's research is more accurate and in-depth, which will continue to expand the application prospects of this compound.
What is the market outlook for 5-iodo-3- (trifluoromethyl) -2 (1h) -pyridinone?
5 - iodo - 3 - (trifluoromethyl) - 2 (1H) - pyridinone is an organic compound with considerable market prospects and many favorable factors.
Looking at the field of medicine, this compound may have significant biological activity due to its unique structure. In the process of drug development, it can be used as a key intermediate. For example, when developing new antimicrobial drugs, through delicate modification and modification of their structures, drugs with a wide antimicrobial spectrum, strong antimicrobial activity and low drug resistance may be created, which is of great significance to solve the current difficult problem of bacterial drug resistance, and the market demand will continue to rise.
In the field of pesticides, 5-iodo-3- (trifluoromethyl) -2 (1H) -pyridinone also has a broad application. With its special chemical properties, new pesticides with high efficiency, low toxicity and environmental friendliness may be developed. These pesticides can precisely act on target pests or weeds, greatly reduce the impact on non-target organisms, and are in line with the development trend of green agriculture today, and must be favored by the market.
Furthermore, with the rapid development of organic synthesis technology, the synthesis method of this compound is continuously optimized, the cost is gradually reduced, and the output is steadily increased. The cost reduction makes the product more price competitive in the market, and the output increase can meet the growing market demand.
In addition, the research on fluorine-containing and iodine-containing compounds in the scientific research community remains high. 5-iodo-3- (trifluoromethyl) -2 (1H) -pyridinone, as a typical representative, has attracted the attention of many researchers. More research results have emerged, or it may open up new application fields and further expand the market space.
In summary, 5-iodo-3- (trifluoromethyl) -2 (1H) -pyridinone has a bright market prospect due to its potential application value in the fields of medicine and pesticides, the development of synthesis technology and the promotion of scientific research. It is expected to occupy an important position in related industries in the future.