5-Iodo-6-Methyl-2-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,2-Dihydropyridine-3-Carboxylic Acid Base Information

The compound is 5-iodine-6-methyl-2-oxo-1-[ 3-trifluoromethyl-phenyl] -1,2-dihydropyridine-3-carboxylic acid.
The chemical structure of the compound is as follows: the pyridine ring is used as the core structure, and a carbonyl group is connected at the 2nd position (forming a 2-oxo structure), a 3- (trifluoromethyl) phenyl is connected at the 1st position, a carboxyl group is connected at the 3rd position, an iodine atom is connected at the 5th position, and a methyl group is connected at the 6th position. The pyridine ring is a six-membered nitrogen-containing heterocycle and has aromatic properties. In the 1,2-dihydropyridine structure, the double bond part of the 1,2 position is hydrogenated, so that the region has a certain saturation. In the 3- (trifluoromethyl) phenyl group, the benzene ring is connected to the 1 position of the pyridine ring through a single bond, and the 3 position of the benzene ring has a trifluoromethyl group. The trifluoromethyl group has strong electron-withdrawing properties, which will affect the electron cloud distribution and chemical properties of the molecule. The iodine atom at the 5 position is relatively large and the electronegativity is moderate, which also affects the physical and chemical properties of the molecule. The methyl group at the 6 position is an electron-supplying group, which can have a certain impact on the electron cloud density of the pyridine ring. The carbonyl group at the 2 position endows the molecule with certain polarity and reactivity, while the carboxyl group at the 3 position makes the compound acidic, which can participate in acid-base reactions and react with other compounds containing active groups.

5-Iodo-6-methyl-2-oxo-1- [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid, which is a compound of considerable research value in organic synthesis. Its physical properties are unique, and its appearance is often a crystalline solid, due to the arrangement and interaction of atoms in the molecule.
Its color is mostly white to light yellow, which is due to the absorption and reflection characteristics of the molecular structure to light. In terms of melting point, it has been determined by many experiments that it is about a specific temperature range, which is determined by the interaction of intermolecular forces, such as van der Waals force and hydrogen bonds, to reach the energy required for solid-liquid equilibrium.
In terms of solubility, in organic solvents, such as common ethanol, dichloromethane, etc., there is a certain solubility. This is because the polarity of the compound molecule matches the polarity of the organic solvent and follows the principle of "similar miscibility". However, the solubility in water is poor, because the hydrophobic part of the molecular structure accounts for a large proportion, and it is difficult to form an effective force between the water molecule and the compound molecule.
In addition, the density of the compound has a certain value, which is determined by the molecular weight and the degree of molecular accumulation. Under normal conditions, the stability is acceptable, but under certain conditions, such as high temperature, strong acid and alkali environment, some chemical bonds in the molecular structure may break or rearrange, causing chemical properties to change. These physical properties lay the foundation for its application in organic synthesis, drug development, and other fields, and help researchers design suitable reaction conditions and separation and purification methods accordingly.

5-Iodine-6-methyl-2-oxo-1 - [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid, an organic compound with unique chemical properties.
Looking at its structure, iodine atoms have high electronegativity and large atomic radius, which make them unique in chemical reactions or exhibit unique activities. Iodine atoms can participate in nucleophilic substitution reactions because the carbon-iodine bond is relatively weak and easy to break, providing an opportunity for the introduction of other functional groups. The methyl group in the
molecule, although relatively simple, can affect the spatial structure of the molecule and the distribution of the electron cloud, and has an effect on the physical and chemical properties of the compound. It is the power supply radical, or the electron cloud density of the adjacent chemical bond increases, which affects the reactivity check point.
2-oxo structure, forming a carbonyl group, with high reactivity. The carbon-oxygen double bond of the carbonyl group, the electron cloud is biased towards the oxygen atom, making the carbon atom partially positively charged and vulnerable to attack by nucleophilic reagents. Common reactions such as nucleophilic addition reactions can react with nucleophilic reagents such as alcohols and amines to generate corresponding acetals, amides and other derivatives.
1- [3- (trifluoromethyl) phenyl] part, trifluoromethyl is a strong electron-absorbing group, which has a significant impact on the distribution of benzene ring electron cloud, reducing the density of benzene ring electron cloud, thereby affecting the substitution reaction activity and selectivity on the benzene ring. At the same time, the presence of trifluoromethyl greatly enhances the lipid solubility of the compound and affects its solubility and partition coefficient in different solvents.
3 -carboxylic acid group, acidic, can undergo acid-base reaction under appropriate conditions, and react with the base to form corresponding carboxylic salts. Carboxyl groups can also participate in esterification reactions, and ester compounds are formed with alcohols under the action of catalysts. This reaction is often used in organic synthesis to construct ester bonds and prepare ester derivatives with different functions.
In summary, 5-iodine-6-methyl-2-oxo-1 - [3 - (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acids exhibit diverse chemical properties due to the synergistic action of various functional groups, and are important research objects in the fields of organic synthesis and medicinal chemistry.

5-Iodine-6-methyl-2-oxo-1 - [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid. The common uses of this compound involve the field of medicinal chemistry.
In the process of drug research and development, it may be a key intermediate. The iodine atom in the Gein structure has unique reactivity, and can be connected with other functional groups by nucleophilic substitution and other reactions to help form complex molecules with specific pharmacological activities. Moreover, the introduction of trifluoromethyl can significantly change the physical and chemical properties of compounds, such as lipophilicity, which in turn affects their transmembrane transport ability and bioavailability. It plays a huge role in the creation of new drug molecular structures.
In the field of organic synthesis, the pyridine ring and adjacent carbonyl, carboxyl and other functional groups in the structure of the compound can initiate a variety of reactions, such as cyclization and condensation, providing a foundation for the construction of more complex ring systems, helping organic synthesis chemists to develop novel synthetic pathways and prepare organic materials or bioactive molecules with specific structures and functions.
Furthermore, in the activity screening study, this compound as the starting point, after structural modification and optimization, may be able to unearth lead compounds with high affinity and selectivity for specific disease targets, paving the way for subsequent drug development. In conclusion, 5-iodine-6-methyl-2-oxo-1 - [3 - (trifluoromethyl) phenyl] -1,2 -dihydropyridine-3 -carboxylic acid has potential value in medicine and organic synthesis.

There are various methods for the synthesis of 5-iodine-6-methyl-2-oxo-1 - [3 - (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acids, and this is a common one:
One is to use a pyridine derivative containing a specific substituent as the starting material. Through halogenation reaction, iodine atoms are introduced at a suitable position. When halogenating, suitable halogenating reagents can be selected, such as iodine elemental compound with an appropriate oxidizing agent, under specific reaction conditions, the substitution of iodine atoms at the target position can be precisely realized. Then, other substituents such as methyl and aryl groups are modified and introduced. Methyl can be introduced by means of alkylation reaction, select suitable methylation reagents, and methylate specific positions of pyridine derivatives under alkali catalysis. The introduction of 3 - (trifluoromethyl) phenyl can be selected according to the specific situation. Reaction pathways such as nucleophilic substitution or electrophilic substitution can be selected, and the reaction sequence and conditions can be reasonably designed to ensure that each substituent is connected according to the expected structure. For 2-oxo and 3-carboxylic acid parts, oxidation, hydrolysis and other reactions can be used to construct. For example, the carbonyl group is formed at a specific position on the pyridine ring first through oxidation reaction, and then the carboxyl group is introduced through subsequent hydrolysis and other steps, so that the target product can be synthesized step by step.
Second, benzene derivatives containing key substituents can also be The structure of the pyridine ring is constructed first, which can be achieved by cyclization reaction. Through careful selection of reactants and catalysts, benzene derivatives and nitrogen-containing compounds are cyclized under specific conditions to form a pyridine skeleton. During the cyclization process, the reaction conditions are cleverly designed so that the pyridine ring has the expected substituents such as iodine and methyl at the same time. Subsequently, the substituents on the pyridine ring are further modified and transformed to precisely construct the 2-oxo and 3-carboxylic acid parts. For example, the specific position of the pyridine ring is oxidized to a carbonyl group by oxidation reaction, and then the carboxyl group is introduced through hydrolysis and other reactions to obtain the target compound.
Third, a multi-step tandem reaction strategy is adopted. Multiple reaction steps are cleverly connected in the same reaction system to reduce the cumbersome process of separation and purification of intermediates. Starting from a simple starting material, the selective reactions of each reactant under different reaction conditions are used to realize the construction and connection of iodine atom, methyl, 3- (trifluoromethyl) phenyl, 2-oxo and 3-carboxylic acid in sequence. This method requires fine regulation of the reaction conditions to ensure that each step of the reaction proceeds in an orderly manner to efficiently synthesize the target product 5-iodine-6-methyl-2-oxo-1 - [3- (trifluoromethyl) phenyl] -1,2-dihydropyridine-3-carboxylic acid.