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What is the main use of 5-iodofuran-2-carboxaldehyde~ 5-iodofurfural?
5-Iodofuran-2-formaldehyde, also known as 5-iodofurfural, is an organic compound with a wide range of uses in the field of organic synthesis.
First, it can be used as an intermediate in drug synthesis. In the process of many drug development, its special chemical structure can be introduced into the molecular structure of the target drug through specific reactions, helping to construct compounds with specific biological activities. For example, new drugs with antibacterial, anti-inflammatory or anti-tumor pharmacological activities can be prepared by condensation and substitution with other compounds containing active groups.
Second, it also has important uses in the field of materials science. It can be used as the cornerstone of building functional materials. Through ingenious chemical modification and polymerization, materials with unique optical, electrical or adsorption properties can be prepared. For example, after polymerization with specific monomers, adsorption materials with selective adsorption capacity for specific substances may be generated, which are applied to the adsorption and removal of environmental pollutants; or organic luminescent materials with special luminescent properties can be prepared for photoelectric display and other technologies.
Third, it plays a key role in the synthesis of fine chemicals. It can derive a series of fine chemicals with high added value, such as special fragrances, dye additives, etc. By modifying their structures, these fine chemicals are endowed with unique properties and application characteristics to meet the special needs of different industries. In conclusion, 5-iodofuran-2-formaldehyde has shown important application value in many fields due to its unique structure and reactivity, providing strong support for the development of organic synthetic chemistry and the progress of related industries.
What are the physical properties of 5-iodofuran-2-carboxaldehyde~ 5-iodofurfural
5-Iodofuran-2-formaldehyde (5-iodofuran-2-carboxaldehyde or 5-iodofurfural) is an organic compound with unique physical properties.
Its appearance is often light yellow to yellow solid, stable at room temperature and pressure. The melting point is in a specific range, which makes the melting point determination an important means when identifying and purifying the substance. Due to the presence of conjugated systems and iodine atoms in the molecule, it has a certain chemical activity.
5-Iodofuran-2-formaldehyde has special solubility and is soluble in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran, but its solubility in water is extremely low. This difference in solubility can be achieved by selecting a suitable solvent when separating and purifying the substance.
The compound is volatile to a certain extent due to the presence of aldehyde groups and iodine atoms, but the volatility is relatively weak. When storing and using, it is necessary to pay attention to this characteristic. It should be stored in a cool and well-ventilated place to avoid its volatilization loss or environmental problems.
5-iodofuran-2-formaldehyde also has certain hygroscopicity and is easy to absorb moisture in a humid environment. When storing, ensure that the environment is dry, or take appropriate moisture-proof measures to prevent its physical and chemical properties from changing due to moisture absorption and affecting the use effect.
What are the chemical synthesis methods of 5-iodofuran-2-carboxaldehyde~ 5-iodofurfural
5-Iodofuran-2-formaldehyde (5-iodofuran-2-carboxaldehyde), that is, 5-iodofurfural (5-iodofurfural), is synthesized as follows:
With furfural as the starting material
1. ** Halogenation reaction **
- The reaction can be carried out with an iodine substitution reagent. For example, in a suitable solvent such as dichloromethane, N-iodosuccinimide (NIS) is used as the iodine source, and in the presence of an initiator (such as benzoyl peroxide), it is heated to reflux. The hydrogen atom at the 5th position on the furan ring of furfural is relatively active, and under such conditions, a substitution reaction can occur. During the reaction, the iodine atom in NIS will replace the hydrogen atom at the 5th position of furfural to generate 5-iodofural.
- The reaction mechanism is roughly as follows: the initiator benzoyl peroxide is thermally decomposed to produce a free radical, which initiates the homogenization of the I-N bond in NIS to produce an iodine radical. The iodine radical attacks the hydrogen atom at the 5th position of the furfuran ring to form an intermediate, and then the intermediate loses another proton to generate 5-iodofural.
- Reaction equation: furfural + NIS $\ xrightarrow [initiator] {solvent} $5 -iodofural + succinimide
2. ** Other halogenation methods **
- The iodine substitution reaction can also be carried out in the system of potassium iodide and hydrogen peroxide. Under acidic conditions, such as acetic acid solution, potassium iodide is oxidized by hydrogen peroxide to form iodine element, which in turn undergoes electrophilic substitution reaction with furfural to generate 5-iodine furfural.
- Reaction equation: furfural + I ² (generated by the reaction of KI and H ² O ³) $\ xrightarrow [H 🥰] {acetic acid} $5 -iodine furfural
Furan as the starting material
1. ** Formalylation reaction and halogenation reaction proceed in steps **
- First, furan, carbon monoxide and hydrogen chloride react with formylation in the presence of a catalyst (such as Lewis acid such as aluminum trichloride) to generate furfural. This is through the classical Gattermann-Koch reaction principle. Carbon monoxide and hydrogen chloride form a formyl positive ion under the action of a catalyst, attack the furan ring, and generate furfural.
- Then, the generated furfural is reacted with an iodine substitution reagent (such as NIS, etc.) according to the above halogenation reaction method to obtain 5-iodofural.
-Total reaction process: furan $\ xrightarrow [catalyst] {CO, HCl} $furfural $\ xrightarrow [initiator] {NIS, etc.} $5 -iodofural
The above is the common synthesis method of 5-iodofural.
What is the price range of 5-iodofuran-2-carboxaldehyde~ 5-iodofurfural in the market?
I don't know what the price range of 5-iodofuran-2-carboxaldehyde (ie 5-iodofurfural, 5-iodofural) is in the market. The price of this chemical often varies due to a variety of factors, such as purity, yield, supply and demand, difficulty in obtaining, and the time and space environment of the transaction.
If its purity is very high, and the preparation process is complicated, the output is limited, and the market demand is strong, its price may be very high; on the contrary, if the purity is ordinary, it is easier to prepare, the supply is sufficient, and the price may be relatively low.
To know the exact price range, you can consult chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent company, etc., and view their official website quotations, or call directly to inquire. Or check in detail on chemical product trading platforms. Such platforms gather quotations from many suppliers, which can help you get more comprehensive price information. You can also participate in industry exhibitions and seminars, communicate with industry insiders, and explore market prices. I regret that I cannot directly state its price range at present. I hope you will get something if you follow the above method.
What are the storage conditions for 5-iodofuran-2-carboxaldehyde~ 5-iodofurfural?
5-Iodofuran-2-carboxaldehyde (5-iodofuran-2-carboxaldehyde) is also known as 5-iodofurfural (5-iodofurfural). The storage conditions of this substance are very critical. It should be avoided from open flames and hot topics because of its flammability. In case of open flames and hot topics, it is easy to cause the risk of combustion and explosion.
It should be stored in a cool and ventilated warehouse. The control of temperature and humidity is extremely important. The temperature should be maintained in a low and stable state to prevent its chemical properties from changing due to high temperature. The humidity also needs to be moderate. If the humidity is too high, it is easy to cause the substance to deteriorate by moisture. If it is too low, it may cause some physical properties to change.
Storage should be separated from oxidants, acids, alkalis, etc., and must not be stored in mixed storage, as contact with them or severe chemical reactions may endanger safety.
Packaging should also be tight to ensure a good seal to prevent it from volatilizing or reacting with outside air components. Immediately after taking it, the packaging should be sealed as before to maintain a stable storage environment. The warehouse needs to be equipped with suitable materials to contain leaks in case of leakage, which can be properly handled in a timely manner to reduce damage hazards.