What is the main use of 5-iodopyrimidin-2 (1h) -one?

5-Iodopyrimidine-2 (1H) -ketone is one of the organic compounds. Its main uses are quite extensive.

In the field of pharmaceutical chemistry, this compound has important functions. First, it can be used as a pharmaceutical intermediate. Through a specific chemical reaction, it can be converted into a drug molecule with a specific biological activity. For example, in the synthesis pathway of some anti-tumor drugs, 5-iodopyrimidine-2 (1H) -ketone can be used as a key starting material. Through multi-step reactions, specific functional groups are introduced to shape a structure that binds to tumor cell targets, and then exerts the effect of inhibiting tumor cell proliferation.

In the field of pesticide chemistry, it also has extraordinary performance. It can be used to create new pesticides. By modifying and optimizing its structure, pesticide varieties that are highly toxic to pests and environmentally friendly can be synthesized. For example, the modified derivatives may act precisely on specific physiological processes of pests, such as interfering with the transmission of the pest's nervous system, achieving the purpose of pest control and reducing the impact on non-target organisms.

Furthermore, in the field of organic synthetic chemistry, 5-iodopyrimidine-2 (1H) -one is an important synthetic building block. Due to the presence of iodine atoms and pyrimidine rings in its structure, it is endowed with unique reactivity. Iodine atoms can participate in a variety of coupling reactions, such as Suzuki coupling, Stille coupling, etc., to construct more complex organic molecular structures, providing powerful tools for the research of new materials and natural product total synthesis, and assisting scientists in exploring the synthesis and properties of novel compounds.

What are the physical properties of 5-iodopyrimidin-2 (1h) -one?

5-Iodopyrimidine-2 (1H) -ketone is a kind of organic compound. Its physical properties are worth exploring.

Looking at its properties, it may be a crystalline solid under normal conditions. Due to the existence of various forces between molecules, it forms a regular lattice structure. Its color may be white to off-white, which is due to the absorption characteristics of molecules for visible light, and does not absorb visible light of specific wavelengths, so it appears this color.

As for the melting point, according to the principle of organic chemistry, the intermolecular force of the compound is determined, which is about a certain temperature range. The exact value of this melting point depends on the compactness of the molecular structure and the strength of the interaction. Or due to the introduction of iodine atoms, the intermolecular van der Waals force is increased, and the melting point is increased.

In terms of solubility, it may have certain solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. Due to the polarity and molecular structure of these organic solvents, it can form interactions such as hydrogen bonds and van der Waals forces with 5-iodopyrimidine-2 (1H) -one molecules to promote dissolution. However, in water, its solubility may be poor. Due to the large difference in molecular polarity from water, it is difficult for water molecules to overcome their intermolecular forces and make them uniformly disperse.

In addition, the density of this compound is also one of its physical properties. Due to the type and number of atoms in the molecule, its density may be different from that of common organic solvents. This density characteristic is also of great significance in experimental operations such as separation and purification.

In summary, the physical properties of 5-iodopyrimidine-2 (1H) -one, such as properties, melting point, solubility, density, etc., are closely related to its molecular structure, and have important reference value in many fields such as organic synthesis and drug development.

What is the chemical synthesis method of 5-iodopyrimidin-2 (1h) -one?

The synthesis of 5-iodopyrimidine-2 (1H) -ketone is an important topic in the field of organic chemistry. The method of synthesis of this compound usually uses pyrimidine-2 (1H) -ketone as the starting material.

In the first step, pyrimidine-2 (1H) -ketone is mixed with an appropriate alkali agent. The alkali agent such as sodium hydride can make pyrimidine-2 (1H) -ketone form carbon negative ions and enhance its nucleophilicity.

In the second step, an iodine source is introduced. Commonly used iodine sources such as iodine element (I 2O), or active iodine substitutes such as N-iodosuccinimide (NIS). Carbon negative ions and iodine sources undergo nucleophilic substitution reactions, and iodine atoms then replace hydrogen atoms at specific positions on the pyrimidine ring to obtain the target product 5-iodopyrimidine-2 (1H) -one.

In the reaction, many factors need to be carefully considered. The temperature has a significant impact on the reaction rate and product selectivity. If the temperature is too high, or side reactions will multiply and reduce the purity of the product; if the temperature is too low, the reaction rate will be slow and take a long time.

Furthermore, the choice of reaction solvent is also critical. Suitable solvents should be able to dissolve the reactants without adverse effects on the reaction. Common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc., are selected according to the specific needs of the reaction.

In addition, the proportion of reactants also needs to be precisely controlled. Excessive or insufficient iodine source may affect the reaction process and product yield. Only by carefully controlling each reaction condition can 5-iodopyrimidine-2 (1H) -one be synthesized with high efficiency and high purity.

What is the price range of 5-iodopyrimidin-2 (1h) -one in the market?

I think what you are asking is about "5-iodopyrimidin-2 (1H) -one" in the market price range. However, the price of this chemical product often changes for many reasons, making it difficult to determine abruptly.

First, its purity is the key. If the purity is extremely high, it is almost flawless, and its price is high; if it contains impurities, the price may drop. Second, the state of market supply and demand also affects its price. If there are many applicants and few suppliers, the price will rise; otherwise, the price will be depressed. Third, the difficulty of preparation also affects. If the preparation process is complicated, delicate methods and precious materials are required, the price will be high; if the preparation is relatively simple, the price may be slightly lower.

Furthermore, in different places, due to differences in logistics, taxation, business environment, etc., the price is also different. Generally speaking, in today's market, if it is of ordinary purity, the price per gram may be between tens and hundreds of yuan; if it is a high-purity high-quality product, the price per gram may exceed 1,000 yuan, or even higher. However, this is only an approximate number, and the actual price depends on the specific time, place, and quality, and cannot be generalized.

What are the safety and toxicity of 5-iodopyrimidin-2 (1h) -one?

5-Iodopyrimidine-2 (1H) -ketone, this is a chemical substance. As for its safety and toxicity, let me elaborate.

In terms of safety, there is currently no comprehensive and conclusive evidence to fully clarify that it is absolutely safe in various complex environments and application scenarios. In laboratory environments, operators must follow strict safety procedures when coming into contact with it. Due to its certain chemical activity or unpredictable reactions with other substances, it should be stored with caution to avoid coexistence with incompatible chemicals to prevent the growth of dangerous situations.

When it comes to toxicity, although the relevant research data is not very rich, some studies have suggested that it may have certain toxicity. Animal experiments have shown that if exposed to this substance in large doses, some tested animals have conditions such as physiological abnormalities. From the chemical structure analysis, it contains iodine atoms and pyrimidinone structures, which are closely related to toxicity in some chemicals. However, the specific degree of toxicity is also influenced by many factors, such as the route of exposure, whether it is oral intake, skin contact or respiratory inhalation. Different routes have different effects on organisms; there are also significant differences in the length of exposure, and the effects of short-term and long-term exposure.

In conclusion, although the safety and toxicity of 5-iodopyrimidine-2 (1H) -one cannot be conclusively determined, according to the current understanding, it should be regarded as a potentially dangerous substance in both industrial production and laboratory operations, and comprehensive protective measures should be taken to ensure the safety of personnel and the environment.