As a leading 5'-O-Dmtr-5-Iodo-2'-Deoxyuridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main applications of 5 '-O-DMTr-5-iodo-2' -deoxyuridine?
5% 27 - O - DMTr - 5 - iodo - 2% 27 - deoxyuridine is one of the organic compounds. Its main application is quite extensive, in the field of medicinal chemistry, and it is often the key raw material for the synthesis of nucleic acid analogs. Such nucleic acid analogs can mimic the behavior of natural nucleic acids and play a great role in the development of antiviral and antitumor drugs.
Looking at the application of antiviral, the nucleic acid analogs prepared by this compound can interfere with the synthesis and replication of viral nucleic acid by being incorporated into the genome of the virus, thus achieving the effect of inhibiting viral proliferation. For example, in some diseases of DNA virus infection, it may be a potential treatment.
As for anti-tumor, due to the rapid proliferation of tumor cells, there is a great demand for nucleic acid synthesis. The nucleic acid analogs derived from this compound can be preferentially taken up by tumor cells and incorporated into their DNA, disrupting the normal division and growth of tumor cells, opening up new avenues for the creation of anti-tumor drugs.
Furthermore, in molecular biology experiments, 5% 27 - O - DMTr - 5 - iodo - 2% 27 - deoxyuridine is also useful. Scientists often use it to mark DNA, and with its special structure and properties, track and analyze complex biological processes such as DNA metabolism and repair, and help to deeply explore the mysteries of life.
What are the chemical properties of 5 '-O-DMTr-5-iodo-2' -deoxyuridine?
5% 27 - O - DMTr - 5 - iodo - 2% 27 - deoxyuridine is also an organic compound. This compound has specific chemical properties.
Looking at its structure, the introduction of 5 - iodine groups adds unique reactivity to the compound. Iodine atoms have a large atomic radius and electronegativity, which affect the electron cloud distribution of molecules. In chemical reactions, they may act as a check point for electrophilic reagents, initiating reactions such as nucleophilic substitution.
2% 27 - deoxyuridine fraction is the basic structure of nucleic acid analogs, giving it the potential to interact with nucleic acids in organisms. It may participate in the synthesis process of nucleic acids, because the structure is similar to that of natural nucleotides, or it can be incorporated into the nucleic acid chain under specific conditions, thereby affecting the function and structure of nucleic acids.
5% 27-O-DMTr group, that is, 4,4 '-dimethoxytriphenyl methyl, is often used as a protective group for oligonucleotide synthesis. It can be selectively removed under specific reaction conditions to protect the hydroxyl group from unintended check points, ensure the regioselectivity of the reaction, and make the synthesis process more accurate and controllable.
In terms of physical properties, the compound may have certain solubility characteristics due to the presence of such different groups. The presence of DMTr groups may enhance its solubility in organic solvents such as dichloromethane, while deoxyuridine and iodine groups also affect the overall solubility, causing it to exhibit specific solubility behaviors in different solvents.
The chemical properties of this compound make it potentially useful in the fields of nucleic acid chemistry, pharmaceutical chemistry, etc., and can be used as an important intermediate for the synthesis of special oligonucleotides or the development of related drugs.
What are the synthesis methods of 5 '-O-DMTr-5-iodo-2' -deoxyuridine?
5% 27 - O - DMTr - 5 - iodo - 2% 27 - deoxyuridine is a key compound in the field of organic synthesis. Its synthesis methods have been explored by chemists throughout the ages. The following are some common ones.
First, use 2 - deoxyuridine as the starting material. First, use an appropriate protective group, such as DMTr (4,4 '-dimethoxytriphenylmethyl), to protect its 5' -hydroxy group. This is because the hydroxy group has high activity and is prone to side reactions. Protection can make the reaction more selective. Then, under specific reaction conditions, iodine atoms are introduced at the 5 position. This step requires careful selection of reaction reagents and conditions. Usually, iodine-containing reagents can be selected. Under the action of suitable solvents and catalysts, iodine atoms can precisely replace hydrogen atoms at the 5th position to obtain the target product.
Second, other related nucleoside analogs can also be started. After multi-step reaction, nucleoside structures similar to 2-deoxyuridine are first constructed, and then 5-iodine and 5 '-O-DMTr groups are introduced one by one. Although this approach is a little complicated, in some specific situations, it can avoid the rare dilemma of starting materials, and can improve the yield and purity of the product by optimizing the reaction conditions of each step.
Third, there are also attempts to use biosynthesis. With the help of specific biological enzymes, 5% 27-O-DMTr-5-iodo-2% 27-deoxyuridine can be synthesized in vivo or simulated in vivo environment. This method has the advantages of green, high efficiency and good selectivity, but it requires strict reaction conditions, and the preparation and purification of biological enzymes is also a major challenge.
What are the precautions for using 5 '-O-DMTr-5-iodo-2' -deoxyuridine?
5% 27 - O - DMTr - 5 - Iodine - 2% 27 - Deoxyuridine, this is a fine chemical substance, and many matters need to be paid attention to during use.
Bearing the brunt of it is related to safety protection. This substance may be toxic and irritating to a certain extent, and appropriate protective equipment must be worn when contacting it. If wearing gloves, choose those with good material, fit the hands and prevent chemical corrosion, which can effectively block their contact with the skin. Goggles are also indispensable, which can prevent them from splashing into the eyes and causing eye damage. Wearing lab clothes can protect the body from pollution.
Furthermore, its storage conditions are quite critical. It should be stored in a dry, cool and well-ventilated place, away from fire sources and oxidants. Due to its active chemical properties, improper environment or deterioration, it will affect the use effect. Sealed storage is also important to prevent moisture and volatilization.
The operation steps must be accurate when using. According to experimental or production requirements, measure with accurate measuring tools, such as pipettes and balances, to ensure accurate dosage. When dissolving, choose a suitable solvent and determine its solubility. When stirring or heating to help dissolve, control the temperature and speed to prevent it from decomposing.
In addition, the place of use should be neat and orderly, and the experimental equipment should be clean. After use, properly dispose of the residue and waste. According to relevant regulations, do not discard it at will to prevent environmental pollution.
In summary, the use of 5% 27-O-DMTr-5-Iodine-2% 27-Deoxyuridine requires comprehensive attention to safety, preservation, handling, and waste disposal to ensure safe and effective use.
What is the market price of 5 '-O-DMTr-5-iodo-2' -deoxyuridine?
5% 27 - O - DMTr - 5 - iodine - 2% 27 - deoxyuridine, the price of this product in the market is difficult to determine. The change in its price depends on a variety of factors.
First, the complexity of the production is related to the cost. If its preparation requires exquisite methods, rare materials, and complicated processes, the cost will be high, and the price will also rise. Such as the ancient secret medicinal pill, which is rare in the world, after ninety-nine and eighty-one processes, its price is unusually comparable.
Second, the supply and demand of the market determines its price. If there are many people seeking, but there are few, the so-called "rare things are expensive", the price will rise; on the contrary, if the supply exceeds the demand, the price will tend to decline. Just like the principle that the valley is cheap in a good year, and the valley is expensive in a barren year.
Furthermore, the quality is also the main reason. Those who are of high quality are pure and flawless, and their efficiency is outstanding, and their price must be higher than those who are shoddy. Like a good horse and a horse, the price is different.
Today in the city, there is no exact price. Either because the transaction is secret, or because it varies with time and place. To know the details, you need to visit the merchants who specialize in this industry, and observe the recent transactions, and compare the offers of many companies to get a general idea. However, the market is impermanent, and the price is also impermanent. It is necessary to pay attention often to obtain real-time prices.
