5 Tert Butyl 1 2 Dichloro 3 Iodobenzene

5- (tert-butyl) -1,2-dichloro-3-iodobenzene is a key organic compound in the field of organic synthesis. It has a wide range of uses and plays an indispensable role in many important organic synthesis reactions.
Bearing the brunt, in the field of medicinal chemistry, this compound is often used as a key intermediate. By transforming and modifying its specific functional groups, complex molecular structures with biological activities can be constructed. Because the activity and structure of drug molecules are closely related, the arrangement and connection of each atom in the molecule can be precisely regulated to develop new drugs with good efficacy and small side effects. With this compound as a starting material, through a series of chemical reactions, such as nucleophilic substitution, coupling reaction, etc., a drug molecular skeleton that fits the target can be gradually built, and then effective drugs for specific diseases can be developed.
Second, in the field of materials science, 5- (tert-butyl) -1,2-dichloro-3-iodobenzene also has important applications. In the preparation of some functional materials, organic molecules with specific structures need to be introduced to endow the material with unique properties. The chlorine atom, iodine atom and tert-butyl group contained in this compound can be combined with other material components through appropriate reactions to affect the electrical, optical and thermal properties of the material. For example, in the preparation of organic optoelectronic materials, its rational introduction can adjust the energy band structure of the material, optimize the charge transport performance, and thereby improve the efficiency and stability of organic optoelectronic devices.
Furthermore, in the field of organic synthesis methodology research, this compound is often used as a model substrate. Scientists can explore new reaction paths, optimize reaction conditions, and discover novel reaction mechanisms by studying various chemical reactions in which it participates. By changing the reaction reagents, reaction temperatures, reaction solvents, and other factors, the reaction behavior of this compound can be observed, which can provide theoretical basis and practical experience for the development of organic synthesis chemistry, and promote the development of organic synthesis technology towards a more efficient, greener, and more selective direction.

In order to prepare 5- (tert-butyl) -1,2-dichloro-3-iodobenzene, the method of organic synthesis is often followed. There are three methods, each with advantages and disadvantages, which are described in detail below.
First, the method of starting the halogenation reaction. First, the chlorine atom is introduced by the halogenation reaction with tert-butyl benzene as the substrate. This step can be used chlorine gas, under the conditions of light or Lewis acid catalysis, to chlorinate the adjacent and para-positions of the benzene ring to obtain the chlorobenzene containing tert-butyl. Then the iodine substitution reaction is carried out, and the iodine element and an appropriate oxidant, such as hydrogen peroxide or nitric acid, are used to introduce iodine atoms into the benz This route is easy to obtain raw materials, but the halogenation reaction has poor selectivity, many by-products, and cumbersome separation and purification.
Second, it is based on the coupling reaction of halogenated aromatics. First, halogenated benzene containing tert-butyl and aromatic hydrocarbon derivatives containing iodine and chlorine are prepared. Subsequently, the coupling reactions catalyzed by transition metals, such as the Ullmann reaction or the Suzuki reaction, are used to couple the two. Taking the Suzuki reaction as an example, a palladium catalyst, a base and a suitable ligand are required to heat the reaction in an organic solvent. This route has good selectivity and high yield, but the preparation of raw materials is more complicated, and the catalyst is expensive and costly.
Third, the method starts from the construction of benzene ring. Using suitable unsaturated hydrocarbons and halides as raw materials, benzene ring is constructed through multi-step reaction, and tert-butyl, chlorine and iodine atoms are introduced at the same time. Synergistic reactions such as Diels-Alder reaction can construct a six-membered ring structure, and then introduce the desired halogen atom through functional group transformation. This method has many steps and a long synthesis route, but has high atomic economy. If the design is reasonable, the target product can be efficiently prepared.
Synthesis of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene requires considering factors such as raw material cost, reaction conditions, yield and selectivity according to the actual situation, and the most suitable method is selected.

5- (tert-butyl) -1,2-dichloro-3-iodobenzene is an organic compound with unique physical properties. It may be in a solid state at room temperature, due to the existence of van der Waals forces between molecules, which are caused by the steric resistance of tert-butyl and the electronegativity of halogen atoms.
Looking at its melting boiling point, due to the large relative mass of the molecule, and the introduction of chlorine and iodine atoms enhances the intermolecular force, the melting boiling point should be higher. If compared with simple benzene derivatives, its boiling point may be significantly increased by the interaction of halogen atoms and tert-butyl groups.
In terms of solubility, the compound is insoluble in water because it is non-polar or weakly polar, and water is a polar solvent. According to the principle of "similar miscibility", the two are insoluble. However, in organic solvents such as toluene and dichloromethane, the solubility is quite good, because the organic solvent is similar to the polarity of the compound.
In addition, the color state of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene may be colorless to light yellow, and the benzene ring and substituent structure do not form a strong conjugated system, resulting in limited absorption of visible light. The density may be greater than that of water, because the relative atomic weight of the halogen atom is large, the molecular weight increases and the density increases.
The physical properties of this compound are of great significance in the fields of organic synthesis and materials science. For example, in organic synthesis, its solubility characteristics help to select suitable reaction solvents, and the melting and boiling point properties are also key factors in separation and purification.

5- (tert-butyl) -1,2-dichloro-3-iodobenzene, the stability of its chemical properties is related to various factors. This compound contains tert-butyl, which has a steric resistance effect and forms a barrier around the molecule, making it difficult for the reaction reagents to approach the core and protecting its stability to a certain extent. Although dichloro and iodine atoms have electron-absorbing properties, they will affect the distribution of electron clouds in the benzene ring. However, the electron superconjugation effect of tert-butyl may be balanced, which increases the overall stability.
It can maintain a relatively stable structure in common organic reaction environments, such as at room temperature and pressure without special catalysts or strong reaction conditions. However, when encountering strong oxidants, such as acidic solutions of potassium permanganate, the tert-butyl group of the side chain of the benzene ring may be oxidized, resulting in structural changes. In addition, when encountering nucleophilic reagents, the electron cloud density of the benzene ring decreases due to the electron absorption of halogen atoms, and the nucleophilic reagents or attack the benzene ring, triggering a nucleophilic substitution reaction. At this time, the stability is damaged.
Under light conditions, the halogen atom may initiate a free radical reaction, which affects its stability. Overall, 5- (tert-butyl) -1,2-dichloro-3-iodobenzene has a certain stability under conventional mild conditions. However, when encountering specific strong reaction conditions, reagents

The price range of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene in the market is difficult to determine. The price varies with many factors, such as the source of the material, the process of preparation, and the situation of demand and supply. The market conditions are complex and changeable, and it is difficult to have a fixed number.
Looking at the price status of various chemical substances in the past, if the material supply is abundant, and the process of preparation is mature and simple, the price may become more and more simple. However, if the material is rare and rare, and the production is difficult, the price will be high.
In today's city, the price of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene, if the material is widely distributed and it is not difficult to produce, may be in the tens of yuan per gram. If the material is rare and difficult to make, the price per gram may be more than a hundred yuan, or even higher, or hundreds of yuan per gram is unknown.
And the demand for supply also affects the price. If there are many people who want to supply but there are few, the price will increase; if the supply exceeds the demand, the price will decrease.
Therefore, if you want to know the exact price, you should consult the chemical material supplier or observe the price of the trading platform to obtain a more accurate price range.