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What are the main uses of 6-amino-3-iodo-2-methylpyridine?
6-Amino-3-iodine-2-methylpyridine is an important compound that has attracted much attention in the field of organic synthesis. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to create various specific drugs.
During the development of Guanfu drugs, many compounds with unique physiological activities often rely on 6-amino-3-iodine-2-methylpyridine as the starting material, and through delicate reaction steps, complex molecular structures are constructed. Due to its specific chemical structure, it can participate in a variety of reactions, such as nucleophilic substitution, coupling reactions, etc., thereby introducing different functional groups to shape drug molecules with specific pharmacological activities.
In the field of materials science, this compound has also emerged. Or it can be chemically modified to integrate into the skeleton of polymer materials, giving the material unique electrical and optical properties. For example, in the preparation of organic optoelectronic materials, its special structure may improve the charge transfer efficiency and luminescence properties of materials, providing an opportunity for the development of new optoelectronic devices.
In addition, 6-amino-3-iodine-2-methylpyridine also plays an important role in the synthesis of fine chemical products. It can be used as an important raw material for the synthesis of fine chemicals such as special dyes and fragrances. With its unique chemical properties, it endows fine chemical products with unique quality and performance.
To sum up, 6-amino-3-iodine-2-methylpyridine has shown extraordinary application potential in many fields such as medicine, materials, and fine chemicals, and has greatly promoted technological innovation and development in related fields.
What are 6-amino-3-iodo-2-methylpyridine synthesis methods?
There are several common methods for synthesizing 6-amino-3-iodine-2-methylpyridine.
First, 2-methylpyridine is used as the starting material. The nitration reaction of 2-methylpyridine is carried out first, and the nitro group can be introduced into the pyridine ring under appropriate conditions. The nitrifying reagent used, such as the mixed acid system of concentrated nitric acid and concentrated sulfuric acid, reacts at a suitable temperature, and the nitro group selectively enters the specific position of the pyridine ring. Subsequently, the resulting nitro compound is reduced, and the nitro group can be converted into an amino group by means of reducing agents such as iron powder and hydrochloric acid, or catalytic hydrogenation. At this time, 6-amino-2-methylpyridine is obtained, and then iodine atoms are introduced through iodine substitution reaction. The iodine substitution reaction can be selected with a suitable oxidant, such as hydrogen peroxide, in a suitable solvent to obtain 6-amino-3-iodine-2-methylpyridine.
Second, start from 2-methyl-3-halo pyridine. If the halogen atom of 2-methyl-3-halopyridine is chlorine or bromine, etc., the halogen atom can be replaced by an amino group through an aminolysis reaction. Under suitable reaction conditions and solvents, liquid ammonia or ammonia water can be used as an ammonia source to generate 6-amino-2-methylpyridine, and then the iodine reaction is carried out. The method is the same as before to obtain the target product.
Third, the cross-coupling reaction catalyzed by palladium is used. The borate derivatives of 6-amino-2-methylpyridine are reacted with an iodide in a suitable base and solvent system in the presence of a palladium catalyst, such as tetra (triphenylphosphine) palladium, etc. This method can efficiently construct carbon-iodine bonds and realize the synthesis of 6-amino-3-iodine-2-methylpyridine, and the reaction has good selectivity and yield.
What are the physical properties of 6-amino-3-iodo-2-methylpyridine?
6-Amino-3-iodine-2-methylpyridine is one of the organic compounds. In terms of its physical properties, this substance is mostly solid at room temperature and pressure, but it also varies due to subtle differences in the environment. Its appearance may be white to off-white powder, or crystalline solid, depending on the synthesis process and the degree of purification.
In terms of its solubility, it is slightly soluble in organic solvents, such as common ethanol and dichloromethane. Ethanol is a commonly used organic solvent. The intermolecular force is moderate, and some groups of 6-amino-3-iodine-2-methylpyridine interact with it to slightly dissolve. In water, although there are amino groups in its molecular structure that can form hydrogen bonds with water, the presence of iodine atoms and methyl groups enhances its overall hydrophobicity, so the water solubility is poor.
When it comes to the melting point, it has been experimentally determined to be within a certain temperature range, which can fluctuate slightly due to the purity of the sample. The melting point is the critical temperature at which a substance changes from solid to liquid. For 6-amino-3-iodine-2-methylpyridine, its melting point characteristics help to identify and purify the substance. When covering samples of different purity, the melting point varies, and the melting point of pure products is more acute. The incorporation of impurities widens the melting point range and decreases the melting point.
Its density is also an important physical property. Although the exact value needs to be determined by professional instruments, it can roughly reflect the degree of compactness of its molecular accumulation. The size of the density is related to factors such as intermolecular forces and atomic mass. The mass of iodine atoms in 6-amino-3-iodine-2-methylpyridine is relatively large, which affects its density and causes its density to be relatively large.
As for the vapor pressure, at room temperature, the vapor pressure is very low. The intermolecular force is strong, and the tendency of molecules to escape from the liquid surface to form a gas phase is small. This property determines that its volatility is weak at room temperature, and it is relatively stable during storage and use, and it is not easy to be lost due to volatilization.
What are the chemical properties of 6-amino-3-iodo-2-methylpyridine?
6-Amino-3-iodine-2-methylpyridine is also an organic compound. It has many unique chemical properties and is of great significance in the field of organic synthesis.
First of all, its alkalinity. The presence of intra-molecular amino groups gives this compound the characteristics of alkalinity. The nitrogen atom in the amino group is rich in lone pair electrons and can accept protons. In acidic media, it is easy to combine with protons to form corresponding salts. This property can play a key role in the process of separation, purification and catalysis of specific chemical reactions.
Describe its nucleophilicity. The conjugation of the nitrogen atom of the amino group with the pyridine ring increases the electron cloud density on the nitrogen atom, thereby enhancing its nucleophilic properties. Therefore, 6-amino-3-iodine-2-methyl pyridine can be used as a nucleophilic reagent and actively participate in nucleophilic substitution reactions. In many reaction scenarios, its amino group can attack the electron-deficient center of the electrophilic reagent, such as the carbon atom of halogenated hydrocarbons, thereby forming novel carbon-nitrogen bonds. This is an extremely important reaction strategy in the synthesis of nitrogen-containing organic compounds.
Furthermore, the activity of the 3-position iodine atom cannot be ignored. The iodine atom acts as a good leaving group, making this compound highly susceptible to nucleophilic substitution. When faced with appropriate nucleophilic reagents, iodine atoms can be substituted, and then various functional groups can be introduced, which greatly enriches the product types and path selection of organic synthesis. For example, when reacted with nucleophilic reagents such as alkoxides and mercaptan salts, corresponding ether and thioether compounds can be generated respectively.
In addition, although the existence of 2-methyl has relatively little effect on the overall electron cloud distribution, due to the steric hindrance effect, the spatial configuration of molecules can be changed to a certain extent, which affects the selectivity of the reaction. In some reactions, the space obstruction caused by methyl groups can promote the reaction to occur preferentially in the part with small space obstruction, which provides a new idea and method for selective control of organic synthesis.
6-amino-3-iodine-2-methylpyridine has rich and diverse chemical properties and plays an indispensable role in the stage of organic synthesis chemistry, providing rich possibilities and broad space for the creation of new organic compounds.
What is the price of 6-amino-3-iodo-2-methylpyridine in the market?
I look at what you are asking, is the price of 6-amino-3-iodine-2-methylpyridine in the market. However, the price of this chemical often changes for many reasons, and it is difficult to hide it in one word.
First, the supply is different, and the price is also different. If you get it from a large factory with a good reputation and stable supply, the quality may be excellent, but the price may be high; if it comes from a small factory, although the price may be cheap, the quality may not be guaranteed.
Second, the amount of quantity has a great impact on the price. If you buy a lot, you can often get discounts, and the wholesale price must be lower than the retail price.
Third, the market supply and demand situation, which determines the price. If the demand for this product exceeds the supply, the price will rise; if the supply exceeds the demand, the price may fall.
Fourth, the difficulty of preparation is also related to the price. If the preparation requires complex processes and high costs, the price is not cheap; if the preparation is relatively simple, the price may be slightly lower.
I have checked "Tiangong Kaiwu", which does not contain the price of this product. At present, the market is unpredictable. If you want to know the exact price, you should consult the chemical raw material supplier, or visit the chemical product trading platform, so that you can get the current more accurate price.
