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What are the chemical properties of 6-amino-5-iodopyrimidin-2 (1h) -one?
6-Amino-5-iodopyrimidin-2 (1H) -one is an organic compound with unique chemical properties. Its molecule contains an amino group (-NH _ 2) and an iodine atom (I), which are connected to the parent nucleus of pyrimidinone. This structure endows the compound with various chemical activities.
In terms of physical properties, considering the conjugate structure of the pyrimidinone ring and the influence of amino and iodine atoms, it may be solid, with a certain melting point and boiling point. Because the molecule contains polar groups, it may have a certain solubility in polar solvents (such as water and alcohols).
Chemically active, amino groups are nucleophilic and can participate in many nucleophilic substitution reactions. For example, when reacting with halogenated hydrocarbons, new carbon-nitrogen bonds are formed, and compounds containing different substituents are derived. In acylation reactions, amino nitrogen atoms can attack acyl carbons to form amide derivatives.
Iodine atoms are relatively large and highly electronegative, but they can also participate in specific reactions. In metal catalytic coupling reactions, such as Suzuki coupling and Stille coupling, carbon-iodine bonds can be broken, forming new carbon-carbon bonds with boron, tin and other reagents, expanding molecular structures and constructing complex organic frameworks.
Pyrimidinone parent nuclei are also not "idle", and their electron cloud distribution characteristics on the ring allow them to participate in cyclization reactions, addition reactions, etc. Under appropriate conditions, the parent nucleus can react with electrophilic reagents to introduce new substituents at specific positions on the ring to enrich the structure and function of the compound.
The chemical properties of this compound make it promising in the fields of organic synthesis and medicinal chemistry. It can be used as a key intermediate to create new bioactive compounds.
What are the synthesis methods of 6-amino-5-iodopyrimidin-2 (1h) -one?
6-Amino-5-iodopyrimidin-2 (1H) -one is an important organic compound, and its synthesis method has attracted much attention in the field of chemistry. Today, I will describe several common methods in detail for you.
One is a compound containing a pyrimidine ring as a starting material, which is prepared by halogenation and amination steps. First, a suitable pyrimidinone derivative is halogenated, so that the 5-position iodine atom is introduced. The halogenation reaction is often carried out with an iodine source, such as iodine elemental substance, and an appropriate oxidizing agent under suitable solvent and reaction conditions. The choice of oxidizing agent is crucial, and its oxidation strength and reaction selectivity need to be considered. Then the halogenated product is aminated and the 6-position amino group is introduced. In this step, a suitable amination reagent can be selected to complete the reaction in the presence of a base. The type and amount of base have a great influence on the reaction process and yield.
Second, you can start from a simple nitrogen-containing and carbonyl-containing compound, and construct a pyrimidine ring through multi-step cyclization, and introduce the target substituent at the same time. First, the nitrogen-containing compound and the carbonyl-containing compound are condensed under specific conditions to form a preliminary cyclic structure. This condensation reaction requires controlling the reaction temperature, time and ratio of reactants to ensure the purity and yield of the product. Subsequent selective halogenation and amination, iodine and amino groups are introduced at specific positions to achieve the purpose of synthesizing 6-amino-5-iodopyrimidin-2 (1H) -one.
Third, the synthesis is catalyzed by transition metals. Transition metal catalysts can effectively promote the formation of carbon-halogen bonds and carbon-nitrogen bonds. Suitable metal catalysts, such as palladium catalysts, are used with specific ligands to couple halogenated pyrimidine derivatives with amine sources to form target products. In the reaction, the selection of metal catalysts and ligands, the type of reaction solvent and base, all need to be carefully regulated in order to achieve efficient and highly selective synthesis.
The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to weigh and choose according to the availability of raw materials, the ease of control of reaction conditions, cost and yield, etc., in order to find the best synthesis path.
6-amino-5-iodopyrimidin-2 (1h) -one is used in which areas
6-Amino-5-iodopyrimidine-2 (1H) -ketones are used in various fields such as medicine and chemical industry.
In the field of medicine, it is a key organic synthesis intermediate and can be used to create new antibacterial drugs. The research and development of antibacterial drugs in the past, many of which are based on pyrimidine compounds, 6-amino-5-iodopyrimidine-2 (1H) -ketones have a unique chemical structure, which can combine with specific targets in bacteria, interfere with the normal physiological metabolism of bacteria, and then inhibit the growth and reproduction of bacteria, so the research and development of antibacterial drugs has a promising future.
In the chemical industry, it is of great value in material synthesis. Using it as a raw material, polymer materials with special properties can be prepared. For example, by polymerizing with specific monomers, the obtained materials may have excellent optical properties and thermal stability. Such materials with excellent properties can be widely used in optical instruments, electronic equipment and many other aspects.
In the agricultural field, after reasonable modification and modification, it can be developed into new pesticides. It can be used for specific crop diseases and pests, and it has lower toxicity and better environmental compatibility than traditional pesticides, which is of great significance to the sustainable development of agriculture.
Furthermore, 6-amino-5-iodopyrimidine-2 (1H) -ketone provides an important research object for chemical researchers in the path of scientific research. By exploring the relationship between its chemical reaction characteristics, structure and properties, it can deepen the understanding of the basic theory of organic chemistry and pave the way for the synthesis and application of more novel compounds.
What is the market outlook for 6-amino-5-iodopyrimidin-2 (1h) -one?
6-Amino-5-iodopyrimidin-2 (1H) -one, Chinese name or 6-amino-5-iodopyrimidin-2 (1H) -one, this substance is gradually emerging in the field of current pharmaceutical research and organic synthesis.
Watching the scene of organic synthesis, with the increasing complexity of pharmaceutical creation and material research and development, the demand for special structural organic blocks is becoming more and more urgent. 6-Amino-5-iodopyrimidine-2 (1H) -ketone, with its unique pyrimidine ring structure and amino and iodine atoms connected at specific check points, paves the way for the synthesis of multiple heterocyclic compounds and bioactive molecules. By common organic methods such as halogenation reaction and nucleophilic substitution, iodine atoms and amino groups can be skillfully converted to expand the possibility of molecular structure. Therefore, in the field of organic synthesis, its application prospect is just like the first light of morning, and the future is promising.
As for the field of pharmaceutical research and development, pyrimidine compounds are closely related to biological activity. 6-Amino-5-iodopyrimidine-2 (1H) -ketone may be used as a key intermediate to construct novel molecules with pharmacological activity. At present, many scientific research teams have dedicated themselves to studying, hoping to use its unique structure to mine targeted drugs for specific diseases. For example, in the process of anti-tumor drug creation, modifying the structure of the compound may create a drug that can precisely act on the target of tumor cells. This direction is like a dark night spark, leading the journey of new drug development.
However, the road ahead for this compound market is not smooth. First, the synthesis process is not mature, and the current methods or existing steps are cumbersome, the yield is poor, and the cost is high, which limits its large-scale preparation and promotion. Second, although it has potential biological activity, the exact pharmacological mechanism and safety still need a lot of experimental data to prove it. Only by crossing the threshold of synthesis and activity verification, 6-amino-5-iodopyrimidine-2 (1H) -ketone can be obtained in the market.
What are the precautions in the preparation of 6-amino-5-iodopyrimidin-2 (1h) -one?
In the process of preparing 6-amino-5-iodopyrimidine-2 (1H) -ketone, there are several key points to pay attention to.
The first to bear the brunt, the selection of raw materials is crucial. The purity and quality of raw materials are directly related to the purity and yield of the product. The selected raw materials need to be strictly tested, and the impurity content must be controlled at a very low level to ensure the smooth progress of the reaction and reduce the occurrence of side reactions.
The control of the reaction conditions cannot be ignored. In terms of temperature, it needs to be precisely regulated according to the reaction mechanism and kinetics. If the temperature is too high, or the reaction is too violent, it will cause many side reactions and reduce the purity of the product; if the temperature is too low, the reaction rate will be slow and take a long time, which may also affect the yield. The reaction pressure also needs to be paid attention to. Some reactions can be carried out efficiently under a specific pressure environment, and improper pressure or reaction cannot achieve the desired effect.
Furthermore, the choice and dosage of catalysts are crucial. Appropriate catalysts can significantly accelerate the reaction rate and reduce the activation energy of the reaction. However, too much or too little catalyst dosage is unfavorable to the reaction. Too much dosage may cause unnecessary side reactions; too little, the catalytic effect is not good, and the reaction is difficult to advance efficiently.
The choice of reaction solvent is also important. The solvent not only needs to have good solubility to the reactants to promote full contact of the reaction, but also needs to be compatible with the reaction system and not participate in side reactions. Different solvents have an impact on the reaction rate, equilibrium and product selectivity, so careful selection is required.
The post-processing steps should not be underestimated. The process of product separation and purification is related to the purity of the final product. Appropriate separation methods, such as crystallization, extraction, chromatographic separation, etc., need to be selected according to the characteristics of the product. The operation process needs to be fine and careful to avoid product loss or the introduction of new impurities.
In short, the preparation of 6-amino-5-iodopyrimidine-2 (1H) -one requires careful treatment in many aspects such as raw materials, reaction conditions, catalysts, solvents and post-processing to obtain high-purity and high-yield products.