As a leading 6-Chloro-2-Iodo-9H-Purine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 6-chloro-2-iodo-9h-purine?
6-Chloro-2-iodine-9H-purine is an organic compound with unique chemical properties, which has attracted much attention in the fields of organic synthesis and medicinal chemistry.
In this compound, chlorine and iodine atoms give it specific reactivity. Chlorine atoms can participate in nucleophilic substitution reactions due to their electronegativity. Nucleophilic agents can attack carbon atoms attached to chlorine, and the chlorine atoms leave with a pair of electrons, thus forming new chemical bonds. For example, alcohol nucleophiles can react with them to form ether compounds, which are very important in the construction of complex organic molecular structures.
Iodine atoms also affect the chemical properties of this compound. Iodine atoms are relatively large and highly polarized, and can participate in some special reactions, such as the coupling reaction involving iodine aromatics. Iodine atoms in 6-chloro-2-iodine-9H-purine can be coupled with compounds containing unsaturated bonds under suitable catalyst and reaction conditions, which helps to construct carbon-carbon bonds or carbon-heteroatom bonds and expand the structural complexity of molecules.
In addition, the structure of the purine ring is also a key part of the chemical properties of the compound. Purine rings are widely present in organisms and participate in many biological processes. The purine ring of 6-chloro-2-iodine-9H-purine gives it a certain potential for biological activity. In the field of drug development, compounds with specific pharmacological activities may be designed based on this structural modification to act on specific targets in organisms, such as enzymes or receptors, thereby demonstrating the efficacy of treating diseases.
In terms of physical properties, the solubility of 6-chloro-2-iodine-9H-purine is affected by molecular polarity. Due to the presence of electronegative atoms such as chlorine and iodine, the molecule has a certain polarity and may have good solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF). This property facilitates its operation and application in chemical reactions and pharmaceutical preparations.
What is 6-chloro-2-iodo-9h-purine synthesis method?
The synthesis of 6-chloro-2-iodine-9H-purine is an interesting topic in organic synthetic chemistry. To synthesize this compound, the following steps can be followed.
First, choose purines as the starting material. Purines are nitrogen-containing heterocyclic compounds with specific structures, which are widely present in many bioactive substances and drug molecules. It is chlorinated to introduce chlorine atoms at the 6-position. Suitable chlorination reagents such as phosphorus oxychloride ($POCl_3 $) and phosphorus pentachloride ($PCl_5 $) can be used for this step. Taking phosphorus oxychloride as an example, purines interact with phosphorus oxychloride under heating and the presence of a suitable catalyst. The catalyst may be selected such as N, N-dimethylaniline, which can promote the reaction, so that the chlorine atom effectively replaces the hydrogen atom at the 6-position to generate 6-chloropurine.
The resulting 6-chloropurine is iodized to introduce the iodine atom at the 2-position. This step often requires the use of a suitable iodine substitution reagent, such as a combination of potassium iodide ($KI $) and hydrogen peroxide ($H_2O_2 $), or the use of N-iodosuccinimide (NIS). If the system of potassium iodide and hydrogen peroxide is used, under mild reaction conditions, in a suitable solvent, such as dichloromethane or acetonitrile, 6-chloropurine reacts with potassium iodide and hydrogen peroxide. Hydrogen peroxide acts as an oxidant to oxidize iodine ions into active iodine species, and then realizes the iodine substitution of the 2-position of 6-chloropurine to obtain 6-chloro-2-iodine-9H-purine.
During the synthesis process, it is necessary to pay attention to the precise control of reaction conditions, such as reaction temperature, reaction time, and dosage of reagents. If the temperature is too high or side reactions occur, the purity and yield of the product will be affected; if the time is too short, the reaction may be incomplete. In addition, the reaction products in each step need to be carefully separated and purified, and the commonly used methods include column chromatography, recrystallization, etc., to ensure the high purity of the obtained 6-chloro-2-iodine-9H-purine and meet the needs of subsequent research or application.
6-chloro-2-iodo-9h-purine in what areas
6-Chloro-2-iodine-9H-purine is used in medicine, chemical synthesis and other fields.
In the field of medicine, it is often used as a key intermediate in drug research and development. Because the purine structure has important physiological activities in organisms, the modification and modification of 6-chloro-2-iodine-9H-purine structure may lead to new drugs with specific pharmacological activities. For example, in the development of antiviral drugs, by optimizing the structure of the purine derivative, drugs with high affinity and inhibitory activity for specific viruses may be obtained, blocking virus replication and transmission, and opening up new avenues for antiviral treatment.
In the field of chemical synthesis, 6-chloro-2-iodine-9H-purine can be used as a building block for organic synthesis. Due to the high reactivity of chlorine and iodine atoms, it can participate in many organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. By ingeniously designing the reaction path to construct complex organic compounds, it provides a variety of options for materials science and fine chemical product synthesis. For example, in the research and development of new functional materials, the purine derivative can introduce specific functional groups to endow the material with unique optical, electrical or mechanical properties, expanding the application range of materials.
In summary, although 6-chloro-2-iodine-9H-purine is a niche chemical substance, it plays an indispensable role in the field of medicine and chemical synthesis, and has broad application prospects and research value.
What is the market outlook for 6-chloro-2-iodo-9h-purine?
6-Chloro-2-iodine-9H-purine has considerable market prospects today. This compound is a key intermediate in the field of medicinal chemistry. Looking at the current trend of pharmaceutical research and development, the creation of many new drugs depends on such purine derivatives containing special substituents.
Taking the development of anti-cancer drugs as an example, many studies have focused on the modification of purine structures, hoping to find new anti-cancer drugs with high efficiency and low toxicity. The unique structure of 6-chloro-2-iodine-9H-purine may be cleverly transformed into an anti-cancer active molecular system, giving it the ability to target tumor cells and inhibit tumor cell proliferation.
In the field of antiviral drugs, purine compounds have also made many achievements. The replication mechanism of viruses is often closely related to the nucleic acid metabolism of host cells, and the purine structure is an important component of nucleic acid. 6-chloro-2-iodine-9H-purine can interfere with the synthesis of viral nucleic acid after appropriate modification, and then achieve antiviral effect.
Furthermore, in the emerging field of materials science, organic optoelectronic materials are developing rapidly. Some organic molecules containing purine structures exhibit unique optoelectronic properties. 6-chloro-2-iodine-9H-purine may be derivatized and integrated into the organic optoelectronic material system to enhance its properties, such as enhancing the charge transport capacity of the material and improving the luminous efficiency.
However, its market prospects are not smooth sailing. The optimization of the synthesis process is crucial. If an efficient, green and low-cost synthesis route can be found, its market competitiveness will be enhanced. At the same time, safety and environmental friendliness considerations are also indispensable to ensure that the harm to the environment and human body during production and use is minimized. In short, although 6-chloro-2-iodine-9H-purine faces challenges, opportunities coexist. With time and research, it will be able to shine in the market.
What are the key points of 6-chloro-2-iodo-9h-purine production process?
6-Chloro-2-iodine-9H-purine is a key intermediate in organic synthesis. Its preparation process involves many key points, and I will explain in detail.
The selection of starting materials is extremely important. It is often started with purine compounds because their structure is similar to the target product, which can lay a good foundation for subsequent reactions. The purity and quality of the selected starting materials have a profound impact on the purity and yield of the product, so it is necessary to strictly control the quality of the raw materials, carefully screen and screen. In the halogenation reaction step, the precise control of the reaction conditions of chlorine and iodine is indispensable. In the chlorination reaction, factors such as reaction temperature, reaction time, and the amount of chlorination reagent have a significant impact on the reaction process and product formation. If the temperature is too high, it may cause more side reactions and reduce the purity of the product; if the temperature is too low, the reaction rate will be delayed, affecting the production efficiency. Similarly, the iodine reaction also requires precise regulation of the reaction conditions to ensure that iodine atoms are accurately introduced into the predetermined position and improve the selectivity of the target product. The choice of reaction solvent should not be underestimated. A suitable solvent can not only dissolve the reactants and promote the smooth progress of the reaction, but also affect the reaction rate and selectivity. In different reaction stages, it may be necessary to choose suitable solvents according to the reactants and reaction mechanism. For example, some polar solvents may promote the halogenation reaction, while other non-polar solvents may be more conducive to subsequent separation and purification.
Separation and purification links, in view of the existence of various by-products and unreacted raw materials in the reaction system, efficient separation and purification methods are essential. Commonly used methods include column chromatography, recrystallization method, etc. Column chromatography can be separated according to the difference in the distribution coefficient of each component between the stationary phase and the mobile phase; recrystallization method uses the solubility of the target product and impurities in different solvents to purify with different temperatures. This process requires optimizing operating conditions, improving product purity and reducing impurity content.
In the entire production process, quality monitoring is carried out throughout. With the help of modern analysis and detection technologies, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), high performance liquid chromatography (HPLC), etc., real-time monitoring of the reaction process and product purity. According to the detection results, adjust the reaction conditions and process parameters in time to ensure that the production process is stable and controllable, and the product quality meets the standard requirements.
When preparing 6-chloro-2-iodine-9H-purine, the starting materials, reaction conditions, solvent selection, separation and purification, and quality monitoring cannot be ignored. Only comprehensive control and fine operation can achieve efficient and high-quality production.