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What is the chemical structure of 6-iodo-1h-quinazolin-4-one?
The chemical structure of 6-iodine-1H-quinazoline-4-one is particularly important. This compound belongs to the quinazoline ketone class and has a unique structure.
Looking at its structure, the quinazoline parent nucleus is the base, which is a nitrogen-containing heterocyclic ring. It is formed by the combination of benzene ring and pyrimidine ring, and has aromatic properties. It is crucial in many biological activities and chemical reactions.
On the quinazoline parent nucleus, there is an iodine atom at position 6 connected. The iodine atom has a large atomic radius and high electronegativity, which has a great influence on the electron cloud distribution, spatial structure and chemical properties of the molecule. It can enhance the lipophilicity of molecules, play a role in drug transmembrane transport and other processes; it can also participate in coupling reactions, etc., and is an important functional group in organic synthesis.
Furthermore, there are hydrogen atoms at the 1H position, which can participate in the formation of hydrogen bonds and affect the interaction between molecules. It has an impact on the crystal structure, solubility and biological activity of compounds.
And 4-keto, that is, carbonyl, is a strong electron-absorbing group. It makes the molecule have a certain polarity and affects the physical and chemical properties of the molecule, such as boiling point, melting point, etc. In chemical reactions, carbonyl groups are active check points, and many reactions such as nucleophilic addition can occur, which are widely used in synthetic chemistry and medicinal chemistry.
The chemical structure of 6-iodine-1H-quinazoline-4-one is composed of quinazoline parent nucleus, 6-iodine atom, 1H-hydrogen atom and 4-ketone group. The interaction of various parts endows the compound with unique chemical and biological properties.
What are the main uses of 6-iodo-1h-quinazolin-4-one?
6-Iodo-1H-quinazolin-4-one is an organic compound with unique chemical structure and properties, which has important uses in many fields.
In the field of medicinal chemistry, this compound is often used as a key intermediate in drug development. Because its structure can be modified to fit specific biological targets, it is widely used in the development of anti-cancer drugs. Many studies have shown that drugs containing this structure exhibit inhibitory activity on cancer cell proliferation. By modifying and optimizing its chemical structure, it can improve drug efficacy, reduce toxic and side effects, and open up new avenues for cancer treatment.
In the field of organic synthetic chemistry, 6-iodo-1H-quinazolin-4-one is an important synthetic block. The structure of iodine atom and quinazolinone gives it unique reactivity and can participate in many organic reactions, such as coupling reactions, nucleophilic substitution reactions, etc. Through these reactions, complex and diverse organic compounds can be constructed, providing rich strategies and methods for organic synthetic chemistry, and assisting the development of new functional materials, total synthesis of natural products and other fields.
In the field of materials science, this compound can exhibit unique optoelectronic properties or become a candidate for new organic optoelectronic materials after appropriate modification and assembly. In organic Light Emitting Diodes, solar cells and other devices, it is expected to improve the performance and efficiency of devices with unique structures and properties, and inject new vitality into the development of materials science.
In summary, 6-iodo-1H-quinazolin-4-one plays a significant role in the fields of medicine, organic synthesis, and materials science. With the deepening of research, its potential uses will continue to be explored and expanded.
What are 6-iodo-1h-quinazolin-4-one synthesis methods?
The synthesis of 6-iodine-1H-quinazoline-4-one involves a variety of methods. One method is to take the appropriate aniline derivative first, let it be co-heated with formamide or its analogs, and undergo a cyclization reaction to obtain the quinazoline-4-one matrix. Subsequently, with a suitable iodizing agent, such as the combination of potassium iodide and hydrogen peroxide, or N-iodosuccinimide (NIS), etc., in a suitable solvent, such as dichloromethane and acetonitrile, the 6-position of the parent compound is iodized to obtain the target product 6-iodine-1H-quinazoline-4-one.
Another method can be used to prepare the quinazoline ring system first. For example, by condensation of anthranilic acid with formamide, the quinazoline-4-one structure is formed by cyclization. Then, through a halogenation reaction, iodine atoms are introduced. In this halogenation step, in addition to the above-mentioned iodizing reagents, iodine can also be used in synergy with appropriate oxidizing reagents to achieve 6-position iodization modification under mild reaction conditions.
Furthermore, there is a strategy to gradually introduce iodine atoms through functional group conversion using quinazoline with specific substituents as the starting material. For example, a group that can be converted into iodine atoms is introduced at a suitable position of the quinazoline ring, such as a diazosalt group, and then after the diazotization reaction, it is treated with potassium iodide and other reagents to replace the diazoyl group with iodine atoms, thereby achieving the synthesis of 6-iodine-1H-quinazoline-4-one. Each of these methods has its own advantages and disadvantages, and the reaction conditions, yield, and selectivity are all different. It is necessary to choose carefully according to specific needs and actual conditions.
What are the physical properties of 6-iodo-1h-quinazolin-4-one?
6-Iodine-1H-quinazoline-4-one is a kind of organic compound. Its physical properties are quite important, and it is related to the characteristics and uses of this compound.
First of all, its appearance is mostly solid at room temperature and pressure. The color of this solid is usually white-like to light yellow powder, and it is uniform and delicate. The reason for its color is the chemical bonds and electron cloud distribution in the molecular structure, which produce specific absorption and reflection of visible light.
As for the melting point, it has been experimentally determined to be about a certain temperature range. The value of the melting point is affected by the forces between molecules, such as van der Waals force, hydrogen bond, etc. The molecular force of this compound is specific, and the melting point is within a certain range. This property is very critical in the identification and purification process.
Solubility is also an important physical property. In common organic solvents, its solubility varies. In organic solvents such as dichloromethane, N, N-dimethylformamide, etc., there is a certain solubility. This is because the organic solvent and the compound molecules can be dispersed by van der Waals force, dipole-dipole interaction, etc. However, in water, its solubility is extremely low. This is because the hydrogen bond between water molecules is strong, and the interaction between the compound and water molecules is weak, making it difficult to fully miscible with water molecules.
Furthermore, its density is also an inherent physical property. Although the exact value needs to be accurately measured experimentally, its density is closely related to the molecular structure. The type, number and spatial arrangement of atoms in the molecule jointly determine the density. This property is of great significance in application scenarios involving the relationship between mass and volume.
In addition, the stability of the compound is also a physical property consideration. Under general environmental conditions, it has certain stability. When exposed to high temperature, strong light or specific chemical reagents, its molecular structure may change. This stability is derived from the strength and stability of chemical bonds within the molecule. Different chemical bonds have different sensitivities to external conditions, which affect the overall stability of the compound.
What is the price range of 6-iodo-1h-quinazolin-4-one in the market?
6-Iodo-1H-quinazolin-4-one, this is an organic compound. However, its price range is difficult to specify above the market. Many factors will affect its price.
First, the difficulty of production and preparation. If the synthesis of this compound requires complicated steps, the raw materials used are rare and difficult to obtain, or the reaction conditions are harsh, the production cost will rise, and the price will be higher.
Second, the amount of market demand. If this compound is widely used in medicine, chemical industry and other fields, the demand is strong, but the supply is limited, the price will rise due to supply and demand; conversely, if the demand is small, the price may be relatively low.
Third, the difference between manufacturers and brands. Different manufacturers have different production processes and product purity, and well-known brands may have different product prices due to strict quality control and good reputation.
Fourth, the situation of market competition. If there are many manufacturers producing this compound in the market and the competition is fierce, in order to compete for market share, manufacturers may compete through price means, resulting in lower prices; conversely, if the market is close to monopoly, prices may be controlled by monopolists.
It can be seen from the above that the price of 6-iodo-1H-quinazolin-4-one is difficult to have a fixed price range in the market due to the above factors, or it is possible to go from a lower price to a relatively high price. It is necessary to consider all factors before making a general judgment.
