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What is the chemical structure of 6-iodo-3h-quinazolin-4-one?
6-Iodo-3h-quinazolin-4-one is also a chemical substance. Its transformation is profound and allows me to explain it.
This compound is related to quinazolinone. Quinazolinone is an important compound skeleton, which is often used in polymers and bioactive molecules.
6-iodo-3h-quinazolin-4-one, "6-iodo" is the introduction of iodine atoms at the 6th position of the quinazolinone parent nucleus. Iodine atoms have large atomic half and special sub-effects. Its introduction can change the physical and chemical properties of the molecule, such as the molecular properties, fat solubility, etc. In the compound, it is often based on the bioavailability of the compound and the interaction of the target.
"3h-quinazolin-4-one" indicates its parent nucleus. Quinazoline is fused from one benzene and one pyrimidine, while "4-one" indicates the presence of a carbonyl group at the 4 position. Carbonyl, which is functional, can also form other molecular interactions, which are very important in the qualitative and biological activity table of molecules.
Therefore, the 6-iodo-3h-quinazolin-4-one chemical compound is composed of iodine substituents, quinazoline thickeners, and 4-position carbonyl groups. This property makes it possible to use it in chemical and biological fields.
What are the main uses of 6-iodo-3h-quinazolin-4-one?
6-Iodine-3H-quinazoline-4-one, an organic compound, has important uses in many fields.
First, in the process of pharmaceutical research and development, its position is quite critical. Because of its unique structure and potential biological activity, it can be used as a lead compound. Through chemical modification and optimization, new drugs may be created. For example, in the development of anti-tumor drugs, studies have found that it exhibits inhibitory effects on the growth of some tumor cells, which may become a key starting point for the development of targeted anti-cancer drugs. Due to the great harm of tumor diseases, the search for high-efficiency and low-toxicity anti-cancer drugs is a top priority in medical research, and this compound opens up new paths for the development of anti-cancer drugs.
Second, in the field of organic synthesis, it is also an important intermediate. Organic synthesis aims to create various complex organic molecules, 6-iodine-3H-quinazoline-4-one can participate in many organic reactions due to its specific chemical structure and reactivity. By reacting with different reagents, organic compounds with diverse structures can be constructed, laying the foundation for the synthesis of organic materials with specific functions and structures.
Third, in the field of materials science, it may have potential applications. With the advancement of science and technology, the demand for materials with special properties is increasing. 6-Iodine-3H-quinazoline-4-one may be able to prepare materials with unique optical and electrical properties through specific processes. For example, in the field of optoelectronic devices, new luminescent materials may be developed for the manufacture of more efficient optoelectronic devices such as display screens, promoting the development of materials science.
What is 6-iodo-3h-quinazolin-4-one synthesis method?
The synthesis of 6-iodine-3H-quinazoline-4-one is one of the important topics in organic synthetic chemistry. Its synthesis often follows a variety of paths, one of which is described in detail today.
First, an appropriate aniline derivative is used as the starting material. This aniline derivative needs to have a specific substituent in order to proceed smoothly in the subsequent reaction. Co-heating it with formamide is a critical reaction condition. The temperature needs to be precisely controlled within a certain range, between [X] ° C and [X] ° C. After a few years, the condensation reaction can occur between the two to generate 2-aminobenzamide compounds.
The resulting 2-aminobenzamide compound is combined with an iodine source and an appropriate oxidant in the reaction system. Iodine sources such as potassium iodide are commonly used, and oxidants such as hydrogen peroxide are more common. This reaction needs to be carried out in a specific solvent, such as dichloromethane, N, N-dimethylformamide. Under this reaction condition, iodine atoms can be selectively introduced into specific positions in the benzene ring to generate 6-iodine-2-aminobenzamide intermediates.
Finally, this intermediate is cyclized under alkaline conditions. Sodium hydroxide, potassium carbonate, etc. can be selected for the base. The reaction temperature also needs to be carefully controlled. At about [X] ° C, after an appropriate period of time, a cyclization reaction occurs in the molecule to form the target product 6-iodine-3H-quinazoline-4-one. After the reaction is completed, the pure product can be obtained by separation and purification methods, such as column chromatography, recrystallization method, etc.
Synthesis of this compound requires precise control of the reaction conditions at each step. The purity of the raw material, the temperature of the reaction, time, and the choice of solvent all have a great impact on the yield and purity of the product. However, with the above steps and careful operation, the required 6-iodine-3H-quinazoline-4-one can be obtained.
What are the physical properties of 6-iodo-3h-quinazolin-4-one?
6-Iodo-3h-quinazolin-4-one is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is mostly in a solid state, which is caused by strong intermolecular forces, resulting in tight molecular arrangement. The color state may be white to light yellow powder, which may be derived from the absorption and reflection characteristics of the molecular structure.
In terms of melting boiling point, the melting point is higher. Due to the existence of various forces in the molecule, such as hydrogen bonds, van der Waals forces, etc., more energy is required to overcome these forces, causing the molecular spacing to increase and melting. The specific melting point value will fluctuate due to factors such as purity. The boiling point is also relatively high. To make it boil, it is necessary to provide enough energy to break the complex interactions between molecules.
In terms of solubility, it has a certain solubility in common organic solvents, such as ethanol, acetone, etc. This is because the molecules of these organic solvents can form similar forces with 6-iodo-3h-quinazolin-4-one molecules, and follow the principle of similar phase dissolution. However, the solubility in water is not good, because the hydrophobic part of the molecular structure accounts for a large proportion, it is difficult for water molecules to form effective interactions with the compound molecules, and it is impossible to disperse them in water.
Density or greater than water, because the relative mass of the molecules is larger and the molecular arrangement is relatively close, resulting in a larger mass per unit volume.
In addition, the compound has certain characteristics of stability to light and heat. Under light, parts such as iodine atoms in the molecule may undergo photochemical reactions, causing structural changes; when heated, up to a certain temperature, chemical bonds in the molecule may break or rearrange, which affects its stability.
What is the market outlook for 6-iodo-3h-quinazolin-4-one?
6-Iodo-3h-quinazolin-4-one is one of the organic compounds. As for its market prospects, in today's world, the research on novel compounds in the field of medicinal chemistry is increasing day by day. This compound may have unique potential in the road of drug development. Because in many drug studies, compounds with nitrogen-containing heterocyclic structures often show a variety of biological activities. 6-Iodo-3h-quinazolin-4-one has the basic structure of quinazolinone and introduces iodine atoms at the 6th position. This unique structure may give it special pharmacological activity.
Looking at the pharmaceutical market, the development of anti-cancer drugs is a top priority. Many studies have revealed that quinazolinone compounds have inhibitory effects on a variety of cancer cell lines. 6-iodo-3h-quinazolin-4-one or due to the introduction of iodine atoms, changing molecular polarity, electron cloud distribution, and enhancing interaction with biological targets, it is expected to become a leading compound of new anti-cancer drugs. In addition, in the field of antibacterial and anti-inflammatory, iodine-containing organic compounds also occasionally have good results. 6-iodo-3h-quinazolin-4-one may find a place in the treatment of such diseases.
However, its market prospects are not smooth. The process of synthesizing this compound may have complicated steps and low yield, resulting in rising production costs. And the metabolic process, toxic and side effects in the organism still need to be further studied. Only by overcoming such difficulties, optimizing the synthesis process, and clarifying the pharmacological mechanism, 6-iodo-3h-quinazolin-4-one has the opportunity to go from the laboratory to the broad market, contributing to human health and well-being.
