6-iodo-4-methoxy (1h)indazole

The chemical structure of 6-iodine-4-methoxy (1H) indazole is as follows.
This compound belongs to indazole derivatives. The indazole ring is a nitrogen-containing double ring structure, which is formed by fusing a benzene ring with a five-membered azole ring. In this compound, iodine atoms are connected to the 6 position of the indazole ring. The iodine atoms have a large atomic radius and electronegativity, which affect the electron cloud distribution and spatial structure of the molecule, and can change the polarity and chemical reactivity of the molecule. The methoxy group is connected at the 4 position, and the oxygen atom in the methoxy group is connected to the carbon of the benzene ring with a single bond. The methoxy group is the power supply group, which can increase the electron cloud density of the benzene ring, which in turn affects the electron cloud density of the entire indazole ring, changing its chemical properties and reaction check point selectivity.
1H indicates that the hydrogen atom is in a specific position of the indazole ring, that is, the hydrogen atom participating in the formation of the azole ring. This hydrogen atom is in a specific electronic environment, and its chemical displacement and other properties will have unique manifestations in spectral analysis. The overall structure of the compound is endowed with unique physical and chemical properties due to the presence of these substituents, which may have potential applications in the fields of medicinal chemistry, organic synthesis chemistry, etc. For example, it can be used as a lead compound to develop drugs with specific biological activities. By modifying its structure, changing the type and position of substituents, etc., to explore the influence on biological activities.

6-Iodine-4-methoxy (1H) indazole, this substance has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. Due to its unique structure, it can interact with specific targets in organisms, helping to develop highly effective and specific therapeutic drugs, such as targeted therapeutic drugs for specific diseases, which are expected to accurately act on diseased cells, reduce damage to normal cells, and improve therapeutic effects.
In the field of materials science, it can be modified and polymerized to prepare materials with special optical and electrical properties. The presence of iodine and methoxy groups may endow materials with unique optoelectronic properties, such as application in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, improving device performance and efficiency.
In the field of organic synthesis, 6-iodine-4-methoxy (1H) indazole is an important raw material. Through various chemical reactions, such as coupling reactions, substitution reactions, etc., to construct more complex organic molecular structures, expand the variety of organic compounds, provide key support for the development of organic synthesis chemistry, and promote research and innovation in related fields.

6-Iodo-4-methoxy (1h) indazole is an organic compound with unique physical properties. Its shape or crystalline solid, often white to pale yellow powder shape, which is determined by the atomic arrangement and electron cloud distribution in the molecular structure, and is quite stable under conventional conditions.
Its melting point is a specific temperature, about 180-185 ° C. Due to intermolecular forces, such as van der Waals force, hydrogen bonding, etc., at this temperature it is sufficient to overcome the lattice energy and cause the substance to change from solid to liquid.
In terms of solubility, this compound has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). Due to the fact that these organic solvents and 6-iodo-4-methoxy (1h) indazole molecules can form similar intermolecular forces, such as dispersion force and dipole-dipole interaction, they are mutually soluble. However, the solubility in water is very small, because the molecular polarity is very different from that of water molecules, it cannot form effective hydrogen bonds with water molecules and other strong interactions.
The density of this compound is about 1.8-1.9 g/cm ³, which is determined by the relative mass of its molecules and the degree of molecular packing compactness.
In addition, 6-iodo-4-methoxy (1h) indazole is chemically stable at room temperature and pressure, but under specific conditions such as high temperature, strong acid base or the presence of specific catalysts, chemical reactions will occur because of its molecular iodine atom, methoxy group and nitrogen atom on the indolazole ring have certain reactivity.

There are various ways to synthesize 6-iodine-4-methoxy (1H) indazole. First, it can be prepared from a suitable starting material through a multi-step reaction. For example, an aniline derivative with a suitable substituent is first taken and condensed with a carbonyl compound under specific conditions to form a nitrogen-containing heterocyclic intermediate. This process requires careful control of the reaction temperature, pH and reaction time to proceed in the desired direction. Then, the resulting intermediate is halogenated to introduce iodine atoms. At the time of halogenation, an appropriate halogenating agent, such as iodine elemental substance and a suitable oxidizing agent, needs to be selected to efficiently obtain iodine substitutes. And the choice of reaction solvent is also very critical, different solvents may have a significant impact on the reaction rate and selectivity.
Furthermore, another strategy is to start from the compound containing the indazole skeleton and introduce the methoxy group first. This can be achieved by nucleophilic substitution reaction, in which a suitable halogenated alkane reacts with an indazole derivative containing phenolic hydroxyl groups under basic conditions to form a methoxy-substituted product. Then, an iodine substitution reaction is carried out, and an iodine atom is added to the target site. In this path, the separation and purification of each step of the reaction cannot be ignored, and high-purity 6-iodine-4-methoxy (1H) indazole products need to be obtained by means such as column chromatography and recrystallization.
Synthesis of this compound requires fine regulation of reaction conditions, attention to the mechanism and influencing factors of each step of the reaction, in order to successfully achieve the goal and obtain the product with ideal yield and purity.

6-Iodine-4-methoxy (1H) indazole This product, when using, many precautions need to be kept in mind.
Bear the brunt, and safety must not be forgotten. Because of its potential hazards, protective gear must be comprehensive when exposed. If you wear suitable gloves to prevent skin contact with it and avoid irritation or allergies; the eyes also need to be properly protected, goggles and the like are essential to prevent accidental splashing into the eyes and causing damage to the eyes.
In addition, the chemical properties must also be understood in detail. How the reactivity of this compound and how it changes under different conditions need to be thoroughly studied. In terms of storage, choose the appropriate place according to its characteristics. It needs to be dry and cool, away from fire and heat sources to avoid decomposition, deterioration, or even danger.
The operation process must be rigorous. Follow the established operating procedures, and do not change the steps and conditions at will. Whether it is weighing, mixing, or reaction control, it must be accurate. If a chemical reaction is involved, the reaction conditions such as temperature, pressure, time, etc. must be strictly controlled. If there is a slight poor pool, the reaction may fail, or unexpected products may be generated, or even safety accidents may be caused.
At the same time, the disposal of waste cannot be ignored. It cannot be discarded at will, and it must be properly disposed of in accordance with relevant regulations to prevent pollution to the environment.
In addition, ventilation in the use place is also crucial. Good ventilation can remove harmful gases in time, reduce the concentration of harmful substances in the air, and protect the health of users.
Only by paying attention to the above things and operating cautiously can the use of 6-iodine-4-methoxy (1H) indazole achieve the desired purpose and ensure safety and environmental harmlessness.