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What is the chemistry of 6-iodo-5h-purin-2-amine?
6-Iodo-5h-purin-2-amine, Chinese name or 6-iodine-5H-purine-2-amine. This is an organic compound with specific chemical properties.
Its structure contains a purine ring, which is common in many bioactive molecules, such as the components of nucleic acids. The 6-position iodine atom and the 2-position amino group give the compound unique reactivity.
The iodine atom has a large atomic radius and electronegativity. Because of its large radius, it will affect the molecular space structure and steric resistance effect. In the case of nucleophilic substitution reaction, the iodine atom can be used as a leaving group and is easily replaced by nucleophilic reagents because the C-I bond is relatively weak. In terms of electronegativity, iodine reduces the electron cloud density of the connected carbon atoms, making this part more susceptible to attack by nucleophilic reagents. The amino group at the
2 position is basic, and the amino nitrogen atom has lone pair electrons, which can bind protons and easily protonate in an acidic environment to form positively charged ammonium ions. And amino groups can participate in a variety of reactions, such as reacting with acylating reagents to form amide bonds. This reaction is often used in organic synthesis to construct amide-containing structural compounds, and amide bonds are key structural units in many drugs and bioactive molecules.
6-iodo-5h-purin-2-amine may have potential applications in organic synthesis and medicinal chemistry due to its special structure. Or as a synthetic intermediate, more complex bioactive compounds can be constructed through series of reactions. In drug development, or based on its structural modification, explore new compounds with specific pharmacological activities.
What are the physical properties of 6-iodo-5h-purin-2-amine?
6-Iodo-5h-purin-2-amine, Chinese name or 6-iodine-5H-purine-2-amine. This is an organic compound with special physical properties.
Looking at its properties, it may be solid at room temperature, because most organic amines are solid. Its color may be white to light yellow powder, and many nitrogen-containing heterocyclic organic compounds are in this state, which is caused by the conjugation system and electronic transition in the molecular structure.
When it comes to melting points, there are hydrogen bonds and van der Waals forces between molecules, or there is a relatively high melting point. However, the exact value varies depending on the experimental conditions and purity. The hydrogen bond acts between the amino group and the purine ring nitrogen atom, enhancing the attractive force between molecules, causing higher energy to destroy the lattice and melt the substance.
In terms of solubility, the solubility in water is poor. The compound has limited polarity, while water is a strong polar solvent. According to the principle of "similar miscibility", the solubility is weak if the polarity difference is large. However, it may have a certain solubility in some organic solvents, such as dichloromethane and ethanol. Methylene dichloride has moderate polarity and good solubility, and can form intermolecular forces with the compound to help it dissolve; ethanol has both polar hydroxyl groups and non-polar alkyl groups, which can form hydrogen bonds with the compound and provide a certain non-polar environment, which is favorable for dissolution.
Its density may be slightly higher than that of water, and the relative atomic weight of iodine atoms in the molecule is large, which increases the molecular weight and causes the mass per unit volume to increase.
The volatility is very small, the intermolecular force is strong, and the molecule needs more energy to break away from the liquid surface and enter the gas phase, so it is difficult to volatilize at room temperature and pressure.
To sum up, the physical properties of 6-iodine-5H-purine-2-amine are significantly affected by the molecular structure, and these properties are of great significance for its application in organic synthesis, drug development and other fields.
What are the main uses of 6-iodo-5h-purin-2-amine?
6-Iodo-5h-purin-2-amine, Chinese name: 6-iodo-5H-purine-2-amine, this is a unique compound, its main use, can be used in many fields.
In the process of research and development, it is often used as an important medium. If you want to make a specific anti-tumor compound, you may need to use it as a starting material. Because of its molecular properties, it can be used to modify anti-tumor compounds with specific biological activities. This compound can target specific proteins or pathways in tumor cells, inhibit tumor cell proliferation, and treat tumor cells.
In the field of chemical synthesis, it also plays an important role. Chemists can use its characteristics to develop a series of synthetic inverse. With its basis, more and more purine derivatives are built. This derivative is useful in materials science, catalysis and other fields. For example, synthesizing materials with special light and performance, it is expected to improve device performance for devices such as optical diodes (OLEDs) and solar cells.
In biological chemical research, 6-iodine-5H-purine-2-amine can be used as a tool molecule. The researchers study the functional properties of biological macromolecules such as nucleic acids and proteins, and use this geophysical exploration to explore the properties of iodine atoms. By means of radioactive or optical techniques, the generation, localization and interaction of biological macromolecules can be traced, helping researchers to gain a deeper understanding of the molecular mechanism of life.
Therefore, 6-iodine-5H-purine-2-amine compounds play an important role in multiple fields such as chemistry, biology, etc., and promote the development of multi-disciplinary research technologies.
What are 6-iodo-5h-purin-2-amine synthesis methods?
6-Iodo-5h-purin-2-amine, Chinese name or 6-iodine-5H-purine-2-amine. The synthesis method is as follows:
The starting material can be selected from purine compounds, which are based on common purine derivatives. Because of the stable structure of the purine ring and the specific reactivity of each point, it is conducive to the subsequent introduction of iodine and amino groups.
First, the amino group is introduced at the 2-position of the purine ring. It can be achieved by nucleophilic substitution reaction, select suitable amino-containing reagents, such as ammonia derivatives, under suitable reaction conditions, such as in organic solvents, control the reaction temperature and time, so that the amino group replaces the group at a specific position on the purine ring. This step requires attention to the selectivity of the reaction, because the activities of different check points on the purine ring are different.
Subsequently, iodine atoms are introduced at the 6-position. Iodization reactions are often used, and suitable iodizing reagents can be selected, such as iodine elementals combined with appropriate oxidants, in a specific reaction system, iodine atoms are selectively added to the 6-position of the purine ring. This process requires strict reaction conditions, and precise control of temperature, pH and other factors is required to ensure that iodine atoms are accurately added to the target position, while avoiding damage to the introduced amino groups and other parts of the purine ring.
After the reaction is completed, the product needs to be separated and purified. Chromatographic separation techniques, such as column chromatography, can be used to achieve effective separation according to the difference in the distribution coefficient of the product and the impurity between the stationary phase and the mobile phase; recrystallization can also be used to select a suitable solvent, and the solubility of the product and the impurity at different temperatures can be used to obtain high-purity 6-iodo-5h-purin-2-amine products through multiple crystallization operations.
Synthesis requires close monitoring of the reaction process, using thin layer chromatography (TLC) or high performance liquid chromatography (HPLC) and other means to adjust the reaction conditions in time to ensure the smooth progress of the reaction and improve the yield and purity of the product.
6-iodo-5h-purin-2-amine need to pay attention to when storing and transporting
6-Iodo-5h-purin-2-amine is a chemical substance. When storing and transporting it, many matters need to be paid attention to.
When storing, the first choice of environment. When placed in a cool and dry place, it is easy to change its properties due to moisture, and high temperature may cause chemical reactions, which will damage its quality. And it should be kept away from fire and heat sources, because it may be flammable or have an unstable reaction with heat.
Furthermore, it should be placed in a well-ventilated place. Good ventilation can avoid the accumulation of harmful gases. If the substance evaporates and produces harmful gases, poor ventilation will endanger the safety of the storage environment. At the same time, it should be stored separately from oxidizing agents, acids and other substances. Due to the chemical properties of 6-iodo-5h-purin-2-amine, or violent reactions with such substances, dangerous accidents can occur.
When transporting, the packaging must be sturdy. Suitable packaging materials should be selected to ensure that it is not damaged by vibration or collision during transportation. If the packaging is damaged, the substance leaks, or pollutes the environment, or poses a hazard to transporters.
During transportation, the appropriate temperature and humidity should also be maintained to avoid sun exposure and rain. Transportation vehicles should also be clean and free of residual chemicals to prevent reactions with 6-iodo-5h-purin-2-amine. And transportation personnel should be familiar with its characteristics and emergency treatment methods. In case of emergencies, they can respond quickly and effectively to ensure transportation safety.
