6 Iodo 7h Purin 2 Amine

6-Iodo-7H-purin-2-amine, the Chinese name can be called 6-iodine-7H-purine-2-amine. Its chemical structure is based on the parent nucleus of purine. Purine is a nitrogen-containing heterocyclic compound with a double-ring structure. It is formed by fusing a six-membered pyridine ring with a five-membered imidazole ring.
In this compound, the second position of the purine parent nucleus is connected to an amino group (-NH2O), which endows the molecule with certain alkalinity and reactivity. It can participate in many chemical reactions, such as reacting with acids to form salts, and can also perform nucleophilic substitution reactions with other compounds under specific conditions. At the sixth position of the purine parent nucleus, an iodine atom (-I) is connected, and the introduction of iodine atoms significantly changes the physical and chemical properties of the molecule. The electronegativity of iodine atoms and the steric resistance effect will affect the reactivity, solubility and intermolecular forces of the molecule. For example, the iodine atom can participate in nucleophilic substitution reactions as a leaving group, so that the compound can be used as an intermediate in organic synthesis for the construction of more complex compounds containing purine structures.
7H - Indicates that the hydrogen atom in the compound is at a specific position at position 7, which is crucial for determining the precise structure and stereochemical characteristics of the molecule. Hydrogen atoms at different positions have different chemical environments, and they will present different signals in spectral analysis (such as nuclear magnetic resonance spectroscopy), so that the structure of the molecule can be accurately determined. In conclusion, the chemical structure of 6-iodine-7H-purine-2-amine is composed of the purine mother nucleus, the amino group at position 2 and the iodine atom at position 6, and the interaction of each part endows the compound with unique chemical properties and potential application value.

6-Iodo-7H-purin-2-amine, that is, 6-iodo-7H-purin-2-amine, is a kind of organic compound. Its physical properties are described in detail as follows:
Looking at its properties, it usually shows a solid state, but the specific color state may vary depending on the purity and crystal form. Most of them are white to white-like powders. This is due to the atomic arrangement and interaction in the molecular structure, resulting in light scattering and absorption characteristics.
As for the melting point, it has been determined by many experiments to be around [X] ° C. The value of the melting point is an important physical constant of a substance and is determined by the intermolecular forces. In this compound, there are hydrogen bonds, van der Waals forces and other interactions between molecules. When the temperature rises to the melting point, these forces are weakened, and the molecule can break free from the lattice binding and convert from solid to liquid.
In terms of solubility, the solubility in water is quite limited. This is due to the relatively weak molecular polarity of the compound, and water is a strong polar solvent. According to the principle of "similar miscibility", the solubility is poor if the polarity difference is large. However, in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., it exhibits some solubility. In dichloromethane, due to the weak polarity of dichloromethane and the partial structure of 6-iodine-7H-purine-2-amine molecules, it can be dissolved through the interaction of intermolecular forces; in DMF, the strong polarity of DMF interacts with the nitrogen-containing atoms in the compound molecules to form hydrogen bonds, etc., which also helps to dissolve.
Its density is about [X] g/cm ³. This density value reflects the mass of the substance per unit volume and is related to the relative molecular weight of the molecule and the way of molecular packing. The relative molecular weight of the compound increases due to the presence of heavier atoms such as iodine atoms, and the degree of molecular packing in the crystal also affects the density.
In addition, the stability of the compound is acceptable at room temperature and pressure. However, under specific conditions such as high temperature and strong oxidants, the molecular structure may change. Due to the certain chemical activity of the purine ring and iodine atom in the molecular structure, the thermal motion of the molecule intensifies at high temperature, and the vibration of the chemical bond is enhanced, which may lead to the fracture and recombination of the bond; the strong oxidant may react with some parts of the molecule that are easily oxidized, changing its chemical structure and thereby affecting its physical properties.

6-Iodo-7H-purin-2-amine is one of the organic compounds. The method of its preparation is often the way of chemical synthesis.
The preparation of this compound in the past depends on the technology of organic synthesis. One method, or starting from purine compounds, undergoes an iodine substitution reaction, so that the iodine atom is introduced into the 6 position of the purine ring, and the amino group at the 2 position is retained at the same time. This iodine substitution reaction often requires suitable reaction conditions and reagents. For example, a specific iodine source, such as iodine elemental or iodine-containing reagents, can be selected in a suitable solvent environment, with a suitable catalyst and reaction temperature, to promote the precise substitution of iodine atoms in the target position.
In addition, or starting from purine derivatives with specific substituents, through a series of stepwise reactions, the molecule is first modified to construct a suitable reaction check point, and then iodine atoms and amino groups are introduced to achieve the purpose of generating 6-iodo-7H-purin-2-amine. In this process, each step of the reaction needs to be carefully controlled to ensure the selectivity and yield of the reaction.
Other related compounds are used as raw materials and gradually converted through ingenious reaction route design. Each step of the reaction is related to the activity of the reactants and the control of the reaction conditions, such as pH, temperature, reaction time and other factors, which have a key impact on the formation of the product. After synthesis, it needs to go through the steps of separation and purification to obtain pure 6-iodo-7H-purin-2-amine, which can be used for subsequent research or application.

To prepare 6-iodine-7H-purine-2-amine, there are three methods.
One is the halogenation method. First take purine-2-amine, put it in a suitable reaction vessel, and dissolve it with a suitable solvent, such as dichloromethane or N, N-dimethylformamide. Then slowly add a halogenating reagent, such as a mixture of potassium iodide and hydrogen peroxide, or a system of iodine and ferric chloride. During the reaction, the temperature should be controlled in a moderate range, between about 0 ° C and room temperature, and constantly stirring. This is because the activity and selectivity of the halogenation reaction need to be carefully regulated. If the temperature is too high, side reactions will easily occur, resulting in impure products. After the reaction is completed, the product can be purified by conventional separation methods, such as column chromatography, to obtain 6-iodine-7H-purine-2-amine.
The second is a coupling method. Boric acid derivatives containing purine-2-amine structure and iodoaromatic hydrocarbons are used as raw materials, and the coupling reaction is carried out under the action of palladium catalyst. First, the boric acid derivatives, iodoaromatic hydrocarbons, palladium catalysts (such as tetra (triphenylphosphine) palladium) and bases (such as potassium carbonate) are placed in the reaction flask in a certain proportion, and an organic solvent such as toluene or 1,4-dioxane is added. The reaction needs to be carried out under the protection of inert gas to avoid the oxidation of raw materials and catalysts. The temperature is heated to a suitable temperature, usually between 80 ° C and 120 ° C, and the reaction is carried out for several hours. After the reaction is completed, pure 6-iodine-7H-purine-2-amine can be obtained through extraction, drying, column chromatography and other steps. The advantage of this coupling method is that it has good selectivity and can accurately construct carbon-iodine bonds.
The third is the protection-halogenation-deprotection method. The specific functional groups of purine-2-amine are first protected to prevent them from being affected during halogenation. The amino group is often protected by acetyl group, and the amino group is reacted with purine-2-amine with an appropriate acylating agent (such as acetic anhydride) to form an amino-protected derivative. Subsequently, the protected derivative is halogenated by the method of isohalogenation. After the halogenation is completed, the protective group is removed under basic conditions (such as sodium hydroxide solution) to restore the activity of the amino group. Finally, after separation and purification, the target product 6-iodine-7H-purine-2-amine can also be obtained. Although this method is a little complicated, it can effectively improve the selectivity of the reaction and the purity of the product.

6-Iodo-7H-purin-2-amine is a chemical substance. Many things need to be paid attention to when storing and using this substance.
When storing, the first environment is dry. If the environment is humid, water vapor is easy to interact with the substance, or cause it to chemically react and change its own chemical properties. Therefore, it should be placed in a dry, well-ventilated place, away from water sources and moisture.
Temperature is also critical. Overheating or overcooling temperatures may affect its stability. Generally speaking, it should be stored in a conventional room temperature environment to avoid high temperature exposure to prevent accelerated decomposition; also avoid extreme cold and low temperature to avoid affecting its physical or chemical properties.
In addition, care should be taken to avoid mixing with other chemicals. This substance may react with certain chemicals, such as strong oxidizing agents, reducing agents, etc. Different chemicals come into contact with each other, or cause violent reactions, or even endanger safety, so be sure to store it separately when storing, away from other potential reactive substances.
When using, safety protection is indispensable. Wear appropriate protective equipment, such as gloves, to prevent skin contact. Due to its irritating or corrosive effect on the skin, direct contact can cause skin damage. At the same time, goggles should be worn to avoid substances splashing into the eyes, causing serious damage to the eyes.
The operation process should be carried out in a fume hood. This substance may evaporate harmful gases during use, and the fume hood can effectively discharge these gases to prevent the accumulation of harmful gases in the laboratory and ensure the safety of users' breathing.
In addition, the dosage must be precisely controlled. Due to its special chemical properties, excessive use not only causes waste, but also may cause uncontrollable chemical reactions and pose safety hazards. Therefore, it is necessary to strictly follow the experimental requirements or production standards to use it accurately.
In short, whether it is storage or use of 6-iodo-7H-purin-2-amine, it is necessary to treat it with caution and strictly abide by relevant norms and requirements to ensure safety and avoid accidents.