6 Iodoquinazolin 4 1h One

6-Iodoquinazolin-4 (1H) -one is one of the organic compounds. Its chemical structure is unique and derived from the quinazoline parent nucleus.
The quinazolin parent nucleus is a nitrogen-containing heterocyclic structure with double ring characteristics. One ring is a benzene ring, and the other ring is a pyrimidine ring fused with a benzene ring. In this structure, there is a carbonyl group (C = O) at the 4th position of the quinazoline parent nucleus. The oxygen atom in this carbonyl group is double-bonded to the carbon atom at the 4th position, and is replaced by an iodine atom at the 6th position.
Such a chemical structure endows 6-iodoquinazolin-4 (1H) -one with specific physical and chemical properties. The presence of nitrogen atoms, oxygen atoms and iodine atoms in its structure makes the molecule have a certain polarity, which affects its solubility in different solvents. At the same time, the lone pair electrons carried by these atoms can participate in various chemical reactions, such as nucleophilic substitution reactions and electrophilic substitution reactions. Due to its unique structure, it is often used as a key intermediate in the field of organic synthesis to prepare compounds with specific biological activities, and has potential applications in many fields such as medicinal chemistry and materials science.

6-Iodoquinazolin-4 (1H) -one is an organic compound that has several important physical properties, as detailed below:
1. ** Appearance **: Usually in solid form, but its exact appearance may vary depending on purity and crystallization conditions. Or in the form of white to light yellow crystalline powder, this color and shape are like the elixir contained in ancient books. Although it is not a fresh and flexible thing, it contains unique chemical wonders. In the process of scientific research, such as hidden clues, it is to be explored by researchers.
2. ** Melting point **: The value of the melting point is about a specific range. Melting point is one of the characteristics of a substance, just like the inherent identification of a substance, just like the ancients named it after the characteristics of a substance. This melting point temperature is crucial for the identification and purification of 6-iodoquinazolin-4 (1H) -one. In the experimental operation, the precise determination of the melting point can judge the purity of it, just like the purity of precious medicinal pills in ancient times, to ensure their medicinal or scientific research value.
3. ** Solubility **: The solubility of organic solvents is also a key characteristic. It has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This solubility characteristic is similar to that of the ancients who prepared pharmaceuticals. It is necessary to find a suitable solvent to make the ingredients blend and play an effective role. In organic synthesis and drug research and development, with this solubility, it can help it participate in various chemical reactions, such as the interaction of atomic groups under the medium of solvents, and deduce the wonderful chapter of chemical changes.
4. ** Density **: Density is one of its physical properties, although intangible, it is closely related to matter. The appropriate density makes 6-iodoquinazolin-4 (1H) -one have specific physical stability during storage and transportation, just like ancient books placed on a bookshelf, each has its own place, and is placed according to its inherent properties to ensure safety and stability.
5. ** Stability **: At room temperature and pressure, if there is no interference from specific external factors, this compound is relatively stable. However, under extreme conditions such as high temperature, strong acid, and strong alkali, the stability may be damaged, triggering a chemical reaction. This stability is like an ancient secret book, which needs to be properly preserved in a suitable environment to avoid damage, so that the secrets of chemistry can be passed on for a long time for future generations to study and explore in depth.

In the synthesis of 6-iodoquinazoline-4 (1H) -one, the following methods are commonly used.
First, quinazoline-4 (1H) -one is used as the starting material and iodine atoms are introduced through halogenation reaction. In this path, quinazoline-4 (1H) -one is first dissolved in suitable organic solvents such as dichloromethane, N, N-dimethylformamide, etc. Then, in the presence of suitable catalysts such as cuprous iodide and palladium catalysts, iodine sources such as iodine elemental substance and N-iodosuccinimide (NIS) are added. The reaction needs to be carried out within a certain temperature and reaction time, and the temperature may be between room temperature and 100 ° C, depending on the specific reaction conditions. Through this halogenation reaction, iodine atoms can replace hydrogen atoms at specific positions of quinazoline-4 (1H) -one to generate 6-iodoquinazoline-4 (1H) -one.
Second, starting from nitrogen-containing heterocycles and iodoaromatic hydrocarbons, the target product is constructed through multi-step reactions. First, the coupling reaction of nitrogen-containing heterocycles and iodoaromatic hydrocarbons occurs under basic conditions and transition metal catalysis. For example, potassium carbonate, sodium carbonate, etc. are used as bases, and palladium complexes such as tetra (triphenylphosphine) palladium are used as catalysts to react in appropriate organic solvents. After forming the preliminary product, the quinazoline-4 (1H) -one structure is constructed through subsequent steps such as cyclization and oxidation, and then 6-iodoquinazoline-4 (1H) -one is obtained. This path step is slightly complicated, but the selectivity and yield of the product can be improved by rationally designing the reaction sequence and conditions.
Third, aniline derivatives are used as starting materials and synthesized by condensation and cyclization with iodine-containing carbonyl compounds. First, the aniline derivative is condensed with the iodine-containing carbonyl compound under the catalysis of acid or base to form an intermediate product. Subsequently, under the action of heating or catalyst, the intermediate undergoes intramolecular cyclization to generate 6-iodoquinazoline-4 (1H) -one. This method requires attention to the selection of starting materials and the control of reaction conditions to ensure the smooth progress of the reaction and obtain the ideal yield and purity of the product.

6-Iodoquinazolin-4 (1H) -one is one of the organic compounds. This compound has applications in various fields such as medicine and pesticides.
In the field of medicine, it has attracted much attention in drug development due to its structural properties. Studies have shown that it may have potential biological activity and can be used as a lead compound to explore drugs with novel mechanisms of action. For example, in some studies aimed at specific disease targets, 6-iodoquinazolin-4 (1H) -one has been used as a starting material and chemically modified to synthesize a series of derivatives, hoping to find drugs with significant inhibitory effects on tumor cells and virus infections.
In the field of pesticides, this compound also shows some potential. Its structure or endows the compound with unique biological activity, which can act on the specific physiological process of pests and achieve the purpose of pest control. For example, insecticides with 6-iodoquinazolin-4 (1H) -one as the core structure can be designed to inhibit the growth and reproduction of pests by affecting the normal physiological functions of the pest's nervous system and digestive system. Compared with traditional pesticides, they may have higher selectivity and environmental friendliness.
Furthermore, in the field of organic synthetic chemistry, 6-iodoquinazolin-4 (1H) -one is often used as an important intermediate. Due to the presence of iodine atoms and quinazolinone structures, it can participate in a variety of organic reactions, such as coupling reactions, etc., to help build more complex organic molecular structures and lay the foundation for the synthesis of new materials and functional compounds. In short, 6-iodoquinazolin-4 (1H) -one has important application value and research potential in many fields.

6-Iodoquinazolin-4 (1H) -one is an organic compound, which can be called 6-iodoquinazolin-4 (1H) -one in Chinese. In the current market, this product has a promising future and some challenges.
From the perspective of application field, it has attracted much attention in the field of medicinal chemistry. Inquinazolinone compounds often have diverse biological activities, such as anti-tumor, antibacterial, anti-inflammatory, etc. 6-iodoquinazolin-4 (1H) -one may be used as a key intermediate for the creation of new drugs. The increasing demand for high-efficiency and novel compounds in pharmaceutical research and development brings them broad market opportunities.
Furthermore, in the field of materials science, organic iodine-containing compounds may exhibit unique properties in optoelectronic materials. With the development of science and technology, the exploration of new functional materials has never stopped. 6-iodoquinazolin-4 (1H) -one may find a place in this field due to its structural characteristics.
However, its market prospects are not without obstacles. First, there are technical problems in synthesizing the compound. The preparation process may involve complex reaction steps and conditions, and cost control is not easy. To achieve large-scale production and marketing activities, efficient and economical synthesis processes must be developed. Second, safety and environmental impact considerations are also indispensable. Before entering the market, it is necessary to carefully evaluate its toxicological properties and potential impact on the environment to ensure compliance with regulatory standards.
Overall, 6-iodoquinazolin-4 (1H) -one has a good market prospect due to its potential applications in the field of medicine and materials. To fully exploit this potential, researchers and industry need to work together to overcome problems such as synthesis technology and security evaluation before it can develop steadily in the market.