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What is the chemical structure of 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one?
6-Iodothiopheno [2,3-d] pyrimidine-4 (3H) -one is one of the organic compounds. Its chemical structure is particularly complex, composed of two heterocycles of thiophene and pyrimidine.
In its structure, the thiophene ring and the pyrimidine ring are fused in a specific way. The thiophene ring is a five-membered heterocycle containing sulfur and has aromatic properties. The pyrimidine ring is a six-membered heterocycle containing two nitrogen atoms, which also has aromatic properties. The two fuse to form a unique fused ring system. The introduction of the halogen atom gives the compound specific chemical activity and physical properties. The iodine atom can affect the polarity, steric resistance and reactivity of the molecule due to its large atomic radius and moderate electronegativity.
At the 4 (3H) position, it is a carbonyl (C = O), which brings significant chemical properties to the compound. The presence of carbonyl groups makes the molecule have certain electrophilicity and can participate in many chemical reactions, such as nucleophilic addition reactions. And this carbonyl group forms a conjugate system with surrounding atoms, which affects the distribution and stability of the electron cloud of the molecule.
The chemical structure of this compound is endowed with unique physical and chemical properties due to the interaction of atoms and groups, and may have potential application value in organic synthesis, medicinal chemistry and other fields. Chemists can develop new compounds with specific properties and biological activities by modifying and modifying their structures.
What are the main physical properties of 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one?
6-Iodothieno [2,3-d] pyrimidin-4 (3H) -one is an organic compound with many important physical properties. Its appearance is mostly solid. Due to the strong interaction forces between molecules, such as van der Waals forces and hydrogen bonds, the molecules are arranged in an orderly manner and appear in a solid state.
When it comes to the melting point, the compound has a high melting point. This is because in its molecular structure, atoms are closely connected by covalent bonds to form a stable structure. To make it melt, it needs to provide enough energy to overcome intermolecular forces and lattice energy, so a higher temperature is required.
In terms of solubility, 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one has limited solubility in common organic solvents. Due to its molecular structure containing heteroatoms such as sulfur and nitrogen, and iodine atoms with large atomic radius and electronegativity, the molecular polarity changes. Although it contains polar parts, the overall molecular structure still has certain hydrophobicity, so the solubility in polar organic solvents is not good, and the solubility in non-polar organic solvents is also limited.
In addition, the compound has certain stability. The intramolecular conjugate system and heterocyclic structure endow it with relatively stable chemical properties. The conjugate system can delocalize electrons, reduce molecular energy, and enhance stability; the heterocyclic structure also contributes to molecular stability due to factors such as ring tension and electronic effects. However, under certain conditions, such as high temperature, strong acid, strong base or strong oxidant, its structure may change, causing chemical reactions.
The physical properties of 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one are closely related to its molecular structure, which has a profound impact on its application in organic synthesis, drug development and other fields.
What are the synthesis methods of 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one?
The synthesis of 6-iodothiopheno [2,3-d] pyrimidine-4 (3H) -one is an important part of the field of organic synthetic chemistry. The synthesis method follows several common paths.
First, the derivative of thiophene and pyrimidine is used as the starting material. The thiophene derivative is first reacted in a specific position to introduce a suitable functional group, which needs to be able to undergo subsequent reactions with the pyrimidine derivative. Common reactions, such as halogenation, can introduce halogen atoms at specific positions in the thiophene ring for subsequent binding with the corresponding activity check point of the pyrimidine derivative. Then, the modified thiophene derivative and pyrimidine derivative are added to a suitable catalyst under suitable reaction conditions, such as in a specific solvent, and the basic skeleton of the target compound is constructed through reactions such as nucleophilic substitution or cyclization.
Second, it can start from the iodine-containing starting material. Select an iodine-containing compound with a suitable structure, which requires an activity check point that can be combined with thiophene and pyrimidine structural units. By ingeniously designing the reaction steps, using organometallic reagents to participate in the reaction, such as the coupling reaction catalyzed by palladium, etc., the iodine-containing part is connected to the thiophenopyrimidine structural fragment. In this process, the choice of solvent, the control of reaction temperature and time all have a great influence on the success or failure of the reaction and the yield of the product.
Furthermore, it can be considered to synthesize through intramolecular cyclization reaction. A linear precursor compound with a specific structure is used as the starting material. The precursor compound needs to contain both structural fragments that can form thiophene rings and pyrimidine rings. Under suitable reaction conditions, such as acidic or alkaline environments, intracellular cyclization reactions occur to form the target thiopheno [2,3-d] pyrimidine-4 (3H) -one structure. During this period, the reaction conditions need to be carefully regulated to ensure that the cyclization reaction selectively occurs and the target product is obtained.
All these synthetic methods have their own advantages and disadvantages. In practical application, the choice needs to be weighed according to the availability of starting materials, the operability of reaction conditions, the yield and purity of the product, etc., in order to achieve the high-efficiency synthesis of 6-iodothiopheno [2,3-d] pyrimidine-4 (3H) -one.
In what fields is 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one used?
6-Iodothiopheno [2,3-d] pyrimidine-4 (3H) -one is an organic compound with great potential and has shown its unique uses in many fields.
In the field of medicinal chemistry, the structural properties of these compounds endow them with diverse biological activities. Many studies have shown that it may have antibacterial properties, which can inhibit its growth and reproduction against specific bacteria, providing the possibility for the development of new antibacterial drugs. And in the direction of anti-cancer drug research and development, 6-iodothiopheno [2,3-d] pyrimidine-4 (3H) -one may act on specific targets of cancer cells and interfere with the proliferation and survival mechanism of cancer cells. Although it is still in the research stage, the prospect is promising.
In the field of materials science, due to its special molecular structure, or unique optoelectronic properties. It can be applied to the field of organic optoelectronic materials, such as the development of organic Light Emitting Diode (OLED). It may improve the luminous efficiency and stability of OLED materials, make the display device have a wider color gamut, lower energy consumption, and improve product performance.
In pesticide chemistry, 6-iodothiopheno [2,3-d] pyrimidine-4 (3H) -one may exhibit insecticidal and herbicidal activities. By rationally modifying its structure, it is expected to develop high-efficiency, low-toxicity and environmentally friendly pesticide products, reduce the impact on the ecological environment, and ensure the efficiency and safety of agricultural production.
In summary, 6-iodothiopheno [2,3-d] pyrimidine-4 (3H) -one has application potential in the fields of medicine, materials and pesticides. With the deepening of research, it may bring new opportunities for the development of various fields.
What is the market outlook for 6-iodothieno [2,3-d] pyrimidin-4 (3H) -one?
6-Iodothiopheno [2,3-d] pyrimidine-4 (3H) -one is an organic compound with a specific structure. In today's market structure, its prospects show a diverse trend.
Looking at the field of scientific research, with the continuous improvement of organic synthetic chemistry, the research on new sulfur-containing and nitrogen-containing heterocyclic compounds remains high. 6-Iodothiopheno [2,3-d] pyrimidine-4 (3H) -one can be used as a key intermediate for the construction of more complex and biologically active organic molecules due to its unique heterocyclic structure. Many scientific research teams are committed to developing innovative drugs with antibacterial, antiviral, and anti-tumor pharmacological activities as a cornerstone. Therefore, in the field of scientific research, as an important research object, the demand is expected to rise steadily.
As for the pharmaceutical industry, in view of the urgent need for new drugs, this compound may hold great potential. With reasonable structural modification and activity screening, it may be able to generate innovative drugs with excellent efficacy and mild side effects. If a drug based on this compound can be successfully developed and commercialized, it will greatly stimulate its market demand. However, the road to drug development is full of thorns, and it needs to go through a lot of rigorous experimentation and approval processes, which also poses a major challenge for it to be converted into actual drugs.
In the chemical industry, it may occupy a place in the synthesis of fine chemicals. With its unique chemical properties, it can be used to prepare special dyes, functional materials, etc. With the pursuit of high-performance and high-value-added products in the chemical industry, if it can be effectively developed in chemical synthesis, it is also expected to open up a broad market space.
However, its market prospects are also constrained by many factors. The complexity and cost of the synthesis process are one of the key factors. If the synthesis process is cumbersome and costly, it will limit its large-scale production and application. Furthermore, the strictness of regulations and policies also has far-reaching implications. In the pharmaceutical field, strict drug approval policies require it to meet extremely high safety and efficacy standards.
Overall, although 6-iodothieno [2,3-d] pyrimidine-4 (3H) -one faces challenges, it shows considerable addressable market prospects in scientific research, medicine and chemical industry. With reasonable development and application, it is expected to gain an important seat in the future market.
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