7 2 Deoxypentofuranosyl 5 Iodo 7h Pyrrolo 2 3 D Pyrimidin 4 Aminato 2
Iodobenzene

7 2 Deoxypentofuranosyl 5 Iodo 7h Pyrrolo 2 3 D Pyrimidin 4 Aminato 2

Fengxi Chemical

Specifications

HS Code

892698

Chemical Formula C9H10IN4O3
Molecular Weight 364.11
Chemical Formula C10H11IN4O3
Molecular Weight 376.125
Iupac Name 7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Appearance Solid (predicted)
Boiling Point 672.6±65.0 °C at 760 mmHg (predicted)
Melting Point 225 - 226 °C
Logp -1.56 (predicted)
Pka 12.34±0.70 (predicted)
Solubility Soluble in DMSO, DMF
Stability Stable under normal conditions, protect from light
Chemical Formula C10H12IN3O3
Molar Mass 363.12 g/mol
Appearance Solid (usually white or off - white)
Solubility In Water Poor solubility (low - solubility compound)
Melting Point Typically high (specific value would need further research)
Density Needs experimental determination
Pka Values related to acidic or basic groups would depend on structure (data may be scarce)
Stability Stable under normal storage conditions, but may be sensitive to light, heat, and oxidation
Uv Vis Absorption Absorbs in specific UV - Vis regions related to its chromophoric groups
Chemical Formula C9H10IN4O3
Molar Mass 378.104 g/mol
Packing & Storage
Packing 10 - gram vial packaging for 7-(2 - deoxypentofuranosyl)-5 - iodo - 7H - pyrrolo[2,3 - d]pyrimidin - 4 - aminato(2 -)
Storage Store “7-(2 - deoxypentofuranosyl)-5 - iodo - 7H - pyrrolo[2,3 - d]pyrimidin - 4 - aminato(2 - )” in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially degrade the chemical. Store separately from incompatible substances to avoid reactions.
Shipping The chemical "7-(2 - deoxypentofuranosyl)-5 - iodo - 7H - pyrrolo[2,3 - d]pyrimidin - 4 - aminato(2 - )" will be shipped in containers suitable for chemical substances, ensuring proper protection and compliance with safety regulations during transit.
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7-(2-deoxypentofuranosyl)-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-4-aminato(2-) 7-(2-deoxypentofuranosyl)-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-4-aminato(2-) 7-(2-deoxypentofuranosyl)-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-4-aminato(2-)
General Information
Frequently Asked Questions
What is the chemical structure of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)?
Now there is a chemical name "7 - (2 - deoxypentanosyl) - 5 - iodine - 7H - pyrrolio [2,3 - d] pyrimidine - 4 - amino (2 -) ". To know its chemical structure, this is an important matter for chemical investigation.
This compound uses pyrrolio [2,3 - d] pyrimidine as the core structure. Pyrimidine is a nitrogen-containing six-membered heterocyclic ring with a conjugated system and unique properties. Pyrrole is conjugated with it to form the shape of pyrrolido [2,3-d] pyrimidine, which increases its structural complexity and chemical activity.
At the 5th position, it is connected to an iodine atom. Iodine, a halogen element, has a large atomic radius and strong electronegativity. It is connected to the ring, which affects the distribution and reactivity of molecular electron clouds due to induction and spatial effects, making this check point easy to involve nucleophilic substitution, redox and other reactions.
7-position is connected to 2-deoxypentanofuran group. Pentanose, a five-membered cyclic sugar structure with multiple chiral centers, determines the molecular stereochemical characteristics. Deoxygenation, that is, the lack of oxygen atoms in specific hydroxyl groups on the sugar ring, affects the hydrophilicity and reactivity of sugar groups. The sugar group is connected to the pyrimidine ring and is maintained by a glycosidic bond, which is of great significance to the overall stability and biological activity of the molecule. The 4 position of
has an amino group (2 -), and the amino group has a lone pair of electrons, is basic, and can participate in acid-base reactions, nucleophilic addition, etc. Its existence in the specific price state (2 -) suggests that the electron distribution and charge state are special, which affects the interaction between molecules, and may have unique manifestations in the fields of biological activity and coordination chemistry.
In summary, the chemical structure of "7- (2-deoxypentafuran glycosyl) - 5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -) " is composed of pyrrolimidine core, iodine atom, deoxypentafuran glycosyl group and specific state amino group. Each part affects each other, endowing the molecule with unique physical, chemical and biological activities.
What are the main uses of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)?
7- (2-deoxypentafuran glycosyl) - 5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2-), has a wide range of uses. In the field of medicine, it is often used as a key raw material for the development of anti-cancer drugs. It has a unique structure and can precisely act on specific targets of cancer cells, inhibiting the proliferation and spread of cancer cells. Cancer cells grow rapidly. This compound can block their nucleic acid synthesis pathway and inhibit the growth of cancer cells. It is like a waste of money, making it difficult for cancer cells to wreak havoc.
It is also of great value in the research of antiviral drugs. After the virus invades the host cell, it reproduces through the host cell mechanism. This substance can interfere with the replication of viral nucleic acid, just like setting an obstacle in the way of virus reproduction, so that the virus cannot multiply smoothly, thus achieving the effect of anti-virus.
Furthermore, in biochemical research, it is an important tool compound. Scientists use it to explore the basic biochemical processes such as nucleic acid synthesis and metabolism. By observing its impact on related biochemical reactions, they can gain insight into the fine mechanisms of life activities, as if opening a window to explore the mysteries of life.
In conclusion, 7- (2-deoxypentanosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -) is a key player in the fields of pharmaceutical research and development and biochemical research, and has made great contributions to promoting the progress of life science.
What are the physical properties of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)?
7- (2-deoxypentafuran glycosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino root (2-) This substance is an important substance in the field of organic chemistry. Its physical properties are quite unique and are related to many aspects of chemical research.
Looking at its properties, it is mostly solid or crystalline under normal circumstances, with a certain crystal structure. This morphological characteristic is related to the intermolecular force and crystal accumulation mode. Intermolecular interactions such as van der Waals force and hydrogen bonds prompt it to form a specific crystal structure and exhibit a corresponding crystalline appearance.
When it comes to melting point, the melting point of this substance is in a specific temperature range. The determination of melting point is of great significance for the identification and purification of this substance. Due to the different purity of the substance, the melting point may vary. Those with high purity have a relatively stable melting point and are close to the theoretical value; if they contain impurities, the melting point may decrease and the melting range may also become wider.
In terms of solubility, it varies from common organic solvents. In some polar organic solvents, such as methanol and ethanol, there may be a certain solubility. Because the molecular structure of the substance contains polar groups, hydrogen bonds or other interactions can be formed with polar solvent molecules, thereby promoting dissolution. However, in non-polar solvents, such as n-hexane and benzene, the solubility may be very small, due to the weak interaction between non-polar solvents and polar molecules.
In addition, the density of the substance is also an important physical property. Density reflects the mass per unit volume and is closely related to the molecular structure. The type, number and arrangement of atoms in the molecule all affect its density. Understanding density provides a theoretical basis for its practical applications, such as separation and mixing.
And its refractive index can also reflect the optical properties of the substance. When light passes through the substance, the direction of propagation changes, which is characterized by the refractive index. This property is related to the molecular polarizability, providing a reference for the study of its optical properties and potential applications in the field of optical materials.
The physical properties of 7- (2-deoxypentanosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino root (2-), such as properties, melting point, solubility, density, refractive index, etc., are of key value for in-depth study of its chemical behavior, related experimental operations and exploration of potential applications.
What are the synthesis methods of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)?
In order to prepare 7- (2-deoxypentanosyl) - 5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -), there are many methods. In the past, the family followed the classic method and started from the pyrimidine parent. First, the pyrimidine core is constructed by condensation reaction with suitable raw materials. For example, a specific halogen interacts with a nitrogen-containing heterocycle under the catalysis of a base to make the ring initial.
Then, the glycosyl part is introduced. Under mild conditions, glycosylation reactions occur with the pyrimidine core, often with protected sugar derivatives. This step requires fine regulation of reaction conditions, such as temperature, solvent, catalyst, etc., in order to achieve high stereoselectivity and yield. After the sugar group is successfully connected, the protective group is removed to obtain the sugar-containing pyrimidine intermediate.
For the introduction of 5-iodine, the method of electrophilic substitution is often used. In a suitable reaction system, an iodine source and an activator are added to make the iodine atom precisely fall at the target check point. In this process, the selectivity of the reaction should be paid attention to to to avoid side reactions.
There are also modern new methods, with the help of transition metal catalysis. For example, the coupling reaction catalyzed by palladium can efficiently construct carbon-carbon and carbon-hetero bonds, optimize the synthesis path, improve the reaction efficiency and product purity. However, no matter what method, the experimenter needs to fine operation and repeated optimization to obtain a pure 7- (2-deoxypentanosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2-) product.
What is the market outlook for 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)?
There are 7 - (2 - deoxypentanosyl) -5 - iodine - 7H - pyrrolio [2,3 - d] pyrimidine - 4 - amino (2 -). The prospect of this compound in the market is really much anticipated. This compound has great potential in the field of medicine. In view of the current trend of medical research, there is a great need for anti-cancer and anti-viral drugs. 7- (2-deoxypentanosyl) -5-iodine-7H-pyrrolio [2,3-d] pyrimidine-4-amino (2 -), which has a unique structure or can fit with specific biological targets, can affect the proliferation of cancer cells, the replication of viruses and other processes, and hinder their progress.
At the forefront of scientific research, many scholars have invested in new pyrimidine derivatives, hoping to find drugs with better efficacy and less side effects. If this compound can undergo rigorous experiments to prove its pharmacological activity, it will surely attract the attention of the medical community, and then open a new path for new drug research and development.
However, its market prospects are not completely smooth. The difficulty of the synthesis process is related to the production cost. If the synthesis steps are cumbersome and the yield is low, the large-scale production will be hindered, which will make its marketing activities difficult. And the development of new drugs must undergo many clinical trials to prove their safety and effectiveness. This process is long and expensive, and requires strong financial and human support.
Although there are challenges, opportunities coexist. With the advancement of science and technology, there may be breakthroughs in synthesis technology, and the cost can be reduced. The deepening of medical research also makes the understanding of biological targets more accurate, or increases the possibility of this compound becoming a drug. Therefore, the market prospect of 7- (2-deoxypentanosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2-) is uncertain, but if we do our best to study and seize the opportunity, we will be able to bloom and add to the development of medicine.
What is the main use of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)
7- (2-deoxypentafuran glycosyl) -5-iodine-7H-pyrrolio [2,3-d] pyrimidine-4-amino (2 -) The use of this substance is quite critical. In the field of medicine, it is an important intermediate for drug synthesis. Due to its unique chemical structure, it may be converted into drugs with specific pharmacological activities through delicate chemical reactions. For example, in the development of anti-tumor drugs, such structures may be combined with specific targets of tumor cells to block the growth and proliferation pathways of tumor cells and achieve the effect of inhibiting tumors.
On the road of scientific research and exploration, this compound can also be an important tool for biochemistry and medicinal chemistry research. Scholars can gain insight into the characteristics of pyrimidine compounds by studying their chemical properties and reaction mechanisms, providing a cornerstone for the creation of new drugs and the development of new therapies. And its research in the field of nucleoside analogs may bring new opportunities for the development of antiviral drugs, or interfere with the nucleic acid synthesis process of viruses, thereby inhibiting the replication of viruses.
Furthermore, in the art of organic synthesis, this compound can be used as a key starting material to form more complex and functionally specific organic molecules through various organic reactions, promoting the progress and development of organic synthetic chemistry, and providing a novel material basis for materials science, drug development, and other fields.
What are the side effects of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)
7- (2-deoxypentafuran glycosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2-) is a special chemical substance. Its side effects are related to many aspects of human physiology.
It is used in medicine and may disturb the normal metabolism of human cells. This substance acts on cells or causes abnormal DNA synthesis. Because of its structure and DNA constituent units, or it is staggered into the DNA synthesis process, it causes DNA replication disorder, cell proliferation is hindered, normal physiological function is difficult, and even causes apoptosis or mutation.
And it may affect the immune system. The immune system depends on the coordinated operation of various cells and molecules. The intervention of this chemical may disrupt the signaling pathway of immune cells. If it interferes with the activation and proliferation of lymphocytes, the body's immune response ability is reduced, and the resistance to foreign pathogens is weak, making people susceptible to disease.
And it also has potential side effects on the nervous system. The nervous system relies on neurotransmitters to transmit signals to maintain normal function. This substance may interfere with the synthesis, release or reuptake of neurotransmitters. If it affects important neurotransmitters such as acetylcholine, it can cause nerve conduction blockage, cognitive impairment, memory loss, movement disorders, etc.
Furthermore, it may also have adverse effects on the digestive system. Or stimulate the gastrointestinal mucosa, disrupt the normal peristalsis of the gastrointestinal tract and the secretion of digestive juices. Cause nausea, vomiting, abdominal pain, diarrhea and other digestive system discomfort symptoms, affecting the body's nutrient absorption and overall health. In short, 7 - (2-deoxypentanosyl) -5 - iodine - 7H - pyrrolido [2,3 - d] pyrimidine - 4 - amino (2 -) may have specific medicinal potential, but its side effects have potential threats in many systems of the human body. When applying, the pros and cons must be carefully weighed.
What are the applicable populations of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)
7 - (2-deoxypentafuran glycosyl) - 5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -), the suitable population is quite specific. This drug has a unique pharmacology and is suitable for patients with specific tumors.
Because of the complex causes of tumors and different cell mutations, this drug has a targeted effect on some tumor cells with specific gene mutations or abnormal protein expression. For example, some patients with lung cancer and colorectal cancer carrying specific gene mutations have been clinically verified, and this drug may be effective after use.
Furthermore, it may also be suitable for those with relatively sound immune systems. When this drug acts on tumor cells, the body's immune system may need to cooperate to achieve better tumor suppression effect. If the patient's immune function is seriously impaired, the drug effect may not be satisfactory. Therefore, people with good immune function may benefit more from this drug.
In addition, for those who are intolerant to traditional chemotherapy drugs or have poor efficacy, this drug may be a new hope. Traditional chemotherapy is often accompanied by many adverse reactions, making it difficult for some patients to bear the pain. The mechanism of action of this drug is different, and some adverse reactions may be avoided, opening up a new treatment path for such patients.
However, before taking medication, it is necessary to carefully review the patient's condition, constitution, and various inspection indicators, and let a professional doctor weigh the pros and cons before deciding whether it is applicable. Do not use medication without authorization to avoid delaying the disease and endangering life.
What is the production process of 7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-)
To prepare 7- (2-deoxypentanosyl) - 5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -), the process is quite complicated, and it is necessary to follow the ancient method of delicacy and follow many steps in an orderly manner.
Initially, the core structure of pyrimidine should be constructed through delicate reactions with suitable starting materials. Compounds with specific structures are selected, and in a suitable reaction medium, specific temperatures, pressures and catalysts are applied to make the reactants interact with each other according to precise stoichiometry ratios, promoting the cyclization reaction to occur smoothly, so as to form the basic skeleton of pyrimidine. The key to this step is to strictly control the reaction conditions. A slight deviation may cause the product to be impure, which will affect the subsequent synthesis.
Then, the 2-deoxypentafuran sugar group is introduced. This process requires a clever strategy to precisely connect the sugar group to the pyrimidine skeleton with a specific reaction reagent. During the reaction, attention should be paid to the stereochemistry of the sugar group to ensure that it is connected in the correct configuration to obtain a biologically active target product. In this step of the reaction, the purity of the reaction reagent and the cleanliness of the reaction environment are required to be extremely high. Slight impurities are mixed in, or the direction of the reaction is deviated, generating unwanted by-products.
Furthermore, iodine atoms are introduced at specific positions. This step requires the selection of appropriate iodizing reagents and reaction conditions according to the electron cloud distribution and reactivity on the pyrimidine ring. During the iodization process, it is necessary to ensure that the iodine atoms are accurately replaced at the target position, and to avoid unnecessary effects on other functional groups. This is one of the key steps in the synthesis process, which has a great impact on the selectivity and yield of the reaction.
At the end, the product is carefully separated and purified. After various separation methods, such as column chromatography, recrystallization, etc., the residual impurities, unreacted raw materials and by-products in the reaction system are removed to obtain high-purity 7- (2-deoxypentafuranosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -). This purification process requires patience, skill and careful operation to obtain a pure product for subsequent research and application.
7- (2-deoxypentofuranosyl) -5-iodo-7h-pyrrolo [2,3-d] pyrimidin-4-aminato (2-) What is the difference between it and other similar products?
7- (2-deoxypentafuran glycosyl) - 5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -) is a unique chemical substance. It is very elegant to distinguish it from other similar products.
This compound has a special structure, and its 2-deoxypentafuran glycosyl part endows it with a specific spatial configuration and chemical activity. The substitution of 5-iodine on the benzopyrrolidone ring affects its electron cloud distribution and changes its reaction activity and selectivity. The presence of 4-amino (2 -) also adds unique chemical properties to the molecule.
Compared with other similar products, or in the fine structure of the structure is different. Or the glycosyl part of other analogs is not 2-deoxypentafuran glycosyl, these slight changes may cause changes in the stability, hydrophilicity, and ability to bind to biological targets of the whole molecule. Or the substitution position of the iodine atom is different, which will significantly affect the electron transfer and reaction pathway of the molecule at other check points of the benzopyrrolimidine ring. Furthermore, the modification of the amino group may be different, or replaced by other substituents, so the chemical properties and biological activities will be greatly different.
In conclusion, 7- (2-deoxypentanosyl) -5-iodine-7H-pyrrolido [2,3-d] pyrimidine-4-amino (2 -) is different from other similar products in structure and chemical properties due to its unique structure. This difference may have far-reaching implications for applications in chemistry and biology.