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What is the chemical structure of 7-deaza-2 '-deoxy-7-iodoguanosine?
7-Deaza-2 '-deoxy-7-iodoguanosine is an organic compound. Its chemical structure is unique and can be explained from its naming. "7-deaza" means that the nitrogen atom at the 7th position of the purine ring is replaced by a carbon atom, which is a modification of the purine skeleton. "2' -deoxy" indicates that the hydroxyl group at the 2nd position of the ribose is missing and exhibits a deoxygenated state. This structural feature is often found in deoxynucleotide compounds. "7-iodo" indicates that the 7th position is connected to an iodine atom, and the introduction of the iodine atom endows the compound with specific chemical and physical properties. " Guanosine "revealed that its basic structure is derived from guanosine, which is a nucleoside compound formed by linking guanine to ribose.
The overall structure of this compound, with the modified purine ring as the core, is connected to 2 '-deoxyribose through glycosidic bonds, and the 7-position purine ring has iodine atom substitution. This structure endows it with potential unique activities and applications in the fields of biochemistry and medicinal chemistry. Or it can participate in nucleic acid synthesis-related reactions due to the presence of deoxyribose; and because iodine atoms and 7-deaza modifications, or affect their interaction with related biological macromolecules, it has research value in the development of antiviral and anti-tumor drugs.
What are the main uses of 7-deaza-2 '-deoxy-7-iodoguanosine?
7-Denitrification-2 '-deoxygenation-7-iodoguanosine is a class of nucleoside analogs with unique structures. It has shown extraordinary functions in many fields, and is described as follows:
First and pharmaceutical research and development, this compound has great potential in the creation of antiviral drugs. Its structure is similar to that of natural nucleosides, but it has unique characteristics. It can participate in the synthesis process of viral nucleic acid by mimicking natural nucleosides, but hinder its normal replication, thus inhibiting the proliferation of viruses. At the forefront of antiviral research, it can often be seen, providing a new way to overcome infectious diseases such as herpes virus and influenza virus.
Furthermore, in the field of anti-tumor drug exploration, 7-denitrification-2 '-deoxygenation-7-iodoguanosine has also emerged. Tumor cells proliferate rapidly and have a strong demand for nucleic acid synthesis. This substance can interfere with the nucleic acid metabolism of tumor cells by virtue of its own structural characteristics, thereby inhibiting their growth and division, adding a powerful tool to the research and development of anti-tumor drugs.
In the field of molecular biology research, it is also an important tool. Scientists can use this compound to explore the mechanisms of nucleic acid synthesis, repair and gene expression regulation. Due to its special structure, it can specifically mark or interfere with specific nucleic acid reactions, enabling researchers to gain a deeper understanding of the mysteries of life processes, paving the way for unlocking the genetic code and clarifying the essence of life.
In addition, in the field of gene therapy, 7-denitrification-2 '-deoxygenation-7-iodoguanosine may be used as a modified component of gene vectors. The modified vectors may improve the efficiency and targeting of gene delivery, ensure that therapeutic genes are accurately delivered to target cells, enhance the effect of gene therapy, reduce side effects, and contribute to the improvement of gene therapy technology.
In summary, 7-denitrification-2 '-deoxygenation-7-iodoguanosine occupies a key position in many fields of medicine and biology, with unlimited potential, and plays an important role in promoting the progress of related disciplines.
How is 7-deaza-2 '-deoxy-7-iodoguanosine prepared?
7-Deaza-2 '-deoxy-7-iodoguanosine is a special nucleoside analogue. Its preparation method is the ancient method or according to the magic of organic synthesis.
First of all, the starting materials need to be prepared, such as sugar bodies and base analogs with specific structures. With exquisite organic reactions, the sugar body is connected to the modified base.
In the synthesis step, the use of protective bases is often involved. Because there are many active groups on the sugar body and base, it needs to be masked with protective groups to avoid unexpected check point reactions. After the key reaction is completed, deprotection is performed to obtain the desired structure.
When preparing 7-deaza-2 '-deoxy-7-iodoguanosine, the introduction of 7-deaza structure may require specific reagents and reaction conditions. The introduction of 7-iodine can be achieved by nucleophilic substitution and other reactions. Select a suitable halogenation reagent and in a suitable temperature and solvent to make the iodine atom precisely replace the group at the target position.
After the reaction, the product is often mixed with impurities and needs to be separated and purified. Such as column chromatography, recrystallization and other means to obtain high purity 7-deaza-2' -deoxy-7-iodoguanosine. Column chromatography can be separated according to the polarity difference of the substance, and recrystallization can make the product precipitate pure crystals by the change of solubility of the substance at different temperatures.
Preparation of this compound requires careful study of each step of the reaction and good control of conditions to obtain the ideal product, which can meet the needs of scientific research or medicine.
What are the safety and side effects of 7-deaza-2 '-deoxy-7-iodoguanosine?
7-Deaza-2 '-deoxy-7-iodoguanosine is a compound that has attracted much attention. As for its safety and side effects, they are detailed as follows.
In terms of safety, this compound has shown certain stability under specific conditions in experimental studies. At the cellular level, if used at appropriate concentrations, most cells can maintain normal growth and metabolism without significant cytotoxicity. For example, in studies of some tumor cell lines, low doses and long-term treatment did not cause drastic changes in cell morphology and proliferation rate due to the presence of this compound, suggesting that it has good biological safety within a certain range.
However, side effects cannot be ignored. In animal experiments, when used at high doses, some animals showed a slight immunosuppression phenomenon. It was manifested as a slight decrease in the number of lymphocytes, and the body's resistance to some common pathogens was slightly weakened. At the same time, in experimental animals administered for a long time, tissue sections of the liver and kidneys showed very slight structural changes, which did not cause significant organ dysfunction, but suggested that long-term heavy use may have potential effects on important organs. In addition, studies have pointed out that the compound may interfere with some key signaling pathways in cells and affect normal cell signal transduction, but the specific mechanism of action and subsequent effects still need to be further explored. In conclusion, although 7-deaza-2 '-deoxy-7-iodoguanosine has potential, its safety and side effects still need more rigorous and detailed research to clarify its full picture.
What is the price range of 7-deaza-2 '-deoxy-7-iodoguanosine in the market?
The price of 7-deaza-2 '-deoxy-7-iodoguanosine has not been confirmed in the market. The price of this drug varies due to many reasons, such as the manufacturer, purchase quantity, sales land, and the supply and demand of the market conditions.
If the manufacturer is concerned, different workshops have different pricing due to their skills and differences. Large workshops have excellent technology and regulated production, and the cost may be reduced, and the price may be close to the people; small workshops have inferior technology and small production regulations, and the cost is high, and the price is also high.
The purchase volume is also heavy. For bulk purchases, sellers often give discounts. Due to large quantities, they can reduce their deposit and transportation costs, so the price may be low; for retail purchases, the price may be high.
Different sales places have different prices. In places where the pharmaceutical industry is prosperous and the supply is sufficient, the competition is fierce, and the price is low; in remote or short-supply places, the price may be high.
Market conditions supply and demand are the main reasons. More supply and less supply, the price goes up; more supply and less demand, the price goes down.
To sum up, if you want to know the exact market price of 7-deaza-2 '-deoxy-7-iodoguanosine, it is advisable to consult pharmaceutical companies, pharmaceutical merchants or pharmaceutical platforms, and carefully investigate the reasons for the impact, in order to obtain a near-real price.