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What is the chemical structure of 7h-pyrrolo [2,3-d] pyrimidin-2-amine, 4-chloro-5-iodo-7- (2-c-methyl-beta-d-ribofuranosyl) -
This is a 7H-pyrrolido [2,3-d] pyrimidine-2-amine compound with the structure of 4-chloro-5-iodine-7- (2-C-methyl - β - D-furan ribosyl). This compound, viewed from a chemical perspective, is derived from the core structure of pyrrolimidine. The fourth position of its core structure is substituted by a chlorine atom; the fifth position is occupied by an iodine atom; the seventh position is connected by a 2-C-methyl - β - D-furan ribosyl group. The furan ribosyl group is a structural fragment of a carbohydrate, in which there is a methyl substitution on the two carbon atoms, and the sugar ring exists in the β-D configuration. The entire molecular structure connects nitrogen-containing heterocycles, halogen atoms and sugar groups. Such a specific structure endows the compound with unique chemical and physical properties, and may have potential application value in organic synthesis, medicinal chemistry and other fields. Due to its complex structure, it may interact with specific targets in organisms and exhibit unique biological activities.
7H-pyrrolo [2,3-d] pyrimidin-2-amine, 4-chloro-5-iodo-7- (2-c-methyl-beta-d-ribofuranosyl) - What are the physical properties
4-Chloro-5-iodine-7- (2-C-methyl - β - D-furan-ribosyl) -7H-pyrrolido [2,3-d] pyrimidine-2-amine, this is an organic compound. Its physical properties are unique, let me tell them one by one.
Looking at its properties, under room temperature and pressure, or in a solid state, mostly in powder form, because of its intermolecular forces, the molecules are arranged in an orderly manner, resulting in a stable solid state.
When it comes to solubility, because its molecular structure contains many polar groups, such as amino groups, it may have a certain solubility in polar solvents such as water. However, due to the relatively large overall molecule, and the halogen atom and heterocyclic structure, its solubility is not very high. In organic solvents, such as methanol, ethanol, etc., its solubility may be better than that of water. Due to the principle of similar miscibility, polar organic solvents and the molecules of the compound can form a variety of intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., to help them dissolve.
As for the melting boiling point, due to the strong forces between molecules, not only Van der Waals forces, but also nitrogen, oxygen and other atoms in the molecule may form hydrogen bonds, so its melting boiling point is relatively high. To make it melt or boil, more energy needs to be supplied to overcome the intermolecular forces.
The physical properties of this compound are due to its unique molecular structure. The interaction of atoms and groups results in such properties, which are of great significance in chemical research and related fields.
What is the main use of 7h-pyrrolo [2,3-d] pyrimidin-2-amine, 4-chloro-5-iodo-7- (2-c-methyl-beta-d-ribofuranosyl) -
This compound is named 4-chloro-5-iodine-7- (2-C-methyl - β - D-furanribosyl) -7H-pyrrolido [2,3-d] pyrimidine-2-amine. Its use is quite critical and is commonly found in the field of pharmaceutical research and development.
In the study of anti-cancer drugs, this compound may show unique effects. Because the structure of pyrrolimidine is often associated with interfering with the nucleic acid synthesis of cancer cells, the introduction of chlorine and iodine atoms may adjust its biological activity and lipophilicity, help it better penetrate the cancer cell membrane, and then inhibit the proliferation of cancer cells. For example, it may hinder the function of specific enzymes in the DNA replication process of cancer cells, preventing cancer-causing cells from dividing normally and achieving the purpose of anti-cancer.
It also has potential value in the field of antiviral drug development. Virus replication in host cells requires specific nucleic acid synthesis steps. With its unique structure, this compound may interfere with viral nucleic acid synthesis, block the virus proliferation cycle, and achieve antiviral effect. For example, it can target certain RNA viruses, or inhibit their reverse transcription process, making it difficult for the virus to integrate into the host genome, thereby reducing viral infectivity.
In addition, in the exploration of new antibacterial drugs, this compound cannot be ignored. The growth and reproduction of bacteria also depend on nucleic acid synthesis, and its special structure may selectively act on bacterial nucleic acid synthesis-related proteins, destroying the normal metabolism and proliferation of bacteria, providing new ideas for solving the problem of bacterial drug resistance.
What are the synthesis methods of 7h-pyrrolo [2,3-d] pyrimidin-2-amine, 4-chloro-5-iodo-7- (2-c-methyl-beta-d-ribofuranosyl) -
The synthesis method of 4-chloro-5-iodine-7- (2-C-methyl - β - D-furan-ribosyl) -7H-pyrrolio [2,3-d] pyrimidine-2-amine is ancient. This synthesis method requires delicate techniques and chemical rules.
First of all, the appropriate raw materials must be selected, which must be pure chemical products to ensure the accuracy of synthesis. Choose 2-amino-4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine as the base and combine with the derivative of 2-C-methyl - β - D-furan ribose. The process of this synthesis requires the use of suitable solvents, such as dichloromethane, N, N-dimethylformamide, etc., to promote the fusion of the two by means of the solvent.
Then it is necessary to select the catalyst to speed the reaction process. Acids or bases can be catalyzed, depending on the nature of the reaction. If a base is selected as the catalyst, such as potassium carbonate, sodium carbonate, etc., at a mild temperature, when stirring, the two will form bonds. Temperature control is crucial. If it is too high, the reaction will be too fast, resulting in clumps of byproducts; if it is too low, the reaction will be slow and time-consuming. Usually the temperature is controlled at room temperature to 60 degrees Celsius.
The reaction process requires analysis methods, such as thin-layer chromatography, to monitor its progress. After the reaction is completed, the pure product is obtained by separation. First, the product is extracted from the reaction solution in the organic phase by extraction method, and then by column chromatography, the adsorption of silica gel is used to separate impurities and products to obtain the pure product.
At the end of the synthesis, the method of identification is required to prove the authenticity of the product. By NMR, mass spectrometry, etc., the symbol of its structure can be observed to measure its high purity. In this way, 4-chloro-5-iodine-7- (2-C-methyl - β - D-furan ribosyl) -7H-pyrrolido [2,3-d] pyrimidine-2-amine is obtained.
7H-pyrrolo [2,3-d] pyrimidin-2-amine, 4-chloro-5-iodo-7- (2-c-methyl-beta-d-ribofuranosyl) - in which areas
4-Chloro-5-iodine-7- (2-C-methyl - β - D-furan-ribosyl) -7H-pyrrolido [2,3-d] pyrimidine-2-amine, this compound has considerable use in pharmaceutical research and development, antiviral and anticancer fields.
In the field of Guanfu pharmaceutical research and development, this compound can be used as a lead compound for novel drugs due to its unique molecular structure. Chemists can improve its pharmacological activity and optimize pharmacokinetic properties by delicately modifying its structure to create new drugs with better efficacy and less side effects.
As for antivirus, many studies have shown that this class of pyrrolidine derivatives has the ability to inhibit specific viruses. For example, some viruses require specific enzymes to participate in the replication process, and this compound can precisely bind to these enzymes to disrupt the normal replication of the virus, thereby inhibiting the proliferation of the virus, and paving the way for the development of antiviral drugs.
In the field of anti-cancer, studies have also found that such compounds exhibit cytotoxicity to some cancer cells. Or because it can interfere with the key metabolic pathways of cancer cells, or affect the DNA synthesis and repair of cancer cells, so that cancer cell growth is inhibited, and even apoptosis. Therefore, in the exploration of anti-cancer drugs, it is also expected to become a budding candidate, contributing to the conquest of cancer problems and helping medicine take a solid step in the journey of fighting the disease.
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