7h Pyrrolo 2 3 D Pyrimidine 4 Chloro 5 Iodo 7 2 C Methyl B D Ribofuranosyl

This is a 7H-pyrrolido [2,3-d] pyrimidine compound, and its specific chemical structure is described as: 4-chloro-5-iodine-7- (2-C-methyl - β - D-furan ribosyl) -7H-pyrrolido [2,3-d] pyrimidine.
To investigate its chemical structure in detail, the main body is 7H-pyrrolido [2,3-d] pyrimidine as the parent nucleus. This parent nucleus structure is formed by fusing a pyrrole ring with a pyrimidine ring. The pyrrole ring and the pyrimidine ring are connected by specific atoms to form a unique fused ring system.
On top of the parent nucleus, the 4-position carbon atom is connected to the chlorine atom. The introduction of this chlorine atom can change the physical and chemical properties of the compound, such as affecting its polarity and reactivity. The 5-position carbon atom is connected to the iodine atom. The relatively large atomic radius and electron cloud structure of the iodine atom also contribute to the overall properties of the compound. For example, it can be used as a leaving group in some reactions or affect intermolecular forces.
And the 7-position 2-C-methyl - β - D-furan ribosyl group is more critical. β-D-furan ribosyl is a carbohydrate structure with multiple chiral centers and hydroxyl groups, which can endow compounds with special spatial configuration and hydrophilicity. Among them, 2-C-methyl represents a methyl group attached to the 2-position carbon atom of the furan ribosyl group. The existence of this methyl group changes the stereochemistry and electronic properties of the carbohydrate part, and affects the interaction between compounds and biological macromolecules. In many drugs or bioactive molecules, such sugar group modifications are often closely related to molecular targeting and metabolic stability.
Overall, the chemical structure of this compound may exhibit specific activities and properties in the fields of chemistry and biology due to the unique positions and properties of each substituent.

4-Chloro-5-iodine-7- (2-C-methyl - β - D-furanribosyl) -7H-pyrrolido [2,3-d] pyrimidine has many physical properties. Its appearance may be a crystalline solid, but the appearance may vary depending on the specific preparation conditions and the degree of purification.
Discuss solubility, because its structure contains polar sugar parts, in polar solvents such as water, methanol, ethanol, or has a certain solubility. However, the halogen atoms and heterocyclic structures in the molecule, such as chlorine and iodine, make it limited in solubility in non-polar organic solvents such as hexane and benzene.
Melting point is also an important physical property. However, the melting point of this substance is not yet public opinion, because the experimental conditions are different from the purity of the sample, and the melting point measurement results may be different. Generally speaking, its melting point is affected by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The interaction of various parts in the molecule makes the melting point in a specific range. However, the exact value needs to be accurately determined by experiments.
Its density may be equivalent to that of similar structural compounds. Due to the large atomic weight of iodine atoms, its density may be relatively high. However, accurate density values need to be determined by special instruments, such as the gravimetric flask method.
In terms of light and thermal stability, halogen atoms and heterocyclic structures are sensitive to light, heat or more. Under light or high temperature, chemical bonds in molecules may break or rearrange, causing structural changes and affecting their properties and activities. Therefore, when storing this substance, it should be placed in a cool and dark place to prevent it from deteriorating due to light and heat factors.

7H-pyrrolido [2,3-d] pyrimidine-4-chloro-5-iodine-7- (2-C-methyl - β - D-furan-ribosyl) is mainly used in the field of pharmaceutical research. In the field of medicinal chemistry, these compounds are often regarded as potential active ingredients due to their unique chemical structures.
The structure of this compound, the substituent of 4-chlorine and 5-iodine, endows it with specific electronic effects and steric hindrance, and the 2-C-methyl - β - D-furan ribosyl group linked at 7-position has a deep impact on its biological activity and metabolic process in vivo.
In the process of antiviral drug development, such compounds may exhibit excellent antiviral activity. The ribosyl part can mimic the natural nucleotide structure and participate in the synthesis process of viral nucleic acid, but the presence of chlorine and iodine substituents interferes with the normal replication of viral nucleic acid, so as to achieve the purpose of inhibiting viral reproduction.
In the field of anticancer drug exploration, we also pay attention to it. Because its structure can interact with specific enzymes or receptors in cancer cells, interfering with key physiological processes such as cancer cell proliferation and signal transduction, it is expected to become a lead compound for new anticancer drugs. Chemical modification and optimization may enhance its targeting and bioavailability to cancer cells and reduce its toxicity and side effects to normal cells.
In conclusion, 7H-pyrrolido [2,3-d] pyrimidine-4-chloro-5-iodine-7- (2-C-methyl - β - D-furan) has potential application value in pharmaceutical research and development, especially in the creation of antiviral and anticancer drugs, which needs to be deeply explored and explored by scientific researchers.

To prepare 4-chloro-5-iodine-7- (2-C-methyl - β - D-furanribosyl) -7H-pyrrolido [2,3-d] pyrimidine, there are many methods, each has its advantages and disadvantages, let me come one by one.
First, ribose can be started from ribose and modified in multiple steps, so that ribose is introduced into methyl group at 2-C position and then connected with appropriate pyrimidine derivatives. This process requires fine regulation of the reaction conditions to maintain the accuracy of the configuration. First, the hydroxyl group of the ribose is protected, and silica ether or ester protective groups are commonly used to prevent it from accidentally participating in the subsequent reaction. Then methyl is introduced at a suitable check point, which can be achieved by nucleophilic substitution. Then the modified ribose is connected to the pyrimidine fragment containing chlorine and iodine. In this step, suitable reagents and catalysts need to be selected to ensure smooth connection, and chlorine and iodine atoms are retained.
Second, using pyrimidine as the starting material, chlorine and iodine atoms are first introduced to construct the core structure of pyrimidine. After glycosylation, 2-C-methyl - β - D-furan ribosyl is added. When introducing chlorine and iodine atoms, it is necessary to consider the selectivity of the reaction, and the choice of halogenating reagents is very critical. In the glycosylation reaction, attention should be paid to the influence of the reaction solvent, temperature and catalyst, so that the glycosyl group can be connected to the 7 position of the pyrimidine with the correct β-configuration.
Third, the aggregation synthesis strategy can be used to prepare the pyrimidine fragment and the sugar fragment containing the appropriate substituent, and then the two are spliced. This strategy can carry out the synthesis of each fragment in parallel to improve the efficiency. However, the splicing step needs to be carefully optimized to ensure the purity and yield of the product.
Although the road to synthesis is fraught with difficulties, chemists with wisdom and experience, carefully designed routes, and strictly controlled conditions will surely be able to obtain this target product.

4-Chloro-5-iodine-7- (2 '-C-methyl-β-D-furan ribosyl) -7H-pyrrolido [2,3-d] pyrimidine, this compound has many wonderful uses in the field of medicine.
It has a significant role in the development of antiviral drugs. Nowadays, viruses are raging and are extremely harmful to human health. This compound can precisely act on the key link of virus replication with its unique chemical structure. For example, when some RNA viruses replicate, it can be cleverly mixed with viral nucleic acid, interfering with its normal synthesis, just like throwing a small pebble into a delicate machine, causing the whole machine to malfunction, thus effectively inhibiting the proliferation of viruses and opening a new path for the development of antiviral drugs.
It also has potential in the exploration of anti-tumor drugs. Tumor cells proliferate abnormally, and this compound may affect the nucleic acid metabolism of tumor cells. Like a highly skilled craftsman, it precisely destroys the supply of "building materials" required for tumor cell growth, interferes with its DNA and RNA synthesis, curbs the crazy growth of tumor cells, and brings new hope for overcoming tumor diseases.
Furthermore, it can be used as a key "key" in improving the drug delivery system. Its structure connected to the ribosyl group may enhance the targeting of drugs. It is like fitting a drug with precise navigation, so that it can avoid normal cells and accurately reach the lesion site. At the same time, it can reduce damage to normal tissues and greatly improve the efficacy and safety of drug treatment.
Although 4-chloro-5-iodine-7- (2 '-C-methyl-β-D-furan ribosyl) -7H-pyrrolido [2,3-d] pyrimidine is currently or is still in the research stage, it has shown great potential in the fields of antiviral, anti-tumor and drug delivery. Over time, through in-depth research and development, it will surely make brilliant achievements for human health and become a shining treasure in the treasure house of medicine.