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What are the physical properties of 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine?
4-Nitrogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine is a class of organic compounds. Its physical properties are particularly important for its application in various fields.
Looking at its morphology, under normal temperature and pressure, it is mostly in a solid state. This is due to the relatively strong intermolecular force, which makes the molecules arranged in an orderly manner and firmly combined to form a solid state.
As for the color, white or off-white powders are common. This color state is easy to observe and identify, and it is easy to distinguish and handle in experiments and industrial production.
When it comes to the melting point, it has been determined by many experiments that the melting point of such compounds is quite high. This is due to the interaction between the conjugated system and hydrogen bonds in the molecular structure, which strengthens the attraction between molecules. To make the molecule break free from the lattice binding, a higher temperature is required to provide enough energy to cause it to melt.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and dichloromethane. However, the solubility in water is not good. Due to its molecular structure, it is composed of carbon, nitrogen, chlorine and other atoms, which has strong hydrophobicity and weak interaction with water molecules, so it is difficult to dissolve in water.
Its density is higher than that of ordinary organic compounds. Because there are many kinds of atoms in the genomic molecule and the relative atomic mass is large, the mass aggregates more in the unit volume, so the density is high.
The physical properties of 4-nitrogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine, such as morphology, color, melting point, solubility and density, have far-reaching influence in organic synthesis, drug development and other fields, providing a key basis for scientific researchers to rationally use this compound.
What are the chemical properties of 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine?
4-Deuterium-6-chloro-7H-indolo [2,3-d] pyrimidine is an organic compound containing special atoms. Its chemical properties are unique and have attracted much attention in many fields.
First of all, its alkalinity is discussed. Because the pyrimidine ring contains nitrogen atoms, has no shared electron pair and can accept protons, it is alkaline to a certain extent. This alkaline property can bind with protons in acidic media to form corresponding salts, and this reaction may affect the solubility and stability of the compound.
Second words, nucleophilic substitution reaction activity. The chlorine atom in the molecule is the active check point. Because of its large electronegativity, the bond connected to the carbon atom has a certain polarity, which is vulnerable to the attack of nucleophilic reagents and occurs nucleophilic substitution reactions. Nucleophilic reagents such as alcohols and amines can react with the location of chlorine atoms, introduce new functional groups, and then expand the chemical diversity of the compound, which is of great significance in the field of organic synthesis.
Furthermore, the compound has a conjugate system. The structure of indolo [2,3-d] pyrimidine forms a large conjugate system, which endows it with special optical and electronic properties. The conjugate system delocalizes the intra-molecular electrons, resulting in the absorption and emission spectra of the compound in a specific range, or can be applied to the field of optoelectronic device materials
In addition, its stability cannot be ignored. The atoms in the molecular structure are connected by covalent bonds to form a stable skeleton. However, under extreme conditions such as high temperature, strong acid, and strong base, the covalent bonds may be destroyed, triggering structural changes and chemical reactions. Therefore, when storing and using, it is necessary to consider the influence of environmental factors on its stability.
4-deuterium-6-chloro-7H-indolo [2,3-d] pyrimidine has rich chemical properties, providing a broad space for research and application in organic synthesis, materials science and other fields. However, when using and studying, it is necessary to fully consider its various properties to achieve the best results.
What are the main uses of 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine?
4-Nitrogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine is widely used in the field of medicine. Its core use lies in drug development, especially in the creation of anti-tumor drugs.
During the occurrence and development of tumors, there are many abnormally activated signaling pathways and protein kinases. 4-Nitrogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine can precisely act on specific protein kinase targets due to its unique chemical structure. For example, some receptor tyrosine kinases play a key role in the proliferation, migration and angiogenesis of tumor cells. This compound can bind closely to specific regions of these kinases, inhibit their phosphorylation process, and then block the signaling pathway, effectively inhibiting the growth and spread of tumor cells.
It has also made a name for itself in the development of immunomodulatory drugs. The body's immune system has an important monitoring and inhibitory function for the occurrence and development of tumors. 4-Nitrogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine can regulate the activity and function of immune cells, enhance the body's immune response to tumor cells, and help the immune system better recognize and eliminate tumor cells.
In addition, in the field of antiviral drug development, the replication and survival of some viruses depend on specific enzymes or proteins. 4-Nitrogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine can interfere with the life cycle of viruses by acting on these key targets, and play an anti-viral effect.
With its unique structure and diverse biological activities, this compound plays a crucial role in the creation of anti-tumor and antiviral drugs, bringing new hope and hope for human beings to conquer major diseases.
What are the synthesis methods of 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine?
The synthesis method of Fu 4-cyanogen-6-chloro-7H-pyrrolido [2,3-d] pyrimidine is a key research in the field of organic synthesis. There are many methods, each with its own advantages.
First, the method of using nitrogen-containing heterocyclic compounds as starting materials. First, take a specific nitrogen-containing heterocyclic ring, and carefully design the reaction conditions, such as in a suitable solvent, add specific catalysts and reagents to make it cyclize. By precisely regulating the reaction temperature and time, the intramolecular chemical bonds are rearranged and closed, and then the core skeleton of pyrrolido [2,3-d] pyrimidine is constructed. Then, for the target position, namely the 4-position and the 6-position, the cyanide group and the chlorine atom are introduced respectively. This introduction process requires selecting suitable cyanide reagents and chlorination reagents according to the reactivity of functional groups, and paying attention to the selectivity and yield of the reaction.
Second, a step-by-step construction strategy is adopted. First, the pyrrole ring part is prepared, and the structural unit of pyrrole is built by classical organic reactions such as nucleophilic substitution and condensation. After that, the pyrimidine ring is connected to it. In this process, the intermediates of each step of the reaction need to be carefully separated and purified to ensure the smooth progress of the reaction and the purity of the product. After the pyrrolidine skeleton is formed, the cyanyl group and the chlorine atom are introduced. When the cyanyl group is introduced, the nucleophilic substitution of the halogen and the cyanide reagent can be used, and the introduction of the chlorine atom can select the appropriate chlorination method depending on the substrate structure, such as the use of chlorine-containing reagents for substitution reaction under specific conditions.
Third, the synthesis path of transition metal catalysis. Transition metal catalysts show unique advantages in this synthesis. For example, metal catalysts such as palladium and copper can promote the coupling reaction between substrates. By selecting suitable ligands, the activity and selectivity of metal catalysts can be adjusted. Using its catalytic action, the reagent containing cyanyl groups and chlorine atoms is efficiently coupled with the precursor of pyrrolido-pyrimidine to achieve the formation of the target product. This path requires precise optimization of the pH of the reaction system, catalyst dosage and other factors to achieve the desired reaction effect.
All these synthetic methods are selected according to their raw materials, reaction conditions and requirements for product purity and yield. They are all effective ways to synthesize 4-cyano-6-chloro-7H-pyrrolido [2,3-d] pyrimidine.
What are the applications of 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine in the field of medicine?
4-Deuterium-6-chloro-7H-purino [2,3-d] pyrimidine has a very important application in the field of medicine. This compound can be used as a key intermediate and plays an indispensable role in the wonderful journey of drug chemical synthesis.
In the creation of anti-tumor drugs, it is like a delicate key. By ingenious modification and carving of its structure, researchers can successfully develop drugs that target specific tumor cells. These drugs are like precise guided weapons that can specifically act on key targets of tumor cells, effectively inhibit the crazy proliferation of tumor cells, and then bring new hope to many tumor patients.
In the exploration of antiviral drugs, 4-deuterium-6-chloro-7H-purino [2,3-d] pyrimidine has also shown extraordinary potential. Viruses, as cunning enemies that endanger human health, have always been a problem to be solved in the field of medical research. And this compound can interact ingeniously with key enzymes in the process of virus replication by virtue of its unique chemical structure, just like quietly setting obstacles to the replication machine of viruses, thus effectively blocking the replication process of viruses and opening up a new path for the development of antiviral drugs.
In the world of antibacterial drugs, it also makes a difference. Bacterial infections often cause trouble to people's health. This compound can subtly disrupt the internal "rhythm of life" of bacteria by affecting the metabolic pathway of bacteria, interfering with the normal growth and reproduction of bacteria, providing valuable clues and possibilities for the development of new antibacterial drugs, and helping humans add powerful weapons in the long battle against bacterial infections.
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