8 Bromo 3 Iodo Quinoline

8-Bromo-3-iodoquinoline is a class of organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
The presence of bromine and iodine atoms in its molecular structure endows this compound with unique reactivity. In the process of building complex organic molecular structures, 8-bromo-3-iodoquinoline can interact with many nucleophiles through typical reactions of halogenated hydrocarbons, such as nucleophilic substitution reactions. In this reaction, bromine or iodine atoms can be replaced by other functional groups, such as hydroxyl and amino groups, and then quinoline derivatives with diverse structures can be derived, which is of great significance in the field of medicinal chemistry.
In the process of drug research and development, quinoline compounds have many biological activities, such as antibacterial, anti-inflammatory, and anti-tumor effects. 8-Bromo-3-iodoquinoline may be modified with specific chemicals to create new drugs with higher activity and selectivity.
Furthermore, in the field of materials science, it also has potential applications. By organic synthesis, 8-bromo-3-iodoquinoline is integrated into conjugated polymer systems, which may change the electronic structure and optical properties of materials, and thus be applied in the field of organic optoelectronic materials, such as the preparation of organic Light Emitting Diodes, solar cells and other devices.
In conclusion, 8-bromo-3-iodoquinoline has shown important application value in many key fields such as organic synthesis, drug development, and materials science due to its unique chemical structure. It is an important compound that cannot be ignored in the field of organic chemistry.

The synthesis method of 8-bromo-3-iodoquinoline, although not directly described in the ancient book "Tiangong Kaiwu", can follow the method of organic synthesis and deduce it from the ancient principle.
First, it can be started from quinoline. Quinoline has an aromatic ring structure and can be reacted by electrophilic substitution. First, brominate with an appropriate brominating agent, such as bromine (Br ²), in the presence of a suitable catalyst, such as iron powder (Fe) or iron tribromide (FeBr ²). Because the electron cloud density of quinoline at the 8-position is relatively suitable for the attack of electrophilic reagents, bromine atoms can be preferentially introduced at the 8-position to obtain 8-bromoquinoline. This process requires attention to the reaction temperature, reagent ratio and other conditions to prevent over-bromination.
Next, 8-bromoquinoline is further converted to 8-bromo-3-iodoquinoline. At this time, an iodine substitution reagent, such as iodine (Iodide), can be used with an appropriate oxidant, such as hydrogen peroxide (H2O) or nitric acid (HNO), in a suitable solvent. The oxidant can activate the iodine and promote its substitution with the 3-position of 8-bromoquinoline. This step also requires careful regulation of the reaction conditions, such as temperature and pH, to ensure that the reaction proceeds in the direction of generating the target product and to avoid affecting the introduced bromine atoms.
Second, there are other methods. The quinoline ring precursor can be constructed first, and the introduction position of bromine and iodine can be pre-planned during the construction process. For example, starting from suitable aniline derivatives and α, β-unsaturated carbonyl compounds containing bromine and iodine, through a series of reactions such as condensation and cyclization, 8-bromo-3-iodoquinoline can be synthesized in one or more steps. This path requires fine design of the reaction steps to control the stereochemistry and chemical selectivity of each step in order to achieve the purpose of efficient synthesis.
To synthesize 8-bromo-3-iodoquinoline, the appropriate synthesis path should be selected according to factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the high or low yield.

8-Bromo-3-iodoquinoline is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
First of all, its appearance is often solid, and the color may be light yellow to brown. The formation of this color is due to the influence of bromine and iodine atoms in its molecular structure. After the introduction of these two, the distribution of electron clouds is changed, and the light absorption characteristics are different, so this color appears.
As for the melting point, due to the force between molecules, the melting point is within a certain range. The bromine and iodine atoms in the molecule increase the polarity of the molecule, which enhances the intermolecular force, so the melting point is relatively high, about a certain temperature range, which is crucial for the purification and identification of compounds.
In terms of solubility, 8-bromo-3-iodoquinoline exhibits different solubility in organic solvents. In common organic solvents such as dichloromethane and chloroform, there is a certain solubility. Because of the structure of the compound, the benzene ring and quinoline ring endow it with certain lipophilicity, and can form interactions such as van der Waals force with the molecules of organic solvents, which is conducive to dissolution. However, in water, due to its relatively small polarity, it is difficult to form strong interactions such as effective hydrogen bonds with water molecules, so the solubility is very small.
Furthermore, its density is also an important physical property. Due to the relatively large atomic masses of bromine and iodine atoms, the density of this compound is higher than that of ordinary organic compounds. This density characteristic has a significant impact on some chemical operations involving phase separation.
In addition, the low volatility of this compound is also attributed to the strong intermolecular forces, which are not easy to change from liquid to gaseous state, and are relatively stable during storage and use. In conclusion, the physical properties of 8-bromo-3-iodoquinoline, such as its appearance, melting point, solubility, density and volatility, are determined by its unique molecular structure, and play a key role in many fields such as organic synthesis and medicinal chemistry.

8-Bromo-3-iodoquinoline is one of the organic compounds. Its chemical properties are unique and have a variety of characteristics.
First of all, in terms of the properties of its halogenated groups, both bromine and iodine atoms are quite electronegative. The presence of bromine and iodine changes the distribution of the electron cloud of the molecule. Bromine and iodine can increase or decrease the density of the electron cloud in the adjacent and para-position, which has a great impact on the electrophilic substitution reaction. Because bromine and iodine are adjacent and para-position groups, when electrophilic reagents attack, they tend to be adjacent and para-position. For example, in the case of electrophilic reagents, such as nitro cation ($NO_ {2 }^{+}$），, the substitution reaction mostly occurs in the adjacent and para-position of the phenyl ring and the quinoline ring. Due to the conjugation effect of the electron given to bromine and iodine, the density of the adjacent and para-electron clouds is relatively high, and it is easier to accept electrophilic reagents.
Furthermore, the halogen atom of 8-bromo-3-iodoquinoline can participate in the nucleophilic substitution reaction. Both bromine and iodine are better leaving groups, and can be replaced under appropriate nucleophilic reagents and reaction conditions. If sodium alcohol is used as the nucleophilic reagent, under heating conditions, the bromine or iodine atom can be replaced by alkoxy groups to form corresponding ether Because the carbon-halogen bond between the halogen atom and the quinoline ring has a certain polarity, the carbon is positively charged and vulnerable to attack by nucleophiles.
In addition, the quinoline ring in this compound is aromatic, making it relatively stable. However, the aromatic ring is also one of the reactive activity check points, and reactions such as hydroreduction can occur. In the presence of appropriate catalysts, such as platinum and palladium, the quinoline ring can be partially or completely hydrogenated to form hydrogenated quinoline derivatives. This reaction can change the spatial structure and electronic properties of the molecule.
In addition, 8-bromo-3-iodoquinoline can participate in the coupling reaction of metal catalysis due to the presence of bromine and iodine atoms. For example, under the catalysis of palladium, Suzuki coupling reaction with aryl boronic acid can form new carbon-carbon bonds and form more complex organic compounds, which are widely used in the field of organic synthesis.

8-Bromo-3-iodoquinoline is in the market, and its price range is difficult to determine. The level of the cap price often varies due to various factors.
First, the source of production is important. If this product comes from a large factory, its quality is high and the source is stable, and the price may be slightly higher; if the source is heterogeneous and the quality is not well controlled, the price may drop.
Second, the amount is also relevant. If there are many seekers and the supply is scarce, the price will rise; if the supply exceeds the demand, the stock will be difficult to sell, and the price will drop.
Third, the difficulty of preparation will also affect its price. If the production of 8-bromo-3-iodoquinoline requires a lot of money, its price will be high; if the production method is gradually simplified, the cost will drop, and the price will also be reduced.
Fourth, the competition in the market is the main reason. If there is a fierce competition in the same industry, each wants to expand its market share, or there may be a price reduction to promote sales; if there is no competitor, the price may be high.
To sum up, the price of 8-bromo-3-iodoquinoline in the market today ranges from tens of yuan to hundreds of yuan per gram, which is difficult to determine the exact value. Only by entering the market and scrutinizing supply and demand, manufacturers, and costs can we get a more accurate price.