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What is the chemical structure of Boc-d-beta-iodo-ala-ome?
Eh, this is an organic chemical substance, called Boc-d - β - iodo- alanine methyl ester. Its chemical structure is composed of several parts. The first is the Boc group, that is, the tert-butoxy carbonyl group, which is connected to the oxygen with the tert-butyl group, and then connected to the carbonyl group. This is a common group to protect the amino group, which can prevent the amino group from changing without reason during the reaction. The second is the β-iodoalanine part, the β position of alanine has iodine atom substitution, and the alanine has an amino group and a carboxyl group. The amino group has been protected by Boc, and the carboxyl group forms an ester with methanol, that is, the methyl ester part, which exists in the form of -COOCH. In this way, the parts are connected according to chemical rules, resulting in the structure of Boc-d - β - iodine-alanine methyl ester. The characteristics and reactivity of this structure depend on the synergy of each part. It is often an important intermediate in organic synthesis and can lead to various reactions to form other organic compounds.
What are the main uses of Boc-d-beta-iodo-ala-ome?
Boc-d-beta-iodo-ala-ome, or tert-butoxycarbonyl-D - β - iodoalanine methyl ester in Chinese, is a crucial compound in the field of organic synthesis. It has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate and participates in the construction of many drug molecules. Gein iodine atoms have unique reactivity and can be connected to other molecular fragments through various organic reactions, such as coupling reactions, to help build complex active pharmaceutical ingredients, playing a key role in the development of innovative drugs.
In the field of peptide chemistry, it can act as an amino acid analogue for the synthesis of polypeptides with special structures. Because β-substituted amino acids can change the spatial structure and physicochemical properties of peptides, the relationship between peptide structure and function can be explored, and the development of new peptide drugs or bioactive peptides can be promoted.
In addition, in the field of materials science, iodine-containing compounds may have applications in the preparation of some functional materials. Boc-d-beta-iodo-ala-ome can be introduced into polymer systems as structural units to endow materials with unique optical, electrical or other physical and chemical properties, providing a novel way for the creation of new functional materials. In short, it is of indispensable value in research and development in many fields.
What is Boc-d-beta-iodo-ala-ome synthesis method?
To make Boc - β - iodo-ala-ome, the following ancient method can be used. First take beta-alanine as the starting material, adjust the pH with alkali solution to make it alkaline. Then put it in a suitable solvent with di-tert-butyl dicarbonate (Boc 2O O), such as dichloromethane or tetrahydrofuran. When stirring at low temperature, such as 0 ° C to 5 ° C, the reaction number, the Boc-protected beta-alanine can be obtained.
This product is then combined with an iodine reagent, such as N-iodosuccinimide (NIS), in a suitable reaction system, in the presence of a catalyst, such as acetic acid, heated to a moderate temperature, about 40 ° C to 60 ° C. When the reaction number, the β position is introduced into the iodine atom.
The resulting iodine-containing product is then co-placed with methanol and a catalytic amount of concentrated sulfuric acid or p-toluenesulfonic acid and reacted at reflux temperature. This step aims to convert the carboxyl group to the methyl ester group to obtain Boc - β - iodo - ala - ome. After the reaction is completed, the saturated sodium bicarbonate solution is neutralized, the organic solvent is extracted, the organic phase is dried, the solvent is removed by rotary evaporation, and then purified by column chromatography to obtain pure Boc - β - iodo-ala-ome. Each step of the reaction needs to pay attention to the control of temperature, time and reagent dosage to achieve good effect.
What are the physical and chemical properties of Boc-d-beta-iodo-ala-ome?
Boc-d-beta-iodo-ala-ome is an organic compound, which has the following physical and chemical properties.
Looking at its properties, it is mostly white to off-white crystalline powder at room temperature, which is easy to store and operate. In terms of melting point, it is about a specific temperature range. Because the precise melting point is related to the purity of the compound, the melting point of high purity is relatively fixed and clear, and it can be used as a purity judgment index.
Solubility is very important. In organic solvents, such as common dichloromethane, chloroform, etc., it shows good solubility. This property makes it effective in the reaction system and promotes the reaction in the organic synthesis reaction. However, the solubility in water is not good, because the molecular structure of hydrophobic groups accounts for a large proportion, resulting in weak interaction with water.
Stability also needs to be considered. Under conventional environmental conditions, it can maintain stability for a certain period of time. In case of strong acids and bases, sensitive parts such as Boc protective groups and ester groups in the structure are prone to react and cause structural changes. High temperature also affects its stability, and high temperature may cause reactions such as decomposition.
The iodine atom in its molecule endows special reactivity, which can participate in key steps of organic synthesis such as coupling reactions and expand the possibility of chemical transformation. At the same time, the structure of Boc protective groups and methoxy esters provides the basis for further modification and derivatization, and has important application value in the field of peptide synthesis.
Boc-d-beta-iodo-ala-ome what are the precautions during storage and transportation?
Boc-d-beta-iodo-ala-ome is an important compound in organic synthesis. During storage and transportation, many matters must be paid attention to.
First, storage, this compound is quite sensitive to environmental factors. First, it should be placed in a low temperature environment, usually 2-8 ° C, because low temperature can slow down its chemical reaction rate and keep its chemical properties stable. Second, it needs to be stored in a cool place away from light. Light can often cause many chemical reactions, causing it to decompose or deteriorate, so dark is the appropriate choice. Furthermore, air and humidity are also key. It should be sealed and stored to prevent the reaction of oxygen, moisture, etc. in the air. Moisture or cause it to hydrolyze, oxygen or cause it to oxidize, can damage its quality.
As for transportation, the same cannot be underestimated. It is necessary to ensure that the packaging is strong and well sealed to prevent the package from being damaged due to bumps and collisions and the leakage of compounds. During transportation, temperature control should not be ignored, and it should be maintained at a suitable storage temperature range as much as possible to ensure its stability. And the transportation environment should be clean, avoid mixing with other substances that may react, in order to prevent accidental chemical reactions from occurring, endangering transportation safety and the quality of compounds. In this way, Boc-d-beta-iodo-ala-ome must be properly stored and transported, so that it can play its due role in organic synthesis and other fields.