What is the chemical structure of Boc-ω-iodo-ala-ome?
Boc-ω-iodo-ala-ome is a kind of organic compound. The structure of this compound can be explained from its name. "Boc", the abbreviation of tert-butyloxycarbonyl, is often used as a protective group for amino groups. In organic synthesis, it can prevent amino groups from participating in the reaction for no reason during the reaction, and then remove them at an appropriate time to restore the activity of the amino group.
"ω-iodo" epiodine atoms are attached to the carbon atoms farthest from the carboxyl group. The iodine atoms at this specific position give the compound unique reactivity. Because the carbon-iodine bond is relatively active, it is easy to participate in nucleophilic substitution and other reactions.
"ala" is the abbreviation of alanine, which is a common amino acid. In this compound, the amino group of alanine is protected by Boc, while the carboxyl group forms methyl ester ("ome", that is, methyl ester group, -COOCH). This structure allows this compound to have both the characteristics of amino acids, and because of the existence of Boc protecting group, iodine atom, and methyl ester group, it has unique chemical properties and reactivity. It can be used in the field of organic synthesis and pharmaceutical chemistry, or as a key intermediate, participating in the construction of many complex compounds.
What are the main uses of Boc-ω-iodo-ala-ome?
Boc-ω-iodo-ala-ome is an important compound in the field of organic synthesis. It has a wide range of main uses and is often used as a key intermediate in the field of medicinal chemistry. During drug development, this compound can build a special molecular structure to obtain drug molecules with specific pharmacological activities. Due to its unique iodine atom and Boc protecting group structure, it can accurately participate in various chemical reactions and help synthesize complex and biologically active compounds.
In peptide synthesis, this compound also plays an important role. It can act as an amino acid derivative to introduce specific structural units and optimize the properties of peptide chains. For example, adjust the stability, solubility or affinity of peptides with receptors. Because the Boc protecting group can protect the amino group from unnecessary side reactions during the reaction process, and the iodine atom can be used as a reaction check point to participate in subsequent coupling reactions, etc., so that the synthesis of peptide chains is more accurate and efficient.
Furthermore, in the field of materials science, Boc-ω-iodo-ala-ome also has potential applications. Or it can be used to prepare functional materials, which can be crosslinked or modified with other materials through their chemical reactivity to give new properties to the material, such as improving the surface properties of the material and improving its biocompatibility. In short, this compound plays an indispensable role in many fields and provides an important chemical tool for scientific research and industrial production.
What is the synthesis method of Boc-ω-iodo-ala-ome?
To prepare Boc - ω - iodo-ala-ome, the method is as follows:
First, alanine (ala) is used as the base, first alanine is taken, and it is reacted with benzyl chloroformate (Boc-Cl) in a suitable alkali environment. Alkalis, such as triethylamine, can maintain the pH of the reaction system and help it proceed smoothly. The amino group of alanine interacts with benzyl chloroformate to form Boc-protected alanine. This step is designed to protect the amino group from unprovoked participation in the subsequent reaction and disorderly reaction order.
Times introduce iodine atoms. With the protected alanine as the substrate, under specific reaction conditions, choose a suitable iodine substitution reagent, such as N-iodosuccinimide (NIS), in a mild reaction environment, such as in inert solvents, such as dichloromethane, and with the help of catalysts, such as trace acids or bases, so that the iodine atom is just in the target position to form Boc - ω - iodo-ala. At the end of
, the product is combined with methanol (MeOH) and a suitable condensing agent, such as dicyclohexyl carbodiimide (DCC), or 1 - (3 - dimethylaminopropyl) - 3 - ethyl carbodiimide hydrochloride (EDC · HCl), and supplemented with 4 - dimethylaminopyridine (DMAP) as a catalyst, at a suitable temperature and reaction time, to form an ester of carboxyl groups and methanol, then Boc - ω - iodo - ala - ome. After each step of the reaction, separation and purification techniques, such as column chromatography, recrystallization, etc. are required to remove impurities and obtain a pure product, so that the reaction is smooth and the product is compatible.
What are the precautions for boc-ω-iodo-ala-ome during storage and transportation?
Boc-ω-iodo-ala-ome is a kind of organic compound. When storing and transporting, it is necessary to pay attention to many matters.
First word storage. Due to its nature or environmental influence, it should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, the heat and radiation of sunlight, or cause the compound to decompose and deteriorate, which will damage its quality. Temperature is also critical and should be controlled within an appropriate range. Usually low temperature is better, but it cannot be generalized. It needs to be determined according to its specific chemical properties. And it should be kept away from fire sources, oxidants, etc., because it may be flammable or easy to react violently with oxidants, causing danger.
Second talk about transportation. The packaging must be sturdy and sealed to prevent leakage. Leakage not only causes the loss of compounds, but also pollutes the environment, endangering the safety of transporters and surrounding people. During transportation, it is also necessary to ensure that the temperature and humidity are stable and avoid bumps and vibrations. Violent vibration or change the molecular structure of the compound, causing chemical reactions. At the same time, transporters should be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies, they can respond quickly and properly to reduce the harm.
In short, when storing and transporting Boc-ω-iodo-ala-ome, there are strict requirements for environmental conditions, packaging and personnel knowledge and skills. Only by adhering to various norms can their safety and stability be guaranteed.
What is the market price range for Boc-ω-iodo-ala-ome?
I look at the "Boc-ω-iodo-ala-ome" you are asking about, which is the category of organic chemistry. However, its market price range is difficult to specify exactly. Because the market conditions are fickle, it is unpredictable. Its price is often affected by many factors. The abundance of raw materials, the difficulty of preparation, and the amount of demand can all make its price fluctuate greatly.
If it is common sense, in the market of fine chemical raw materials, these compounds have different purity and different prices. For high purity, if it reaches the scientific research level, the price may be very high; for industrial grade, the price may be slightly lower. If you want to get an accurate price range, you need to visit all chemical raw material suppliers or refer to the records of recent market transactions. However, such information often changes over time, making it difficult to generalize. And the market varies widely from place to place, with differences between north and south, and between China and foreign countries. Therefore, it is difficult to determine an exact price range. If you want to know the details, you can ask the chemical trading platform and professional chemical suppliers to get a closer price range.
