Diacetoxyiodo Benzen

Iodobenzene diacetate is a commonly used reagent in organic synthesis. Its main use is in oxidation reactions. Alcohols can be oxidized to corresponding carbonyl compounds, such as primary alcohols, which can be oxidized to formaldehyde, and secondary alcohols can be converted to ketones. In this process, iodobenzene diacetate exhibits unique oxidation properties. Compared with other oxidation reagents, the reaction conditions are often milder and the selectivity is also quite good.
Furthermore, in the formation of carbon-carbon bonds, iodobenzene diacetate also plays an important role. For example, it participates in some coupling reactions to help build complex organic molecular structures and expand molecular construction strategies for organic synthesis chemists.
In addition, it can play a role in the modification of phenolic compounds. Promote specific substitution reactions of phenols, introduce various functional groups, enrich the types of phenolic derivatives, and provide a way to create novel compounds in the fields of medicinal chemistry and materials science.
In addition, in the synthesis of heterocyclic compounds, iodobenzene diacetate is also used. With its special reactivity, it promotes the construction of heterocyclic frameworks and contributes to the synthesis of biologically active heterocyclic compounds. All these uses make it an indispensable reagent in the field of organic synthesis, helping chemists explore and create a variety of organic compounds, and promoting the continuous progress of chemical science.

The synthesis method of diacetoxy iodobenzene has been known in ancient times and is recorded in many ancient books. The first method is to co-heat benzene iodoyl dichloride with anhydrous sodium acetate. Put benzene iodoyl dichloride in a reactor, slowly add anhydrous sodium acetate, and co-heat at a moderate temperature. During this time, pay attention to the change of temperature, do not make it too high or too low, so as not to affect the purity and yield of the product. After the reaction, after cooling, separation and purification steps, diacetoxy iodobenzene can be obtained.
There is another method, using iodobenzene, acetic anhydride and hydrogen peroxide as raw materials. First dissolve the iodobenzene into an appropriate amount of solvent, such as glacial acetic acid, and then slowly add acetic anhydride and stir well. Then hydrogen peroxide is added dropwise, and the reaction is carried out within a specific temperature and time. In this process, the dropwise rate of hydrogen peroxide is very important. If it is too fast, the reaction will be violent and prone to side reactions; if it is too slow, it will take a long time and the efficiency will be low. When the reaction is complete, diacetoxy iodobenzene can also be obtained by distillation, crystallization and other means.
Another method is to react with phenyloxy acid and acetic anhydride. Take an appropriate amount of phenyloxy acid, mix it with acetic anhydride in a certain proportion, and react under suitable conditions. This reaction requires attention to control the pH of the reaction environment. Due to changes in pH, the reaction process and product quality are affected. After the reaction is completed, pure diacetoxy iodobenzene can be obtained according to the conventional separation and purification steps.
All kinds of synthesis methods have their own advantages and disadvantages, and they should be used according to actual needs, such as the availability of raw materials, cost considerations, and product purity requirements.

Diacetoxy iodobenzene has many advantages in organic synthesis reactions. It is active and a strong oxidizing agent, which can lead to many oxidation reactions, such as the conversion of alcohols to carbonyl compounds. This reaction condition is mild, does not require harsh temperature and pressure, and has good selectivity. It can accurately act on specific functional groups, making the reaction product single and easy to separate and purify.
In addition, diacetoxy iodobenzene is also wonderfully useful in aromylation reactions. It can combine aromatic hydrocarbons with nucleophiles to form arylated products. This process has high reaction efficiency, can effectively shorten the reaction time and improve the yield of products. And the reaction system it participates in is relatively simple, without complicated catalytic systems, reducing the cost and difficulty of synthesis.
In addition, due to its structure containing iodine atoms, iodine functional groups can be introduced to expand the path for subsequent reactions. Iodine functional groups have high activity and can further undergo substitution, coupling and other reactions, which add more possibilities for organic molecular structure and play a significant role in the total synthesis of complex natural products and drug research and development.
From this perspective, diacetoxy iodobenzene, with its mild reaction conditions, high selectivity, high efficiency and the characteristics of introducing active functional groups, is an extremely powerful reagent in organic reactions and promotes the progress of organic synthesis chemistry.

Diacetoxy iodobenzene is an important reagent in organic synthesis. When using it, many aspects need to be paid attention to.
Bear the brunt, this reagent has certain toxicity and irritation. When operating, be sure to wear appropriate protective equipment, such as gloves, goggles, and laboratory work clothes, to prevent it from coming into contact with the skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately, and seek medical attention according to the specific situation.
Secondly, diacetoxy iodobenzene is quite sensitive to moisture. When storing, it needs to be stored in a dry environment, and it should be quickly sealed after use to avoid contact with moisture in the air to prevent deterioration and affect the reaction effect.
Furthermore, in the reaction system, its reactivity is quite high. When using, it is necessary to precisely control the dosage and reaction conditions. The reaction temperature, time and the choice of solvent will all affect the reaction process and the yield and purity of the product. Before entering the reaction, the reaction mechanism and conditions should be deeply explored, and necessary pre-experiments should be carried out to determine the best reaction parameters.
In addition, some of the reactions involving diacetoxy iodobenzene will generate by-products with certain hazards. Therefore, the treatment steps after the reaction cannot be ignored. The reaction waste needs to be properly disposed of, and relevant environmental protection regulations should be followed to prevent environmental pollution.
In short, when using diacetoxy iodobenzene, the experimenter needs to be rigorous and meticulous, fully understand its properties and reaction characteristics, and strictly follow the operating procedures to ensure the safety and smooth progress of the experiment and obtain the ideal experimental results.

What you are asking is the market price of diacetoxy iodobenzene. However, the price of the market often changes with time and varies from place to place, so it is difficult to tell the exact number.
This chemical substance has its uses in all parties. The determination of its price is related to various reasons. First, the price of raw materials, if the raw material is difficult to find and expensive, the price of this product will rise. Second, the difficulty of making, if the system is difficult, laborious and time-consuming, the price will also be high. Third, if you ask for more and less, if you ask for more and less, the price will increase; on the contrary, if you ask for less and supply more, the price will be reduced.
If you want to know the detailed price, you can visit the city of chemical industry and consult the merchants. Or ask for it on the Internet, and look at the trading platform, depending on the state of its price, and if you look at it comprehensively, you can get a near-real price. However, the price changes at any time, and it cannot be determined uniformly.