E Methyl 3 Iodoacrylate

The chemical structure of (E) -methyl-3-iodoacrylate is an organic compound structure with a specific spatial configuration and atomic connection. In this compound, "acrylate" indicates that its basic skeleton belongs to acrylate, that is, it contains acrylic acid structure and ester group. The acrylic structure contains carbon-carbon double bonds and is a part of the olefin structure, which imparts unsaturation to the compound and can undergo reactions such as addition.
"methyl" is expressed on the acrylate skeleton, with a methyl (-CH 🥰) substitution. And "3-iodine" means that the iodine atom is connected to the third carbon atom of the acrylate backbone from the carboxyl end.
" (E) " is the configuration of the double bond, which is the E configuration, that is, when the priority group connected at both ends of the double bond is on the opposite side of the double bond, it is represented by E. In this compound, according to the group priority rule, the spatial arrangement of the groups on both sides of the double bond is determined to be in the E configuration.
Overall, the chemical structure of (E) -methyl-3-iodoacrylate is: acrylate as the parent, methyl and iodine atoms are substituted at specific positions, and the double bond is in the E configuration. This unique structure determines that it has specific physical and chemical properties and may have important applications in organic synthesis, medicinal chemistry and other fields.

(E) -methyl-3-iodoacrylate is also an important compound in organic chemistry. It has a wide range of uses and has been demonstrated in various fields.
In the field of organic synthesis, (E) -methyl-3-iodoacrylate is often a key intermediate. Based on it, chemists can construct complex organic molecular structures through a variety of chemical reactions, such as nucleophilic substitution and addition reactions. For example, nucleophilic substitution with nucleophiles containing active hydrogen, such as alcohols and amines, can prepare a series of esters and amides with special structures and functions, which is of great significance in medicinal chemistry and materials science, or can provide opportunities for creating new drug molecules and optimizing material properties.
In the field of materials science, (E) -methyl-3-iodoacrylate can participate in the polymerization reaction. By means of free radical polymerization, it can be integrated into the polymer backbone and endow the material with novel properties. Due to its iodine-containing atoms, it may improve the flame retardant properties of materials; while the alkenyl and ester-based structures can adjust the hydrophobicity and mechanical properties of materials, making materials useful in electronic devices, coatings, fibers and other fields.
In terms of pharmaceutical chemistry, its unique structure can be used as the basis for modification of lead compounds. By modifying and modifying its structure, derivatives with specific biological activities can be synthesized, or drugs for treating specific diseases can be developed. For example, adjusting substituents and changing their interactions with biological targets to achieve better pharmacological effects.
In addition, in the total synthesis of natural products, (E) -methyl-3-iodoacrylate may be a key building block for the construction of the complex carbon skeleton of natural products, enabling chemists to successfully realize the total synthesis of natural products and promoting the progress of natural product chemistry research.

The synthesis of (E) -methyl-3-iodoacrylate is an important topic in the field of organic synthesis. Its synthesis usually requires a multi-step reaction, which is delicate and requires precise control of the reaction conditions.
The starting material is often an acrylate compound with suitable substituents. In the first step, a suitable halogenation reagent, such as an iodide reagent, can be selected by using a halogenation reaction to introduce iodine atoms into the specific position of the acrylate. In this step, factors such as reaction temperature, reaction time and reagent dosage need to be carefully observed. If the temperature is too high, it may cause more side reactions; if the temperature is too low, the reaction rate will be slow.
After the halogenation reaction is completed, it is often necessary to adjust the configuration to obtain the (E) configuration of the target. This process or by means of stereoselectivity reaction, by selecting a specific catalyst or reaction conditions, the double bond configuration is promoted to achieve the desired trans structure. In this process, the activity and selectivity of the catalyst are very important. If the choice is improper, it may be difficult to obtain the ideal configuration product. In the synthesis process of
, the separation and purification steps are also indispensable. Because the reaction system often contains impurities, such as unreacted raw materials and by-products. Column chromatography, recrystallization and other methods can be used to separate the target product from the mixture to improve the purity of the product.
During each step of the reaction, the intermediate product needs to be accurately characterized, and the structure and purity can be confirmed by means of nuclear magnetic and mass spectrometry analysis. In this way, (E) -methyl-3-iodoacrylate can be synthesized efficiently and with high purity through carefully designed and operated reactions in multiple steps.

(E) -methyl-3-iodoacrylate, its physical properties are as follows:
At room temperature, this substance is often colorless to light yellow liquid. When it is pure, its appearance is clear and transparent, and there are no impurities visible to the naked eye. It has a certain volatility and is placed in an open container. After a while, its amount will be reduced.
When it comes to density, this substance is heavier than water. If it is placed in a container with water, when it is left to stand, it will be seen sinking at the bottom of the water. The boundaries between the two are clear. The exact value of its density, according to accurate measurement, is about [X] grams per cubic centimeter. This value varies slightly depending on the temperature and pressure conditions at the time of measurement. The boiling point of
is also one of its important physical properties. Under standard atmospheric pressure, the boiling point of (E) -methyl-3-iodoacrylate is about [X] degrees Celsius. When heated to this value, it can be seen that it gradually changes from liquid state to gaseous state, and violent vaporization occurs.
In terms of solubility, it has good solubility in organic solvents, such as ethanol, ether, dichloromethane, etc., and can be miscible with various organic solvents in any ratio to form a uniform phase system. However, in water, its solubility is very small. After the two are mixed, they are quickly layered. This is due to the characteristics of its molecular structure, which contains iodine atoms and ester groups in the molecule, resulting in poor hydrophilicity.
In addition, the refractive index of this substance also has a specific value, which is about [X]. The determination of the refractive index requires the use of sophisticated instruments, and the temperature and other conditions at the time of measurement are strictly required. The value reflects the degree of refraction of light when passing through the substance, which is an important basis for identifying this substance and studying its purity.

(E) -Methyl-3-iodoacrylate is an organic compound, and its safety precautions are detailed as follows:
The first to bear the brunt, because of its chemical activity, it is necessary to wear suitable protective equipment when operating. Such as protective gloves, which can avoid direct contact with the skin to prevent irritation or absorption, causing skin damage; goggles can properly protect the eyes, if this substance accidentally splashes into the eyes, or causes serious injury. Wearing laboratory clothes is also key, which can act as a barrier to the body.
Furthermore, the substance should be handled in a well-ventilated area. Due to the possible volatilization of harmful gases, good ventilation can disperse in time, reduce the concentration of harmful substances in the air, and reduce the risk of inhalation. It is best to operate in a fume hood, which can effectively capture and discharge volatile gases.
For storage, be sure to store in a cool, dry and well-ventilated place. Keep away from fires, heat sources, and cause dangerous reactions due to heat or chemical reactions. At the same time, store separately from oxidants, reducing agents, acids, and alkalis to prevent mutual reactions.
When transporting, specific rules must also be followed. Proper packaging to ensure that the container is well sealed to avoid leakage. And in accordance with relevant regulations, choose suitable transportation methods and tools, and pay close attention during transportation to prevent collision and dumping.
In addition, operators should be familiar with emergency treatment measures. If they accidentally come into contact with the skin, they should immediately rinse with a large amount of flowing water; if they splash into the eyes, they should quickly rinse with a large amount of water and seek medical attention. In the event of a leak, personnel from the contaminated area of the leak should be quickly evacuated to a safe area and quarantined, and access should be strictly restricted. Emergency personnel wear self-contained positive pressure respirators and anti-toxic clothing to cut off the source of the leak as much as possible to prevent it from flowing into restricted spaces such as sewers and drainage ditches. A small amount of leakage should be mixed with sand, dry lime or soda ash, or it can be rinsed with a large amount of water. After the washing water is diluted, it can A large number of leaks are built embankments or excavated for containment, covered with foam to reduce vapor hazards, and transferred to a tanker or dedicated collector by pump for recycling or transportation to a waste treatment site for disposal.