Ethyl 3 Iodobenzoate

Ethyl 3-iodobenzoate is an important raw material for organic synthesis. In the field of organic synthesis, it has a wide range of uses.
First, it can be used to prepare a variety of benzoate ester derivatives. After various chemical reactions, such as nucleophilic substitution, its iodine atom can be replaced with other functional groups, and then complex compounds can be constructed. This is of great significance in the field of medicinal chemistry, because it can be modified by structure to create new drug molecules with unique pharmacological activities.
Second, it is also used in materials science. After a specific reaction, it can be introduced into the structure of polymer materials to change the physical and chemical properties of the materials, such as improving the thermal stability and solubility of the materials, to meet the special needs of material properties in different fields.
Third, in the multi-step reaction sequence of organic synthesis, ethyl 3-iodobenzoate often acts as a key intermediate. By ingeniously designing the reaction path, complex carbon skeleton structures can be constructed through it, laying the foundation for the synthesis of natural products, functional organic molecules, etc.
Furthermore, in organometallic catalytic reactions, it can be used as a substrate to participate in the reaction, synergize with metal catalysts, achieve precise chemical bond construction and conversion, and assist in the synthesis of high-purity, high-stereoselectivity organic compounds, promoting the development and progress of organic synthesis chemistry.

Ethyl 3-iodobenzoate, ethyl 3-iodobenzoate, is an organic compound. Its physical properties are as follows:
Viewed at room temperature, this compound is a colorless to pale yellow liquid with a clear texture. This color and properties are quite common in organic liquids, and also conform to the general characteristics of this class of halogen-containing benzoates.
Smell, it has a special aromatic smell, which is derived from the structural characteristics of benzene rings and ester groups. The existence of aromatic smell is also common to many benzoic acid ester compounds.
Its boiling point is within a certain range, and it boils at a higher temperature due to intermolecular forces. Among them, the presence of ester groups and iodine atoms increases the intermolecular forces, resulting in an increase in the boiling point. The melting point of
is relatively low, and it is liquid at room temperature, which is closely related to the spatial structure of the molecule and the interaction between molecules. The molecular structure does not form a close and regular arrangement, so the melting point is not high.
The density is greater than that of water, and when mixed with water, it will sink to the bottom. This is due to the large relative atomic weight of iodine atoms in the molecule, resulting in an increase in the overall density.
In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, chloroform, etc. This is because the compound is an organic molecule and follows the principle of "similar miscibility". Water molecules are polar molecules, and the polarity of the organic molecule is relatively weak, so it is difficult to dissolve in water and easily soluble in non-polar or weakly polar organic solvents.

There are several ways to make ethyl 3-iodobenzoate.
First, it can be obtained by esterification of 3-benzoic acid and ethanol, and then by the action of iodizing reagents. First, take an appropriate amount of 3-benzoic acid and place it in a reactor, add an appropriate amount of ethanol and a catalyst amount of concentrated sulfuric acid, heat it to a certain temperature, and maintain the reflux state for a period of time. This is the esterification process, and ethyl benzoate can be obtained. After that, ethyl benzoate and iodizing reagents, such as sodium iodide, potassium iodide, etc., are heated in an appropriate organic solvent, such as acetone. After a series of separation and purification operations, ethyl 3-iodobenzoate can be obtained.
Second, react with 3-iodobenzoyl chloride with ethanol. First prepare 3-iodobenzoyl chloride, take 3-iodobenzoic acid and react with thionyl chloride to obtain 3-iodobenzoyl chloride. Slowly drop it into a reaction vessel containing ethanol, control the reaction temperature, and after the reaction is completed, remove impurities through washing, drying, and distillation to obtain pure ethyl 3-iodobenzoate.
Third, use the Grignard reagent method. First prepare Grignard reagent from 3-iodobromobenzene, and react 3-iodobromobenzene with magnesium chips in anhydrous ether. Then the Grignard reagent is reacted with carbon dioxide, and then acidified and esterified. That is, 3-iodobenzoic acid is first reacted with carbon dioxide, and then esterified with ethanol. According to the previous method, ethyl 3-iodobenzoate can also be obtained.
These methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction conditions.

Ethyl 3 - iodobenzoate is an organic compound. When storing and transporting, there are several precautions to be taken.
First, it is related to storage. This compound should be placed in a cool, dry and well-ventilated place. Since it is more sensitive to heat, it is easy to decompose or deteriorate due to heat, so it should be avoided in a high temperature environment and must not be near fire or heat sources. In addition, it must be sealed and stored to prevent contact with air, moisture, etc. Because moisture may cause hydrolysis reactions, its purity and stability should be affected. When storing, it should be separated from oxidants, acids, bases, etc. to prevent chemical reactions.
Second, about transportation. During transportation, ensure that the packaging is complete and tightly sealed to prevent leakage. This substance may be dangerous in the event of vibration, collision, etc., so proper fixing and buffering measures need to be taken to ensure smooth transportation. The means of transportation should also be clean and dry, and no substances that can react with it should remain. In addition, the transporter needs to be familiar with its characteristics and emergency treatment methods, and can respond quickly and correctly in case of leakage.
In short, when storing and transporting Ethyl 3-iodobenzoate, it is necessary to strictly follow the relevant safety regulations and operating procedures, so as to ensure its quality and safety, and avoid potential dangers and losses.

Ethyl 3-iodobenzoate is an organic compound, the Chinese name is ethyl 3-iodobenzoate. Its market price varies due to a variety of factors, and it is difficult to determine exactly.
First, the preparation method will affect the price. If ethyl benzoate is used as the starting material and iodine atoms are introduced into the halogenation reaction to prepare, the cost of raw materials and reaction conditions will be related to the price. If the raw materials are easily available and the reaction conditions are mild, the cost may be reduced; conversely, if special reagents and harsh reaction conditions are required, the cost will be high and the price will rise accordingly.
Second, the purity has a great impact on the price. High-purity Ethyl 3-iodobenzoate is in high demand in scientific research and high-end chemical industries, because it has few impurities and can ensure the accuracy and stability of experiments and production. In order to achieve high purity, finer separation and purification processes are required, which will undoubtedly increase costs and lead to high prices; while those with lower purity are suitable for scenarios with low requirements, and the price is relatively cheap.
Third, the market supply and demand relationship determines the price. In the fields of pharmaceutical research and development, materials science, etc., if the demand for Ethyl 3-iodobenzoate suddenly increases, and the production supply is difficult to keep up in time, the price will rise; if the market demand is weak and the supply is sufficient, merchants may reduce prices for promotional sales.
Fourth, the scale of production also has an impact. In large-scale production, due to the scale effect, the unit production cost may be reduced, and the price is more affordable; in small-scale production, the unit cost is high, and the price is naturally higher.
In summary, the market price of Ethyl 3-iodobenzoate is in dynamic change, ranging from tens of yuan per gram to hundreds of yuan or even higher. For the exact price, please consult the chemical product supplier in detail, and the real-time market conditions shall prevail.