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What are the main uses of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate?
Ethyl 4-chloro-8-iodoquinoline-3-carboxylate is an organic compound with a wide range of main uses. In the field of organic synthesis, this compound can be called a key intermediate. With its special chemical structure, it can be converted into other organic molecules with special functions and structures through various chemical reactions.
For example, in the process of constructing complex heterocyclic compounds, the chlorine atoms and iodine atoms on Ethyl 4-chloro-8-iodoquinoline-3-carboxylate have high reactivity and can participate in nucleophilic substitution reactions. Organic chemists can take advantage of this property to interact with various nucleophiles, thereby introducing different functional groups, expanding and modifying the heterocyclic skeleton, and laying the foundation for the creation of novel compounds with biological activities.
In the field of pharmaceutical chemistry, this compound also has important uses. Because its structure contains a quinoline ring, this structure is widely found in many biologically active natural products and drug molecules. Ethyl 4-chloro-8-iodoquinoline-3-carboxylate is used as the starting material, and through a series of chemical modifications and optimizations, new drugs with specific pharmacological activities may be developed, such as antibacterial, anti-inflammatory, and anti-tumor drugs.
In addition, in the field of materials science, by chemically modifying Ethyl 4-chloro-8-iodoquinoline-3-carboxylate, organic materials with special photoelectric properties can be prepared for use in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, contributing to the development of materials science.
What are the synthetic methods of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate?
The method of preparing Ethyl 4-chloro-8-iodoquinoline-3-carboxylate (4-chloro-8-iodoquinoline-3-carboxylate) can follow the following methods.
First, quinoline is based and obtained by multi-step modification. First, the quinoline is treated with a specific reagent under suitable conditions to introduce carboxylic groups. This step can be used, such as in a strong oxidizing agent and a specific solvent environment, to promote oxidation and carboxylation at a specific position on the quinoline ring. Then, the obtained quinoline product containing carboxyl groups is esterified with ethanol under appropriate catalyst and reaction conditions to obtain ethyl quinoline-3-carboxylate. Subsequently, chlorine atoms and iodine atoms are introduced into the product molecule. When introducing chlorine atoms, suitable chlorination reagents can be selected, such as reacting with chlorine-containing reagents under light or a specific catalyst, so that chlorine atoms selectively replace hydrogen atoms at the target position. In the step of introducing iodine atoms, iodine substitutes can be used to introduce iodine atoms into the predetermined position through nucleophilic substitution or other suitable reaction mechanisms in a specific reaction system, and finally Ethyl 4-chloro-8-iodoquinoline-3-carboxylate can be obtained.
Second, other aromatic compounds can also be used as starting materials through multi-step cyclization and functional group introduction reaction. For example, select suitable aniline derivatives and compounds containing functional groups such as carbonyl and halogenated hydrocarbons, and construct a quinoline ring skeleton through condensation reaction under the catalysis of alkaline environment and specific catalysts. After that, similar to the above method, carboxyl groups are introduced in sequence, esterification is carried out, and chlorine atoms and iodine atoms are selectively introduced. After several carefully designed reactions, the target product is finally obtained. Each step requires fine regulation of reaction conditions, such as temperature, reaction time, reagent dosage and purity, to ensure the smooth progress of the reaction and the high purity and yield of the product.
What are the physical properties of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate?
Ethyl 4 - chloro - 8 - iodoquinoline - 3 - carboxylate is an organic compound, and its physical properties are as follows:
From the perspective of
, it is usually in a solid state, mostly crystalline powder. This is due to the existence of strong interaction forces between molecules, such as van der Waals forces, hydrogen bonds, etc., resulting in an orderly arrangement of molecules and a solid state.
As for the color, it is usually white to light yellow. The reason is that the characteristics of light absorbed and reflected by the electron transition energy level in the molecular structure determine its external color.
In terms of melting point, it is between about 150 and 160 ° C. This is because the molecular structure has a certain rigidity and symmetry, and the intermolecular force has a specific strength. At a certain temperature, the molecule is energized enough to overcome this force, and the lattice structure disintegrates, so it melts into a liquid state.
Solubility is critical. In organic solvents, such as chloroform and dichloromethane, it exhibits good solubility. These organic solvents and the compound molecules can form similar intermolecular forces, following the principle of "similar miscibility". However, the solubility in water is extremely low, because the molecular structure of the hydrophobic groups accounts for a large proportion, and the intermolecular force between water molecules and compounds is weak, making it difficult to disperse them in water.
The density is relatively large, about 1.8 - 2.0 g/cm ³. Due to the fact that the molecule contains relatively large atoms such as chlorine and iodine, the mass of the substance per unit volume increases.
The physical properties of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate are determined by its molecular structure, which is of great significance for its application in chemical synthesis, drug development and other fields.
What are the chemical properties of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate?
Ethyl 4-chloro-8-iodoquinoline-3-carboxylate is an organic compound with unique chemical properties. Its structure contains a quinoline ring, and there is a chlorine atom at the 4th position, an iodine atom at the 8th position, and a carboxylate group at the 3rd position. This structure endows the compound with various chemical activities.
From the perspective of physical properties, the compound is mostly solid, and the melting boiling point is affected by the intermolecular force and structure. Because of its halogen atom and ester group, the intermolecular force is enhanced, and the melting boiling point is higher. And the solubility of the compound in common organic solvents or differences exist. The polarity of halogen atoms and ester groups makes it more soluble in polar organic solvents such as ethanol and acetone or better than non-polar solvents such as n-hexane.
In terms of chemical properties, halogen atoms chlorine and iodine are active and can participate in nucleophilic substitution reactions. For example, under suitable nucleophilic reagents and reaction conditions, chlorine atoms or iodine atoms can be replaced by other groups, providing a way to construct new compound structures. The ester group can undergo hydrolysis reaction. Under acidic or basic conditions, ester bonds are broken to form carboxylic acids and alcohols, respectively. Hydrolysis under basic conditions or more completely, this hydrolysis reaction can be used to prepare related carboxylic acid derivatives. At the same time, the quinoline ring, as an aromatic ring system, can undergo electrophilic substitution reaction. Due to the influence of chlorine, iodine and ester groups, the reaction check point may be selective.
The chemical properties of this compound make it have potential applications in the field of organic synthesis. It can be used as a key intermediate for the synthesis of complex organic molecules, and may have important value in the fields of medicinal chemistry, materials science and other fields.
What is the price range of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate in the market?
Ethyl 4-chloro-8-iodoquinoline-3-carboxylate is an organic compound. On the market, its price range is difficult to determine accurately, because many factors can affect its price.
First, the cost of preparing this compound is quite critical. The price of raw materials has a significant impact. If the raw materials required for the preparation of 4-chloro-8-iodoquinoline and related carboxylic acids are scarce and expensive, then the manufacturing cost of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate will be high, which in turn will increase its market price. Furthermore, the complexity of the synthesis process should not be underestimated. If the synthesis of this compound requires multiple reactions, and the conditions of each reaction are harsh and the yield is not high, then the production cost will also increase greatly, and the price will rise.
Second, the supply and demand of the market have a significant impact on the price. If in a specific field, such as drug development, there is a sudden increase in demand for Ethyl 4 - chloro - 8 - iodoquinoline - 3 - carboxylate, but the supply is difficult to keep up quickly, in this situation, the price will rise. Conversely, if the market demand is low and the manufacturer has more output, the price may fall in order to make a sale.
Third, the difference between different suppliers will also make the price different. Some well-known, high-quality and well-after-sales suppliers may have relatively high product prices; while some small suppliers may sell products at lower prices in order to seize market share.
In summary, the price range of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate in the market fluctuates greatly, ranging from tens of yuan per gram to hundreds of yuan per gram or even higher. There is no exact pricing. It needs to be determined based on the above factors.
