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What are the main uses of Ethyl 4-iodo-1h-pyrazole-5-carboxylate?
Ethyl 4-iodo-1H-pyrazole-5-carboxylate (ethyl 4-iodo-1H-pyrazole-5-carboxylate) is widely used in the field of organic synthesis.
First, it is often used as a key intermediate to prepare various compounds containing pyrazole structures. Pyrazole compounds have significant biological activities in the field of medicine, such as antibacterial, anti-inflammatory, and anti-tumor equivalents. With this compound as a starting material, through delicate chemical reactions, a specific molecular structure can be constructed and target products with specific pharmacological activities can be obtained. For example, through appropriate substitution reactions, cyclization reactions, etc., the groups around the pyrazole ring can be modified, and the biological activity and pharmacokinetic properties of the compounds can be precisely regulated, thus paving the way for the development of new drugs.
Second, in the field of materials science, it also has extraordinary performance. Because the pyrazole structure can endow materials with unique photoelectric properties, it can be used as a raw material to synthesize derivatives, or can be applied to organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices. By optimizing its structure, key parameters such as charge transfer performance and luminous efficiency of materials can be improved, and the performance and innovation of optoelectronic devices can be promoted.
Third, it also plays an important role in the field of pesticide chemistry. Many pesticides containing pyrazole structure have high control effect on pests and diseases. Ethyl 4-iodo-1H-pyrazole-5-carboxylate can be used as a key building block for the synthesis of such pesticides. It is chemically modified to have specific biological activity and targeting, so as to achieve precise prevention and control of crop diseases and insect pests and contribute to the sustainable development of agriculture.
What are the synthetic methods of Ethyl 4-iodo-1h-pyrazole-5-carboxylate?
The synthesis method of Ethyl 4-iodo-1H-pyrazole-5-carboxylate (4-iodo-1H-pyrazole-5-carboxylate) is often involved in the field of organic synthesis. The methods are diverse, and the common numbers are briefly described below.
First, pyrazole is used as the starting material. Appropriate protective group modification of pyrazole is first carried out to prevent unnecessary side reactions on the pyrazole ring in the reaction. Then, iodine atoms are introduced at specific positions in the pyrazole ring. In this step, a suitable iodine substitution reagent can be selected by means of a nucleophilic substitution reaction, such as iodine elemental substance in combination with an appropriate oxidizing agent, or iodine alkanes with higher activity can be used to react in a suitable base and solvent system. After the iodine atom is successfully introduced, the carboxyl group is converted into ethyl ester group through an esterification reaction. Ethanol and a suitable dehydrating agent, or in the reaction system of acid chloride and ethanol, can be used to complete the esterification process to obtain the target product 4-iodine-1H-pyrazole-5-carboxylate.
Second, other nitrogen-containing heterocyclic compounds can also be used as starting materials to construct pyrazole rings through multi-step reactions. For example, the skeleton of the pyrazole ring is constructed by the condensation reaction of the nitrogen-containing bifunctional compound with a suitable carbonyl compound under basic conditions. After the formation of the pyrazole ring, the iodine atom is introduced first, and then the ethyl ester group is constructed according to the above-mentioned similar method. During the reaction process, the choice of solvent is very critical. Commonly used organic solvents such as dichloromethane, N, N-dimethylformamide, etc. need to be carefully selected according to the characteristics of each step of the reaction. At the same time, the reaction temperature and reaction time also need to be carefully adjusted to ensure the efficiency and selectivity of each step of the reaction, and finally achieve the effective synthesis of 4-iodine-1H-pyrazole-5-carboxylate ethyl ester.
What are the physical properties of Ethyl 4-iodo-1h-pyrazole-5-carboxylate?
Ethyl 4 - iodo - 1H - pyrazole - 5 - carboxylate is an organic compound with unique physical properties. Its appearance is often solid, mostly white or off-white crystalline powder, which is easy to identify and handle in experiments and industrial operations.
In terms of melting point, it is usually in a specific temperature range, which is of great significance for the determination of the purity of the compound. Under different purity conditions, the melting point may vary, and the purity can be evaluated by accurately measuring the melting point.
The solubility of this compound is critical. In organic solvents, such as common dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc., or exhibit a certain solubility, which is conducive to participating in various chemical processes as reactants or intermediates in organic synthesis reactions. With suitable solvents, homogeneous reactions can be achieved, and reaction efficiency and selectivity can be improved. However, in water, its solubility or poor, due to the large proportion of hydrophobic parts in the molecular structure, the interaction with water molecules is weak.
Ethyl 4-iodo-1H-pyrazole-5-carboxylate density may be different from that of water, which has a significant impact when it comes to operations such as liquid-liquid separation. According to the density difference, a suitable method can be selected to separate the mixture containing this compound. In addition, its stability may change under certain conditions. When exposed to light, heat, or certain chemical substances, reactions such as decomposition and isomerization may occur. Therefore, when storing and using, it is necessary to avoid light, temperature control, and contact with incompatible substances to ensure its chemical stability and maintain its proper efficacy and quality.
What are the chemical properties of Ethyl 4-iodo-1h-pyrazole-5-carboxylate?
Ethyl 4 - iodo - 1H - pyrazole - 5 - carboxylate is an organic compound. It has unique chemical properties.
This compound contains iodine atoms, which endow it with certain reactivity. Iodine atoms are relatively large and have strong electronegativity, which can affect the electron cloud distribution of molecules, and then affect their chemical behavior. In many organic reactions, iodine atoms are often good leaving groups and can participate in nucleophilic substitution reactions. For example, in the presence of appropriate nucleophiles, iodine atoms can be replaced by nucleophiles to form new carbon-heteroatomic bonds, whereby more complex organic molecular structures can be constructed.
There is a pyrazole ring structure in the molecule. The pyrazole ring has certain aromatic properties, which makes it relatively stable in chemical properties. However, the nitrogen atom on the ring has lone pairs of electrons, which can participate in coordination reactions and form complexes with metal ions. Such complexes may have potential applications in the field of catalysis or materials science.
In addition, the presence of ethyl ester groups also has a significant impact on its chemical properties. Ethyl ester groups are electron-withdrawing groups, which can affect the electron cloud density on the pyrazole ring through induction effects and change the reactivity at different positions on the ring. At the same time, ethyl ester groups can undergo hydrolysis reactions under basic or acidic conditions to generate corresponding carboxylic acids or their salts. This hydrolysis reaction is a common conversion step in organic synthesis and can be used to prepare derivatives with different functional groups.
Furthermore, the polarity of Ethyl 4 - iodo - 1H - pyrazole - 5 - carboxylate is moderate, which determines its solubility in different solvents. Moderate polarity makes it soluble in some organic solvents such as ethanol and acetone. This solubility property is crucial in the reaction operation of organic synthesis and the process of product separation.
What is the price range of Ethyl 4-iodo-1h-pyrazole-5-carboxylate in the market?
"Tiangong Kaiwu" was written in the Ming Dynasty. At that time, the concept of chemical substances and such specific organic compounds were not yet recognized, and there was no way to record relevant price information. However, it is not easy to answer according to the ancient classical method and speculate on the price of this substance.
In today's world, the price of chemicals is determined by many factors, such as the difficulty of synthesis, the amount of raw materials, and the market supply and demand. Ethyl 4 - iodo - 1H - pyrazole - 5 - carboxylate, this organic compound, if its synthesis process is complicated, the raw materials are rare and rare, and the market demand is strong, its price will be high; if the synthesis is simple, the raw materials are full, and the demand is normal, the price will be flat.
However, based on the current market conditions, it is difficult to determine the price range without knowing the specific specifications and quality. If it is a laboratory-grade small amount of reagent with excellent quality, it may reach tens to hundreds of gold per gram; if it is an industrial mass production grade, it may range from tens of thousands to hundreds of thousands of gold per ton depending on the purity and batch size. This is only a guess. The actual price should be determined by consulting the chemical raw material market and reagent suppliers in detail.