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What are the physical properties of Ethyl 4-iodopyrazole-5-carboxylate?
Ethyl 4-iodopyrazole-5-carboxylate (ethyl 4-iodopyrazole-5-carboxylate) is an organic compound with unique physical properties. It is mostly solid at room temperature, and its appearance may be white to light yellow crystalline powder, which is easy to store and handle.
Melting point is one of the key physical properties of the substance, but the specific melting point of the substance has not been widely disclosed. It is speculated that it is in a specific temperature range. Due to the existence of iodine atoms and ester groups in the molecular structure, it has an impact on the intermolecular force, and the melting point is affected by specific factors.
In terms of solubility, the compound exhibits specific solubility properties in organic solvents. Like common organic solvents such as ethanol, dichloromethane, and acetone, they may be well soluble by virtue of the principle of similar miscibility. Because their molecular structure contains lipophilic parts, they can interact with organic solvents. However, the solubility in water may be poor. Due to the strong overall hydrophobic characteristics of its molecules, the force between water molecules and compound molecules is weak, and it is difficult to overcome the interaction between compound molecules to dissolve them.
Density is also an important physical property. Although the exact density data is not available, it is inferred from its molecular composition and the characteristics of compounds with similar structures that the density may be within a certain range. The relative atomic weight of iodine atoms in the molecule is large, which will make the density of the compound higher than that of general organic compounds containing carbon, hydrogen, and oxygen.
In addition, the compound has a certain stability, but the iodine atom in the molecule is highly active. Under certain conditions, such as encountering nucleophiles, high temperatures or light, or initiating chemical reactions, its stability is affected. In the field of organic synthesis, this property may be exploited to achieve specific transformations.
What are the chemical properties of Ethyl 4-iodopyrazole-5-carboxylate?
Ethyl 4 - iodopyrazole - 5 - carboxylate is an organic compound with unique chemical properties, which are described as follows:
First, it has the characteristics of halogenated hydrocarbons. The molecule contains iodine atoms, and this halogen atom is highly active. When encountering nucleophiles, iodine atoms are easily replaced. Take sodium alcohol as an example, the anion of alcohol oxide acts as a nucleophile, which can attack the carbon atoms connected to iodine, and the iodine ions leave to form corresponding ether derivatives. This substitution reaction is often used in organic synthesis to form carbon-heteroatomic bonds, providing a way to introduce new functional groups.
Second, it contains ester functional groups. The ester group is active and can undergo hydrolysis reactions. Under acidic conditions, hydrolysis generates 4-iodopyrazole-5-carboxylic acid and ethanol. This reaction goes through the steps of protonation, hydrophilic nucleophilic attack, and elimination of ethanol. If in basic conditions, hydrolysis is more rapid, carboxylic salts and ethanol are formed, and the reaction is irreversible. This hydrolysis property can be used in organic synthesis to prepare carboxylic acids.
Third, the pyrazole ring gives it special reactivity. The nitrogen atom on the pyrazole ring has a lone pair of electrons, making it alkaline and can react with acids to form salts. At the same time, the electron cloud of the pyrazole ring has a special distribution and can participate in various electrophilic and nucleophilic substitution reactions. For example, under suitable conditions, halogenation, alkylation and other electrophilic substitution reactions can occur on the pyrazole ring, providing the possibility for molecular modification.
Fourth, the compound can participate in multi-step tandem reactions because it contains multiple functional groups. By rationally designing reaction conditions and reagents, complex organic molecular structures can be constructed from simple starting materials, which has broad application prospects in drug synthesis, material chemistry and other fields.
What is the synthesis method of Ethyl 4-iodopyrazole-5-carboxylate?
Ethyl 4 - iodopyrazole - 5 - carboxylate (4 - iodopyrazole - 5 - carboxylate ethyl ester) synthesis method, ancient recipe, follow the number of ways to seek.
First, start with pyrazole. First, under suitable conditions, pyrazole is esterified by carboxylic acid, so that it reacts with ethanol and suitable catalysts to obtain pyrazole - 5 - carboxylate ethyl ester. Then, by the method of halogenation, a suitable halogenating agent, such as the halogenating agent of iodine, is selected to interact with pyrazole-5-carboxylate. After fine regulation of the reaction temperature, time and the ratio of the reactants, Ethyl 4-iodopyrazole-5-carboxylate is obtained.
Second, start from the starting material containing iodine. Find a suitable iodine-containing organic compound, and a substance with a similar structure to pyrazole-5-carboxylate, through the method of coupling reaction. In the reaction, it is necessary to make good use of catalysts, such as palladium and other metal catalysts, with suitable ligands to create a suitable reaction environment, such as inert gas atmosphere, to control the pH of the reaction. After this reaction, the iodine-containing part is combined with the structure of pyrazole-5-carboxylate, and Ethyl 4-iodopyrazole-5-carboxylate can also be prepared.
Third, other heterocyclic compounds are used as the base. If there is a related heterocyclic structure, a series of reactions such as ring opening, ring closing and halogenation can be used to gradually construct pyrazole rings and introduce iodine atoms and ethyl ester groups. This approach requires meticulous planning of reaction steps and proper control of the process of each step to prevent side reactions from occurring, thereby obtaining pure Ethyl 4-iodopyrazole-5-carboxylate. In short, the synthesis method requires detailed investigation of the reaction mechanism and precise control of the reaction conditions before it can be achieved.
What are the main uses of Ethyl 4-iodopyrazole-5-carboxylate?
Ethyl-4-iodopyrazole-5-carboxylic acid esters have a wide range of uses. In the field of medicinal chemistry, this compound is often a key intermediate for the creation of new drugs. Due to its unique structure, the pyrazole ring has specific biological activities, and the iodine atom and ethyl ester group can participate in a variety of chemical reactions. After chemical modification, it may generate substances with unique pharmacological activities to deal with various diseases, such as inflammation and tumors.
In the field of materials science, it can also be seen. Because of its structure, it can impart specific properties to materials. For example, in organic optoelectronic materials, by introducing them into the molecular structure, the electronic transport properties and optical properties of the material can be adjusted, and then applied to the research and development of organic Light Emitting Diodes, solar cells and other devices.
Furthermore, in the field of organic synthetic chemistry, ethyl-4-iodopyrazole-5-carboxylic acid esters are often used as starting materials and participate in the construction of various complex organic molecules. Iodine atoms are highly active and can undergo coupling reactions such as coupling reactions. By combining with other organic fragments, they can build a diverse molecular skeleton, providing organic synthetic chemists with a rich strategy for synthesizing organic compounds with novel structures and unique functions. In conclusion, ethyl-4-iodopyrazole-5-carboxylic acid ester has important application value in many fields such as medicine, materials and organic synthesis due to its unique structure.
Ethyl 4-iodopyrazole-5-carboxylate What are the precautions in storage and transportation?
Ethyl-4-iodopyrazole-5-carboxylic acid esters are organic compounds. When storing and transporting, many key matters should be paid attention to to to avoid changes in their properties or potential safety hazards.
First storage environment. It should be placed in a cool, dry and well-ventilated place. This compound may be sensitive to heat and humidity, and high temperature and humidity can easily cause it to decompose or deteriorate. If stored in a humid warehouse, water vapor may interact with the compound, affecting the quality. And the warehouse temperature should be maintained stable to avoid large fluctuations.
Second, ensure that the container is sealed when storing. Ethyl-4-iodopyrazole-5-carboxylic acid ester is exposed to air or reacts with gases such as oxygen and carbon dioxide. The sealed container can prevent it from contacting with the outside gas and ensure its chemical stability. After taking it, be sure to seal the container in time.
Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc. Because of its specific chemical properties, it can mix with these substances, or cause severe chemical reactions, causing serious accidents such as fire and explosion.
In terms of transportation, relevant regulations and standards must be followed. Ensure that the packaging is firm to prevent the container from being damaged due to collision and vibration during transportation, and the compound leaks. The means of transportation should also be clean and dry, and there should be no residues that may react with the compound.
Transportation personnel should be professionally trained and familiar with the characteristics of ethyl-4-iodopyrazole-5-carboxylate and emergency treatment methods. In the event of an accident such as a leak, they can respond quickly and correctly to minimize harm.