What is the chemical structure of M-iodo-benzamid?

"M-iodo-benzamid", according to the chemical nomenclature, "M" often refers to the interdigit (meta -), "iodo" means iodine, and "benzamid" means benzamide. Therefore, its chemical structure is the introduction of iodine atoms at the interposition of benzamide.

Looking at the structure of benzamide, the benzamide ring is a six-membered carbon ring with a conjugated π bond, and its properties are stable. The hydrogen atom on the benzene ring can be replaced, and the iodine atom occupies the interposition. In the benzamide group, the carbonyl group (C = O) is connected to the benzene ring with an amino group (-NH2O). The carbonyl group is polar, and the amino group can participate in the formation of hydrogen bonds, which affects the physical and chemical properties of the compound. The introduction of the

meta-iodine atom can absorb electrons due to the large electronegativity of the iodine atom, resulting in the change of the electron cloud density of the benzene ring, which affects the activity of the electrophilic substitution reaction of the benzene ring. Moreover, the iodine atom is large in size, and its steric resistance also plays a role in the intermolecular interaction and reaction selectivity. In this case, the chemical structure of "M-iodo-benzamid" is the benzamide replaced by meta-iodine, and its structural characteristics play a key role in its chemical behavior and properties.

What are the main uses of M-iodo-benzamid?

M-iodobenzamide has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate that helps pharmaceutical developers create new drugs. Due to the affinity of benzamide structure with a variety of biological targets, iodine atoms can optimize the physical and chemical properties and biological activities of compounds. For example, in the synthesis of some anti-cancer drugs, M-iodobenzamide plays an important role. By participating in the reaction, it can construct molecular structures with precise anti-cancer activity.

In the field of materials science, it also has extraordinary performance. Due to the characteristics of iodine atoms, materials containing M-iodobenzamide may have unique photoelectric properties. Scientists can use this to develop new organic optoelectronic materials for organic Light Emitting Diodes (OLEDs), solar cells and other devices. In OLEDs, the material can be rationally designed and modified to optimize the luminous efficiency and stability and improve the display effect.

Furthermore, in the field of organic synthetic chemistry, M-iodobenzamide is an important synthetic block. Chemists take advantage of the activity of iodine atoms to construct complex organic molecular structures through various organic reactions such as halogenation reactions and coupling reactions, expanding the types and functions of organic compounds, and contributing to the development of organic synthetic chemistry.

What are the physical properties of M-iodo-benzamid?

M-Iodobenzamide is also an organic compound. Its physical properties are quite wonderful, let me come one by one.

Looking at its shape, at room temperature, it is mostly white to light yellow crystalline powder. This shape is also like the initial condensation of fine snow, pure and moist in color, showing a sense of cleanliness. Its powder is delicate and smooth on the tentacles, just like jade powder, but it is chemically active and cannot be touched lightly.

In terms of its melting point, it is about 140-144 ° C. When the temperature gradually rises, the originally stable crystal structure gradually disintegrates, gradually changing from solid to liquid, just like ice and snow melting when warm. The characteristics of this melting point are very useful in the separation and purification process of organic synthesis. Chemists can precisely control the temperature according to this temperature to change the state of the substance for the purpose of separation or purification.

As for solubility, M-iodobenzamide has a certain solubility in organic solvents, such as dichloromethane, chloroform, N, N-dimethyl formamide (DMF), etc. In dichloromethane, like a fish in water, the intermolecular interaction is harmonious and can be evenly dispersed to form a clear solution. In water, its solubility is very small, just like oil floating in water, the two are difficult to blend. The difference in solubility is due to the fact that there are both organic phase groups and hydrophobic parts in the molecular structure, so it exhibits such characteristics.

Its density is also an important physical property. Although there is no exact detailed value in the literature, according to similar compounds, its density should be higher than that of water. If it is put into water, it will sink to the bottom of the water, such as a stone abyss, which is also closely related to its molecular composition and atomic arrangement.

The physical properties, morphology, melting point, solubility, and density of M-iodobenzamide are the cornerstones of organic chemistry research and industrial applications. Chemists use these characteristics to control it to participate in various chemical reactions and create new substances for the benefit of the world.

What are the synthesis methods of M-iodo-benzamid?

The method of making M-iodine-benzamide has been studied by chemists throughout the ages, and there are several common ones.

One is to start with benzoic acid. First, benzoic acid is co-heated with dichlorosulfoxide to obtain benzoyl chloride. This step requires temperature control to prevent side reactions. The chemical reaction formula is: $C_ {6} H_ {5} COOH + SOCl_ {2}\ stackrel {\ Delta} {\ longrightarrow} C_ {6} H_ {5} COCl + SO_ {2}\ uparrow + HCl\ uparrow $.

Then, M-iodine-benzoyl chloride can be obtained by reacting with an iodine-substituted reagent such as N-iodosuccinimide (NIS) with benzoyl chloride in an appropriate solvent such as dichloromethane, and adding a catalyst such as iron powder at room temperature. The reaction principle is electrophilic substitution, and iodine atoms are substituted in the interposition. Reaction formula: $C_ {6} H_ {5} COCl + NIS\ stackrel {Fe, CH_ {2} Cl_ {2}}} {\ longrightarrow} m - IC_ {6} H_ {4} COCl + NHS $.

Finally, M-iodine-benzoyl chloride is reacted with ammonia or amines to obtain M-iodine-benzamide. If reacted with ammonia: $m - IC_ {6} H_ {4} COCl + 2NH_ {3}\ longrightarrow m - IC_ {6} H_ {4} CONH_ {2} + NH_ {4} Cl $.

Second, aniline is used as the source. First, aniline is acetylated, and acetic anhydride is reacted with aniline to obtain acetaniline. This reaction protects the amino group from being overactivated in subsequent reactions. $C_ {6} H_ {5} NH_ {2} + (CH_ {3} CO) _ {2} O\ longrightarrow C_ {6} H_ {5} NHCOCH_ {3} + CH_ {3} COOH $.

Then, with iodine substitution reagent iodine and potassium iodide and an appropriate amount of acid, such as hydrochloric acid, p-acetylaniline is interiodinated to generate M-iodine-acetylaniline. $C_ {6} H_ {5} NHCOCH_ {3} + I_ {2} + KI + HCl\ longrightarrow m - IC_ {6} H_ {4} NHCOCH_ {3} + KCl + HI $.

Finally, M-iodine-acetaniline can be obtained by hydrolyzing M-iodine-acetaniline with acid or alkali. If hydrolyzed with acid, $m - IC_ {6} H_ {4} NHCOCH_ {3} + H_ {2} O + HCl\ stackrel {\ Delta} {\ longrightarrow} m - IC_ {6} H_ {4} CONH_ {2} + CH_ {3} COOH + HCl $.

All kinds of production methods have their own advantages and disadvantages, and they need to be selected according to the factors such as the availability of raw materials, the cost, and the yield.

What is the market outlook for M-iodo-benzamid?

M-iodo-benzamid is one of the organic compounds. Its market prospect is related to various factors.

View its use, this compound is often used as a synthetic intermediate in the field of medicinal chemistry. The way of medicine is related to people's livelihood and has constant demand. In today's world, there are various diseases, and pharmaceutical research and development has not stopped for a while. If M-iodo-benzamid helps in the creation of new drugs, its demand will grow with the rise of pharmaceutical research and development. In the research of anti-cancer drugs, many new compounds are the key. If M-iodo-benzamid is involved, its market can be expanded.

The chemical industry is also its place of use. Chemists have a wide range of categories and products. If M-iodo-benzamid has its own capabilities in the synthesis of special materials and the preparation of fine chemical products, the vigorous chemical industry can lead to an increase in demand.

However, its market also has challenges. If the synthesis method is complicated and expensive, and the cost is high, it will hinder marketing activities. And similar substitutes, if they are convenient and cheap, can also share the market.

Furthermore, regulations and supervision are also an important reason. Pharmaceuticals and chemicals all focus on safety and environmental protection. If the production and use of M-iodo-benzamid do not conform to regulations, they will be constrained.

In summary, M-iodo-benzamid market prospects, opportunities and challenges coexist. If we can seek innovation in synthesis technology, reduce its cost, and expand the application field in response to the requirements of regulations, it is expected to emerge in the market and achieve considerable development.