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What are the main uses of Methyl 3-hydroxy-4-iodobenzoate?
Methyl 3-hydroxy-4-iodobenzoate has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of drugs. Due to its special structure and specific chemical activity, it can be linked to other compounds through a series of chemical reactions to construct complex molecular structures with specific pharmacological activities, helping to develop new drugs and treat various diseases.
In the field of materials science, it can participate in the preparation of functional materials. With its unique chemical structure, it endows materials with special properties, such as improving the optical, electrical or thermal properties of materials, to meet the special needs of different fields for material properties.
In the field of organic synthetic chemistry, it is an extremely important starting material or intermediate. Chemists can synthesize organic compounds with diverse structures and functions by performing various functional group conversion reactions, such as esterification, halogenation, and redox, which greatly expands the variety and application range of organic compounds and promotes the continuous development of organic synthesis chemistry.
What are the synthetic methods of Methyl 3-hydroxy-4-iodobenzoate?
The method of preparing methyl 3-hydroxy-4-iodobenzoate has been explored by many scholars in the past, but it is common today.
First, 3-hydroxy benzoic acid is used as the starting material. First, 3-hydroxy benzoic acid and methanol are esterified under acid catalysis. Commonly used acids such as concentrated sulfuric acid or p-toluenesulfonic acid are used. This reaction requires heating and refluxing to make the two fully react to generate 3-hydroxy benzoate methyl ester. Then, in a suitable solvent, such as dichloromethane, an iodine source and a suitable oxidant are added. The common iodine source is iodine elemental substance, and the oxidant is hydrogen peroxide or N-iodosuccinimide (NIS). Controlling the reaction temperature and time, iodine atoms will selectively replace hydrogen atoms at specific positions on the benzene ring to obtain methyl 3-hydroxy-4-iodobenzoate.
Second, starting from 4-iodine-3-methoxybenzoic acid. First, 4-iodine-3-methoxybenzoic acid is demethylated. Generally, boron tribromide and other reagents can be used. Under low temperature conditions, such as -78 ° C to room temperature, boron tribromide reacts with methoxy to remove methyl groups and generate 3-hydroxy-4-iodobenzoic acid. Then the esterification method similar to the above is used to react with methanol under acid catalysis to finally obtain methyl 3-hydroxy-4-iodobenzoate.
Third, 3-hydroxy-4-nitrobenzoic acid is used as the starting material. First, it is esterified with methanol to obtain methyl 3-hydroxy-4-nitrobenzoate, and then through reduction reaction, the nitro group is reduced to amino group by iron powder, hydrochloric acid or palladium carbon hydrogenation, etc., to obtain methyl 3-hydroxy-4-aminobenzoate. Then, diazotization was used to react with sodium nitrite under acidic conditions to form diazonium salt, and then reacted with potassium iodide, the diazonium group was replaced by iodine atom, and the final product was methyl 3-hydroxy-4-iodobenzoate.
What are the physical properties of Methyl 3-hydroxy-4-iodobenzoate?
Methyl-3-hydroxy-4-iodobenzoate is an organic compound. Its physical properties are as follows:
Under normal temperature and pressure, it is mostly white to light yellow crystalline powder. This is due to the intermolecular forces and arrangements. The state of the powder is easy to store and use, and in many chemical reactions, a large specific surface area is conducive to improving the reaction rate.
When it comes to the melting point, it is about a specific temperature range, and this temperature characteristic is closely related to its molecular structure. Chemical bonds and functional group interactions within the molecule determine the lattice energy, so that the lattice structure of the substance disintegrates at a specific temperature and changes from a solid state to a liquid state.
In terms of solubility, the substance is slightly soluble in water. Although there are hydroxyl groups in the molecule of this compound that can form hydrogen bonds with water, there are also hydrophobic benzene rings and ester groups. The combined effect of the two makes its solubility in water limited. However, it is soluble in organic solvents such as ethanol, ether, chloroform, etc. Because the molecular structure of these organic solvents and methyl-3-hydroxy-4-iodobenzoate have similar polarities or can form specific intermolecular forces with them, such as van der Waals forces, they can be miscible with each other.
In addition, the density is heavier than that of water. Due to the large relative atomic weight of iodine atoms in the molecule, the overall molecular weight increases, and then the mass is larger at the same volume, showing the characteristics of density greater than that of water.
In addition, this compound has certain stability, and it is not easy to decompose or other chemical reactions in a short time under conventional environmental conditions. However, under specific conditions, such as high temperature, strong acid and alkali or the existence of specific catalysts, its ester groups, hydroxyl groups and iodine atoms can participate in various reactions, showing the active side of chemical properties, which also reflects the physical properties of its physical properties to support chemical stability to a certain extent.
What are the chemical properties of Methyl 3-hydroxy-4-iodobenzoate?
Methyl 3-hydroxy-4-iodobenzoate is an organic compound with unique chemical properties. In its structure, benzoate ester groups endow certain stability and reactivity.
Let's talk about the hydroxyl group first. Due to the strong electronegativity of oxygen atoms and the acidic nature of hydroxyl hydrogen, it can participate in acid-base reactions and neutralize with bases to form corresponding salts. And the hydroxyl group can participate in the esterification reaction and form new ester compounds with acids under the action of catalysts. This reaction is often a key step in the construction of complex molecular structures in organic synthesis.
Iodine atoms also play an important role in this compound. The large atomic radius and high polarizability of iodine atoms make the C-I bond more active. It is prone to nucleophilic substitution reactions. The nucleophilic tester can attack the carbon atoms connected to iodine, replace the iodine atoms, and then introduce new functional groups to create conditions for the synthesis of more diverse compounds. In addition, iodine-containing compounds can be used as catalysts or reaction intermediates in some reactions, showing unique reactivity.
The benzoate part not only provides molecular skeleton stability, but also its benzene ring is aromatic and can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Under appropriate conditions, the electrophilic reagent attacks the benzene ring and generates different substitution products, which greatly enriches the chemical transformation possibility of the compound.
These chemical properties of this compound are of great significance in the fields of organic synthesis, medicinal chemistry, etc., providing a variety of reaction paths and bases for the creation of new compounds and the development of drugs.
What is the price range of Methyl 3-hydroxy-4-iodobenzoate in the market?
I have not heard the price of methyl 3-hydroxy-4-iodobenzoate in the market. The price of this compound often varies due to many factors. One is purity, and the price of high purity must be higher than that of low purity. If it is used in precision chemical experiments or pharmaceutical research and development, the purity required is extremely high, and its price is also high; if it is only for general industrial use, the purity requirement is slightly lower, and the price may be slightly reduced.
The second is supply and demand. If the market demand for this substance is strong and the supply is limited, the price will rise; if the supply exceeds the demand, the price may drop. Furthermore, the difficulty of production also affects its price. If the synthesis of this compound requires complicated steps, special raw materials or harsh reaction conditions, the cost will be high, and the price will also be high.
In addition, the seller and the purchase volume are all related to the price. Large suppliers may offer better prices due to economies of scale, and large purchases are often discounted. Therefore, for the exact price range, consult chemical reagent suppliers, chemical product trading platforms, or communicate with industry insiders to obtain its approximate price.