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What are the main uses of Methyl 4-iodopyridine-2-carboxylate?
Methyl 4-iodopyridine-2-carboxylate is an important compound in organic chemistry. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its unique structure, it can be used to construct complex molecular structures with specific biological activities through various chemical reactions for the development of new drugs.
In the field of materials science, it also has its uses. Or it can participate in polymerization reactions to prepare polymer materials with special properties, such as those with specific electrical and optical properties, to meet the needs of different material application scenarios.
In organic synthetic chemistry, it is an important starting material for the synthesis of many compounds containing pyridine structures. Chemists can achieve precise regulation of the structure and properties of the target product by chemical modification of its iodine atom and carboxyl ester group, and achieve efficient synthesis of complex organic molecules.
In summary, methyl 4-iodopyridine-2-carboxylic acid esters play a key role in many scientific fields and contribute greatly to the research and development of related fields.
What are the synthetic methods of Methyl 4-iodopyridine-2-carboxylate?
Methyl pyridine-2-carboxylic acid esters are synthesized using pyridine-2-carboxylic acid as the starting material. Methyl pyridine-2-carboxylic acid esters can be obtained by esterification reaction between pyridine-2-carboxylic acid and methanol catalyzed by acid. This step requires selecting a suitable acid catalyst, such as sulfuric acid or p-toluenesulfonic acid, and controlling the reaction temperature and time to fully promote the esterification reaction.
Thereafter, the obtained methyl pyridine-2-carboxylic acid esters are introduced into iodine atoms. Iodization reagents can be used, such as N-iodosuccinimide (NIS) or iodine elemental substance. In appropriate solvents, such as dichloromethane, chloroform, etc., with initiators or under lighting conditions, iodine atoms are selectively substituted for hydrogen atoms at the 4-position of the pyridine ring to obtain methyl 4-iodopyridine-2-carboxylic acid esters.
There are also those who use 4-halogenated pyridine-2-carboxylic acid as raw material. If it is 4-bromopyridine-2-carboxylic acid, the corresponding ester can be esterified first, and then the halogen atom exchange reaction can be used. Using potassium iodide and other iodine sources, in the presence of suitable solvents and catalysts, such as potassium carbonate as a base, in DMF solvent, heating the reaction, so that the bromine atom is replaced by the iodine atom, and the target product can also be obtained.
In addition, there are also pyridine derivatives as starters, through multi-step reactions to construct a pyridine ring and introduce iodine atoms and ester groups. However, such methods may be more complicated and require fine reaction planning and condition control to achieve the purpose of synthesis. To be sure, all synthesis methods have their own advantages and disadvantages. In practical application, the choice should be weighed according to factors such as the availability of raw materials, the difficulty of reaction, yield and purity requirements.
What are the physical properties of Methyl 4-iodopyridine-2-carboxylate?
Methyl-4-iodopyridine-2-carboxylic acid ester, this is an organic compound. Its physical properties are unique, related to material characteristics and uses, and it is the key to chemical research.
When it comes to appearance, under room temperature and pressure, it often takes the state of white to light yellow crystalline powder. This color and shape may vary depending on the molecular structure and crystal arrangement. Its color is light, or it is determined by the characteristics of light absorption and reflection of molecules; crystalline powder morphology reflects the intermolecular forces and arrangement laws.
Melting point is also an important physical property. At about [X] ° C, this compound changes from a solid state to a liquid state. The melting point is determined by intermolecular forces, such as van der Waals forces, hydrogen bonds, etc. Methyl and iodine atoms interact with pyridine rings and carboxylic acid ester groups to build a specific lattice structure, which requires specific energy to overcome the force to cause melting.
In terms of boiling point, under a specific pressure, it boils at about [X] ° C. The boiling point is related to the intermolecular force and the relative molecular weight. The molecule of the compound has a certain polarity, and the intermolecular force causes it to vaporize at a specific temperature.
The solubility cannot be ignored. In organic solvents such as dichloromethane and chloroform, it exhibits good solubility, but its solubility in water is limited. This is due to the matching of the polarity of the compound and the polarity of the solvent. The polarity of the organic solvent is similar to that of the compound, and it is easily miscible according to the principle of "similarity and miscibility"; the polarity of water is large,
In terms of density, under certain conditions, the density is about [X] g/cm ³. The density is related to the molecular mass and the degree of close arrangement of molecules. The molecular structure and composition of the compound determine its specific density value.
In addition, the compound may have a certain odor, but the odor description may vary depending on individual sensory differences.
All kinds of physical properties lay the foundation for its application in organic synthesis, medicinal chemistry and other fields. Knowing these properties will help chemists to control the reaction conditions and achieve efficient synthesis and application.
What are the chemical properties of Methyl 4-iodopyridine-2-carboxylate?
Methyl 4-iodopyridine-2-carboxylic acid ester is a crucial compound in the field of organic synthesis. Its chemical properties are unique and play a key role in many reactions.
From the structural point of view, the pyridine ring endows this compound with certain aromatic and basic properties. The nitrogen atom of the pyridine ring is rich in lone pair electrons, which can react with protons or other electrophilic reagents to exhibit alkaline properties. This alkalinity allows the compound to form salts with acids and participate in reactions such as acid-base neutralization under specific conditions.
The iodine atom, as a halogen atom, has strong electronegativity. Because of its separability, it is active in nucleophilic substitution reactions. For example, when a suitable nucleophilic reagent is present, the iodine atom is easily replaced by the nucleophilic reagent, thereby forming a new carbon-heteroatomic bond or carbon-carbon bond, which is of great significance in the construction of complex organic molecular structures.
In addition, the carboxylic acid ester group has both the properties of a carbonyl group and its own characteristics because it is connected to an alkoxy group. Carbonyl carbons are positively charged and vulnerable to attack by nucleophilic reagents and undergo nucleophilic addition reactions. For example, in hydrolysis reactions, under acidic or basic conditions, ester groups will gradually hydrolyze to form corresponding carboxylic acids and alcohols. Hydrolysis is relatively complete under basic conditions, and this property can be used for the conversion of functional groups in organic synthesis.
In addition, different functional groups in the compound interact with each other. The electron cloud distribution of the pyridine ring affects the reactivity of the iodine atom with the carboxylic acid ester group, and vice versa. This interaction makes it necessary to carefully consider the reaction conditions and the reaction selectivity of each functional group when participating in the reaction of the compound in order to achieve the desired synthesis goal. In short, methyl 4-iodopyridine-2-carboxylic acid esters have broad application prospects in the field of organic synthetic chemistry due to their special structure and diverse chemical properties.
What is the price of Methyl 4-iodopyridine-2-carboxylate in the market?
What is the price of methyl-4-iodopyridine-2-carboxylic acid ester in the market? This is a fine chemical, related to organic synthesis, pharmaceutical research and development and other fields. However, it is not easy to know its exact price. The price is determined by many factors, such as quality specifications, market supply and demand, origin, and purchase quantity.
If the quality is high and the purity is quite high, it is suitable for high-end pharmaceutical synthesis, and the price must be high; on the contrary, if the quality is slightly inferior, the price may be slightly lower. Market supply and demand are also key. Demand is strong, supply is scarce, and the price will rise; supply and demand are balanced, and the price may be stable. Different origins have different costs and different prices. The price of the importer may be higher than that of the domestic product due to tariffs, transportation costs, etc.
The purchase volume also affects the price. For bulk purchases, merchants may give discounts, and the unit price will be reduced; for small purchases, the unit price may be higher. For accurate prices, you need to consult chemical raw material suppliers and reagent sellers in detail. Or you can search on the chemical product trading platform and refer to the recent transaction price. However, the price fluctuates frequently, and it is advisable to pay attention to market dynamics in real time to know its current price.