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What is the main use of Methyl N- (tert-butoxycarbonyl) -3-iodo-l-alaninate?
Methyl N- (tert-butoxycarbonyl) -3-iodo-L-alaninate, that is, methyl N- (tert-butoxycarbonyl) -3 -iodine-L-alanine ester, is widely used. In the field of organic synthesis, it is often used as a key intermediate. Due to its structure, tert-butoxycarbonyl can effectively protect the amino group and prevent the amino group from participating in unnecessary reactions during the reaction process, so as to ensure that the reaction can proceed smoothly in the expected direction. The iodine atom is highly active, and various functional groups can be introduced through many chemical reactions, such as nucleophilic substitution reactions, or complex carbon-carbon bonds can be constructed to synthesize organic compounds with diverse structures.
In the field of peptide synthesis, this compound is also of great value. Because peptide synthesis often requires selective protection and deprotection of amino acid functional groups, methyl N- (tert-butoxycarbonyl) -3 -iodine-L -alanine ester can not only protect the amino group, but also introduce other amino acid fragments by iodine atoms to help build longer polypeptide chains without affecting the correct sequence and structure of the polypeptide chain.
In addition, in drug development, because it can be used as a basic module for building the molecular structure of drugs, it is expected to create new drugs with specific pharmacological activities by means of chemical modification and modification. For example, by changing the group attached to the iodine atom or adjusting the tert-butoxycarbonyl group, the pharmacokinetic properties of the drug can be optimized, the affinity between the drug and the target can be enhanced, thereby improving the efficacy of the drug and reducing adverse reactions.
What are the synthesis methods of Methyl N- (tert-butoxycarbonyl) -3-iodo-l-alaninate?
The method of synthesizing Methyl + N-% 28tert - butoxycarbonyl% 29 - 3 - iodo - l - alaninate, the ancients may follow various paths. First, you can take L - alanine and treat it with tert-butoxycarbonyl (Boc) reagent. In this case, dissolve L - alanine in a suitable solvent, such as dichloromethane or tetrahydrofuran, and slowly add a reagent containing Boc protecting group, such as di-tert-butyl dicarbonate (Boc -2 O), and add an appropriate amount of organic base, such as triethylamine or N, N - diisopropyl ethylamine, to catalyze the reaction. The purpose of this step is to make the amino group of L-alanine protected by the Boc group to generate N- (tert-butoxycarbonyl) -L-alanine.
Then, the resulting product is iodized. In this case, N - (tert-butoxycarbonyl) -L - alanine can be dissolved in a specific solvent, such as dichloromethane, and an iodizing agent, such as N-iodosuccinimide (NIS), is added, and an initiator, such as azobisisobutyronitrile (AIBN), is added to react at a suitable temperature. In this process, NIS provides the iodine source, and the initiator prompts the reaction to start, so that the iodine atom is introduced into the alpha-carbon of alanine to obtain N- (tert-butoxycarbonyl) -3-iodine-L-alanine.
Finally, the product is reacted with methanol under acid catalysis to achieve esterification. For example, concentrated sulfuric acid or p-toluenesulfonic acid is used as a catalyst, and heated to reflux, so that the carboxyl group is esterified with methanol to form Methyl + N-% 28tert - butoxycarbonyl% 29 - 3 - iodo - l - alaninate.
There are other methods, or the L-alanine methyl ester is used as the starting material, and the amino group is also protected by Boc 2O O, and then the iodization reaction is carried out. Although the steps are different, the synthesis of the target product can be achieved. All synthesis methods need to be weighed against many factors such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield.
What are the physical and chemical properties of Methyl N- (tert-butoxycarbonyl) -3-iodo-l-alaninate?
Methyl N- (tert-butoxycarbonyl) -3-iodine-L-alanine ester, this is an organic compound. Its physical and chemical properties are unique and closely related to many chemical reactions and applications.
Looking at its physical properties, at room temperature and pressure, this substance is usually a solid, or due to strong intermolecular forces, it has a certain melting point and boiling point. Specifically, the melting point is about a certain range, and the boiling point also corresponds to a specific value, which is rarely known to me. Its appearance may be white to off-white crystalline powder, which is caused by the orderly arrangement of molecular structures and light reflection.
As for chemical properties, in this compound, the tert-butoxycarbonyl is relatively stable, but under specific conditions, such as strong acidic environment or the presence of a specific catalyst, a deprotection reaction can occur, and the tert-butoxycarbonyl leaves, exposing the amino group. The 3-iodine group has high reactivity and can participate in nucleophilic substitution reactions. The iodine atom is easily replaced by other nucleophilic reagents to form new compounds. The L-alanine ester part, because of its chiral center, gives the compound optical activity, which is of great significance in asymmetric synthesis and other fields. At the same time, the ester group can undergo hydrolysis reaction under acid-base conditions, hydrolysis under acidic conditions to form corresponding acids and alcohols, and carboxylate and alcohol under basic conditions.
In addition, its solubility is also an important property. In organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., it may have good solubility due to the similar principle of dissolution between the molecular structure and the organic solvent; while in water, the solubility may be poor due to the large proportion of molecular hydrophobicity.
The above physical and chemical properties are crucial for their application in organic synthesis, pharmaceutical chemistry and other fields. During the synthesis process, suitable reaction conditions and solvents can be selected according to their properties to achieve the expected reaction effect.
Methyl N- (tert-butoxycarbonyl) -3-iodo-l-alaninate What to pay attention to during storage and transportation
Methyl-N- (tert-butoxycarbonyl) -3-iodine-L-alanine ester is an important compound in organic chemistry. When storing and transporting, many matters must not be ignored.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Its properties may be affected by changes in temperature and humidity. High temperature or cause it to decompose, and humidity can cause it to absorb moisture and deteriorate. Therefore, the temperature and humidity of the warehouse must be properly regulated. Generally, the temperature should be controlled between 5 and 25 degrees Celsius, and the relative humidity should be between 40% and 60%.
Furthermore, this compound may be sensitive to light. Under light, or lead to luminescent chemical reactions, causing its structure to change and activity to decrease. Therefore, when storing, it should be stored in a brown bottle or an opaque container, away from the dark.
As for transportation, also pay attention to. Because it may be dangerous, it must be properly packaged in accordance with relevant regulations. Packaging materials must be leak-proof and shockproof to ensure that there is no risk of leakage during transportation. And transportation tools should also be clean, dry, and away from fire and heat sources.
In addition, when handling, operators should be careful and wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact with this object and cause injury. In short, when storing and transporting methyl-N- (tert-butoxycarbonyl) -3-iodine-L-alanine ester, it is necessary to consider its physical and chemical properties carefully to ensure its quality and safety.
What is the market price of Methyl N- (tert-butoxycarbonyl) -3-iodo-l-alaninate?
Guanfu "Methyl + N- (tert - butoxycarbonyl) -3 - iodo - l - alaninate" is a fine compound of organic chemistry. However, its market price cannot be hidden. Due to the influence of many factors, the price fluctuates indeterminately.
The first to bear the brunt is the price of raw materials. The wide and narrow sources of raw materials required to prepare this product, the amount of production, and the difficulty of obtaining them all affect its cost. If the raw materials are scarce, or the collection and refining are difficult, the price will be high. For example, the specific ingredients need to be extracted from rare resources, or the preparation process is complicated, which will lead to the cost of raw materials rising, and then push up the price of the compound.
The second is the simplicity of the preparation process. The synthesis of this compound may require delicate reaction steps, severe reaction conditions, such as precise temperature and pressure control, and specific catalysts. If the process is complex, high-end equipment and professional technicians are required, and the reaction yield is not high, the loss is large, the cost will increase, and the market price will also rise.
Furthermore, the state of market supply and demand is the key. If the compound is in strong demand in fields such as pharmaceutical research and development, materials science, etc., and the supply is limited, the demand will exceed the supply, and the price will rise. On the contrary, if the market demand is low, and there are many manufacturers and excess supply, the price will inevitably fall.
In addition, regional differences, market competition, policies and regulations, etc., also play a role in prices. Different regions may have different prices due to differences in economic levels, tax policies, and logistics costs. Where market competition is intense, manufacturers may reduce prices to compete for share; changes in policies and regulations, such as increased production costs due to increased environmental protection requirements, will also be reflected in the price.
In summary, in order to determine the market price of "Methyl + N- (tert - butoxycarbonyl) -3 - iodo - l - alaninate", it is necessary to carefully investigate various factors such as raw materials, processes, supply and demand, and pay attention to changes in market dynamics, in order to obtain a relatively accurate price.
